CN1965991A - 一种治疗精索静脉曲张的中药制剂 - Google Patents
一种治疗精索静脉曲张的中药制剂 Download PDFInfo
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- CN1965991A CN1965991A CNA2006101548220A CN200610154822A CN1965991A CN 1965991 A CN1965991 A CN 1965991A CN A2006101548220 A CNA2006101548220 A CN A2006101548220A CN 200610154822 A CN200610154822 A CN 200610154822A CN 1965991 A CN1965991 A CN 1965991A
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Abstract
一种治疗精索静脉曲张的中药制剂,其活性成分由下列重量配比的原料制成:防风6-12、白芷6-9、陈皮8-10、赤芍6-9、当归9-12、炮山甲9-12、皂角刺9-12、没药3-5、甘草4-6、金银花10-15、天花粉10-15、柴胡4-6、浙贝母9-12、乳香3-6、黄柏8-10、车前子8-10。制备的药物为下列之一的剂型:口服液、胶囊、片剂、丸剂或散剂。本发明不仅能行气活血、清热解毒、疏肝开郁,改善精索、睾丸内血液循环,有效地缓解症状、提高精子成活率,而且对人体气血及五脏生理功能具有协调平衡,调理气机,达到治病求本的目的,且具有剂量轻、疗效确切、疗程短、治愈率高、减少复发率、副作用小等优点。
Description
技术领域
本发明涉及一种中药制剂,更具体的是涉及一种治疗精索静脉曲张的中药制剂,适合于治疗原发性精索静脉曲张。
背景技术
精索静脉曲张系精索静脉回流受阻或者瓣膜失效血液返流引起血液瘀滞,导致蔓状静脉迂曲扩张。发病率在男性人群中为10-15%,多见于青壮年。在男性不育人群中占15-20%。原发性精索静脉曲张,除外下腔静脉内形成癌拴或腹膜后肿瘤压迫、肾积水或异位血管等引起继发性精索静脉曲张,左侧精索静脉成直角回流于肾静脉、缺少瓣膜或者瓣膜功能不全等因素导致精索内静脉血液返流、蔓状静脉丛淤血扩张。由于精索静脉扩张,睾丸、副睾内血液瘀滞、缺氧和毒性代谢产物堆积,妨碍精子生成和成熟,从而导致了男性不育症。患此症病人站立时阴囊胀大,有沉重坠胀感,可向下腹部、腹股沟或腰部放射,久立后加重,平卧休息后减轻。
目前治疗现状,对于精索静脉曲张伴有不育或者精液异常者、有明显症状者采用手术治疗。药物治疗效果不佳。
发明内容
本发明的目的提供是一种治疗原发性精索静脉曲张中药制剂,其活性成分由下列重量配比的原料制成:防风6-12、白芷6-9、陈皮8-10、赤芍6-9、当归9-12、炮山甲9-12、皂角刺9-12、没药3-5、甘草4-6、金银花10-15、天花粉10-15、柴胡4-6、浙贝母9-12、乳香3-6、黄柏8-10、车前子8-10。
本发明制备的药物为下列之一的剂型:口服液、胶囊、片剂、丸剂、散剂。
在上述制剂组成中,金银花含绿原酸、异绿原酸、黄酮类物质、忍冬甙、肌醇及微量挥发油等,浙贝母含甾醇类生物碱,含蛋白质、多糖类、氨基酸类等,天花粉含蛋白质、多糖类、氨基酸类等,甘草含三萜皂甙甘草素(即甘草甜素),还含有还原糖、淀粉及胶质等成分。金银花、浙贝母、天花粉、甘草清热散结作用。当归含藁本内酯、正丁烯内酯、当归酮、香荆芥酚等,赤芍含芍药甙、芍药内酯甙、氧化芍药甙、苯甲酰芍药甙、芍药吉酮、芍药新甙、胡萝卜甙等,乳香含树脂、树胶、挥发油等,没药含树脂、,挥发油(主为丁香酚、间苯甲酚等)、树胶(解成阿拉伯糖、半乳糖及木糖等)等。当归、赤芍、乳香、没药活血散瘀作用。炮山甲含蛋白质、无机盐等,皂角刺含皂荚皂甙B-G、棕榈酸、硬酯酸、油酸、亚甾醇、谷甾醇、二十九碳烷等。炮山甲、皂角刺消肿攻坚作用。陈皮含挥发油,油中主要成分为右旋柠檬烯、柠檬醛等。黄酮类化合物等;理气作用。防风含挥发油、甘露醇、苦味甙、酚类、多糖类及有机酸等,白芷含异欧前胡素、欧前胡素)、佛手柑内酯、珊瑚菜素、氧化前胡素等。防风、白芷走经络而行诸药。黄柏含小蘖碱、黄柏碱、黄柏内酯、黄柏酮、木兰花碱、掌叶防已碱等,车前子含多量粘液质、桃叶珊瑚甙,并含车前子酸、胆碱、腺嘌呤、琥珀酸、树脂等。黄柏、车前子泄下焦之火作用。柴胡含柴胡皂甙a~d,并含菠甾醇、豆甾醇、Δ22-豆甾烯醇、福寿草醇)及少量挥发油;引药入肝经。全方达到破瘀解毒散结之功效。
本发明的优点是:不仅能行气活血、清热解毒、疏肝开郁,改善精索、睾丸内血液循环,有效地缓解症状、提高精子成活率,而且对人体气血及五脏生理功能具有协调平衡,调理气机,达到治病求本的目的。本发明能改善或者消除原发性精索静脉曲张临床症状和男性不育症,根据门诊疗效随访,临床不适症状改善或者消失有效率可达82%,治愈男性不育症有效率达46%。而且具有剂量轻、疗效确切、疗程短、治愈率高、减少复发率、副作用小等优点。
具体实施方式
下面结合实施例对本发明作进一步的说明。
实施例1
组方及各组分重量份比为:防风7、白芷7、陈皮7、赤芍7、当归10、炮山甲12、皂角刺12、没药3、甘草5、金银花12、天花粉12、柴胡5、浙贝母12、乳香3、黄柏10、车前子10。
将上述组分按重量份称取后,将原料按常规口服液生产工艺制成口服液。
实施例2
组方及各组分重量份比为:防风9、白芷9、陈皮10、赤芍8、当归12、炮山甲10、皂角刺9、没药3、甘草4、金银花10、天花粉12、柴胡4、浙贝母12、乳香3、黄柏8、车前子8。
将上述组分按重量份称取后,将原料按常规蜜丸生产工艺制成蜜丸。
实施例3
组方及各组分重量份比为:防风8、白芷8、陈皮10、赤芍9、当归12、炮山甲12、皂角刺10、没药3、甘草4、金银花10、天花粉12、柴胡4、浙贝母9、乳香5、黄柏8、车前子8。
将上述组分按重量份称取后,将原料按常规片剂生产工艺制成片剂。
实施例4
组方及各组分重量份比为:防风12、白芷9、陈皮10、赤芍9、当归12、炮山甲12、皂角刺10、没药5、甘草6、金银花15、天花粉15、柴胡6、浙贝母12、乳香6、黄柏10、车前子10。
将上述组分按重量份称取后,将原料按常规胶囊生产工艺制成胶囊。
实施例5
组方及各组分重量份比为:防风10、白芷8、陈皮10、赤芍9、当归12、炮山甲10、皂角刺9、没药5、甘草6、金银花15、天花粉12、柴胡6、浙贝母12、乳香6、黄柏10、车前子10。
将上述组分按重量份称取后,将原料按常规散剂生产工艺制成散剂。
实施例6
取实例1制备的口服液选择临床诊断为原发性精索静脉曲张的患者100例,给予服用口服液,服药剂量根据年龄、体重、疾病严重程度等变化,每日2次,每次10-30ml,3周为一疗程,随访36月。疗效判断标准:临床症状消失、精液恢复正常,停药后无复发,为临床治愈;临床症状减轻或者精液好转为有效;仅临床症状减轻为缓解。结果:治愈42例,治愈率42%;有效19例,有效率19%;症状缓解21例,缓解率21%;总有效率达82%。
无需进一步详细阐诉,相信采用前面所公开的内容,本领域技术人员可最大限度的应用本发明。因此,前面的实施方案应理解为仅为举例说明,而非以任何形式限制本发明的范围。
Claims (2)
1.一种治疗精索静脉曲张中药制剂,其特征是:其活性成分由下列重量配比的原料制成:
防风6-12 白芷6-9 陈皮8-10 赤芍6-9
当归9-12 炮山甲9-12 皂角刺9-12 没药3-5
甘草4-6 金银花10-15 天花粉10-15 柴胡4-6
浙贝母9-12 乳香3-6 黄柏8-10 车前子8-10
2.根据权利要求1所述的一种治疗精索静脉曲张中药制剂,制备的药物为下列之一的剂型:口服液、胶囊、片剂、丸剂或散剂。
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Cited By (4)
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CN101199794B (zh) * | 2007-12-17 | 2010-10-20 | 邓兰芹 | 一种治疗精索静脉曲张的药物 |
CN101199792B (zh) * | 2007-12-17 | 2010-12-01 | 朱红民 | 一种治疗精索静脉曲张的药物组合物 |
CN101204455B (zh) * | 2007-12-19 | 2012-05-30 | 赵秀荣 | 一种治疗精索静脉曲张的中药制剂 |
CN109288979A (zh) * | 2018-11-16 | 2019-02-01 | 南京长江医院集团有限公司 | 生精育子汤 |
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CN1247233C (zh) * | 2004-06-04 | 2006-03-29 | 刘俊清 | 一种治疗静脉曲张的中药 |
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Cited By (4)
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CN101199794B (zh) * | 2007-12-17 | 2010-10-20 | 邓兰芹 | 一种治疗精索静脉曲张的药物 |
CN101199792B (zh) * | 2007-12-17 | 2010-12-01 | 朱红民 | 一种治疗精索静脉曲张的药物组合物 |
CN101204455B (zh) * | 2007-12-19 | 2012-05-30 | 赵秀荣 | 一种治疗精索静脉曲张的中药制剂 |
CN109288979A (zh) * | 2018-11-16 | 2019-02-01 | 南京长江医院集团有限公司 | 生精育子汤 |
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