CN1957879A - Composite trace element products of promoting synthesis of fat collagen, and preparation method - Google Patents

Abstract

A composite trace element product without exclusiveness and anaphylaxis for promoting fatty collagen synthesis, locally increasing fat (such as rounding breast) and beautifying skin is prepared from potassium bichromate, copper gluconate and magnesium stearate. Its preparing process is also disclosed.

Description

Promote synthetic composite trace element product of fat collagen and manufacture method

Technical field: the invention belongs to cosmetics and production thereof, application.

Background technology: adult and middle-aged and elderly people be subjected to " three-hypers " be in the harm of diseases of cardiovascular and cerebrovascular systems such as hyperglycemia, hypertension, hyperlipidemia and the body depot fat too much or its metabolism bad promptly fat direct and closely related, to this, existing investigation confirm to show the daily dietary fat of China especially animal fat exceed standard, cause over nearly 10 years the chronic diseases in China M ﹠ M to rise rapidly and become rejuvenation trend, as present China adult hypertension prevalence is 18.8%, and the estimation whole nation now trouble number is 1.6 hundred million; Adult's dyslipidemia prevalence is 18.6%, estimates that national dyslipidemia now suffers from number 1.6 hundred million; The overweight rate of being grown up is 22.8%, and obesity rates is 7.1%, estimates that the existing overweight and fat number in the whole nation is respectively more than 200,000,000 and 6,000 ten thousand.China Disease Control and Prevention Center is prediction and warning therefore: as not taking effective Preventing Countermeasures, will having up to more than one hundred million Chinese in 10 years from now on and die from hypertension, hypercholesterolemia, diabetes, obesity, cancer chronic diseases.The archaism cloud: " man is that intimate person is dead, the woman is intimate person's appearance ", so women colony goes after like a flock of ducks especially to fat-reducing; Because the development and the progress of society, social and many male self to traditional male with thick spacious serve as beautiful and sophisticated aesthetic conceptions are taken exception to then advocated good health and a long life and add the main forces' ranks of losing weight with proceeding without hesitation, and the development of this trend advances swiftly unhindered, thereby makes fat-reducing become social fashion's main flow rapidly and obviously present flourishing long time general trend.Yet things all have positive and negative two aspects need compatible with take into account, otherwise lose more than gain even can go to extremes, the end that appears in the newspapers as usual is no lack of the report that is possessed by the Devil even therefore gets killed because of fat-reducing, the sign of making us holding one's own wrist.Just because of this, influence surface that the present invention aims at taking into account, balance and solving relates in this class problem and crowd be some main flow problem and principal contradiction greatly.

In sum and in conjunction with investigation practice and result that social practical situation carries out, it is evident that: a pair of contradiction of this field maximum is lost weight and to cause mastatrophy to be lost most important beautiful because of fat-reducing for beautiful no more than the women at present.Ma Lilian. Ya Long says in " history of breast ": " about breast, the baby sees be food, man see what be that sexual love, doctor see is the money that disease, businessman see "." breast is this most beautiful in the world ' mountain peak ' ", but but be enough to make woman's beautiful even life precarious, be accompanied by women's all one's life.This factor to two aspects of contradiction is that obesity provides sufficient fat to make breast full and plentiful and because of the high and fat relevant growth of safeguarding and strengthening breast of estrogen level makes breast more plentiful more lasting on the one hand, but to emit obesity and bring out cyclomastopathy in addition breast carcinoma to the significant damage threat risk of beautiful and life; Then be to change high fat diet on the other hand, control appetite and body weight are promptly lost weight, but this hardly may the merciless repeatedly already proof of the fact for the fat women of the overwhelming majority, can accomplish that just right winner is very few especially, because well-knownly can go beyond for a long time and keep such as almost rare people of serial difficulty such as " bounce-backs ", provide enough fat to be difficult to maintain the plentiful of breast to breast and remove the state basic policy overwhelming majority that especially has one child per couple of short duration age of sucking for a long time because of body is unable for NO women, often post great expectations in all kinds of breast enlargement products or operation for this reason, can nearly all be " glad; as to come back disappointed ", even to disable be rare yet, cost of paying and consequence are very heavy and irreversible.Reason is also very simple in fact: combining and to return this series products or operation at present, is nothing but that foreign body such as silica gel or autologous fat are put pad or for oral administration and external (smearing) medicine (mostly be hormones or contain hormones) stimulates breast and makes breast enlargement tall and straight to stimulate physical methods such as cyclomastopathy or similar massage, ray; But conspicuous serial adverse consequences is respectively: foreign body is put inhomogeneous, easily transposition bursts report or produces rejection etc. as diving etc. with breaking even burst breast, and is difficult to repair and takes out and follow the painful and risk that disables of new operation fully; It is a good selection comparatively speaking that autologous fat is put, but but fat can be by body constantly and promptly transport breast and in breast, constantly degraded and need constantly to replenish own fat and the position is provided and fatty reserves always limited, and take out, greasing is especially constantly taken out, the misery of greasing, risk and sequela and also can not regard as unimportant to subside hematocele and its additive effect and consequence and misery etc. of infringement attractive in appearance such as liposuction position, so feasibility also be extremely limited, at least be difficult to persistent; Comprise that as for the hormone of oral administration and externally or the medicine that contains hormones the Chinese medicine consequence is then more serious: can cause endocrine regulation, irregular menstruation and aforesaid cyclomastopathy and breast carcinoma etc., though great majority are cyclomastopathy and the not canceration of most of cyclomastopathy promptly is benign, but many need excisions are also arranged and have a strong impact on beauty treatment, go back on one's original intentions on the contrary, and the galactophore epithelial cell variation that form takes place to a certain degree on exuberant basis causes the atypical hypertrophy relevant with the danger of breast carcinoma promptly easily to cause breast carcinoma, and cyclomastopathy and breast carcinoma may exist simultaneously and incur loss through delay detecting and treating of breast carcinoma sometimes, and consequence will be more serious; Physiotherapys such as massage are just like " the cleverest housewife can't cook a meal without rice ", because of its principle only is to improve blood flow in the hope of being with nutrients such as staying some fat in breast more more, but this must be constantly to carry out just having positive effect in some months, only depend on every day or of short duration massage of a few days etc. absolutely void, because only depending on the retention of nutrient substance such as food fat is continuous and very long process, and " fat-reducing " health does not have superabundant fats, can be compared to water without a source, like a tree without roots, massage waits in any case all can not too many practical significance and effect; Massage so why etc. that physiotherapy seems and effectively of short duration and effect " well " sometimes, answer is also very simple: this only is that excessively massage waits the undermined swelling of breast (illusion of the excessive congested water-filling retention of mammary gland) that causes, obviously and the fact prove repeatedly after the detumescent all as usual, effect far from, if leave no choice but have " effect ", that is exactly down to damage breast and mammary gland normal configuration and function for a long time even cause the pathological changes serious consequence.

Goal of the invention: the present invention synthesizes composite trace element product and manufacture method for addressing the above problem the promotion fat collagen that designs, and existing main scientific and technological principle and innovation with its foundation is that advantage is described below:

Chromium promote insulin function, insulin reduce c-AMP cyclic adenosine monophosphate level, c-AMP promote steatolysis and suppress (fat) cell division with hypertrophy and unfavorable fat stores with stablize, insulin also is beneficial to sugar and is converted into fat, so chromium is beneficial to the synthetic of increasing fat locally and desired fats with stable, chromium also balance serum cholesterol, cholesterol is the estrogen raw material, causes the generation of cyclomastopathy and breast carcinoma so chromium also is beneficial to the obesity etc. stablized, prevent of weight gaining part and even whole body estrogen level; Magnesium is the important cofactor of fat (acid) synzyme, and copper promotes collagen protein synthesis.Science of the present invention is used above-mentioned principle and objective fact dexterously, utilize synthetic the reaching of own fat to stablize the local autologous fat of weight gaining with the stabiliser increase, utilize partial fatty demand and store difference and reach the increasing fat locally breast enlargement and don't influence the i.e. fat-reducing rationally of normal controlling body weight and beauty treatment as increase collagen to improve skin elasticity anti crease and anti senile prepared and increase the support of fat and volume etc., it is big to overcome fat molecule of the same race and molecular weight, the problem that mobile difference and allosome and even heterogeneity biological fat are same and may cause organize incompatible rejection, the goal of the invention of problems such as allergy, that is really solved aforesaid " taking into account " contradiction.

Embodiment of the present invention: the present invention is by compound microelement potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part, when other material that adopts GB2760 or GB14880 to allow replaces, should form by the active substance conversion.

The manufacture method of product of the present invention is got potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part in sterilizing room, in nonmetal mortar, grind stirred in 3-5 minute product.

The purposes of product of the present invention, usage and consumption: as increasing fat locally agent such as medical preparation for making breast plump; The usage breast enlargement is external; Every newborn three times of consumption external every day, each 3-5 milligram.

Embodiment: in sterilizing room, proportionate relationship by 10 milliliters of sucrose ester 0.01 grams, compound microelement 0.01 gram, sterilized water is taken, join in the nonmetallic vessel of belt stirrer, 30-60 rev/min stirred in 3-5 minute product, be used as breast enlargement product, external, every newborn three times of every day, each 3-5 milliliter.Sucrose ester is odorless lipophilic hydrophilic emulsifying agent, with water the various compositions of compound microelement is had fine double dissolubility and protectiveness, and easily metabolic degradation, skin-friendliness (sticking and absorb fast) are also very outstanding; This contained product design of the present invention of filling a prescription is about 1 mg/ml, can do the other products reference.

Animal experiment and result and explanation and prompting:

Acute toxicological experiment	The per os rat of feeding, 2 gram/kg/day are 1 totally month, no any unusual.
		The sub-acute toxicity experiment	The per os rat of feeding, 1 gram/kg/day is 2 totally months, no any unusual.
Chronic toxicological experiment	The per os rat of feeding, 0.5 gram/kg/day is 3 totally months, no any unusual.
		Side effect (sticking allergy) experiment	The classical rabbit basal part of the ear sticks experiment, 10 days, does not have irritated (any reactions such as redness, incrustation, heating).
Increasing fat locally-breast enlargement contrast experiment	1 milligram/kg body weight/day of this product is outer, and to be coated with the breast group of going on a diet plentiful March, the matched group atrophy of going on a diet.

Explanation; 1, trial target is 100% original.2, per 20 of rat is one group, and experiment respectively feeds intake with feed for 3 times every day.3, because of about 900 days of rat average life, event are equivalent to human in March, 10, be enough to as validation criteria.4, animal experiment is up to 40 examples, and the tool animal replaces clinical trial reference statistical meaning, routinely tool proof property and proof.

Prompting: evidence product safety of the present invention, effect are rapidly, significantly and stable.

Claims (3)

1, the synthetic composite trace element product of a kind of promotion fat collagen is made up of potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part, and other material that adopts GB2760 or GB14880 to allow replaces and should convert by active substance.

2, the manufacture method of the synthetic composite trace element product of the described promotion fat collagen of claim 1 is in sterilizing room, get potassium dichromate 0.001-0.003 part, magnesium stearate 1-3 part, copper gluconate 0.01-0.03 part, in nonmetal mortar, grind stirred in 3-5 minute product.

3, claim 1 promotes the purposes of the synthetic composite trace element product of fat collagen: external breast enlargement, every newborn three times of consumption every day, each 3-5 milligram.