CN1973918B - Cluster stimulating micro electrode array capable of being implanted into nerve system of human body - Google Patents
Cluster stimulating micro electrode array capable of being implanted into nerve system of human body Download PDFInfo
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Abstract
The stimulating cluster micro electrode array capable of being implanted into nerve system of human body belongs to the field of medical prothesis. The present invention includes stimulating metal wire micro electrode, supporting metal wire micro electrode, stimulating metal wire micro electrode cluster, stimulating metal wire micro electrode cluster array, and micro electrode substrate. Several stimulating metal wire micro electrodes are adhered onto the outer wall of one supporting metal wire micro electrode to constitute one stimulating metal wire micro electrode cluster; several stimulating metal wire micro electrode clusters are fixed onto one micro electrode substrate to constitute one stimulating metal wire micro electrode cluster array; and lead wires are led out from the micro electrode substrate for connection with outer equipment. The electrodes are made with biocompatible metal material. The present invention is used in stimulating nerve system in limited space.
Description
Technical field
What the present invention relates to is a kind of implantable microelectrode of medical prosthese technical field, neural bunch of shape stimulating micro electrode array of particularly a kind of human implantable.
Background technology
The nerve prosthesis field comprises nervus motorius prosthese, artificial cochlea's (cochlear implantation prosthesis) and optic nerve prosthese etc.The nervus motorius prosthese is the nervous system microelectronic component by deep brain stimulation treatment dyskinesia disease such as parkinson disease (PD) exploitation.The embedded electric stimulation of deep brain stimulation art multiselect, this system generally is made up of implant electrode, connection lead to subcutaneous receptor and electrostimulator three parts.Electrode is selected certain stimulus parameter and different electrode stimulatings contact after implanting, and implants effect and writes down the parameter of different contacts simultaneously to observe, for the postoperative reference.To guarantee in the experimentation that electrode is not subjected to displacement, in order to avoid affect the treatment.Therefore electrode design is the pith of nervus motorius prosthesis system.
People's cochlear hair cell is a sensory cell of accepting sound.When cochlear hair cell injury was serious, serious deafness will appear.The artificial cochlea is made up of device two parts in external and the body, and outer body comprises mike, speech transducer, transmitting coil; Intravital part comprises receiving coil, processor, stimulating electrode and reference electrode composition.The number of active lanes that stimulating electrode adopts is many more, electrode just can stimulate more multipoint acoustic fibers in the cochlea, maximally utilise the natural structure of patient's cochlea, set up out more complete audition scale, the design of electrode shape also is artificial cochlea's a key.
The optic nerve prosthese is the medical apparatus that regains bright and vision for the patient who helps retina or other visual organ generation pathological changes.Wherein, the electrod-array of implantation directly acts on maincenter and peripheral nervous system, and the normal process that forms of analog vision is given stimulating micro electrode array electrical signal transfer by coding with specific impulse form, acts on visual cortex, retina or optic nerve.The pulse signal of stimulating electrode transmission wants enough big so that causing to stimulate, action potential partly takes place, and to visual cortex, is recorded as the waveform of picture by neurotransmission by the cerebral cortex recording electrode.In whole nerve prosthesis system, stimulating micro electrode is vital, and it must have good biocompatibility, is easy to processing, characteristics such as pliable and tough, space availability ratio height flexibly.
Find by prior art documents, number of patent application is 03159801.3, the open date is: on March 30th, 2005, patent name is: " multiple electrode array and manufacture method thereof ", this invention provides a kind of electrod-array that be easy to process, highdensity, and very row, single electrode and fixing resin are formed by micropore.Though this invention has also considered to realize the high density problem of electrod-array, and four electrod-arrays only are provided.Because the length of electrode is identical, do not consider when being used on the nerve tract, nerve fiber to different depth stimulates, and fundamentally do not solve the efficient and the practical problems of nerve system of human body being carried out electricity irritation, so the combination property of this class electrode requires further improvement also.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art and defective, a kind of bunch shape microelectrode array that can carry out effective high density electricity irritation to nerve system of human body is provided, make them can be according to the anatomy and the morphologic characteristics of nerve system of human body, system can more effectively excite nerve in the confined space.
The present invention is achieved by the following technical solutions, the present invention includes: tinsel stimulating micro electrode, wire support microelectrode and microelectrode substrate, Q different tinsel microelectrode of length is bonded in forms metal microelectrode bunch on the outer wall of wire support microelectrode, the microelectrode substrate is a three-decker, and m*n tinsel microelectrode bunch is fixed in the tinsel stimulating micro electrode cluster array of forming m*n in the microelectrode substrate.Drawing lead-in wire from the microelectrode substrate links to each other with external equipment.The material of the little support microelectrode of tinsel stimulating micro electrode and tinsel is the metal material of good biocompatibility.M represents the line number of array, and n represents the columns of array, and Q represents the number of tinsel microstimulation electrode on the little support electrode of each tinsel.
The metal material of described good biocompatibility is meant the wherein a kind of of tungsten filament, spun gold, platinumiridio silk.
The bar portion process insulation processing of described tinsel stimulating micro electrode and wire support microelectrode, the most advanced and sophisticated microelectrode that exposes.
It is described that tinsel stimulating micro electrode and wire support microelectrode are carried out insulating material is C type Parylene.
Described tip to tinsel stimulating micro electrode and wire support microelectrode adopts light laser to expose.
The diameter of described tinsel stimulating micro electrode is 10-20 μ m.
The tip diameter of described tinsel stimulating micro electrode is about 1 μ m.
The diameter of described wire support microelectrode is 50-80 μ m.
Described tinsel stimulating micro electrode length range is 300-1000 μ m.
The tip diameter of described tinsel stimulating micro electrode is about 3 μ m.
Described wire support microelectrode length is 1.2mm.
The overall diameter of described tinsel stimulating micro electrode bunch is 70-120 μ m.
Bunch to be the different tinsel stimulating micro electrode of Q length stick on the wire support microelectrode outer wall according to the Distribution Strategy of certain-length described tinsel stimulating micro electrode.Is the Design of length of stimulating electrode different in size, is in order to stimulate to the nerve fiber of different depth and to realize the stimulation of multidigit point.The tinsel stimulating micro electrode that length is differed is staggered according to a graded, is in order to guarantee the stability and the mechanical strength of each tinsel stimulating micro electrode in the whole tinsel stimulating micro electrode cluster array bunch.
The described bonding agent that is used for bonding metal silk stimulating micro electrode and wire support microelectrode is: cyanoacrylate adhesive.
The Distribution Strategy of described tinsel stimulating micro electrode length is: tinsel stimulating micro electrode length is made as l
p=l
l+ (p-1) * Δ l, p altogether, promptly electrode length is from l
lTo l
p, the adjacent lengths difference is Δ l.
The arrangement strategy of described tinsel stimulating micro electrode cluster array is: establishing array is A={m*n}, the element l of A
I, j (k)Be that to be positioned at tinsel stimulating micro electrode array i capable, the length of k tinsel microstimulation electrode in the j row tinsel microelectrode bunch, l
I, j (k)=l
l+ [(i-1) * m+ (j-1)] * Δ l+m*n* (k-1) * Δ l (i=1,2...m, j=1,2 ... n, k=1,2 ... Q).L represents the length of tinsel microstimulation electrode, and A represents electrod-array (Array), and m represents the line number of array, and n represents the columns of array, and Q represents the number of tinsel microstimulation electrode on the little support electrode of each tinsel, p=m*n*Q.
The line space of described tinsel stimulating micro electrode cluster array is 0.35-1.2mm, and column pitch is 0.35-1.2mm.
The formation of described triple electrode substrate is: the silastic-layer on top layer, intermediary conductive layer, the silastic-layer of bottom.
The silastic-layer thickness on described top layer is 0.5-1mm.
Described intermediary conductive layer thickness is 0.5-1mm.
The silastic-layer thickness of described bottom is 1-2mm.
Compared with prior art, main innovate point technology of the present invention is as follows:
1) taken into full account the characteristics of nerve system of human body, the defective at existing Neural stimulation electrodes technology has designed neural bunch of shape stimulating micro electrode array of this human implantable.Because the length difference of the microstimulation electrode of the present invention's design, and regular permutation and combination can efficiently stimulate the nerve fiber of different depth.Simultaneously can design more experimental program, allow in test the more information input and output, improve the success rate of experiment, allow people grasp relation between more environmental stimuli and the human nerve tissue reaction.
2) taken into full account the biocompatibility and the electrical characteristics of selected electrode material: metal microelectrode has the advantage that resistance is low, mechanical strength is high, electrical noise is low.Metal microelectrode is particularly advantageous in the needs of chronic implantation experiment, is comparatively ideal stimulating electrode.Tinsels such as tungsten filament, spun gold, platinumiridio silk all can be used as raw material.The tungsten filament biocompatibility is better, intensity is big, cheap, manufacture conveniently, be in experiment and scientific research use the earliest also be the electrode material that is in daily use.The biocompatibility excellence of platinumiridio, physicochemical characteristics are stablized, and especially are fit to the needs that body is implanted into, and are optimal electrode materials.Prove that by zoopery stainless steel silk, tungsten filament, platinum, platinumiridio all have less toxicity, tissue inflammation reaction's minimum that platinumiridio causes in vivo, tungsten filament and stainless steel silk take second place.
3) to the Insulation Problems of wire electrode; taken into full account the biocompatibility issues of insulant and tissue; selected insulant does not cause tissue reaction and inflammatory reaction and can protect implant devices not to be subjected to the erosion of physiological environment that the used insulant of the present invention is a C type Parylene (Parylene-C).
The invention has the beneficial effects as follows: taken into full account the form and the anatomic characteristic of the implant into body of wanting part, the pliable and tough stimulating micro electrode array of the present invention's design is particularly useful for nerve system of human body is stimulated.People utilize micro-processing technology to manufacture high-density electrode and obtain higher stimulation efficient, thereby can be clinical experiment and scientific research provides significant data.The material that is used to make nerve stimulator has excellent biological compatibility and can guarantee the not erosion of physiological environment in the receptor of device.The physical dimension of electrode can be controlled according to the size of wanting stimulation location, and the number, diameter and the length that are attached to the stimulating electrode that supports microelectrode in the electrode bunch can change according to actual needs, so, this electrode bunch can be realized accurate stimulation, helps people and seeks the relation that the difference that stimulates the site causes the different stimulated effect.
Description of drawings
Fig. 1 is the sketch map of tinsel stimulating micro electrode bunch
Fig. 2 is a structural representation of the present invention
Fig. 3 is the sketch map of electrode basement three-decker
Fig. 4 is the sketch map of electrode basement intermediate conductive layer winding displacement
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment has provided detailed embodiment and process being to implement under the prerequisite with the technical solution of the present invention, but protection scope of the present invention is not limited to following embodiment.
Shown in Fig. 1,2,3,4, present embodiment comprises: tinsel stimulating micro electrode 1, wire support microelectrode 2, tinsel stimulating micro electrode bunches 3, tinsel stimulating micro electrode cluster array 4, microelectrode substrate 5, Q tinsel microelectrode 1 is bonded in forms metal microelectrode bunches 3 on the outer wall of wire support microelectrode 2, microelectrode substrate 5 is three-deckers, m*n metal microelectrode bunches 3 is fixed in the tinsel stimulating micro electrode cluster array 4 of forming m*n in the microelectrode substrate 5, draws lead-in wire and link to each other with external equipment from microelectrode substrate 5.The material of tinsel microelectrode 1 and wire support microelectrode 2 is metal materials of good biocompatibility.M represents the line number of array, and n represents the columns of array, and Q represents the number of tinsel microstimulation electrode on the little support electrode of each tinsel.
During work, external device is with the signal of telecommunication that is provided with, be sent to body by lead and be implanted into part, with near the nervous system of electric pulse tinsel stimulating micro electrode 1 stimulating electrode tip, promptly tinsel stimulating micro electrode 1 is that body is implanted into the part and the interface of human nerve tissue.Because the tinsel microstimulation electrode 1 length different designs of present embodiment, can the nerve of different depth be stimulated, can remedy the defective on the surgical technic precision, and the high density of present embodiment stimulates the site, having improved stimulation efficient, is the advantage that conventional art can not be compared.
The metal material of described good biocompatibility is meant: tungsten filament, spun gold, platinumiridio silk wherein a kind of.
The bar portion of described tinsel stimulating micro electrode 1 and wire support microelectrode 2 is through insulation processing, most advanced and sophisticated exposed electrodes.
It is described that tinsel stimulating micro electrode 1 and wire support microelectrode 2 are carried out insulating material is C type Parylene.
Described tip to tinsel stimulating micro electrode 1 and wire support microelectrode 2 adopts light laser to expose.
The diameter of described tinsel stimulating micro electrode 1 is 10-20 μ m.
The tip diameter of described tinsel stimulating micro electrode 1 is about 1 μ m.
The diameter of described wire support microelectrode 2 is 50-80 μ m.
The length range of described tinsel stimulating micro electrode 1 is l=300-1000 μ m.
The tip diameter of described tinsel stimulating micro electrode 1 is about 3 μ m.
The length of described wire support microelectrode 2 is 1.2mm.
The overall diameter of described tinsel stimulating micro electrode bunches 3 is 70-120 μ m.
Described tinsel stimulating micro electrode bunches 3 is that Q the different tinsel stimulating micro electrode 1 of length sticks on the outer wall of wire support microelectrode 2 according to the strategy that certain-length distributes.
The described bonding agent that is used for bonding metal silk stimulating micro electrode 1 and wire support microelectrode 2 is: cyanoacrylate adhesive.
The Distribution Strategy of the length of described tinsel stimulating micro electrode 1 is: the length of tinsel stimulating micro electrode 1 is made as l
p=l
l+ (p-1) * Δ l, p is that the length of tinsel stimulating micro electrode 1 is for from l altogether
lTo l
p, the adjacent lengths difference is Δ l.
It is A={m*n} that being arranged as of described tinsel stimulating micro electrode cluster array 4 established array, the element l of A
I, jkBe that to be positioned at the i of tinsel stimulating micro electrode array 4 capable, the length of k tinsel microstimulation electrode 1 in the j row tinsel microelectrode bunches 3, l
I, j (k)=l
l+ [(i-1) * m+ (j-1)] * Δ l+m*n* (k-1) * Δ l (i=1,2...m, j=1,2 ... n, k=1,2 ... Q).L represents the length of tinsel microstimulation electrode, and A represents electrod-array (Array), and m represents the line number of array, and n represents the columns of array, and Q represents the number of tinsel microstimulation electrode on the little support electrode of each tinsel, p=m*n*Q.
The line space of described tinsel stimulating micro electrode cluster array 4 is 0.35-1.2mm, and column pitch is 0.35-1.2mm.
The diameter of the tinsel microstimulation electrode 1 on the described tinsel stimulating micro electrode cluster array 4 in the tinsel microstimulation electrode bunches 3 is identical, but length has nothing in common with each other; The diameter of wire support microelectrode 2 is identical with length.
The formation of described triple electrode substrate 5 is: the silastic-layer 6 on top layer, intermediary conductive layer 7, the silastic-layer 8 of bottom.
Silastic-layer 6 thickness on described top layer are 0.5-1mm.
Described intermediary conductive layer 7 thickness are 0.5-1mm.
Silastic-layer 8 thickness of described bottom are 1-2mm.
Claims (10)
1. one kind implantable bunch shape optic nerve stimulating micro electrode array, it is characterized in that, comprise: tinsel stimulating micro electrode (1), wire support microelectrode (2) and microelectrode substrate (5), wherein: Q different tinsel stimulating micro electrode (1) of length is bonded on the outer wall of wire support microelectrode (2) forms tinsel stimulating micro electrode bunch (3), microelectrode substrate (5) is a three-decker, m*n tinsel microelectrode bunch (3) is fixed in microelectrode substrate (5) and goes up the tinsel stimulating micro electrode cluster array (4) of forming m*n, drawing lead-in wire from microelectrode substrate (5) links to each other with external equipment, the material of the little support microelectrode of tinsel stimulating micro electrode (1) and tinsel (2) is the metal material of good biocompatibility, and it is C type Parylene that tinsel stimulating micro electrode (1) and wire support microelectrode (2) are carried out insulating material;
Described m represents the line number of array, and n represents the columns of array, and Q represents the number of tinsel microstimulation electrode on the little support electrode of each tinsel.
2. neural bunch of shape stimulating micro electrode array of human implantable according to claim 1 is characterized in that the metal material of described good biocompatibility is meant the wherein a kind of of tungsten filament, spun gold and platinumiridio silk; The bar portion of described tinsel stimulating micro electrode (1) and wire support microelectrode (2) is through insulation processing and most advanced and sophisticated light laser exposed electrodes.
3. neural bunch of shape stimulating micro electrode array of human implantable according to claim 1 and 2 is characterized in that, the length range of described tinsel stimulating micro electrode (1) is 1=300-1000 μ m, and diameter is 10-20 μ m, and tip diameter is 1-3 μ m.
4. neural bunch of shape stimulating micro electrode array of human implantable according to claim 1 and 2 is characterized in that the length of described wire support microelectrode (2) is 1.2mm, and diameter is 50-80 μ m, and tip diameter is 1-3 μ m.
5. neural bunch of shape stimulating micro electrode array of human implantable according to claim 1 is characterized in that described tinsel stimulating micro electrode (1) is bonded in wire support microelectrode (2), specifically is to carry out bonding with cyanoacrylate adhesive; The overall diameter of described tinsel stimulating micro electrode bunch (3) is 70-120 μ m.
6. neural bunch of shape stimulating micro electrode array of human implantable according to claim 1, it is characterized in that, the number Q of the tinsel stimulating micro electrode (1) that each tinsel stimulating micro electrode bunch (3) is comprised is 4 or 6 or 8 or 10, and the length difference of each tinsel stimulating micro electrode (1), the length of tinsel stimulating micro electrode (1) is made as l
p=l
1+ (p-1) * Δ l, p altogether, promptly the length of tinsel stimulating micro electrode (1) is from l
1To l
p, the adjacent lengths difference is Δ l, and l represents the length of tinsel microstimulation electrode, and A represents electrod-array, and m represents the line number of array, and n represents the columns of array, and Q represents the number of tinsel microstimulation electrode on the little support electrode of each tinsel, p=m*n*Q.
7. neural bunch of shape stimulating micro electrode array of human implantable according to claim 1, it is characterized in that, being arranged as of described tinsel stimulating micro electrode cluster array (4): establishing array is A={m*n}, the ranks of tinsel stimulating micro electrode cluster array (4) are several to be adjusted according to needs, be that array A is m*n, m, n=1,2,3,4 ..., the element l of A
I, j (k)Be that to be positioned at the i of tinsel stimulating micro electrode array (4) capable, the length l of k tinsel microstimulation electrode 1 in the j row tinsel microelectrode bunches 3
I, j (k)=l
1+ [(i-1) * m+ (j-1)] * Δ l+m*n* (k-1) * Δ l, i=1,2...m, j=1,2 ... n, k=1,2 ... Q.
8. according to claim 1 or neural bunch of shape stimulating micro electrode array of 7 described human implantables, it is characterized in that, the diameter that described tinsel stimulating micro electrode cluster array (4) is gone up the tinsel microstimulation electrode (1) in the tinsel microstimulation electrode bunch (3) is identical, but length has nothing in common with each other; The diameter of described wire support microelectrode (2) is identical with length.
9. according to claim 1 or neural bunch of shape stimulating micro electrode array of 7 described human implantables, it is characterized in that the line space of described tinsel stimulating micro electrode cluster array (4) is 0.35-1.2mm, column pitch is 0.35-1.2mm.
10. neural bunch of shape stimulating micro electrode array of human implantable according to claim 1, it is characterized in that, described microelectrode substrate (5) is a three-decker, specifically comprise: the silastic-layer (8) of the silastic-layer on top layer (6), intermediary conductive layer (7) and bottom, wherein: the thickness of the silastic-layer on top layer (6) is 0.5-1mm, the thickness of intermediary conductive layer (7) is 0.5-1mm, and the thickness of the silastic-layer of bottom (8) is 1-2mm.
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| CN101172185B (en) * | 2007-09-21 | 2011-06-01 | 中国科学院上海微系统与信息技术研究所 | Process for producing implantation type two-sided flexible tiny array electrode |
| CN102793592B (en) * | 2012-08-09 | 2014-09-10 | 上海交通大学 | Optic nerve implantable neural interface device with fan-shaped attaching function |
| CN104055598B (en) * | 2014-06-25 | 2016-09-07 | 上海交通大学 | Implantable flexible nervus of piscine organism robot and preparation method thereof |
| EP3632503B1 (en) * | 2018-08-31 | 2021-07-21 | Nederlands Herseninstituut | A neuroprosthetic system for substituting a sensory modality of a mammal by high-density electrical stimulation of a region of the cerebral cortex |
| CN109663208B (en) * | 2019-02-15 | 2022-04-26 | 上海交通大学 | Flexible nerve electrode based on multilayer stacked structure substrate and manufacturing method |
| CN111053554A (en) * | 2019-11-28 | 2020-04-24 | 开封市学国生物科技有限公司 | Ultramicro flexible linear deep brain electrode |
| WO2021114119A1 (en) * | 2019-12-11 | 2021-06-17 | 中国科学院深圳先进技术研究院 | Flexible recording electrode, and preparation method and implantation method therefor |
| CN111603159A (en) * | 2020-05-18 | 2020-09-01 | 北京航空航天大学 | Composite optical fiber device for realizing trace drug delivery and photoelectric detection and preparation method thereof |
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| CN1600264A (en) * | 2003-09-25 | 2005-03-30 | 中国科学院生物物理研究所 | Multiple electrode array and manufacturing method |
| WO2006116968A2 (en) * | 2005-04-29 | 2006-11-09 | Valerij Ortmann | Biostable neuroelectrode |
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| CN1600264A (en) * | 2003-09-25 | 2005-03-30 | 中国科学院生物物理研究所 | Multiple electrode array and manufacturing method |
| WO2006116968A2 (en) * | 2005-04-29 | 2006-11-09 | Valerij Ortmann | Biostable neuroelectrode |
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