CN1966019A - Effervescence tablet having hawthorn, preparation process and testing method thereof - Google Patents
Effervescence tablet having hawthorn, preparation process and testing method thereof Download PDFInfo
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- CN1966019A CN1966019A CN 200610117738 CN200610117738A CN1966019A CN 1966019 A CN1966019 A CN 1966019A CN 200610117738 CN200610117738 CN 200610117738 CN 200610117738 A CN200610117738 A CN 200610117738A CN 1966019 A CN1966019 A CN 1966019A
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Abstract
The invention relate to effervescent tablets of haw thorn, process of preparation, method for detection and quality control, wherein the effervescent tablets are the conversion to the dose form of electuary, and are prepared from prescription of haw thorn, medicated leaven and malt through steps of extracting, concentrating, spray drying, charging pharmaceutically acceptable excipient, palletizing and tabletting.
Description
Technical field
The present invention relates to a kind of big Fructus Crataegi effervescent tablet and preparation method thereof and quality control, detection method.
Background technology
Dyspepsia is a more general notion, and multiple disease can both cause the symptom of dyspepsia and inappetence, and there is different intensions in each patient's main suit.Comprise inappetence, feed back abdominal distention, dull pain or discomfort, the companion feels sick and belch, and health check-up often has thick fur greasy and dark tenderness of upper abdomen or discomfort.These nonspecific symptoms and sign both can be the performances of some organic disease, also can be nervous dyspepsia, so the sickness rate height.
At present, be used for the treatment of dyspeptic Chinese medicine preparation, as infusion of hawthorn fruit, one of adjuvant of employing is a sucrose, for the use of suffering from some disease such as diabetics, has been subjected to certain limitation, and the adaptation population is narrow.Simultaneously, do not have suitable detection method yet, make the quality control of this medicine be subjected to certain limitation.
Summary of the invention
The technical issues that need to address of the present invention are to disclose a kind of big Fructus Crataegi effervescent tablet and preparation method thereof and detection method, to overcome the above-mentioned defective that prior art exists.
Big Fructus Crataegi effervescent tablet of the present invention comprises treatment effective amount of actives and adjuvant, and the weight content of preferred active component is 0.1～99%;
Said active component is by the feedstock production of following parts by weight ratio:
Fructus Crataegi 5-8 part, Fructus Hordei Germinatus (stir-fry) 1-2 part, Massa Medicata Fermentata 1-2 part;
Every 1g contains total flavones with rutin (C
27H
30O
16) meter, must not be less than 2.5mg.
Fructus Hordei Germinatus (stir-fry) refers to by " regulation of Chinese pharmacopoeia is got clean Fructus Hordei Germinatus and put in the heat pot, constantly stirs, and fries to pale brown color with slow fire.
Said adjuvant comprises sour agent, alkaline agent, correctives and lubricant;
Said sour agent is selected from anhydrous citric acid, malic acid, tartaric acid, fumaric acid or adipic acid, preferably apple acid;
Said alkaline agent is selected from sodium bicarbonate, potassium bicarbonate, natrium carbonicum calcinatum or Anhydrous potassium carbonate, preferred sodium bicarbonate, sodium carbonate;
Said correctives is selected from acesulfame potassium (acesulfame potassium), aspartame or cyclamate etc., preferred acesulfame potassium or cyclamate;
Said lubricant is selected from polyethylene glycol 6000, leucine, magnesium stearate or micropowder silica gel etc., preferred polyethylene glycol 6000 or leucine.
In the side: the Fructus Crataegi sour in the mouth is sweet, and slightly warm in nature is returned spleen, stomach, Liver Channel, and the energy promoting digestion and removing stagnation is good at digesting greasy meat; The Fructus Hordei Germinatus sweet in the mouth, property is flat, and promoting digestion and invigorating the stomach is good at digesting starchiness foods such as rice and flour Rhizoma Dioscoreae; Massa Medicata Fermentata sweet in the mouth suffering, warm in nature, the function stomach function regulating that helps digestion, its acrid in the mouth also has a little effect of inducing sweat, and can be used for the food stagnation dyspepsia that diseases caused by exogenous pathogenic factor cause.Three medicines all have the effect of promoting digestion and removing stagnation, can take into account meat, three kinds of food stagnations that different reason caused of rice and flour and diseases caused by exogenous pathogenic factor again.
The preparation method of the big Fructus Crataegi effervescent tablet of the present invention comprises the steps:
The decocting that raw material Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Massa Medicata Fermentata is added 10～20 times of weight boiled 1～3 hour, extract, extracting solution is concentrated into the clear paste that relative density is 1.04～1.10 (20 ℃), add adjuvant then, spray drying, the method that adopts this area to know altogether again, the back tabletting of granulating promptly obtains big Fructus Crataegi effervescent tablet.
For the ease of the control of quality, the invention provides following detection method:
Qualitative identification:
Get the big Fructus Crataegi effervescent tablet of the present invention 5-10g, porphyrize adds water 30-50ml and makes dissolving, uses the 30-50ml chloroform extraction, divides and gets chloroform layer, and water bath method adds acetone 0.2-0.5ml and makes dissolving as need testing solution.Get 2-5 Keshan short, bristly hair or beard medical material, added the 50-100ml decocting in water 1 hour, use the 50-100ml chloroform extraction, shine medical material solution in pairs with legal system.
Drawing above-mentioned two kinds of solution, 10 μ l respectively, put on same silica GF254 lamellae, is developing solvent with chloroform-methanol (35: 1), launches, and takes out, and dries, and puts under the ultra-violet lamp (254nm) and inspects.In the test sample chromatograph, with the corresponding position of control medicinal material on, show the principal spot of same color.
Assay:
The preparation precision of reference substance solution takes by weighing 5 hours control substance of Rutin 20mg of 120 ℃ of dryings, puts in the 100ml measuring bottle, adds methanol 10ml, and slight fever makes dissolving, puts coldly, adds 60% ethanol dilution to scale, shakes up, and promptly gets (0.2mg/ml).
The preparation precision of standard curve is measured reference substance solution 1.0ml, 2.0ml, 3.0ml, 4.0ml, 5.0ml, puts respectively in the 25ml measuring bottle, respectively adds water to 10ml, add 5% sodium nitrite solution 1ml, mixing was placed 6 minutes, added 10% aluminum nitrate solution 1ml, shake up and placed 6 minutes, hydro-oxidation sodium test solution 10ml adds water to scale again, shakes up, placing 15 minutes, is blank with the reagent corresponding.Measuring trap according to spectrophotography (appendix of Chinese Pharmacopoeia version in 2005) at the wavelength place of 500nm, is vertical coordinate with the trap, and concentration is abscissa, the drawing standard curve.
Algoscopy:
Get the big Fructus Crataegi effervescent tablet of the present invention 10-20g, porphyrize is got 0.5-1.0g, and accurate the title decides, added the 40-60% alcohol reflux 1 hour, filter, clean filtering residue and filter with 40-60% ethanol, merging is placed on and is concentrated into 2-5ml in the water-bath, quantitatively be transferred to the polyamide column (2g that has handled, 100～200 orders, column internal diameter 1.6cm, wet method dress post, water in advance 50ml eluting) on, placed 15 minutes, water 50-100ml eluting discards water liquid, reuse 40-60% ethanol 100ml eluting, collect eluent and put in the 100ml measuring bottle, add water to scale, shake up.Precision is measured 10ml, puts in the 25ml measuring bottle, and the method under the preparation of sighting target directrix curve from " adding 5% sodium nitrite solution 1ml ", is measured trap in accordance with the law, filters before measuring, and reads the weight of rutin the need testing solution from standard curve, calculates, promptly.
Animal experiment proves that big Fructus Crataegi effervescent tablet of the present invention can reduce rat gastric juice pH value, increases gastric secretion, improves free acidity, obviously increases the ability of rat gastric juice digesting protein, shows that it is aid digestion, the appetizing function is remarkable.General dosage is 5～15.5 gram crude drug in whole/sky/people, specifically can be determined by the doctor according to patient's concrete conditions such as the state of an illness.
Big Fructus Crataegi effervescent tablet of the present invention adopts advanced drying process with atomizing on the basis that keeps the former technology of infusion of hawthorn fruit, dry granulation, tabletting form.Deducted adjuvant sucrose in the prepared process, adopted the Sugarless type adjuvant, simultaneously, because the dissolving of effervescent tablet effervescent is interesting strong, the dosage form novelty also is applicable to high-grade white collar crowd, fashion youth and child etc., has enlarged suitable crowd.
The specific embodiment
Embodiment 1
(1) batching takes by weighing Fructus Crataegi 500kg, Fructus Hordei Germinatus 100kg, Massa Medicata Fermentata 100kg part, maltodextrin 100kg, citric acid 100kg, sodium carbonate 20kg, sodium bicarbonate 10kg, polyethylene glycol 6000 20kg part, acesulfame potassium 2kg, cyclamate 5kg, leucine 20kg.
(2) extract, concentrate Fructus Crataegi, Fructus Hordei Germinatus (stir-frys), the Massa Medicata Fermentata got after the weighing and add water and extract twice, add 8 times of water gagings for the first time, add 6 times of water gagings the second time, decocted 1 hour at every turn, and it is 1.05 (20 ℃) that extracting solution is concentrated into relative density.
(3) spray drying is got the clear paste after concentrating, and adds maltodextrin 100kg spray drying.
(4) granulate: spray drying powder is mixed dry granulation with citric acid 100kg, sodium carbonate 20kg, sodium bicarbonate 10kg, polyethylene glycol 6000 20kg part, acesulfame potassium 2kg, cyclamate 5kg.
(5) tabletting: add leucine 20kg in the granule and mix the back tabletting.
Embodiment 2
Take by weighing Fructus Crataegi 800kg, Fructus Hordei Germinatus (stir-fry) 200kg, Massa Medicata Fermentata 200kg, maltodextrin 200kg, citric acid 20kg, sodium carbonate 40kg, sodium bicarbonate 20kg, polyethylene glycol 6000 40kg, acesulfame potassium 4kg, cyclamate 10kg, leucine 40kg.
Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), the Massa Medicata Fermentata got after the weighing add water and extract twice, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, and each 1 hour, it was 1.10 that extracting solution is concentrated into relative density.
Get the clear paste after concentrating, add the maltodextrin spray drying.
Spray drying powder is mixed dry granulation with citric acid, sodium carbonate, sodium bicarbonate, polyethylene glycol 6000, acesulfame potassium, cyclamate.
Add leucine in the granule and mix the back tabletting.
Embodiment 3
The qualitative identification of big Fructus Crataegi effervescent tablet
Get the product 8g of embodiment 1, porphyrize adds water 50ml and makes dissolving, uses the 50ml chloroform extraction, divides and gets chloroform layer, and water bath method adds acetone 0.5ml and makes dissolving as need testing solution.
Get 5 Keshan short, bristly hair or beard medical materials, added the 100ml decocting in water 1 hour, use the 100ml chloroform extraction, shine medical material solution in pairs with legal system.
Drawing above-mentioned two kinds of solution, 10 μ l respectively, put on same silica GF254 lamellae, is developing solvent with chloroform-methanol (35: 1, volume ratio), launches, and takes out, and dries, and puts under the ultra-violet lamp (254nm) and inspects.In the test sample chromatograph, with the corresponding position of control medicinal material on, show the principal spot of same color.
Embodiment 4
The assay of big Fructus Crataegi effervescent tablet
The preparation precision of reference substance solution takes by weighing 5 hours control substance of Rutin 20mg of 120 ℃ of dryings, puts in the 100ml measuring bottle, adds methanol 10ml, and slight fever makes dissolving, puts coldly, adds 60% ethanol dilution to scale, shakes up, and promptly gets (0.2mg/ml).
The preparation precision of standard curve is measured reference substance solution 1.0ml, 2.0ml, 3.0ml, 4.0ml, 5.0ml, puts respectively in the 25ml measuring bottle, respectively adds water to 10ml, add 5% sodium nitrite solution 1ml, mixing was placed 6 minutes, added 10% aluminum nitrate solution 1ml, shake up and placed 6 minutes, hydro-oxidation sodium test solution 10ml adds water to scale again, shakes up, placing 15 minutes, is blank with the reagent corresponding.Measuring trap according to spectrophotography (appendix of Chinese Pharmacopoeia version in 2005) at the wavelength place of 500nm, is vertical coordinate with the trap, and concentration is abscissa, the drawing standard curve.
Algoscopy is got the product 20g of embodiment 1, porphyrize is got 0.8g, and accurate the title decides, added volumetric concentration and be 60% alcohol reflux 1 hour, filtering, is that 60% ethanol cleans filtering residue and filter with volumetric concentration, merges to be placed on to be concentrated into 5ml in the water-bath, quantitatively be transferred to the polyamide column (2g that has handled, 100～200 orders, column internal diameter 1.6cm, wet method dress post, water in advance 50ml eluting) on, placed 15 minutes, water 100ml eluting discards water liquid, the reuse volumetric concentration is 60% ethanol 100ml eluting, collect eluent and put in the 100ml measuring bottle, add water to scale, shake up.Precision is measured 10ml, puts in the 25ml measuring bottle, and the method under the preparation of sighting target directrix curve from " adding 5% sodium nitrite solution 1ml ", is measured trap in accordance with the law, filters before measuring, and reads the weight of rutin the need testing solution from standard curve, calculates, promptly.
The every 1g of this product contains total flavones with rutin (C
27H
30O
16) meter, be 3.3mg.
Embodiment 5
Pharmacodynamics test
Experiment material
One, animal: Wistar rat, 180-250g.
Two, medicine and reagent
The big Fructus Crataegi effervescent tablet of embodiment 1
Infusion of hawthorn fruit: Shanghai Fuxing Linxi Medicine Industry Co., Ltd provides.Lot number: 051001
Compound method: take by weighing an amount of Fructus Crataegi effervescent tablet, infusion of hawthorn fruit greatly and be dissolved in the distilled water, be concentrated into and use concentration.
Ether, 0.01mol/L NaOH solution, 0.05mol/L hydrochloric acid solution etc.
Method and result
One, to the excretory influence of rat gastric juice
Get rat and be divided into big Fructus Crataegi effervescent tablet group, infusion of hawthorn fruit group and matched group at random.Big Fructus Crataegi effervescent tablet, infusion of hawthorn fruit group, ig administration 0.5g/kg (primary dose, below all by primary dose), once a day, totally three days; Matched group waits the normal saline of capacity.Equal fasting is 24 hours after the last administration, can't help water.Under etherization, adopt pylorus ligature law to collect gastric juice.Behind the surgical ligation pylorus, again at duodenal administration once, fasting is prohibited water and is won full stomach after 3 hours, cleans bloodstain with filter paper, cuts off gastral cavity along the bight side, goes out gastric content just, is collected in the graduated centrifuge tube record gastric juice amount.Survey the gastric content pH value with special pH test paper, centrifugal 10 minutes again with 2000r/min speed, accurately write down the gastric juice amount, get supernatant 1ml, adopt acid-base titrations, to the orange-yellow NaOH solution amount that is spent for the free acid terminal point occurring, continue titration to cherry-red occurring with 0.02mol/L NaOH titration, the NaOH total amount that record spends is the total acidity terminal point.
Gastric juice amount (ml) * 1000 is got in free acid (mol/L)=0.02 * free acid terminal point amount (ml)/titration
Gastric juice amount (ml) * 1000 is got in total acidity (mol/L)=0.02 * total acid terminal point amount (ml)/titration
The result: big Fructus Crataegi effervescent tablet, infusion of hawthorn fruit all can reduce rat gastric juice pH value, increase gastric secretion, and improve free acidity (seeing Table 1).
Two, to the pepsic influence of rat
Animal grouping, administration and gastric juice collection method are with experiment one.Take wheat Te Shi method to survey pepsic activity.Get the conical flask that gastric juice 1ml to be measured puts into the hydrochloric acid 15ml that fills 0.05mol/L, after shaking up, put into 2 of previously prepared albumen capillary glass tubies, jump a queue, 370C was hatched 24 hours, surveyed the length of broken pipe both sides transparent part, with the pepsic unit of meansigma methods 2 * 16 expressions of four ends.Find out that by table 1 big Fructus Crataegi effervescent tablet, infusion of hawthorn fruit can obviously increase the ability of rat gastric juice digesting protein.
Table 1 rat gastric juice and pepsic influence (x ± SD)
| Group | Number of animals (only) | Gastric juice PH value | Gastric juice amount (ml) | Free acid (mol/L) | Total acidity (mol/L) | Pepsin |
| Matched group groups of grains effervescent tablet group | 12 11 11 | 3.5±0.7 2.4±0.4 2.2±0.8 | 3.2±0.6 4.2±0.3 * 4.0±0.8 * | 65.3±9.6 84.1±8.8 ** 82.5±5.3 * | 121.3±14.2 146.4±11.5 141.3±10.1 | 160.1±51.7 217.5±40.5 201.1±62.0 |
Three, to the influence of rat blood serum pancreatic amylase (AMS)
Animal grouping, medication are with experiment one.After the last administration 1 hour, get blood, centrifuging and taking serum is surveyed pancreatic amylase.
Though the big Fructus Crataegi effervescent tablet of result, infusion of hawthorn fruit increase than matched group, learn by statistics and handle no significant difference (seeing Table 2).
The influence of table 2 pair rat blood serum pancreatic amylase (x ± SD)
| Group | Number of animals (only) | Serum pancreatic amylase (unit) |
| Matched group groups of grains effervescent tablet group | 10 10 10 | 1102.5±165.2 1231.4±173.1 1196.3±191.7 |
Sum up
Dyspepsia is a more general notion, and multiple disease can both cause the symptom of dyspepsia and inappetence, so the sickness rate height.
Big Fructus Crataegi effervescent tablet of the present invention is a dosage changing form and getting on the infusion of hawthorn fruit basis, is made up of Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus.The Fructus Crataegi sour in the mouth is sweet, and slightly warm in nature is returned spleen, stomach, Liver Channel, and the energy promoting digestion and removing stagnation is good at digesting greasy meat; The Fructus Hordei Germinatus sweet in the mouth, property is flat, and promoting digestion and invigorating the stomach is good at digesting starchiness foods such as rice and flour Rhizoma Dioscoreae; Massa Medicata Fermentata sweet in the mouth suffering, warm in nature, the function stomach function regulating that helps digestion, its acrid in the mouth also has a little effect of inducing sweat, and can be used for the food stagnation dyspepsia that diseases caused by exogenous pathogenic factor cause.Three medicines all have the effect of promoting digestion and removing stagnation, can take into account meat, three kinds of food stagnations that different reason caused of rice and flour and diseases caused by exogenous pathogenic factor again, and real is the good medicine of appetite-stimulating indigestion-relieving, can be widely used in inappetence, dyspepsia.
Pharmacological evaluation shows that big Fructus Crataegi effervescent tablet can reduce rat gastric juice pH value, increases gastric secretion, improves free acidity, obviously increases the ability of rat gastric juice digesting protein, shows that it is aid digestion, the appetizing function is remarkable, and is consistent with clinical practice.
Claims (6)
1. one kind big Fructus Crataegi effervescent tablet is characterized in that, comprises treatment effective amount of actives and adjuvant, and said active component is by the feedstock production of following parts by weight ratio:
Fructus Crataegi 5-8 part, Fructus Hordei Germinatus (stir-fry) 1-2 part, Massa Medicata Fermentata 1-2 part;
Said adjuvant comprises sour agent, alkaline agent, correctives and lubricant.
2. big Fructus Crataegi effervescent tablet according to claim 1 is characterized in that every 1g contains total flavones with rutin (C
27H
30O
16) meter, must not be less than 2.5mg.
3. big Fructus Crataegi effervescent tablet according to claim 1 is characterized in that said sour agent is selected from anhydrous citric acid, malic acid, tartaric acid, fumaric acid or adipic acid;
Said alkaline agent is selected from sodium bicarbonate, potassium bicarbonate, natrium carbonicum calcinatum or Anhydrous potassium carbonate;
Said correctives is selected from acesulfame potassium, aspartame or cyclamate;
Said lubricant is selected from polyethylene glycol 6000, leucine, magnesium stearate or micropowder silica gel.
4. the method for preparing the described big Fructus Crataegi effervescent tablet of claim 1, it is characterized in that, comprise the steps: raw material Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Massa Medicata Fermentata are added water and extract, extracting solution is concentrated into the clear paste that relative density is 1.04～1.10 (20 ℃), add adjuvant then, spray drying, the method that adopts this area to know altogether again, tabletting after granulating promptly obtains the suitable big Fructus Crataegi effervescent tablet of taste.
5. method according to claim 4 is characterized in that, the decocting that raw material Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Massa Medicata Fermentata is added 10～20 times of weight boiled 1～3 hour, extracted.
6. test right requires quality control, the detection method of 1 described big Fructus Crataegi effervescent tablet, it is characterized in that, comprises the steps:
Qualitative identification:
Get the big Fructus Crataegi effervescent tablet of the present invention 5-10g, porphyrize adds water 30-50ml and makes dissolving, uses the 30-50ml chloroform extraction, divides and gets chloroform layer, and water bath method adds acetone 0.2-0.5ml and makes dissolving as need testing solution.Get 2-5 Keshan short, bristly hair or beard medical material, added the 50-100ml decocting in water 1 hour, use the 50-100ml chloroform extraction, shine medical material solution in pairs with legal system.
Drawing above-mentioned two kinds of solution, 10 μ l respectively, put on same silica GF254 lamellae, is developing solvent with chloroform-methanol (35: 1), launches, and takes out, and dries, and puts under the ultra-violet lamp (254nm) and inspects.In the test sample chromatograph, with the corresponding position of control medicinal material on, show the principal spot of same color.
Assay:
The preparation precision of reference substance solution takes by weighing 5 hours control substance of Rutin 20mg of 120 ℃ of dryings, puts in the 100ml measuring bottle, adds methanol 10ml, and slight fever makes dissolving, puts coldly, adds 60% ethanol dilution to scale, shakes up, and promptly gets (0.2mg/ml).
The preparation precision of standard curve is measured reference substance solution 1.0ml, 2.0ml, 3.0ml, 4.0ml, 5.0ml, puts respectively in the 25ml measuring bottle, respectively adds water to 10ml, add 5% sodium nitrite solution 1ml, mixing was placed 6 minutes, added 10% aluminum nitrate solution 1ml, shake up and placed 6 minutes, hydro-oxidation sodium test solution 10ml adds water to scale again, shakes up, placing 15 minutes, is blank with the reagent corresponding.Measuring trap according to spectrophotography at the wavelength place of 500nm, is vertical coordinate with the trap, and concentration is abscissa, the drawing standard curve.
Algoscopy:
Get the big Fructus Crataegi effervescent tablet of the present invention 10-20g, porphyrize is got 0.5-1.0g, and accurate the title decides, added the 40-60% alcohol reflux 1 hour, filter, clean filtering residue and filter with 40-60% ethanol, merging is placed on and is concentrated into 2-5ml in the water-bath, quantitatively be transferred to the polyamide column (2g that has handled, 100～200 orders, column internal diameter 1.6cm, wet method dress post, water in advance 50ml eluting) on, placed 15 minutes, water 50-100ml eluting discards water liquid, reuse 40-60% ethanol 100ml eluting, collect eluent and put in the 100ml measuring bottle, add water to scale, shake up.Precision is measured 10ml, puts in the 25ml measuring bottle, and the method under the preparation of sighting target directrix curve from " adding 5% sodium nitrite solution 1ml ", is measured trap in accordance with the law, filters before measuring, and reads the weight of rutin the need testing solution from standard curve, calculates, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610117738 CN1966019A (en) | 2006-10-30 | 2006-10-30 | Effervescence tablet having hawthorn, preparation process and testing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610117738 CN1966019A (en) | 2006-10-30 | 2006-10-30 | Effervescence tablet having hawthorn, preparation process and testing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1966019A true CN1966019A (en) | 2007-05-23 |
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ID=38075112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610117738 Pending CN1966019A (en) | 2006-10-30 | 2006-10-30 | Effervescence tablet having hawthorn, preparation process and testing method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315361A (en) * | 2013-07-15 | 2013-09-25 | 于法周 | Processing method for haw electuary |
| CN104705762A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Plum juice effervescent tablet |
| CN108426959A (en) * | 2018-05-14 | 2018-08-21 | 山东省中医药研究院 | A kind of construction method of haw flavonoids substances UPLC finger-prints |
| CN112076294A (en) * | 2020-10-15 | 2020-12-15 | 贵州省生物技术研究开发基地 | Stomach-power-promoting medicine and preparation method and application thereof |
-
2006
- 2006-10-30 CN CN 200610117738 patent/CN1966019A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315361A (en) * | 2013-07-15 | 2013-09-25 | 于法周 | Processing method for haw electuary |
| CN103315361B (en) * | 2013-07-15 | 2014-10-08 | 于法周 | Processing method for haw electuary |
| CN104705762A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Plum juice effervescent tablet |
| CN108426959A (en) * | 2018-05-14 | 2018-08-21 | 山东省中医药研究院 | A kind of construction method of haw flavonoids substances UPLC finger-prints |
| CN108426959B (en) * | 2018-05-14 | 2021-06-01 | 山东省中医药研究院 | Method for constructing UPLC fingerprint spectrum of hawthorn flavonoid component |
| CN112076294A (en) * | 2020-10-15 | 2020-12-15 | 贵州省生物技术研究开发基地 | Stomach-power-promoting medicine and preparation method and application thereof |
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