CN1965816A - Medicament for preventing and treating bacterial disease of domestic silkworm and preparation process thereof - Google Patents
Medicament for preventing and treating bacterial disease of domestic silkworm and preparation process thereof Download PDFInfo
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- CN1965816A CN1965816A CN 200610070388 CN200610070388A CN1965816A CN 1965816 A CN1965816 A CN 1965816A CN 200610070388 CN200610070388 CN 200610070388 CN 200610070388 A CN200610070388 A CN 200610070388A CN 1965816 A CN1965816 A CN 1965816A
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- bacterial disease
- florfenicol
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Abstract
The invention relates to a drug used to prevent cultivated silkworm bacterial, wherein said drug is formed by fluorobenzene and 99-95% alcohol at 0.5-5:100 ration. And the production comprises that: using 60-80% of 99-95% alcohol into liquid pot; adding fluorobenzene powder into liquid pot; mixing, dissolving, and adding left alcohol into liquid pot, mixing for 5-10min; mixing and using 0.8um titanium rod filter to filter the drug into liquid storage pot; packing, and sealing. The inventive drug can completely treat silkworm bacterial, and restrain bacterial.
Description
Affiliated technical field
The present invention relates to silkworm and use the anti-disease medicines technical field, specifically a kind of be used to breed silkworms freshen the medicine of food.
The invention still further relates to a kind of preparation method of preventing and treating the bacterial disease of domestic silkworm medicine.
Background technology
In recent years, because the change of sericulture mode, the adjustment of sericulture structure and the variation of climate, all multifactor influences such as mulberry tree breed and the variation of fertile training management mode, family's flacherie is the situation that large tracts of land is broken out, and average attack rate reaches about 5%, accounts for more than 20% of silkworm sickness rate.Wherein, bacterial disease is one of main disease of harm silkworm production, and especially sickness rate height, the scope in summer and autumn is wide, loss is big.And the main medicine of current control bacterial disease of domestic silkworm is chloromycetin, erythromycin and xacin-series etc.Though these medicines have certain curative effect to the control of bacterial disease of domestic silkworm, be not very desirable as the special-purpose medicaments of preventing and treating bacterial disease of domestic silkworm.Long and disabled as, chloromycetin because of residence time in vivo, erythromycin then because of poorly water-soluble, quality is unstable is difficult to promote aborning, the prevention effect of xacin-series medicine is poor, is difficult to reach the purpose of killing the silkworm antibacterial.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, provide a kind of prevention effect good, technology is simple, and production cost is low, the control bacterial disease of domestic silkworm medicine that does not pollute the environment.
Another purpose of purpose of the present invention provides a kind of preparation method of preventing and treating the bacterial disease of domestic silkworm medicine.
Florfenicol (Florfeninol) claims Florfenicol or fluorinated chloramphenicol again, is the chemical improvement product of chloromycetin, and it is the broad spectrum antimicrobicide of the known veterinary's of being usually used in purpose.Florfenicol has active antibiotics to multiple pathogenicity veterinary bacteria.The medicine of this control bacterial disease of domestic silkworm of the present invention is with the antibacterial of florfenicol as the control bacterial disease of domestic silkworm.Specifically combined by florfenicol and 99-95% ethanol, its proportioning is 0.5～5: 100.
A kind of preparation method of preventing and treating the bacterial disease of domestic silkworm medicine of the present invention: elder generation packs into 60～80% of 99-95% amount of alcohol in the Agitation Tank, slowly add florfenicol powder in the Agitation Tank by proportioning again, again the ethanol of surplus 20～40% is packed into after the stirring and dissolving in the Agitation Tank, continue to stir 5～10 minutes, fully behind the mixing with the titanium rod filter of 0.8um with medical filtration to storing in the liquid filling, canned at last, seal made medicine.
Through evidence, medicine of the present invention reaches 100% to the control rate of bacterial disease of domestic silkworm, but also can suppress the generation of virosis effectively, compares with chloromycetin, erythromycin and xacin-series medicine commonly used at present, has better prevention effect and application prospect.
1, preventive effect
From following table 1 as can be seen: each concentration of treatment of florfenicol all has preventive effect to bacterial disease, when drug level was 60mg/L, the sickness rate of septicaemia only was 1.7%, and comparison is according to medicine low 8.3%, the septicemic cemia sickness rate of spirit bacterium is 33.3%, and comparison is according to medicine low 31.7%.Preventive effect is very remarkable, obviously is better than contrasting medicament.
Table 1 florfenicol solution is to the preventive effect of bacterial disease
| Handle | Black breast deteriorated blood bacterium | The spirit bacterium | |||
| Medicine | Concentration (mg/L) | Sick silkworm is counted % | Sickness rate (%) | Sick silkworm number | Sickness rate (%) |
| Florfenicol | 20 | 1.7 | 8.5 | 9.3 | 46.5 |
| 60 | 0.3 | 1.7 | 6.7 | 33.3 | |
| 120 | 0 | 0 | 5.3 | 26.7 | |
| 180 | 0 | 0 | 5.7 | 28.3 | |
| Chloromycetin | 250 | 2 | 10 | 13 | 65 |
| Poison is right | 20 | 100 | 20 | 100 | |
| Empty right | 0 | 0 | 0 | 0 | |
2, therapeutic effect
From following table 2 as can be seen: each concentration of treatment of florfenicol all has therapeutic effect to bacterial disease.When drug level was 120mg/L, the sickness rate of septicaemia was zero, and comparison is low by 10% according to medicine, and the septicemic cemia sickness rate of clever bacterium is 35%, and comparison is according to medicine low 30%.Therapeutic effect is very remarkable, obviously is better than contrasting medicament chloromycetin.
Table 2 florfenicol solution is to the therapeutic effect of bacterial disease
| Handle | Black breast deteriorated blood bacterium | The spirit bacterium | |||
| Medicine | Concentration (mg/L) | Sick silkworm number | Sickness rate (%) | Sick silkworm number | Sickness rate (%) |
| Florfenicol | 20 | 3.7 | 18.3 | 12.3 | 61.7 |
| 60 | 2.3 | 11.7 | 9.7 | 48.3 | |
| 120 | 0 | 0 | 7 | 35 | |
| 180 | 0 | 0 | 7.3 | 36.7 | |
| Chloromycetin | 250 | 2 | 10 | 13 | 65 |
| Poison is right | 20 | 100 | 20 | 100 | |
| Empty right | 0 | 0 | 0 | 0 | |
3, prophylactic treatment effect
From following table 3 as can be seen: each concentration of treatment of florfenicol all has the prophylactic treatment effect to bacterial disease.When drug level reached 60mg/L, the sickness rate of septicaemia was zero, and comparison is low by 11.6% according to medicine, and the septicemic cemia sickness rate of clever bacterium is 25%, and comparison is according to medicine low 38.3%.Therapeutic effect is very remarkable, obviously is better than contrasting medicament chloromycetin.
Table 3 florfenicol solution is to the prophylactic treatment effect of bacterial disease
| Handle | Black breast deteriorated blood bacterium | The spirit bacterium | |||
| Medicine | Concentration (mg/L) | Sick silkworm number | Sickness rate (%) | Sick silkworm number | Sickness rate (%) |
| Florfenicol | 20 | 1 | 5 | 9 | 45 |
| 60 | 0 | 0 | 5 | 25 | |
| 120 | 0 | 0 | 4.7 | 23.3 | |
| 180 | 0 | 0 | 4.7 | 23.3 | |
| Chloromycetin | 250 | 2.3 | 11.6 | 12.7 | 63.3 |
| Poison is right | 20 | 100 | 20 | 100 | |
| Empty right | 0 | 0 | 0 | 0 | |
4, pilot production
Selected three sericulture families of multiple bacterial gastroenteritis over the years in the scope of Juxian County, Shandong Province, its number kind of breeding silkworms is by 25000 calculating.
From following table 4 as can be seen: chemicals treatment district average attack rate is 0.3%, and blank district sickness rate is 14.6%, has reduced by 14.3%, and cure rate reaches 97.9%, add the food medicament after the bacterial gastroenteritis at three families significantly reduce.Wherein, householder B chemicals treatment district sickness rate is 0.5%, and blank district sickness rate is 26.6%, has reduced by 26.1%, and cure rate reaches 98.5%, and effect is very remarkable.And silkworm physiology, cocoon quality, silk quality all had no adverse effects
Table 4 pilot production drug effect result
| Householder's numbering | The chemicals treatment district | The blank district | ||||
| A sericulture number | A morbidity number | Sickness rate (%) | A sericulture number | A morbidity number | Sickness rate (%) | |
| A | 23500 | 25 | 0.1 | 4700 | 17 | 0.4 |
| B | 35250 | 167 | 0.5 | 11750 | 3126 | 26.6 |
| C | 32900 | 76 | 0.2 | 7050 | 286 | 4.1 |
| On average | 91650 | 268 | 0.3 | 23500 | 3429 | 14.6 |
The specific embodiment
Embodiment 1:
Preparation 100ml medicine.With florfenicol 1.5g and 95% ethanol 100ml.Elder generation packs into 95% ethanol 70ml in the Agitation Tank; Florfenicol powder with 1.5g slowly adds in the Agitation Tank then, in the Agitation Tank of the more remaining 30ml of 95% ethanol being packed into after the stirring and dissolving, continue to stir 10 minutes, fully behind the mixing with 0.8um titanium rod filter with medical filtration to storing in the liquid filling; Last fill, seal, make 50 medicines, every 2ml, every contains florfenicol 30mg.
Using method:
1, food is freshened in prevention: every adds water 500ml, and three, each is once before the four-aged silkworm, hibernating worm; Playing silkworm five ages begins every other day once.
2, the treatment freshen food: per two add water 500ml, and 8 hours are once, add continuously the food three times after, freshen food every day once.
Medicinal liquid is 1: 10 with the Folium Mori ratio, promptly the medicinal liquid of 500ml is sprayed on 5 kilograms the Folium Mori and raises food.
Embodiment 2:
Preparation 100ml medicine.With florfenicol 1g and 97% ethanol 100ml.Elder generation packs into 97% ethanol 65ml in the Agitation Tank; Florfenicol powder with 1g slowly adds in the Agitation Tank then, in the Agitation Tank of the more remaining 35ml of 97% ethanol being packed into after the stirring and dissolving, continue to stir 8 minutes, fully behind the mixing with 0.8um titanium rod filter with medical filtration to storing in the liquid filling; Last fill, seal, make 50 medicines, every 2ml, every contains florfenicol 20mg.
Using method:
1, food is freshened in prevention: every adds water 350ml, and three, each is once before the four-aged silkworm, hibernating worm; Playing silkworm five ages begins every other day once.
2, the treatment freshen food: per two add water 350ml, and 8 hours are once, add continuously the food three times after, freshen food every day once.
Medicinal liquid is 1: 10 with the Folium Mori ratio, promptly the medicinal liquid of 350ml is sprayed on 3.5 kilograms the Folium Mori and raises food.
Embodiment 3:
Preparation 100ml medicine.With florfenicol 2g and 98% ethanol 100ml.Elder generation packs into 98% ethanol 80ml in the Agitation Tank; Florfenicol powder with 2g slowly adds in the Agitation Tank then, in the Agitation Tank of the more remaining 20ml of 98% ethanol being packed into after the stirring and dissolving, continue to stir 7 minutes, fully behind the mixing with 0.8um titanium rod filter with medical filtration to storing in the liquid filling; Last fill, seal, make 50 medicines, every 2ml, every contains florfenicol 40mg.
Using method:
1, food is freshened in prevention: every adds water 650ml, and three, each is once before the four-aged silkworm, hibernating worm; Playing silkworm five ages begins every other day once.
2, the treatment freshen food: per two add water 650ml, and 8 hours are once, add continuously the food three times after, freshen food every day once.
Medicinal liquid is 1: 10 with the Folium Mori ratio, promptly the medicinal liquid of 650ml is sprayed on 6.5 kilograms the Folium Mori and raises food.
Claims (2)
1, a kind of medicine of preventing and treating bacterial disease of domestic silkworm, it is characterized in that: the ethanol by florfenicol and 99-95% combines, and its proportioning is 0.5～5: 100.
2, the preparation method of the control bacterial disease of domestic silkworm medicine of claim 1: it is characterized in that: elder generation packs into 60～80% of 99-95% amount of alcohol in the Agitation Tank, by proportioning florfenicol powder is added in the Agitation Tank again, again the ethanol of surplus 20～40% is packed into after the stirring and dissolving in the Agitation Tank, continue to stir 5～10 minutes, fully behind the mixing with the titanium rod filter of 0.8um with medical filtration to storing in the liquid filling, canned at last, seal made medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100703888A CN100518728C (en) | 2006-11-21 | 2006-11-21 | Medicament for preventing and treating bacterial disease of domestic silkworm and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100703888A CN100518728C (en) | 2006-11-21 | 2006-11-21 | Medicament for preventing and treating bacterial disease of domestic silkworm and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1965816A true CN1965816A (en) | 2007-05-23 |
| CN100518728C CN100518728C (en) | 2009-07-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100703888A Expired - Fee Related CN100518728C (en) | 2006-11-21 | 2006-11-21 | Medicament for preventing and treating bacterial disease of domestic silkworm and preparation process thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919588A (en) * | 2012-11-02 | 2013-02-13 | 韩益飞 | Flacherie-preventing feed |
-
2006
- 2006-11-21 CN CNB2006100703888A patent/CN100518728C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919588A (en) * | 2012-11-02 | 2013-02-13 | 韩益飞 | Flacherie-preventing feed |
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| Publication number | Publication date |
|---|---|
| CN100518728C (en) | 2009-07-29 |
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Granted publication date: 20090729 Termination date: 20191121 |