CN1258082C - Photodetector on micro biochemical chip - Google Patents

Photodetector on micro biochemical chip Download PDF

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Publication number
CN1258082C
CN1258082C CN 200310115909 CN200310115909A CN1258082C CN 1258082 C CN1258082 C CN 1258082C CN 200310115909 CN200310115909 CN 200310115909 CN 200310115909 A CN200310115909 A CN 200310115909A CN 1258082 C CN1258082 C CN 1258082C
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CN
China
Prior art keywords
detector
optical
optical fiber
sample tank
micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 200310115909
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Chinese (zh)
Other versions
CN1546990A (en
Inventor
吴一辉
李锋
张平
王淑荣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Changchun Institute of Optics Fine Mechanics and Physics of CAS
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Changchun Institute of Optics Fine Mechanics and Physics of CAS
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Application filed by Changchun Institute of Optics Fine Mechanics and Physics of CAS filed Critical Changchun Institute of Optics Fine Mechanics and Physics of CAS
Priority to CN 200310115909 priority Critical patent/CN1258082C/en
Publication of CN1546990A publication Critical patent/CN1546990A/en
Application granted granted Critical
Publication of CN1258082C publication Critical patent/CN1258082C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

The present invention belongs to the field of micro machinery and integrated optics, and relates to an optical detector on a micro biochemical chip. A first detector comprises an optical source 1, optical fibers 2, optical fiber cores 3, a sample tank 4 and a support frame 5. A second detector comprises an end cover 6, a support structure and low cost, a detector lens A 8, an optical source to the, a mixing ditch 10, a sample tank 1 and a lens B 12. An optical fiber elapsed-wave detector solves the problem that an optical waveguide is difficult to manufacture and couple, and has the characteristics of high detection sensitivity and low manufacture cost. In a lens type detector of the present invention, the lenses are small, and the diameter of collimated optical beams is also small so that the optical beams penetrate through the sample tank and the sample tank has small volume. The detection sensitivity can be directly changed by adjusting the optical path between the two lenses. The optical fiber elapsed-wave detector and the lens type detector of the present invention are applied to the absorption spectrum spectrophotometric analysis of the biochemical chip.

Description

Photo-detector on the micro biochemical chip
Technical field: the invention belongs to micromechanics and integrated optics field, relate to the photo-detector on the micro biochemical chip.
Background technology: it is a kind of widely used universal optical detection method that absorbance detects, and it successfully is applied in the measurement of the structure analysis of biological sample and concentration.
Miniature biochemical chip is expected a sample cell, and probe unit and other parts are integrated on the chip, to realize microminiaturization, portability, the consumption sample size traceization of system.Be used to miniature biochemical chip though absorbance detects, because micro biochemical chip detection pond is little, it is short to cause absorbing light path, and the relative sensitivity of absorption spectrum is low, and application is very restricted.Utilize optical waveguide coupled difficulty on the micro biochemical chip, cost of manufacture is higher.
Detailed content of the present invention:
Detect the problem that sample cell is little, light path is short, sensitivity is low, optical waveguide is made and coupling is difficult that exists at the absorbance on the biochemical chip, the objective of the invention is can be on micro-fluid chip integrated photometry detector, can further reduce to survey the pond volume, solution requires the little and highly sensitive contradiction of sample cell, for this reason, the present invention will provide the photo-detector on the high micro biochemical chip of microminiaturization, portability, consumption sample size traceization, detection sensitivity.
The present invention utilizes absorption spectrophotometry integrated light detector on micro-fluid chip.
First kind of detector principle surveyed for the disappearance ripple, and its structure is as implementing shown in the illustration 1,2: comprise optical fiber, fiber cores, sample cell, bracing frame, light source among the figure.Optical fiber one side connects light source, and the opposite side of optical fiber connects spectrometer or other photoelectric sensor, and optical fiber removes covering, exposes fiber cores, is equipped with fiber cores in the sample cell, and fiber cores places on the body of sample cell, or fiber cores places on the bracing frame.
Principle of work of the present invention:, make fiber cores place the sample of sample cell by peelling off one section fibre cladding of optical fiber.When the optically-coupled of light source enters the optical fiber input end, total reflection takes place in light in fiber cores, the ripple that disappears this moment enters and is detected sample, the outer evanescent field of fiber cores be detected sample and have an effect, output intensity weakens relatively, by relatively entering the light intensity that is detected before and after the sample, can determine the sample absorbance, and then the concentration of certain composition in definite sample.
Optical fiber type disappearance wave detector of the present invention has been avoided the problem that optical waveguide is made and coupling is difficult, has the detection sensitivity height, the characteristics that cost of manufacture is lower.
Solve the absorbance on the biochemical chip and detected the problems such as sample cell is little, light path is short, sensitivity is low that exist.The present invention is integrated photometry detector on micro-fluid chip, can further reduce to survey the pond volume, solution requires the little and highly sensitive contradiction of sample cell, the invention provides the photo-detector on the high micro biochemical chip of microminiaturization, portability, consumption sample size traceization, detection sensitivity.
The present invention is applied to the absorption spectrum spectrophotometric analysis on the biochemical chip.
Description of drawings
Fig. 1 is the front view that the disappearance ripple is surveyed inventive embodiments
Fig. 2 is the vertical view that the disappearance ripple is surveyed inventive embodiments
Embodiment:
First kind of detector comprises light source 1, optical fiber 2, fiber cores 3, sample cell 4, bracing frame 5.
Optical fiber 2 adopts multimode optical fiber or single-mode fiber.After optical fiber 2 removes covering, expose fiber cores 3.Sample cell 4 adopts materials such as PDMS polymkeric substance, plastics, glass.Bracing frame 5 adopts silicon, glass or plastic or other material.Fiber cores 3 directly places sample cell 4, also fiber cores 3 can be placed on the bracing frame 5.Light source 1 can adopt halogen tungsten lamp or LASER Light Source.

Claims (1)

1, the photo-detector on the micro biochemical chip, comprise: light source (1), sample cell (4), it is characterized in that also comprising: optical fiber (2), fiber cores (3), bracing frame (5), optical fiber (2) removes covering, expose fiber cores (3), be equipped with fiber cores (3) in the sample cell (4), fiber cores (3) places on the bracing frame (5).
CN 200310115909 2003-12-11 2003-12-11 Photodetector on micro biochemical chip Expired - Fee Related CN1258082C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200310115909 CN1258082C (en) 2003-12-11 2003-12-11 Photodetector on micro biochemical chip

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200310115909 CN1258082C (en) 2003-12-11 2003-12-11 Photodetector on micro biochemical chip

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN 200510125244 Division CN1782696A (en) 2003-12-11 2003-12-11 Lens type detector on micro biochemical chip

Publications (2)

Publication Number Publication Date
CN1546990A CN1546990A (en) 2004-11-17
CN1258082C true CN1258082C (en) 2006-05-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN 200310115909 Expired - Fee Related CN1258082C (en) 2003-12-11 2003-12-11 Photodetector on micro biochemical chip

Country Status (1)

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CN (1) CN1258082C (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101887008A (en) * 2010-07-19 2010-11-17 中国科学院长春光学精密机械与物理研究所 Multifunctional detection chip for optical fiber sensor, and manufacturing and packaging method for optical fiber sensor
CN104330401A (en) * 2014-10-24 2015-02-04 清华大学 Micro sensor applied to detection of nitrogen, phosphorus and potassium in soil
CN106198951B (en) * 2016-06-24 2018-12-07 中国科学院长春光学精密机械与物理研究所 A kind of bio-sensing scaling method, calibration system and disease detecting system
CN109632660A (en) * 2019-01-17 2019-04-16 京东方科技集团股份有限公司 Fluid detection panel

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