CN100558426C - Implantable sheet type optic nerve micro stimulating electrode - Google Patents

Implantable sheet type optic nerve micro stimulating electrode Download PDF

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CN100558426C
CN100558426C CN 200610025215 CN200610025215A CN100558426C CN 100558426 C CN100558426 C CN 100558426C CN 200610025215 CN200610025215 CN 200610025215 CN 200610025215 A CN200610025215 A CN 200610025215A CN 100558426 C CN100558426 C CN 100558426C
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electrode
lead
micro
optic
substrate
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CN1820799A (en
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任秋实
周传清
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上海交通大学
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Abstract

一种生物医学工程技术领域的可植入的片型视神经微刺激电极,包括:电极基底、微电极、电极内引线、引线基底、引线接口和电缆束。 BACKGROUND A biomedical engineering implantable stimulation electrode sheet-type micro-optic, comprising: an electrode substrate, a microelectrode, the electrode lead, the lead substrate, the lead connector and cable bundle. 微电极分布在电极基底上并突出于电极基底的表面,在水平方向上由两个或两个以上微电极组成微电极对,所组成的微电极对之间在垂直方向上的空间错开;电极内引线连接微电极和引线接口,并行走在电极基底的表面或层间;引线基底和电极基底直接相连;引线接口分布在引线基底的表面;电缆束是由连接引线接口和外部设备的电缆组成。 Microelectrodes distributed on the electrode substrate and the electrode surface of the substrate protrudes, in the horizontal direction microelectrode by two or more micro-electrodes of the space in the vertical direction between the pair of electrodes composed of micro offset; electrode the lead connecting microelectrodes and a lead wire interfaces, and travel between the surface or layer of the electrode substrate; wiring substrate and an electrode substrate are directly connected; lead distribution of the interface surface of the lead substrate; cable harness is connected to the lead interface and external equipment cables composition . 本发明能有效地刺激视神经纤维,视神经纤维将刺激器产生的刺激电流传导到视皮层,使视皮层产生类似光刺激视网膜后产生的兴奋,从而产生光幻视,且能记录视神经纤维的电位。 The present invention can effectively stimulate the optic nerve fibers, the nerve fiber stimulation current stimulus generated is conducted to the visual cortex, the visual cortex after light stimulation produced a similar retina excited to produce phosphenes, and can record the potential of optic nerve fibers.

Description

可植入的片型视神经微刺激电极 The implantable stimulation electrode sheet-type micro-optic

技术领域 FIELD

本发明涉及的是一种生物医学工程技术领域的电极,具体的说,涉及一种可植入的片型视神经微刺激电极。 The present invention relates to the technical field of electrode biomedical engineering, particularly, relates to an implantable stimulation electrode sheet type micro-optic. 背景技术 Background technique

对于具有正常视觉功能的眼睛,能将外界所注视的物体成像在视网膜上, 视网膜上的感光细胞将图像信号转换为生物电信号,然后经水平细胞、双极细胞和神经节细胞构成的视网膜神经网络对感光细胞的生物电信号进行初步处理后由神经节细胞发出的视觉神经纤维传导到大脑视皮层,大脑视皮层对获得的生物电信号进行再次处理并感知产生视觉。 For eyes with normal retinal visual function, the outside world can watch the object image on the retina, photoreceptor cells in the retina converts the image signal into a bioelectrical signal, and then by horizontal cells, bipolar cells and ganglion cells composed of after the network of the bioelectric signal preliminary processing of photoreceptor cells were emitted from the optic nerve fibers ganglion cells transmitted to the brain visual cortex, visual cortex of the brain bioelectric signal obtained again and processed to produce visual perception. 但是由于一些疾病,如视网膜色素变性,老年性黄斑变性等,会对视网膜的感光细胞产生影响,破坏了视觉电信号的来源,降低了视力甚至造成失明。 However, due to a number of diseases, such as retinitis pigmentosa, senile macular degeneration, retinal photoreceptor cells will have an impact, undermining the visual source of electrical signals, reducing vision and even cause blindness. 针对这种威胁正常视觉的疾病,人们试图用人工的办法模拟类似的视觉电信号,将具有一定幅值和波形的剌激电流经神经纤维传导到视皮层,使视皮层产生类似光剌激视网膜后产生的兴奋,从而产生光幻视。 In response to this threat normal vision disorders, attempts artificial way similar visual analog electrical signal, the stimulation current having a certain amplitude and the waveform transmitted to the visual cortex via nerve fibers, similar to the visual cortex to produce light stimuli retina after the excitement generated, to produce phosphenes. 目前的方法主要有视网膜刺激法、视神经刺激法和皮层刺激法。 Current methods include stimulation of the retina, optic nerve stimulation and cortical stimulation. 视神经刺激法是直接将刺激电流经视神经纤维传导视皮层,产生光幻视。 Optic Nerve stimulation is by directly stimulating current conduction visual cortex nerve fiber, produce phosphenes. 视神经具有束状结构,并由很多纤维小束组成。 Optic bundle structure having, by many small fiber bundles. 各纤维小束之间由神经束膜包裹而隔离。 Between each fiber bundle are separated by a small wrap nerve bundle. 因此刺激电极的设计和植入方法是视神经刺激能否有效产生光幻视的关键。 Therefore, the design and method of implantation of stimulating electrodes is critical to the optic nerve stimulation can effectively produce phosphene. 本发明的目的是提供一种有效刺激视神经的可植入的微刺激电极及其设计方法。 Object of the present invention is to provide an effective stimulus micro-optic implantable stimulation electrode and its design method.

经对现有技术的文献检索发现,美国专利号为US6442431B1,名为"DEVICE AND METHOD FOR PRODUCTION OF VISUAL SENSATIONS BY OPTIC NERVE STIMULATION"("通过视神经刺激产生视感觉的器械和方法")专利文献自述为: "一种能使盲人产生视知觉的方法和装置,包括围绕盲人视神经安装一种自调节尺寸的嫘旋型的手铐型神经电极,然后传导电脉冲到神经使患者在视野内产生光幻视"。 By the prior art literature search for found, U.S. Patent No. US6442431B1, entitled "DEVICE AND METHOD FOR PRODUCTION OF VISUAL SENSATIONS BY OPTIC NERVE STIMULATION" ( "visual sensation produced by optic nerve stimulation devices and methods") for the readme PTL : "an apparatus and a method for producing the blind enables visual perception, including rayon spin around the blind mounting type optic handcuffs neural a self-adjusting the size of the electrode, and then conduct electrical impulses to the nerve so that patients phosphenes in the visual field . " 该发明采用电场刺激而非电流刺激,电场刺激效率和准确度都没有电流刺激好。 The invention is the use of electric current stimulation rather than stimulation, electrical field stimulation efficiency and accuracy are not good current stimulation. 发明内容 SUMMARY

本发明的目的是针对现有技术的不足,提供一种可植入的视神经微刺激电极,使其能有效地刺激视神经纤维,视神经纤维将刺激器产生的具有一定幅值和波形的刺激电流传导到视皮层,使视皮层产生类似光刺激视网膜后产生的兴奋,从而产生光幻视,并且能记录视神经纤维的电位。 Object of the present invention is the lack of the prior art, there is provided an implantable micro optic nerve stimulation electrodes, so that it can effectively stimulate the optic nerve fibers, conducting stimulation current waveform having a certain amplitude and the optic nerve fibers to stimulate generated the visual cortex, the visual cortex to produce a similar retina after light stimulation excited to produce phosphenes, and the potential of the optic nerve fibers can be recorded.

本发明是通过以下技术方案实现的,本发明可植入的片型视神经微刺激电极包括:电极基底、微电极、电极内引线、引线基底、引线接口和电缆束。 The present invention is achieved by the following technical solutions, the present invention is an implantable micro-optic sheet-type stimulation electrode comprising: an electrode substrate, a microelectrode, the electrode lead, the lead substrate, the lead connector and cable bundle. 所述微电极分布在所述电极基底上并突出于所述电极基底的表面,在水平方向上由两个或两个以上微电极组成微电极对,并且所组成的微电极对之间在垂直方向上的空间错开;所述电极内引线连接所述微电极和所述引线接口,并行走在所述电极基底的表面或层间;所述引线基底和所述电极基底直接相连;所述引线接口分布在所述引线基底的表面;所述电缆束是由连接所述引线接口和所述的可植入的视神经微刺激电极的外部设备的电缆组成。 Vertically between the microelectrodes of the microelectrode distributed on the substrate and the electrode surface of the electrode protruding to the substrate, micro-electrodes in the horizontal direction by two or more microelectrodes of the composition, and consisting of shifted spatial direction; micro-electrode lead connecting said leads and said interface to said inner electrode, and between the walking surface or layer of the electrode substrate; said wiring substrate and said substrate electrode are directly connected; the lead Interface distributed on the surface of the lead substrate; said cable is a cable bundle by an external device connected to the optic implantable lead interface and the micro-stimulation electrode composition.

所述可植入的片型视神经微刺激电极具有片状结构。 The implantable stimulation electrode sheet having a micro-optic type sheet-like structure.

所述电极基底具有一定的柔韧性,并且具有良好的生物相容性,能长期植入于视神经,其厚度约100微米左右。 The electrode substrate having a certain degree of flexibility, and has excellent biocompatibility, long-term implantation in the optic nerve, which is about a thickness of about 100 microns.

所述微电极通过微加工技术制作于所述电极基底上,直径约100微米,突出于所述电极基底10〜30微米,所述微电极之间的距离约200~300微米,所述微电极的分布使水平方向上至少具有一个刺激微电极和一个记录微电极组成微电极对,并且所组成的微电极对之间在垂直方向上的空间错开。 The microelectrode made by microfabrication techniques on the electrode substrate, about 100 microns in diameter, protruding from the electrode substrate 10~30 microns, distances between the microelectrodes of about 200 to 300 microns, said microelectrode distribution in the horizontal direction having at least a microelectrode and microelectrode recording a composition microelectrode stimulation of the space in the vertical direction between the pair of electrodes and composed of micro offset.

所述电极内引线由低电阻率材料制成,行走于所述电极基底表面或层间, 经所述电极基底的表面或层间后增粗到每条引线约100微米左右。 Said electrode lead of a low resistivity material, walking on the surface of the electrode substrate or layer after layer, or between the surfaces of the electrode substrate of each lead to thickening of about 100 microns.

所述引线基底由柔韧性好的材料加工而成,并和所述电极基底直接相连。 The lead substrate fabricated from a material with good flexibility made and directly connected to the substrate and the electrode.

使用时,在视神经束横断面的不同位置沿视神经束走向切开,沿视神经束的走向放置一个或一个以上的本发明可植入的片型视神经微刺激电极,然后缝合切口使可植入的片型视神经微刺激电极挟持在切口之间;电缆束经皮引出体外;在体外的刺激器的作用下,刺激双极脉冲电流经电缆束,引线接口,引线基底内的引线和电极内引线到达微电极;视神经纤维和微电极的端面接触,接触面积大,并且不易戳断视神经纤维;刺激电流传导到神经纤维上,并经神经纤维传导到视皮层产生光幻视;沿神经纤维走向的每个电极对能同时起到刺激神经纤维和记录视神经电位的作用,提高了刺激效率;同时也能起到记录神经纤维电位的作用。 When the present invention is used, the beam cross-section at different positions along the optic beam to cut the optic nerve, the optic nerve bundle to be placed along one or more implantable stimulation electrode sheet-type micro-optic, then the incision so that the implantable micro-optic sheet-type stimulation electrode sandwiched between the cutout; transdermal led outside the cable bundle; in vitro stimulator stimulates bipolar pulsed current through the cable bundle, the interface leads, the inner lead and an electrode lead wire reaches the base microelectrodes; microelectrodes and nerve fiber end-face contact, a large contact area, and the optic nerve fibers break easily poke; conduction of current to stimulate nerve fibers, and conducted to produce phosphenes visual cortex via nerve fibers; along the nerve fibers toward each a pair of electrodes to stimulate nerve fibers can play simultaneously recording and optic nerve action potentials, increases the efficiency of stimulus; recording but also can play a role in nerve fibers potentials.

将本发明可植入的片型视神经微刺激电极沿视神经走向植入并夹持在视神经束内后,刺激电流通过微刺激电极剌激视神经,通过视神经传导到视皮层使患者产生光幻视。 After the present invention is an implantable micro-optic sheet-type stimulation electrode implanted along the optic nerve to the beam and held in the optic nerve, the stimulation electrodes to stimulate the micro-current stimulation by the optic nerve, visual cortex conducted to the patient through the optic nerve to produce phosphenes. 同时由于和受刺激的视神经纤维束接触的电极数量在两个以上,在软件控制下,沿视神经纤维走向的微电极对既起到刺激的作用,又能起到实时记录视神经纤维束的电位,这样便能实时记录视神经纤维电刺激的有效性。 And because the number of electrodes and the optic nerve fiber bundle is stimulated in contact with two or more, under software control, the optic nerve fibers along the direction of microelectrodes for stimulation both play the role, but also play the real time recording potential optic fiber bundle, such will be able to record in real time the effectiveness of electrical stimulation of the optic nerve fibers. 在视神经束的不同部位植入本发明片型微刺激电极,便能提高刺激的密度, 提高患者光幻视的分辨率。 In different parts of the optic nerve bundle implants micro stimulation electrode of the invention, it can increase the density of the stimulation, the patient improved resolution phosphene.

本发明的有益效果是:通过电刺激视神经能使患者达到更大视野和更高分辨率的光幻视。 Advantageous effects of the invention are: electrical stimulation through the patient reaches the optic nerve can phosphenes higher resolution and a larger field of view. 本发明的电极设计和电极植入途径不会导致神经纤维被微电极剌断而达不到刺激的目的;另外本发明在视神经纤维走向上布置了不止一个电极,这样使微刺激电极端面和视神经纤维有效地接触,提高了视神经纤维电刺激的效率,而且还能同时记录神经纤维的电位,为实时观察视神经纤维电刺激的有效性以及其它神经电生理提供了方法和途径;本发明能够在视神经束的不同位置同时植入所述微刺激电极,提高视神经纤维电刺激的密度,从而提高盲人人工视觉的分辨率。 Electrode and the electrode design of the present invention will not lead to implant route is broken nerve fibers reach the punching microelectrode stimulation purposes; Further the present invention more than one electrode disposed on the optic fiber orientation, so that the stimulating electrode end and the micro-optic contacting the fibers effectively, the optic nerve fibers to improve the efficiency of electrical stimulation, but also the potential of nerve fibers simultaneously recorded, a method and approach for real-time observation of the effectiveness of the optic nerve fiber electrical stimulation and other neural electrophysiological; the present invention can be in the optic nerve different positions while the beam density of the micro implant stimulation electrodes, electrical stimulation improve the optic nerve fibers, thereby improving the resolution of the blind artificial vision.

附图说明 BRIEF DESCRIPTION

图l是本发明结构示意图。 Figure l is a schematic structural diagram of the present invention. 图2是本发明側面结构图。 FIG 2 is a side structural view of the present invention. 图3是本发明工作原理图。 FIG 3 is a working principle diagram of the present invention. 具体实施方式 Detailed ways

如图l、 2、 3所示,本发明包括:电极基底l、微电极2、引线接口3、电极内引线5、引线基底6和电缆束4。 L in FIG, 2, 3, the present invention comprises: an electrode substrate L, a microelectrode 2, a lead interface 3, the inner electrode lead 5, 6 of the wiring substrate 4 and the cable bundle. 所述微电极2分布在所述电极基底1上并突出于所述电极基底1的表面,在水平方向上由两个或两个以上微电极2组成 The microelectrode 2 distributed on the electrode substrate 1 and the surface of the projecting electrode substrate 1, in the horizontal direction by two or more microelectrodes 2 Composition

微电极对,并且所组成的微电极对之间在垂直方向上的空间错开;所述电极内 Microelectrode pair, and between the pair of electrodes composed of micro shifted in a direction perpendicular to the space; the inner electrode

引线5连接所述微电极2和所述引线接口3,并行走在所述电极基底1的表面或层间;所述引线基底6和所述电极基底1直接相连;所述引线接口3分布在所述引线基底6的表面;所述电缆束4是由连接所述引线接口3和所述的可植入的视神经微刺激电极的外部设备的电缆组成。 Lead 5 connected to the microelectrode 2 and the lead interface 3, and the travel between the electrode layer or the surface of the substrate 1; the wiring substrate 6 and the substrate 1 is directly connected to the electrode; the lead distribution of the interface 3 6 of the lead base surface; the cable harness 4 is a cable connection interface to the external lead and the implantable device of the optic nerve stimulation electrode 3 a micro composition.

所述可植入的片型视神经微刺激电极具有片形结构。 The implantable stimulation electrode sheet having a micro-optic type sheet-shaped structure.

所述电极基底1具有一定的柔韧性和良好的生物相容性,是植入视神经的部分,其长度为1至3毫米,高度1至3毫米。 The electrode substrate 1 has a certain flexibility and excellent biocompatibility is implanted optic portion having a length of 1-3 mm, height 1-3 mm.

所述微电极2布置于电极基底1上,直径约100至300微米,空间间隔约200〜900微米,在水平方向上由两个或两个以上微电极2组成微电极对,并且所组成的微电极对之间在垂直方向上的空间错开。 The microelectrode 2 arranged on the electrode substrate 1, a diameter of about 100 to 300 micrometers, spatial separation of about 200~900 microns, in a horizontal direction of two or more microelectrodes 2 Microelectrodes composition, and consisting of space between the microelectrodes is shifted in the vertical direction.

所述引线接口3是所述可植入的片型视神经微刺激电极内的电极内引线5 和电缆束4的接口,布置于引线基底6上,直径约100至300微米,空间间隔100至900微米以上。 The lead 3 is the interface of the implantable stimulation interface micro optic sheet-type internal electrode in the electrode lead 5 and the cable harness 4, 6 disposed on the wiring substrate, a diameter of about 100 to 300 microns, spaced-apart 100-900 m or more.

所述引线基底6由柔韧性和生物相容性好的材料加工而成,并和所述电极基底1直接相连。 The wiring substrate 6 and the processing of a flexible material with good biocompatibility formed, and the electrode and the substrate 1 is directly connected. 表面或层间布有电极引线和电极内引线连接,该段引线比电极内引线5粗,直径为100〜300微米,有利于减少电阻。 Surface or layer between the fabric and the inner electrode lead electrode lead is connected to a wire segment is thicker than the inner electrode lead 5, 100~300 microns in diameter, helps to reduce resistive.

所述电缆束4将从各引线接口的引线绑成束状引出所述可植入的片型视神经微刺激电极,或通过在引线基底6上布置一分线器,将分线器上的引线绑成束状引出所述可植入的视神经微刺激电极。 The sheet optic bundle 4 from the cable interface of each lead wire tied into a bundle out of said stimulation electrodes may be implanted micro, or by arranging a splitter on the wiring substrate 6, the lead on the splitter tied into bundles out of said micro optic implantable stimulation electrode. 电缆束4是所述可植入的片型视神经微刺激电极和外部的刺激器或记录器的连接电缆束,该电缆束4直径约lmm 左右。 Stimulator or recorder is connected to a cable harness cable bundle 4 is the implantable stimulation electrode sheet-type micro-optic and outside of the cable bundle diameter of about 4 about lmm.

Claims (8)

1、一种可植入的片型视神经微刺激电极,包括:电极基底(1)、微电极(2)、引线接口(3)、电极内引线(5)、引线基底(6)和电缆束(4),其特征在于,所述微电极(2)分布在所述电极基底(1)上并突出于所述电极基底(1)的表面,在水平方向上由两个或两个以上微电极(2)组成微电极对,并且所组成的微电极对之间在垂直方向上的空间错开,所述电极内引线(5)连接所述微电极(2)和所述引线接口(3),并行走在所述电极基底(1)的表面或层间;所述引线基底(6)和所述电极基底(1)直接相连,所述引线接口(3)分布在所述引线基底(6)的表面,所述电缆束(4)是由连接所述引线接口(3)和所述的可植入的视神经微刺激电极的外部设备的电缆组成。 1. A micro-optic sheet-type implantable stimulation electrode comprising: an electrode substrate (1), the micro-electrode (2), a lead interface (3), the inner electrode lead (5), the wiring substrate (6) and cable bundle (4), characterized in that the microelectrode (2) distributed on the electrode substrate (1) and projecting on the surface of the electrode substrate (1) by two or more micro in the horizontal direction electrode (2) between the microelectrodes of the microelectrode on the composition, and consisting of a space in the vertical direction is shifted, the inner electrode lead (5) connected to the micro-electrode (2) and the lead interface (3) , traveling between the electrodes and the substrate (1) or a surface layer; said wiring substrate (6) and the electrode substrate (1) directly connected to the lead interface (3) distributed in the wiring substrate (6 ) surface of the cable bundle (4) is connected by a cable to the external device interfaces lead (3) and the implantable stimulation electrodes of the micro-optic components.
2、 根据权利要求1所述的可植入的片型视神经微刺激电极,其特征是,具有片形结构。 2. The implantable sheet optic type according to claim 1 micro-stimulation electrode, characterized in that a sheet-shaped structure.
3、 根据权利要求1所述的可植入的片型视神经微刺激电极,其特征是,所述电极基底(1),是植入视神经的部分,其长度为1至3毫米,高度1至3毫米。 3, according to claim 1 implantable micro-optic sheet-type stimulation electrode, wherein the electrode substrate (1), is implanted optic portion having a length of 1 to 3 mm and a height of 1 to 3 mm.
4、 根据权利要求1所述的可植入的片型视神经微刺激电极,其特征是,所述微电极(2)布置于电极基底(1)上,直径为100至300微米,空间间隔为200〜900微米。 4. The implantable optic type according to claim 1 micro stimulation electrode, characterized in that the microelectrode (2) disposed on the electrode substrate (1), having a diameter of 100 to 300 micrometers, spatial separation of 200~900 microns.
5、 根据权利要求1所述的可植入的片型视神经微刺激电极,其特征是,所述引线接口(3)是所述可植入的片型视神经微刺激电极内的电极内引线(5)和电缆束(4)的接口,布置于引线基底(6)上,直径为100至300微米,空间间隔100至900微米。 5, according to claim 1 implantable micro-optic sheet-type stimulation electrode, characterized in that the lead interface (3) is a sheet type of the implantable micro optic nerve stimulating electrode in the electrode lead ( Interface 5) and cable bundle (4) is arranged in the wiring substrate (6), 100 to 300 microns in diameter, 100-900 microns spatial separation.
6、 根据权利要求1所述的可植入的片型视神经微刺激电极,其特征是,所述引线基底(6)表面或层间布有电极引线和电极内引线(5)连接,该段引线比电极内引线(5)粗,直径为100〜300微米。 6, according to the type 1 sheet implantable micro optic nerve stimulation electrode according to claim, characterized in that said wiring substrate (6) between the surface layer of cloth or the electrode leads and the inner electrode lead (. 5) is connected, the segment leads (5) thicker than the inner lead electrodes 100~300 microns in diameter.
7、 根据权利要求1所述的可植入的片型视神经微刺激电极,其特征是,所述电缆束(4)将从各引线接口的引线绑成束状引出所述可植入的片型视神经微刺激电极,或通过在引线基底(6)上布置一分线器,将分线器上的引线绑成束状引出所述可植入的视神经微刺激电极。 7, according to claim 1 implantable micro-optic sheet-type stimulation electrode, characterized in that said cable bundle (4) from the interface of each lead wire tied into bundles out of said implantable sheet micro optic nerve stimulation electrode type, or by arranging a splitter on the wiring substrate (6), on the lead into a beam splitter out of said tie implantable micro optic nerve stimulation electrodes.
8、根据权利要求1或者7所述的可植入的片型视神经微刺激电极,其特征是,电缆束(4)是所述可植入的片型视神经微刺激电极和外部的刺激器或记录器的连接电缆束,该电缆束(4)直径为lmm。 8. The implantable claim 1 or claim 7 type micro-optic stimulation electrode, characterized in that the cable harness (4) the implantable micro-optic sheet-type electrodes and the external stimulus or stimuli beam recorder connecting cable, the cable harness (4) having a diameter of lmm.
CN 200610025215 2006-03-30 2006-03-30 Implantable sheet type optic nerve micro stimulating electrode CN100558426C (en)

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