CN1943684A - A composition used for regulating blood-fat and its preparation method - Google Patents
A composition used for regulating blood-fat and its preparation method Download PDFInfo
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Abstract
This invention relates to the field of the medical products, especially a composition used for regulating blood-fat and its preparation method. This composition is prepared mainly by using obtuse leaf senna seed, hawthorn fruit, giantarum,chitose. The weight ratio of the above ingredients is as follows: obtuse leaf senna seed 500-5000, hawthorn fruit 500-500, giantarum 50-500, chitose 5-50. Its preparing method is: take the obtuse leaf senna seed, hawthorn fruit(without seeds)by weight prescribed in the prescription and crush them into rough powder, add 6-8 times of the quantity of 60-80% ethanol to have them dipped in ethanol for 0.5-1 hour, then recycle them by heating 2-3 times by 1.0-2.0 hr, then filter the recycled liquid, combine the filtered liquids, reclaim the ethanol and condense them into cream by using pressure reducing films, then leave the cream standby. Take giantarum and chitose, have them crushed into fine powder by more than 150 orders and 60 orders of fineness separately, add the above cream and uniformly mix them, use 60-95% ethanol to process them into granules, then dry them under 50-60deg.C for 3hrs, add an amount of auxillary material to process them into pharmacological solidified preparation.
Description
Technical field
The present invention relates to the pharmaceutical products field, particularly a kind of composition and method of making the same of scalable blood fat.
Background technology
Blood fat is a kind of important material in the human body, and many very important functions are arranged, but can not surpass certain scope.If hyperlipoidemia causes " blood is thick " easily, on blood vessel wall, deposit, form little speckle (being exactly " atherosclerosis " that we often say) these " specklees " gradually and increase, increase, artery-clogging makes blood flow slack-off gradually, and blood flow is interrupted when serious.If this situation occurs in heart, just cause coronary heart disease; Occur in brain, apoplexy will occur; If the obstruction optical fundus blood vessel will cause visual deterioration, blind; If occur in kidney, will cause renal arteriosclerosis, renal failure; Occur in lower limb, limb necrosis can occur, fester etc.In addition, hyperlipidemia can cause hypertension, brings out cholelithiasis, pancreatitis, increases the weight of hepatitis, causes male sexual disorder, disease such as senile dementia.Current research prompting hyperlipidemia may be relevant with the morbidity of cancer.Hyperlipidemia is not rare in China, blood T-CHOL (TC) or triglyceride (TG) rising person account for 10% to 20% in becoming according to investigations, even also there are nearly 10% blood fat to raise among the child, reasons such as and the incidence rate of hyperlipidemia also has the trend that rises gradually, and this and China people's living standard obviously improves, dietary habit changes have substantial connection.Because the patient often also has the reduction of high-density lipoprotein-cholesterol (HDL-C) simultaneously, so that " hyperlipemia " renames as " dyslipidemia " is more suitable.The medicine that much is used for blood fat reducing is arranged at present, as Xuezhikang, para-aminosalicylic acid, thyroxin, insoral, chlortetracycline, long-life and fat-reducing powder etc., but unsatisfactory curative effects all, bounce-back easily, the preparation technology who has is quite complicated.
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of can be evident in efficacy, stop will the back being difficult for the compositions of bounce-back.
Another technical problem to be solved by this invention is, a kind of process for preparing above-mentioned composition is provided.
Technical problem to be solved by this invention is achieved by the following technical solution:
A kind of compositions of scalable blood fat mainly is made up of Semen Cassiae, Fructus Crataegi, Rhizoma amorphophalli, chitosan, and the weight proportion of above-mentioned each component is as follows: Semen Cassiae 500-5000 Fructus Crataegi 500-5000
Rhizoma amorphophalli 50-500 chitosan 5-100
In the above-mentioned composition, described chitosan is low macromolecule water-solubility chitosan;
In the above-mentioned composition, described Fructus Crataegi is for removing the Fructus Crataegi after examining;
A kind of method for preparing above-mentioned composition, get recipe quantity Semen Cassiae, Fructus Crataegi (removing nuclear) and be ground into 20 purpose coarse powder, add 6-8 and doubly measure 60-80% ethanol, after soaking 0.5-1h, reflux refluxes 2-3 time altogether, each 1.0-2.0h, filter, merging filtrate reclaims ethanol through the decompression thin film concentration and becomes clear paste standby.Recipe quantity Rhizoma amorphophalli micropowder is broken into the above fine powder of 150 orders adds above-mentioned clear paste with recipe quantity chitosan, the appropriate amount of auxiliary materials pulverized more than 60 mesh sieves, mix homogeneously, the 60-95% alcohol granulation, 50-60 ℃ dry 1-3 hour, add an amount of adjuvant, make the solid preparation on the pharmaceutics.
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae (Cassia obtusifolia L.) or little Semen Cassiae (Cassia tora I.).Sweet in the mouth, hardship, salty, cold nature; Has clearing away heat to improve acuity of vision, the function of loosening bowel to relieve constipation; Be used for the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision, constipation.The Semen Cassiae main chemical compositions is the anthraquinone class, based on emodin (emodin), physcione (physcion), aloe-emodin (alone-emodin), chrysophanol (chrysophanol).Modern pharmacological research is the result show, Semen Cassiae has blood pressure lowering, blood fat reducing, antiinflammatory, antiviral, rushes down inferior effect.
Fructus Crataegi is a rosaceous plant.Has promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, the effect of invigorating the spleen and benefiting QI.Studies show that the flavonoid in the Fructus Crataegi is blood pressure lowering, blood fat reducing, increase coronary flow, antiarrhythmic effective ingredient.
Rhizoma amorphophalli is the tuber of Araeceae (Araceae) Amorphophallus (AmorphophallusBlume) herbaceos perennial, also name mill taro, Rhizoma Arisaematis ringentis, thunder magnitude, be distributed widely in the Yangtze river basin and on the south wide geographic area.The traditional Chinese medical science is used for the treatment of carbuncle pathogenic wind toxic etc.Recent studies finds wherein to contain abundant glucomannan (being called for short KGM), and the konjak glucomannan water absorption is very strong, and expansive force is very big, but 80～100 times of imbibitions.KGM can form a kind of very heavy-gravity colloidal sol after being dissolved in cold water, is the main effective ingredient in the Rhizoma amorphophalli.Liu Wei etc. report at " Rhizoma amorphophalli extract is to the effect of animal experiment type hyperlipidemia " literary composition: extract white monomer from Rhizoma amorphophalli, to the lipid-lowering test that normal rabbits is carried out, confirmed that Rhizoma amorphophalli has tangible effect for reducing blood fat.
Chitosan (chitosan) is to be obtained through deacetylation by the chitin (chitin) that nature extensively exists, and is found in late 1970s to have blood fat reducing and cholesterol reducing effect.Fatty acid all stores with the triglyceride form usually, and triglyceride increases can cause that blood fat increases.Therefore, body fat acid reduces the ability that has also just reduced esterified formation triglyceride.Stearic acid is the abundantest common in an animal body fatty acid, is a kind of digestive acid, and lauryl sulphate acid is the predecessor of synthetic cholesterol, also is a kind of digestive acid.Chitosan can combine with above-mentioned two kinds of digestive acids in intestinal after oral, thereby suppresses the latter in the absorption of intestinal and they are excreted with feces, thus blood fat reducing.
Below by pharmacodynamic experiment, further introduce curative effect of the present invention.
Pharmacodynamic experiment
1, animal is selected and feedstuff:
SPF level SD kind healthy white rat (150-200g), the animal quality certification number: 2004A050.Available from Guangdong Medical Lab Animal Center.Totally 55.High lipid food (78.8% normal feedstuff, 1% cholesterol, 10% yolk powder and 10% Adeps Sus domestica, 0.2% cholate).
2, instrument and reagent
Cholesterol (TC), triglyceride (TG) adopt enzymatic assays, and HDL-C (HDL-C) adopts selectivity inhibition method to measure.Agents useful for same and standard are by supporting the providing of U.S.'s Beckman one Coulter Corporation and Britain Randox company, the strict operation of the equal by specification of all test items, and on BECKMAN CX5delta fully-automatic analyzer (CX5 delta, U.S.'s Beckman one Coulter Corporation produces), test.
3. medicine and dosage:
Be subjected to the reagent thing: the fat eliminating clearing capsule.Lot number: 20040812.The unit of providing: LiZhu Medicine Group Co., Ltd Chinese medicine center.
Usage and consumption: recommend day clothes every day three times, each 4.The adult calculates by 60 kg body weight, and recommending a day dosing is 0.10g/kg b.w..Recommend day dosing to establish basic, normal, high three dosage groups to be respectively 0.5g/kg b.w, 1.0g/kg b.w, 3.0g/kg b.w by being equivalent to 5,10,30 times, other establishes the pure water matched group.Gastric infusion, twice of every day.
4, experimental technique
55 SD kinds are rat, and feed and give the base particle feedstuff wherein 11 (pure water matched group) every days; Feed all the other 44 every days and give high fat nutrient fodder (prescription is: 79% normal feedstuff powder, 1% cholesterol, 10% yolk powder and 10% Adeps Sus domestica, in 80 ℃ of baking ovens, dry, make the high fat nutrient fodder of strip), before being tried thing, detect the total gallbladder alcohol of serum (TC) level, be divided into high fat matched group at random and basic, normal, high dosage group is given given the test agent according to serum total cholesterol level.Every group 11, divide 5 cages to raise.Experimental group and high fat matched group all give high lipid food, and the pure water matched group is fed and given a basis material feedstuff.Weigh weekly, tried thing according to body weight, continue 35d, after 36d weighs, get whole blood, separation of serum is surveyed serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C) level.
5, experimental result
5.1 this capsule that influences to the animal subject body weight is seen Table 1 to trying the heavy influence of object.Each dosage group and high fat matched group compare, there was no significant difference (P＞0.05), and sample is to the negative result of the influence of animal subject body weight.
Table 1 pair is tried the heavy influence of object
| Group | n | Before body weight (g) is given sample | Off-test | Weightening finish (g) |
| The pure water matched group | 11 | 141.9±17.7 | 248.1±47.5 | 106.2 |
| High fat matched group | 11 | 145.4±18.5 | 253.9±30.8 | 107.5 |
| Low dose group | 11 | 142.1±9.9 | 225.8±36.1 | 83.7 |
| Middle dosage group | 11 | 131.9±21.3 | 216.4±26.6 | 105.5 |
| High dose group | 11 | 132.7±17.4 | 228.8±29.8 | 96.1 |
| The F value | 1.35(P＞0.05) | 2.16(P＞0.05) |
5.2 after giving this capsule 35d to the influence of animal subject total serum cholesterol (TC) and triglyceride (TG), the Serum TC of high, middle dosage group, TG level are starkly lower than high fat matched group, difference has the significance meaning; The result shows that sample is to the positive result of the influence of T-CHOL index.See Table 2.
Influence (x ± s, the mmolL of table 2 pair Serum TC and TG
-1)
| Group | TC(mmol/L) | TG(mmol/L) |
| The pure water matched group | 1.27±0.23 | 0.61±0.232 |
| High fat matched group | 2.10±0.27 | 2.17±0.35 |
| Low dose group | 1.93±0.34 | 1.87±0.41 |
| Middle dosage group | 1.78±0.24 * | 1.44±0.37 ** |
| High dose group | 1.32±0.21 ** | 1.41±0.39 * |
Annotate: compare .*P＜0.05 with high fat matched group; * P＜0.01
HDL-C (HDL-C) level of the middle and high dosage group of influence of 33 pairs of HDL-C (HDL-C) raises, and the result shows that sample is to the positive result of the influence of HDL-C index.
Influence (x ± s, the mmolL of table 3 couple HDL-C
-1)
| Group | n | HDL-C |
| The pure water matched group | 11 | 2.252±0.562 |
| High fat matched group | 11 | 3.613±0.641 |
| Low dose group | 11 | 3.874±0.774 |
| Middle dosage group | 11 | 3.936±0.523 * |
| High dose group | 11 | 4.003±0.642 ** |
| The F value | 3.67 | |
| The P value | ＜0.05 |
Annotate: compare .*P＜0.05 with high fat matched group; * P＜0.01
Above experimental result illustrates that this product has the effect of tangible blood lipid regulation
The specific embodiment
Embodiment one
Take by weighing following each component by weight: Semen Cassiae 500g Fructus Crataegi 500g
Rhizoma amorphophalli 50g chitosan 5g
Depend on that pine torch, Fructus Crataegi (removing nuclear) are ground into 20 purpose coarse powder, add 6 times of amount 60-80% ethanol, behind the immersion 0.5-1h, reflux refluxes 2 times altogether, the 1st 2h, and the 2nd 1.5h filters, and merging filtrate reclaims ethanol through the decompression thin film concentration and becomes clear paste standby.The Rhizoma amorphophalli micropowder is broken into the above fine powder of 150 orders adds above-mentioned clear paste with low macromolecule water-solubility chitosan, the appropriate amount of auxiliary materials pulverized more than 60 mesh sieves, mix homogeneously, the 60-95% alcohol granulation, 50-60 ℃ dry 1-2 hour, add the moderate lubrication agent, canned one-tenth capsule.
Embodiment two
Take by weighing following each component by weight: Semen Cassiae 5000g Fructus Crataegi 5000g
Rhizoma amorphophalli 500g chitosan 100g
Depend on that pine torch, Fructus Crataegi (removing nuclear) are ground into 20 purpose coarse powder, add 8 times of amount 60-80% ethanol, behind the immersion 0.5-1h, reflux, reflux the 1st 1.5h, the 2nd 1.5h altogether 3 times, the 3rd time 1h filters, and merging filtrate reclaims ethanol through the decompression thin film concentration and becomes clear paste standby.The Rhizoma amorphophalli micropowder is broken into the above fine powder of 150 orders adds above-mentioned clear paste with low macromolecule water-solubility chitosan, the appropriate amount of auxiliary materials pulverized more than 60 mesh sieves, mix homogeneously, the 60-95% alcohol granulation, 50-60 ℃ dry 1-3 hour, become granule.
Embodiment three
Take by weighing following each component by weight: Semen Cassiae 2000g Fructus Crataegi 2000g
Rhizoma amorphophalli 200g chitosan 40g
Depend on that pine torch, Fructus Crataegi (removing nuclear) are ground into 20 purpose coarse powder, add 7 times of amount 60-80% ethanol, behind the immersion 0.5-1h, reflux refluxes 2 times altogether, the 1st 2h, and the 2nd 1.5h filters, and merging filtrate reclaims ethanol through the decompression thin film concentration and becomes clear paste standby.The Rhizoma amorphophalli micropowder is broken into the above fine powder of 150 orders adds above-mentioned clear paste with low macromolecule water-solubility chitosan, the appropriate amount of auxiliary materials of pulverizing 60 mesh sieves, mix homogeneously, the 60-95% alcohol granulation, 50-60 ℃ dry 1-3 hour, add the moderate lubrication agent, tabletting.
Claims (10)
1, a kind of compositions of blood lipid regulation mainly is made up of Semen Cassiae, Fructus Crataegi, Rhizoma amorphophalli, chitosan.
2, the compositions of a kind of blood lipid regulation according to claim 1 is characterized in that, described each
The weight proportion of component is as follows: Semen Cassiae 500-5000 Fructus Crataegi 500-5000
Rhizoma amorphophalli 50-500 chitosan 5-100.
3, the compositions of a kind of blood lipid regulation according to claim 1 is characterized in that, the weight proportion of described each component is as follows: Semen Cassiae 2000 Fructus Crataegis 2000
Rhizoma amorphophalli 200 chitosans 40.
4, the compositions of a kind of blood lipid regulation according to claim 1 is characterized in that, described chitosan is low macromolecule water-solubility chitosan.
5, the compositions of a kind of blood lipid regulation according to claim 1 is characterized in that, described Fructus Crataegi is for removing the Fructus Crataegi after examining.
According to the compositions of claim 1 or 2 or 3 or 4 or 5 described a kind of blood lipid regulation, it is characterized in that 6, described compositions can be made said any solid dosage forms on the pharmaceutics.
7, the compositions of a kind of blood lipid regulation according to claim 6 is characterized in that, described dosage form is capsule or granule or sheet.
8, any described method for compositions among a kind of preparation claim 1-7, it is characterized in that, get the recipe quantity Semen Cassiae, the Fructus Crataegi powder of removing after examining is broken into 20 purpose coarse powder, add 6-8 and doubly measure 60-80% ethanol, after soaking 0.5-1h, reflux refluxes 2-3 time altogether, each 1.0-2.0h, filter, merging filtrate reclaims ethanol through the decompression thin film concentration and becomes clear paste standby, recipe quantity Rhizoma amorphophalli micropowder is broken into above fine powder of 150 orders and the recipe quantity chitosan of pulverizing more than 60 mesh sieves, appropriate amount of auxiliary materials adds above-mentioned clear paste, mix homogeneously, the 60-95% alcohol granulation, 50-60 ℃ dry 1-3 hour, add an amount of adjuvant, make the solid preparation on the pharmaceutics.
9, the described method for compositions of a kind of preparation according to claim 8 is characterized in that, after oven dry in 50-60 ℃ of baking oven 1-3 hour, adds lubricant, canned one-tenth capsule.
10, the described method for compositions of a kind of preparation according to claim 8 is characterized in that, after oven dry in 50-60 ℃ of baking oven 1-3 hour, adds lubricant, tabletting.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367788A (en) * | 2014-10-31 | 2015-02-25 | 海南金海岸生物技术研究所 | Pharmaceutical composition compounded with marine organism polysaccharide as well as preparation method and application of pharmaceutical composition |
| CN104886435A (en) * | 2015-06-16 | 2015-09-09 | 青岛浩大海洋保健食品有限公司 | Chitosan-containing health care capsule with blood lipid regulation efficacy |
| CN108272087A (en) * | 2018-01-30 | 2018-07-13 | 山东汇润膳食堂股份有限公司 | A kind of blood fat reducing food and preparation method thereof |
| CN110200113A (en) * | 2019-07-12 | 2019-09-06 | 哈尔滨工业大学 | A kind of preparation method of heat-clearing lipid-loweringing polysaccharide composite wild vegetables tea bag |
-
2005
- 2005-11-04 CN CNB2005101009220A patent/CN100560112C/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367788A (en) * | 2014-10-31 | 2015-02-25 | 海南金海岸生物技术研究所 | Pharmaceutical composition compounded with marine organism polysaccharide as well as preparation method and application of pharmaceutical composition |
| CN104886435A (en) * | 2015-06-16 | 2015-09-09 | 青岛浩大海洋保健食品有限公司 | Chitosan-containing health care capsule with blood lipid regulation efficacy |
| CN108272087A (en) * | 2018-01-30 | 2018-07-13 | 山东汇润膳食堂股份有限公司 | A kind of blood fat reducing food and preparation method thereof |
| CN110200113A (en) * | 2019-07-12 | 2019-09-06 | 哈尔滨工业大学 | A kind of preparation method of heat-clearing lipid-loweringing polysaccharide composite wild vegetables tea bag |
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| Publication number | Publication date |
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| CN100560112C (en) | 2009-11-18 |
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Effective date of registration: 20100802 Address after: 519020, Zhuhai Special Economic Zone, Guangdong, Gongbei Osmanthus Road No. 132 Co-patentee after: Zhuhai Free Trade Zone Lida Pharmaceutical Co., Ltd. Patentee after: Lizhu Medicine Group Co., Ltd. Address before: 519020 No. 132, Guihua North Road, Zhuhai, Guangdong, Gongbei Patentee before: Lizhu Medicine Group Co., Ltd. |