CN1973865A - Medicine composition for treating apoplexy and its prepn - Google Patents
Medicine composition for treating apoplexy and its prepn Download PDFInfo
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- CN1973865A CN1973865A CNA2006101680756A CN200610168075A CN1973865A CN 1973865 A CN1973865 A CN 1973865A CN A2006101680756 A CNA2006101680756 A CN A2006101680756A CN 200610168075 A CN200610168075 A CN 200610168075A CN 1973865 A CN1973865 A CN 1973865A
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Abstract
The present invention discloses one kind of medicine composition, belongs to the field of Chinese medicine technology, and is especially one kind of Chinese medicine composition for treating apoplexy. The Chinese medicine composition is prepared with astragalus root, red peony root, red sage, angelica, Chuanxiong rhizome and other Chinese medicinal materials in certain weight proportion. The Chinese medicine composition has obvious curative effect on apoplexy, cerebral infarction, coronary heart disease and angina caused by qi deficiency, blood stagnation and meridian stasis. The present invention also discloses the preparation process of the Chinese medicine composition and the preparation process is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, especially a kind of Chinese medicine composition that is used for the treatment of apoplexy belongs to the field of Chinese medicines.
Background technology
With apoplexy, myocardial infarction is that the cardio-cerebralvascular diseases of representative has become the serious disease that threatens the human life most except that malignant tumor after the fifties in last century.In recent years, the increase of the raising of China's living standards of the people, survival pressure at any time, the sickness rate of this class disease is just in rising trend.Although it is also more to treat the medicine of this type of disease in the market, can not satisfy clinical needs all the time, especially, lack effective medicine especially for the treatment of stroke in convalescent stage.
Summary of the invention
One of purpose of the present invention provides a kind of pharmaceutical composition, is used for the treatment of apoplexy; Another object of the present invention provides this preparation of pharmaceutical compositions method.
The present invention seeks to realize by following technical solution.
Pharmaceutical composition of the present invention is to be made by the raw material of following weight ratio:
3～4 parts of 3～4 parts of Radix Angelicae Sinensis of 3～4 parts of Radix Salviae Miltiorrhizaes of 9～10 parts of Radix Paeoniae Rubra of the Radix Astragali
1～2 part of 1～2 part of Olibanum (processed) of 3～4 parts of Flos Carthamis of 3～4 parts of Semen Persicaes of Rhizoma Chuanxiong
2～3 parts of 3～4 parts of Ramulus Cinnamomi of 2～3 parts of Radix Achyranthis Bidentataes of 1～2 portion of Caulis Spatholobi of Myrrha (processed)
3～4 parts of 1～2 portion of Hirudos of 3～4 portions of Scorpios of 3～4 parts of Pheretimas of Ramulus Mori.
The optimum ratio of each crude drug is after preferred:
27 parts of 27 parts of Radix Angelicae Sinensis of 27 parts of Radix Salviae Miltiorrhizaes of 66 parts of Radix Paeoniae Rubra of the Radix Astragali
13 parts of 13 parts of Olibanum (processed)s of 27 parts of Flos Carthamis of 27 parts of Semen Persicaes of Rhizoma Chuanxiong
20 parts of 27 parts of Ramulus Cinnamomi of 20 parts of Radix Achyranthis Bidentataes of 13 portions of Caulis Spatholobis of Myrrha (processed)
27 parts of 13 portions of Hirudos of 27 portions of Scorpios of 27 parts of Pheretimas of Ramulus Mori.
For making things convenient for clinical practice, this pharmaceutical composition is made into several formulations, comprises tablet, capsule, granule, soft capsule etc.
Above preparation of drug combination method is:
Get crude drug in proportion,, be ground into fine powder Pheretima, Scorpio; All the other Radixs Astragali etc. 14 flavor is ground into fine powder, with above-mentioned powder facing-up, sieves, and mixing adds suitable adjuvant/or directly make required dosage form again.
Specifically, the method for making tablet when above pharmaceutical composition is:
Get crude drug in proportion,, be ground into fine powder Pheretima, Scorpio; 14 flavors such as all the other Radixs Astragali are ground into fine powder, with above-mentioned powder facing-up, sieve, and add 10～40% pregelatinized Starch again, with 80% alcohol granulation, add 0～5% Pulvis Talci again, mixing, and compacting is in flakes.
In the method, pregelatinized Starch can also carboxymethylstach sodium etc. binding agent replace, but Pulvis Talci also lubricant such as micropowder silica gel replace; Can also add disintegrating agent and other relevant auxiliary materials such as microcrystalline cellulose.
In addition, the preparation method of capsule is:
Get crude drug in proportion,, be ground into fine powder Pheretima, Scorpio; 14 flavors such as all the other Radixs Astragali are ground into fine powder, with above-mentioned powder facing-up, sieve, and mixing incapsulates, promptly.
In the method, for reaching better preparation characteristic, also can add conventional binding agent, disintegrating agent, fluidizer etc.
The pharmaceutical composition that makes by technical solution of the present invention, through animal and clinical trial certificate, has benefiting QI for activating blood circulation, the effect of disperse blood stasis and dredge collateral, to apoplexy apoplex involving the channels and collaterals due to blood stagnancy due to deficiency of QI, the venation block, hemiplegia, numb limbs and tense tendons, facial hemiparalysis, the stiff tongue language is stuttering and obstruction of qi in the chest and cardialgia, uncomfortable in chest, cardiopalmus, breathe hard; Cerebral infarction, angina pectoris belong to above-mentioned patient all the obvious treatment effect.
The specific embodiment
Embodiment 1:
Prescription: Radix Astragali 66g Radix Paeoniae Rubra 27g Radix Salviae Miltiorrhizae 27g Radix Angelicae Sinensis 27g
Rhizoma Chuanxiong 27g Semen Persicae 27g Flos Carthami 13g Olibanum (system) 13g
Myrrha (processed) 13g Caulis Spatholobi 20g Radix Achyranthis Bidentatae 27g Ramulus Cinnamomi 20g
Ramulus Mori 27g Pheretima 27g Scorpio 13g Hirudo 27g
Method for making: above ten Six-elements, get Pheretima, Scorpio, be ground into fine powder; 14 flavors such as all the other Radixs Astragali are ground into fine powder, with above-mentioned powder facing-up, sieve, and mixing incapsulates, and makes 1000, promptly.
Embodiment 2:
Prescription: Radix Astragali 66g Radix Paeoniae Rubra 27g Radix Salviae Miltiorrhizae 27g Radix Angelicae Sinensis 27g
Rhizoma Chuanxiong 27g Semen Persicae 27g Flos Carthami 13g Olibanum (system) 13g
Myrrha (processed) 13g Caulis Spatholobi 20g Radix Achyranthis Bidentatae 27g Ramulus Cinnamomi 20g
Ramulus Mori 27g Pheretima 27g Scorpio 13g Hirudo 27g
Method for making:, be ground into fine powder with Pheretima, Scorpio; 14 flavors such as all the other Radixs Astragali are ground into fine powder, with above-mentioned powder facing-up, sieve, and add the pregelatinized Starch of 80g again, with 80% alcohol granulation, add the Pulvis Talci of 5g again, mixing, and compacting is in flakes.
Claims (7)
1, a kind of pharmaceutical composition that is used for the treatment of apoplexy is characterized in that this pharmaceutical composition is to be made by the raw material of following weight ratio:
3～4 parts of 3～4 parts of Radix Angelicae Sinensis of 3～4 parts of Radix Salviae Miltiorrhizaes of 9～10 parts of Radix Paeoniae Rubra of the Radix Astragali
1～2 part of 1～2 part of Olibanum (processed) of 3～4 parts of Flos Carthamis of 3～4 parts of Semen Persicaes of Rhizoma Chuanxiong
2～3 parts of 3～4 parts of Ramulus Cinnamomi of 2～3 parts of Radix Achyranthis Bidentataes of 1～2 portion of Caulis Spatholobi of Myrrha (processed)
3～4 parts of 1～2 portion of Hirudos of 3～4 portions of Scorpios of 3～4 parts of Pheretimas of Ramulus Mori.
2, pharmaceutical composition as claimed in claim 1 is characterized in that the best proportioning of each crude drug is:
27 parts of 27 parts of Radix Angelicae Sinensis of 27 parts of Radix Salviae Miltiorrhizaes of 66 parts of Radix Paeoniae Rubra of the Radix Astragali
13 parts of 13 parts of Olibanum (processed)s of 27 parts of Flos Carthamis of 27 parts of Semen Persicaes of Rhizoma Chuanxiong
20 parts of 27 parts of Ramulus Cinnamomi of 20 parts of Radix Achyranthis Bidentataes of 13 portions of Caulis Spatholobis of Myrrha (processed)
27 parts of 13 portions of Hirudos of 27 portions of Scorpios of 27 parts of Pheretimas of Ramulus Mori.
3, pharmaceutical composition as claimed in claim 1 or 2 is characterized in that being made into useful clinically dosage form, comprises tablet, capsule, granule, soft capsule.
4, preparation is characterized in that this method is: get crude drug in proportion, with Pheretima, Scorpio, be ground into fine powder as the method for pharmaceutical composition as described in the claim 3; All the other Radixs Astragali etc. 14 flavor is ground into fine powder, with above-mentioned powder facing-up, sieves, and mixing adds suitable adjuvant/or directly make required dosage form again.
5, as preparation of drug combination method as described in the claim 4, it is characterized in that the preparation method of tablet is: get crude drug in proportion,, be ground into fine powder with Pheretima, Scorpio; 14 flavors such as all the other Radixs Astragali are ground into fine powder, with above-mentioned powder facing-up, sieve, and add 10～40% pregelatinized Starch mixing again, with 80% alcohol granulation, add 0～5% Pulvis Talci again, mixing, and compacting is in flakes.
6, as preparation of drug combination method as described in the claim 4, it is characterized in that the preparation method of capsule is: get crude drug in proportion,, be ground into fine powder with Pheretima, Scorpio; 14 flavors such as all the other Radixs Astragali are ground into fine powder, with above-mentioned powder facing-up, sieve, and mixing incapsulates, promptly.
7, pharmaceutical composition is used for the treatment of the apoplexy apoplex involving the channels and collaterals in preparation as claimed in claim 1 or 2, and hemiplegia, numb limbs and tense tendons, facial hemiparalysis, the stiff tongue language is stuttering and obstruction of qi in the chest and cardialgia, uncomfortable in chest, cardiopalmus, breathe hard; Cerebral infarction, angina pectoris belong to the application in the medicine of above-mentioned syndrome.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101680756A CN1973865A (en) | 2006-12-25 | 2006-12-25 | Medicine composition for treating apoplexy and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101680756A CN1973865A (en) | 2006-12-25 | 2006-12-25 | Medicine composition for treating apoplexy and its prepn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1973865A true CN1973865A (en) | 2007-06-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101680756A Pending CN1973865A (en) | 2006-12-25 | 2006-12-25 | Medicine composition for treating apoplexy and its prepn |
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| CN (1) | CN1973865A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010053456A1 (en) * | 2008-11-10 | 2010-05-14 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
| CN105106873A (en) * | 2015-10-09 | 2015-12-02 | 李丽芬 | Traditional Chinese medicine recipe for treating cerebral thrombosis sequela |
-
2006
- 2006-12-25 CN CNA2006101680756A patent/CN1973865A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010053456A1 (en) * | 2008-11-10 | 2010-05-14 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
| US8852578B2 (en) | 2008-11-10 | 2014-10-07 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
| US9393290B2 (en) | 2008-11-10 | 2016-07-19 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
| CN105106873A (en) * | 2015-10-09 | 2015-12-02 | 李丽芬 | Traditional Chinese medicine recipe for treating cerebral thrombosis sequela |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Li Jian Document name: Notification that Application Deemed to be Withdrawn |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070606 |