CN1957892A - Mixture of fatty acid for external increasing fat locally, and preparation method - Google Patents

Abstract

An exterior-applied fatty acid mixture for synthesis of local fat and beautifying skin is prepared from oleic acid-glycerin composition, vitamin composition, trace element composition, and fat degradation resistant hormone. Its preparing process is also disclosed.

Description

Mixture of fatty acid for external increasing fat locally and manufacture method

Technical field: the invention belongs to cosmetics and production thereof, application.

Background technology: adult and middle-aged and elderly people be subjected to " three-hypers " be in the harm of diseases of cardiovascular and cerebrovascular systems such as hyperglycemia, hypertension, hyperlipidemia and the body depot fat too much or its metabolism bad promptly fat direct and closely related, to this, existing investigation confirm to show the daily dietary fat of China especially animal fat exceed standard, cause over nearly 10 years the chronic diseases in China M ﹠ M to rise rapidly and become rejuvenation trend, as present China adult hypertension prevalence is 18.8%, and the estimation whole nation now trouble number is 1.6 hundred million; Adult's dyslipidemia prevalence is 18.6%, estimates that national dyslipidemia now suffers from number 1.6 hundred million; The overweight rate of being grown up is 22.8%, and obesity rates is 7.1%, estimates that the existing overweight and fat number in the whole nation is respectively more than 200,000,000 and 6,000 ten thousand.China Disease Control and Prevention Center is prediction and warning therefore: as not taking effective Preventing Countermeasures, will having up to more than one hundred million Chinese in 10 years from now on and die from hypertension, hypercholesterolemia, diabetes, obesity, cancer chronic diseases.The archaism cloud: " man is that intimate person is dead, the woman is intimate person's appearance ", so women colony goes after like a flock of ducks especially to fat-reducing; Because the development and the progress of society, social and many male self to traditional male with thick spacious serve as beautiful and sophisticated aesthetic conceptions are taken exception to then advocated good health and a long life and add the main forces' ranks of losing weight with proceeding without hesitation, and the development of this trend advances swiftly unhindered, thereby makes fat-reducing become social fashion's main flow rapidly and obviously present flourishing long time general trend.Yet things all have positive and negative two aspects need compatible with take into account, otherwise lose more than gain even can go to extremes, the end that appears in the newspapers as usual is no lack of the report that is possessed by the Devil even therefore gets killed because of fat-reducing, the sign of making us holding one's own wrist.Just because of this, influence surface that the present invention aims at taking into account, balance and solving relates in this class problem and crowd be some main flow problem and principal contradiction greatly.

In sum and in conjunction with investigation practice and result that social practical situation carries out, it is evident that: a pair of contradiction of this field maximum is lost weight and to cause mastatrophy to be lost most important beautiful because of fat-reducing for beautiful no more than the women at present.Ma Lilian. Ya Long says in " history of breast ": " about breast, the baby sees be food, man see what be that sexual love, doctor see is the money that disease, businessman see "." breast is this most beautiful in the world ' mountain peak ' ", but but be enough to make woman's beautiful even life precarious, be accompanied by women's all one's life.This factor to two aspects of contradiction is that obesity provides sufficient fat to make breast full and plentiful and because of the high and fat relevant growth of safeguarding and strengthening breast of estrogen level makes breast more plentiful more lasting on the one hand, but to emit obesity and bring out cyclomastopathy in addition breast carcinoma to the significant damage threat risk of beautiful and life; Then be to change high fat diet on the other hand, control appetite and body weight are promptly lost weight, but this hardly may the merciless repeatedly already proof of the fact for the fat women of the overwhelming majority, can accomplish that just right winner is very few especially, because well-knownly can go beyond for a long time and keep such as almost rare people of serial difficulty such as " bounce-backs ", provide enough fat to be difficult to maintain the plentiful of breast to breast and remove the state basic policy overwhelming majority that especially has one child per couple of short duration age of sucking for a long time because of body is unable for NO women, often post great expectations in all kinds of breast enlargement products or operation for this reason, can nearly all be " glad; as to come back disappointed ", even to disable be rare yet, cost of paying and consequence are very heavy and irreversible.Reason is also very simple in fact: combining and to return this series products or operation at present, is nothing but that foreign body such as silica gel or autologous fat are put pad or for oral administration and external (smearing) medicine (mostly be hormones or contain hormones) stimulates breast and makes breast enlargement tall and straight to stimulate physical methods such as cyclomastopathy or similar massage, ray; But conspicuous serial adverse consequences is respectively: foreign body is put inhomogeneous, easily transposition bursts report or produces rejection etc. as diving etc. with breaking even burst breast, and is difficult to repair and takes out and follow the painful and risk that disables of new operation fully; It is a good selection comparatively speaking that autologous fat is put, but but fat can be by body constantly and promptly transport breast and in breast, constantly degraded and need constantly to replenish own fat and the position is provided and fatty reserves always limited, and take out, greasing is especially constantly taken out, the misery of greasing, risk and sequela and also can not regard as unimportant to subside hematocele and its additive effect and consequence and misery etc. of infringement attractive in appearance such as liposuction position, so feasibility also be extremely limited, at least be difficult to persistent; Comprise that as for the hormone of oral administration and externally or the medicine that contains hormones the Chinese medicine consequence is then more serious: can cause endocrine regulation, irregular menstruation and aforesaid cyclomastopathy and breast carcinoma etc., though great majority are cyclomastopathy and the not canceration of most of cyclomastopathy promptly is benign, but many need excisions are also arranged and have a strong impact on beauty treatment, go back on one's original intentions on the contrary, and the galactophore epithelial cell variation that form takes place to a certain degree on exuberant basis causes the atypical hypertrophy relevant with the danger of breast carcinoma promptly easily to cause breast carcinoma, and cyclomastopathy and breast carcinoma may exist simultaneously and incur loss through delay detecting and treating of breast carcinoma sometimes, and consequence will be more serious; Physiotherapys such as massage are just like " the cleverest housewife can't cook a meal without rice ", because of its principle only is to improve blood flow in the hope of being with nutrients such as staying some fat in breast more more, but this must be constantly to carry out just having positive effect in some months, only depend on every day or of short duration massage of a few days etc. absolutely void, because only depending on the retention of nutrient substance such as food fat is continuous and very long process, and " fat-reducing " health does not have superabundant fats, can be compared to water without a source, like a tree without roots, massage waits in any case all can not too many practical significance and effect; Massage so why etc. that physiotherapy seems and effectively of short duration and effect " well " sometimes, answer is also very simple: this only is that excessively massage waits the undermined swelling of breast (illusion of the excessive congested water-filling retention of mammary gland) that causes, obviously and the fact prove repeatedly after the detumescent all as usual, effect far from, if leave no choice but have " effect ", that is exactly down to damage breast and mammary gland normal configuration and function for a long time even cause the pathological changes serious consequence.

Goal of the invention: the present invention is exactly mixture of fatty acid for external increasing fat locally and the manufacture method that designs for addressing the above problem, and existing main scientific and technological principle and innovation with its foundation is that advantage is described below:

People and many higher mammals all have rejection as protection mechanisms such as macromole allergy for resisting exotic invasion and harm thereof, but fat all is unified triglyceride because of its molecular structure, just the whether saturated quantity number that reaches of the length of fatty acid chain and chemical bond is distinguished, so its compatibility is higher, that is reaction such as rejection allergy etc. is more weak or do not have, to this, essential fatty acid such as available linoleic acid such as human body skin allergy directly spread upon does not only have rejection on the skin, also can cure allergy rapidly is exactly strong evidence, this is because epithelial cell membrane fat and molecular structure thereof and extraneous essential fatty acid are in full accord, so " lacked the disease that causes by essential fatty acid; can only could prevent and treat with essential fatty acid ", other medicines do not have substitutability; First directly the absorbing with skin that digest and absorb of fat do not have essential distinction for the first time yet: while fat is broken down into micromolecule such as short-chain fat with fatty acid and glycerol etc., synthesize long-chain even complete fatty acid chain and fat again constantly again at intestinal, so go into blood and transport the interior fat constituent of liver and related situation also with above-mentioned identical; These fat constituents are just thoroughly resolved into fatty acid and glycerol after being transported into each cell, body institute's energy requirement is provided or synthesizes many life structures and adjusting material by different approaches and machine-processed oxidation exoergic (ATP) respectively afterwards with other materials, promptly when being the glucose shortage, carbohydrate replace them to provide the energy and carbon source to earn a bare living, unnecessary then be stored in adipose cell and other tissue, the organ standbyly, when surpassing their normal storage ability, just cause well-known multiple disease; Because different cells, carefully knit, organ is to demand and storage capacity and the storage and the running of fat, metabolic capacity and condition difference are huge, as adipose cell, breast, blood vessel, so the body different parts cannot treat different things as the same to the demand of fat, that is can not be simply with the body overall weight promptly whether obesity that to be standard weigh the position is fat or thin and aesthetic, these principles and objective fact just for body local as breast weight gaining established good basis, the increasing fat locally at other positions of body such as the injection of wrinkle is filled and led up and principle such as long term maintenance is similar to breast no longer repeats superfluous stating.

For helping to understand the present invention, existing effect and principle, advantage with raw material of the present invention is summarized as follows:

The fatty acid of human body depot fat all is oleic acid more than 85% in constituting, and change little with lubricant component in the food, promptly very stable, glycerol is the common component that all fatty acids constitute fat (triglyceride), be that each oleic acid triglyceride molecule proportionate relationship that all to contain identical three oleic acid moleculars and glycerol molecule be oleic acid and glycerol is 3: 1, though the oleic acid molecular amount is bigger than glycerol, but consider that some glycerol can be used as sugar and energy (with co-conversion form involved in sugar and the energy metabolism mutually of the common intermediate product dihydroxyacetone phosphate of carbohydrate metabolism) transformation and consumption and oleic acid and also can (all can change from sugar interior though each carbon atom on the triglyceride molecule promptly comprises glycerol from the sugar transformation, but be transformed into acetone acid and be difficult to change saccharogenesis because of the primary product S-acetyl-coenzyme-A of fatty acid metabolism can not drive in the wrong direction, so glycerol with respect to easy transformation saccharogenesis, oleic acid then has the quantity of having more) etc. balancing, the present invention with the two proportionate relationship be designed to 3: 1 obviously comparatively reasonable, VB ₁Shortage is obstructed sugar (acetone acid) metabolism energy supply, is that non-fat heat energy reduces, must increase fat and energy supply consumption, unfavorable to increasing fat locally purpose of the present invention; VB ₂With VB ₁Equally in close relations with the non-fat heat energy metabolism, shortage can cause that also energy metabolism is disorderly and various clinical symptom such as angular cheilitis, seborrheic dermatitis etc. occur; VB ₆Simultaneously with albumen, fat, carbohydrate metabolism is in close relations and increase VB, VB ₂Curative effect, shortage cause the substance metabolism disorder to weaken with balanced capacity; VC promotes collagen protein synthesis and cholesterol drainage, be beneficial to weight gaining position and even whole skin, the anti crease and anti senile prepared beauty treatment of organ and prevent atherosclerosis, the more important thing is because of the reduction of cholesterol reduces the estrogen synthesis cholesterol has positive correlation (cholesterol is changed by lipometabolic S-acetyl-coenzyme-A) with fat, thus avoid the weight gaining part because of the canceration risk of estrogen increase and balance insulin (stating as follows) to the synthetic promotion of cholesterol and c-AMP to the synthetic inhibitory action of cholesterol; Chromium promotes insulin function, is beneficial to the synthetic and stable of increasing fat locally fat, chromium also the balance serum cholesterol, be beneficial to the stable of estrogen level; Magnesium is the important cofactor of fat (acid) synzyme, copper promote collagen protein synthesis, so and VC synergism and strengthen effect mutually each other; It is insulin that the interior main lipotropism of human body is separated hormone, be the first messenger of hormonal action, its mechanism of action and effect are that to reduce in the cell second message,second messenger c-AMP enzyme be the activity of adenyl cyclase and reduce cyclic adenosine monophosphate level in the cell, reduce c-AMP and promote lipocatabolic speed and inhibition (fat) cell division and outgrowth effect, c-GMP is the second message,second messenger of the first messenger lipolytic hormone opposite with insulin, it is just opposite with c-AMP action principle and effect, that is reduce lipocatabolic speed and promotion (fat) cell division and hypertrophy and be beneficial to fat stores, the two effect that conditions each other is as the negative and positive of restriction or checking relation in five elements relation each other in the theory of Chinese medical science.

The present invention then just in time science use above-mentioned principle and objective fact dexterously, employing is the synthetic and reconstruction of body material and own fat with identical oleic acid of human body depot fat main body fatty acid composition (accounting for more than 85%) and glycerol, synthetic again the reaching of balance and stability mechanism stablized autologous fat, utilize above-mentioned local demand and store difference and directly absorb, the easily infiltration and absorb soon and how can't reject and allergy reaches increasing fat locally such as breast enlargement of synthetic and storage and micromolecule, fill out wrinkle and don't influence the rationally i.e. fat-reducing of normal controlling body weight and beauty treatment as increase collagen to improve skin elasticity anti crease and anti senile prepared and increase the support of fat and volume etc., it is big to overcome fat molecule of the same race and molecular weight, the problem that mobile difference and allosome and even heterogeneity biological fat are same and may cause organize incompatible rejection, the goal of the invention of problems such as allergy, that is really solved aforesaid " taking into account " contradiction.

Embodiment of the present invention:

The present invention is by oleic acid glycerol complex 5-10 part, wherein oleic acid 3-6 part, glycerol 1-2 part, compound vitamin 0-0.1 part, VB wherein ₁0.1-0.3 part, VB ₂0.1-0.3 part, VB ₆0.1-0.3 part, VC1-3 part, when other material that adopts GB2760 or GB14880 to allow replaces, should convert by active substance; Compound microelement 0-0.01 part, wherein potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part are when other material that adopts GB2760 or GB14880 to allow replaces, should convert by active substance; Lipotropism is separated hormone 0-0.01 part, when wherein insulin 0.001-0.01 part, c-GMP0.01-0.1 part, other material of adopting Chinese Pharmacopoeia to allow replace, should form by the active substance conversion.

The manufacture method of product of the present invention is as follows:

The preparation of oleic acid glycerol complex is got oleic acid 3-6 part, glycerol 1-2 part in sterilizing room, join in the nonmetallic vessel of belt stirrer, and 30-60 rev/min stirred standby in 3-5 minute;

The preparation of compound vitamin is got VB in sterilizing room ₁0.1-0.3 part, VB ₂0.1-0.3 part, VB ₆0.1-0.3 part, VC1-3 part, in nonmetal mortar, grind 3-5 minute standby;

The preparation of compound microelement is got potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part in sterilizing room, in nonmetal mortar, grind 3-5 minute standby;

Lipotropism is separated the preparation of hormone in sterilizing room, by the proportionate relationship of insulin 0.001-0.01 part, the c-GMP0.01-0.1 part amount of getting respectively, in nonmetal mortar, grind 3-5 minute standby;

The preparation of product of the present invention is in sterilizing room, get oleic acid glycerol complex 5-10 part, compound vitamin 0-0.1 part, compound microelement 0-0.1 part, lipotropism and separate hormone 0-0.01 part, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute product.

The purposes of product of the present invention, usage and consumption: be used as increasing fat locally agent such as medical preparation for making breast plump and fill out the wrinkle agent; The usage breast enlargement is external; Every newborn three times of consumption external every day, each 3-5 gram, also injectable or external combine with injection, but must professional shaping and beauty doctor determine consumption and number of times and operation, filling out wrinkle does not limit, is as the criterion to fill and lead up for injection, consumption, need professional shaping and beauty doctor to determine consumption and number of times and operation equally, to guarantee safety and expection and the effect of getting instant result.

Embodiment:

1, in sterilizing room, get oleic acid glycerol complex, press 0.5-1 milliliter/specification encapsulation, injection being filled out the wrinkle beauty treatment with, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

2, in sterilizing room, get oleic acid glycerol complex, press 3-5 milliliter/specification encapsulation, breast enlargement external, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

3, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 0.5-1 milliliter/specification encapsulation, injection being filled out wrinkle beauty treatment with, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

4, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 3-5 milliliter/specification encapsulation, breast enlargement external, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

5, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.001 part of compound microelement, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 0.5-1 milliliter/specification encapsulation, injection being filled out wrinkle beauty treatment with, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

6, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.001 part of compound microelement, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 3-5 milliliter/specification encapsulation, breast enlargement external, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

7, in sterilizing room, get 5 parts of oleic acid glycerol complex, lipotropism is separated 0.001 part of hormone, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 0.5-1 milliliter/specification encapsulation, injection being filled out wrinkle beauty treatment with, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

8, in sterilizing room, get 5 parts of oleic acid glycerol complex, lipotropism is separated 0.001 part of hormone, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 3-5 milliliter/specification encapsulation, breast enlargement external, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

9, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, 0.001 part of compound microelement, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 0.5-1 milliliter/specification encapsulation, injection being filled out wrinkle beauty treatment with, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

10, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, 0.001 part of compound microelement, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 3-5 milliliter/specification encapsulation, breast enlargement external, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

11, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, 0.001 part of compound microelement, lipotropism and separate 0.001 part of hormone, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 0.5-1 milliliter/specification encapsulation, injection being filled out wrinkle beauty treatment with, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

12, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, 0.001 part of compound microelement, lipotropism and separate 0.001 part of hormone, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 3-5 milliliter/specification encapsulation, breast enlargement external, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

13, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, 0.001 part of compound microelement, lipotropism and separate 0.001 part of hormone, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 0.5-1 milliliter/specification encapsulation, injection being filled out wrinkle beauty treatment with, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

14, in sterilizing room, get 5 parts of oleic acid glycerol complex, 0.01 part of compound vitamin, 0.001 part of compound microelement, lipotropism and separate 0.001 part of hormone, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, press a 3-5 milliliter/specification encapsulation, breast enlargement external, disposable use, before the Kaifeng if any broken or Kaifeng use the back if any residue all make discard processing, to guarantee safety.

15, in sterilizing room, get 10 parts of oleic acid glycerol complex, 0.1 part of compound vitamin, 0.01 part of compound microelement, lipotropism and separate 0.01 part of hormone, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute, be used as breast enlargement or fill out wrinkle product host or main effect material, consumption is the ordinary production needs by GMP.

The present invention replenishes principle and advantage:

Because raw material of the present invention and product all are micromolecule liquid, not only to reach composition by force identical with the human body depot fat and easily to change into depot fat, flowability also good rapidly and with the body fat affinity for osmotic absorption, no matter so be injection or external all easily initiatively and passive transport and be distributed to need the position and change into depot fat and can be not uneven, even also outward appearance well-balanced aesthetic feeling attractive in appearance, natural in increasing fat locally position is good, this is one of advantage of the present invention; Owing to be new synthetic fat and depot fat and have lipotropism separate hormone etc. Stabilization thus transhipment few decompose store slowly many, the life-span is long from the body depot fat than the direct injection human body, this also is one of advantage of the present invention; No pain also can arbitrarily be regulated and control the two newborn plentiful degree and the uniformitys, especially to correct two breasts asymmetric as small one and large one etc. attractive in appearance and aesthetic feeling difficult problem effect significantly and take effect rapid, and operation is also very convenient: only need to regulate consumption, bigger breast less with or need not or reduce frequency of utilization, little opposite getting final product, this is a biggest advantage of the present invention.

2, though product of the present invention be used for breast enlargement also injectable to take effect fast, but can not transform into fat this moment yet except that filling effect, also easy centrifugation because of fatty acid and glycerol causes skewness to influence the synthetic and distributing equilibrium of fat from now on, though this can not produce any material injury (this is one of main advantages of the present invention) to human body, because all to be human body self just have and can synthetic nutrient substance and can thoroughly dispel by metabolism for they, but concerning beauty treatment and effect, then show blemish in an otherwise perfect thing, though also can repair, but this complete using up originally can be avoided, need only have slightly patience promptly by the external mode also need only be short several months can obtain same effect, do not regret and relative permanent effect but have, do not act with undue haste so advise first-selected external mode, though trouble but do not have injection and injection volume and the injection site misery that causes such as inaccurate and imperfect, so repayment is worth, why not do it.

Animal experiment and result and explanation and prompting:

Animal (rat) toxic and side effects and increasing fat locally-breast enlargement contrast experiment and method:

Acute toxicological experiment	The per os rat of feeding, 2 gram/kg/day are 1 totally month, no any unusual.
		The sub-acute toxicity experiment	The per os rat of feeding, 1 gram/kg/day is 2 totally months, no any unusual.
Chronic toxicological experiment	The per os rat of feeding, 0.5 gram/kg/day is 3 totally months, no any unusual.
		Side effect (sticking allergy) experiment	The classical rabbit basal part of the ear sticks experiment, and 10 is big, does not have irritated (any reactions such as redness, incrustation, heating).
Increasing fat locally-breast enlargement contrast experiment	This product 0.5 gram/kg body weight/mouth is outer, and to be coated with the breast group of going on a diet plentiful January, the matched group atrophy of going on a diet of no this product.

Illustrate: 1, trial target is 100% original.2, per 20 of rat is one group, and experiment respectively feeds intake with feed for 3 times every day.3, because of about 900 days of rat average life, event are equivalent to human in March, 10, be enough to as validation criteria.4, animal experiment is up to 40 examples, and the tool animal replaces clinical trial reference statistical meaning, routinely tool proof property and proof.

Prompting: evidence product safety of the present invention, effect are rapidly, significantly and stable.

Claims (3)

1, a kind of mixture of fatty acid for external increasing fat locally, by oleic acid glycerol complex 5-10 part, wherein oleic acid 3-6 part, glycerol 1-2 part, compound vitamin 0-0.1 part, VB wherein ₁0.1-0.3 part, VB ₂0.1-0.3 part, VB ₆0.1-0.3 part, VC 1-3 part, when other material that adopts GB2760 or GB14880 to allow replaces, should convert by active substance; Compound microelement 0-0.01 part, wherein potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part are when other material that adopts GB2760 or GB14880 to allow replaces, should convert by active substance; Lipotropism is separated hormone 0-0.01 part, when wherein insulin 0.001-0.01 part, c-GMP0.01-0.1 part, other material of adopting Chinese Pharmacopoeia to allow replace, should form by the active substance conversion.

2, the manufacture method of the described mixture of fatty acid for external increasing fat locally of claim 1 is as follows:

The preparation of a oleic acid glycerol complex is got oleic acid 3-6 part, glycerol 1-2 part in sterilizing room, join in the nonmetallic vessel of belt stirrer, and 30-60 rev/min stirred standby in 3-5 minute;

The preparation of b compound vitamin is got VB in sterilizing room ₁0.1-0.3 part, VB ₂0.1-0.3 part, VB ₆0.1-0.3 part, VC 1-3 part, in nonmetal mortar, grind 3-5 minute standby;

The preparation of c compound microelement is got potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part in sterilizing room, in nonmetal mortar, grind 3-5 minute standby;

The d lipotropism is separated the preparation of hormone in sterilizing room, by the proportionate relationship of insulin 0.001-0.01 part, the c-GMP0.01-0.1 part amount of getting respectively, in nonmetal mortar, grind 3-5 minute standby;

The preparation of e mixture of fatty acid for external increasing fat locally is in sterilizing room, get oleic acid glycerol complex 5-10 part, compound vitamin 0-0.1 part, compound microelement 0-0.1 part, lipotropism and separate hormone 0-0.01 part, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute product.

3, the purposes of the described mixture of fatty acid for external increasing fat locally of claim 1: external breast enlargement, every newborn three times of consumption every day, each 3-5 gram; Wrinkle is filled out in injection, and consumption is as the criterion to fill and lead up.