CN1923247B - Medicine for eliminating cancer pain drastically and curing late cancers and its preparation method - Google Patents
Medicine for eliminating cancer pain drastically and curing late cancers and its preparation method Download PDFInfo
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- CN1923247B CN1923247B CN2005100319179A CN200510031917A CN1923247B CN 1923247 B CN1923247 B CN 1923247B CN 2005100319179 A CN2005100319179 A CN 2005100319179A CN 200510031917 A CN200510031917 A CN 200510031917A CN 1923247 B CN1923247 B CN 1923247B
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Abstract
The invention provides a plant medicament for treating cancer, pharmaceutical composition and its preparation, wherein the medicament comprises scrophularia root 100-1000g, pork soup and eggs. The medicament can be made into dosage forms including decoction, oral liquids, capsules, granules and tablets.
Description
One, technical field:
The present invention relates to a kind of medicine of eliminating cancer pain and treatment terminal cancer and preparation method thereof.
Two, background technology:
Cancer is one of the most serious principal disease of harm humans health, is called as incurable disease.The defective of radiotherapy maximum is to form coke button in focus, has stayed the seed of trouble of recurrence.And easily cause the damage of normal structure, limited giving tumor tissues bigger dosage, powerless to the case that has potential amphi position to shift.The chemotherapy good and evil are all decreased, and the whole body toxic and side effects is arranged.Though interventional therapy is the progress of chemotherapy, all ratios of decreasing of good and evil have had significantly to be adjusted, and can be described as local chemotherapy, though do not injure whole body, bigger to the infringement of local internal organs organ, it is depleted to be easy to cause organ to poison.The greatest drawback of operative treatment has two kinds: the one, during the cutting carcinoma, also destroyed the organic whole balance of human body.The 2nd, cutting carcinoma operation is totally not thorough, can stay the seed of trouble of diffusion transfer at full speed, and the local diffusion and the potential amphi position of tumor shifted, and may cause the consequence of " press calabash get up wooden dipper " fully.The greatest drawback of gene therapy is the appropriate litigation fees costliness.Biotherapy is invalid to immune negation oncotherapy.Present treatment by Chinese herbs has overcome above most of defective, pays attention to organic conception, distinguishes that disease executing control.Yet treating the poisonous disease with poisonous drugs exists toxic and side effects, and low dose of Chinese medicine curative effect is slow, and the treatment phase is long and effect is unstable, and heavy dose of prescription medicine composition is assorted, obeys toxic side effect for a long time.So far not seeing has single medicinal material or plant amedica to be used for the treatment of cancer.
There is major defect in the three step analgesia schemes that the WHO of World Health Organization (WHO) recommends: the one, cure the symptoms, not the disease, and can only ease pain, can not control cancer; The 2nd, dosage needs to increase gradually the ability pain management; The 3rd, cause using addiction; The 4th, it is not thorough to ease pain; The 5th, can not treat comprehensively, do not reach and eliminate that stool is tight, the xerostomia larynx is dry and fire-toxin is made a psychological attack, the vexed and hot-tempered disease that causes.The way of handling cancer ascites at present is to extract hydroabdomen out.Its defective is to cure the symptoms, not the disease, and need carry out repeatedly, ignores the mass action of function of human body, and circulation ascites itself has just injured the life power of human body.
Radix Scrophulariae is the root of Scrophulariaceae herbaceos perennial Radix Scrophulariae, another name Radix Scrophulariae, black ginseng.Nature,taste and action: sweet, bitter, salty, be slightly cold, go into lung, stomach, kidney channel.Nourishing YIN to lower pathogenic fire, heat-clearing and toxic substances removing, eliminating stagnation eliminating carbuncle, control the calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, night are slept peaceful, spontaneous sweating, constipation, hematemesis and epistaxis, laryngopharynx swelling and pain, swollen, the scrofula of pain are hindered in Tianjin.
Usage and dosage: for oral administration: fry in shallow oil soup 3-5 money, or go into ball, diffusing.External: smash and apply or grind art and transfer and apply.
This plant amedica has the advantage that abundant, the convenient sources of exploiting natural resources, cost are lower, be easy to promote.
Three, summary of the invention:
The purpose of this invention is to provide a kind of medicine of eliminating cancer pain and treatment cancer and preparation method thereof, a kind of treatment terminal cancer especially is provided, particularly be at death's door, cachectic medicinal plants, its composition and method of making the same occur, overcome the deficiency that chemicotherapy, interventional therapy and present Chinese medicine are controlled cancer.
The objective of the invention is to be achieved through the following technical solutions:
A kind of medicine of eliminating cancer pain and treatment cancer, the preparation that forms by following parts by weight of raw materials combined preparation: Radix Scrophulariae 100-1000, Radix Angelicae Sinensis 10-100, Radix Codonopsis 10-100, Rhizoma Chuanxiong 10-150, Radix Rehmanniae Preparata 5-150, Rhizoma Atractylodis Macrocephalae 5-150, Rhizomadioscoreae 5-150, Semen Coicis 5-150, Nodus Nelumbinis Rhizomatis 5-100, Radix Glycyrrhizae 5-100.Be preferably following parts by weight of component: Radix Scrophulariae 200-800, Radix Angelicae Sinensis 20--90, Radix Codonopsis 20-100, Rhizoma Chuanxiong 20-120, Radix Rehmanniae Preparata 10-120, Rhizoma Atractylodis Macrocephalae 10-120, Rhizomadioscoreae 10-120, Semen Coicis 10-120, Nodus Nelumbinis Rhizomatis 10-80, Radix Glycyrrhizae 10--80.Most preferably decoct is following parts by weight of component: Radix Scrophulariae 300g, Radix Angelicae Sinensis 50g, Radix Codonopsis 50g, Rhizoma Chuanxiong 50g, Radix Rehmanniae Preparata 50g, Rhizoma Atractylodis Macrocephalae 50g, Rhizomadioscoreae 60, Semen Coicis 50g, Nodus Nelumbinis Rhizomatis 30g.Radix Glycyrrhizae 30g.The decoct of most preferably converting lean meat 500g is following parts by weight of component: Radix Scrophulariae 800g, Radix Angelicae Sinensis 60g, Radix Codonopsis 60g, Rhizoma Chuanxiong 50g, Rhizoma Atractylodis Macrocephalae 50g, Rhizomadioscoreae 60, Semen Coicis 50g, Nodus Nelumbinis Rhizomatis 30g, Radix Glycyrrhizae 30.
The present invention is a kind of to eliminate the preparation method of cancer pain and treatment cancer drug, and may further comprise the steps: get twice mixing of described component decocting, convert steamed lean meat soup every days two clothes or three clothes, the thing of getting it filled adds egg decocting twice, the liquid medicine egg of taking after mixing it with water, every days two clothes or three clothes.Described preparation method can also add pharmaceutically available adjuvant, and described medicament is meant said oral administered dosage form, especially granule, capsule, tablet, effervescent tablet and oral liquid on any pharmaceutics, and the best is a decoction.
The pharmacology of pharmaceutical composition prescription of the present invention is:
Described component is Radix Angelicae Sinensis, Radix Rehmanniae Preparata, have enrich blood, invigorate blood circulation, the YIN nourishing effect, be monarch drug with it; The Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong have spleen reinforcing, the blood-activating and qi-promoting qigong to imitate, and are ministerial drug with it; Rhizomadioscoreae, Semen Coicis have the spleen reinforcing diuretic, the consolidating superficial resistance that is good for the stomach, detumescence and apocenosis effect, are adjuvant drug with it; The effect of Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae invigorating the spleen and replenishing QI, change silt preventing or arresting vomiting, coordinating the actions of various ingredients in a prescription is a messenger drug with it.
The present invention has following effect and advantage:
1, the invention provides a kind of medicinal plants, its main component is a Radix Scrophulariae.Get the medicament that its root decocting extracts preparation, can thoroughly eliminate cancer pain, be used for the treatment of terminal cancer, occur the cancer patient of cachexia, progressive emaciation in particular for treatment late period after the diffusion.Can reach dose and remove cancer pain (except the neuropathic pain that oncothlipsis causes), can reach mental status more than ten doses or ten doses and be clearly better, take care of oneself, of pink and healthy-looking.The present invention pays attention to strengthening life power, strengthens the organism energy, adjusts life organic whole balance, nourishes congenital kidney qi, and the health care taste day after tomorrow are given full play to the strength of getting rid of evils of human body organism itself.Cooperate function of human body work on the one hand, on the one hand through focus is assaulted fortified position; Removing burning wood away under the boiler is optimized rehabilitation environment on the one hand, makes the cancerous cell shock on the one hand.The Radix Scrophulariae detoxifcation of relieving inflammation or internal heat, the through focus of relieving inflammation or internal heat, removing burning wood away under the boiler makes the cancer cell shock, worsens the living environment of cancerous cell, and the through focus of detoxifcation is external the eliminating of the cancerous cell of shock.
2, overcome present treatment terminal cancer, particularly treated cancer pain, the treatment diffusion cachectic cancer patient in back cures the symptoms, not the disease, even has only the shortcoming of announcing the time of death release hospital gate; Overcome the toxic and side effects shortcoming of chemicotherapy, interventional therapy and Chinese herbal medicine treating the poisonous disease with poisonous drugs.
3, the curative effect spy is good, has no side effect.
After the patient obeys potion, can remove cancer pain, and mental status takes a turn for the better the quality of life raising.
Four, clinical case report
Spread cancer patient's 15 examples late period with the direct oral medication of Radix Scrophulariae decoct, or compound prescription decoctum 12 examples, the PRELIMINARY RESULTS brief summary is as follows:
Radix Scrophulariae water decoction therapeutic outcome
1, physical data
1.1 case is selected
In 15 examples, later period of hepatocarcinoma spreads 4 examples, renal carcinoma 1 example, mammary cancer 1 example, uterus carcinoma, ovarian cancer, bladder cancer 1 example, nasopharyngeal carcinoma 2 examples, osteocarcinoma 2 examples, gastric cancer 2 examples, intestinal cancer 2 examples.
1.2 sex and age
Man's 10 examples, women 5 examples, 20-30 year 3 examples, 40-50 year 4 examples, 50-60 year 2 examples, 60-70 year 4 examples, 70-80 year 2 examples.
1.3 malignant tumor situation
1. Zui Da malignant tumor is a liver cancer patient of 42 years old, and except that a plurality of tuberositys, maximum lump is 165mm * 148mm, splenomegaly, ascites.
2. the most serious patient is the renal carcinoma hepatic metastases, and enlarged abdomen was as 6 months anemia of pregnant woman, and both legs swelling is quite serious, and seat must not must not stand and must not sleep, and has to recline, and hospital announces to prepare funeral affairs in the week.
3. oldest patient is 76 years old, suffers from uterus carcinoma, ovarian cancer and bladder cancer, worn to a shadow, skin grey black, and defecation can not be taken care of oneself, and has to make a call in the middle of bed a hole.
Cachexia, progressive emaciation, lesions position pain appear in all patients.
2, Therapeutic Method
Radix Scrophulariae 250 gram water decoctions, potion two was obeyed or three clothes in one day.
3, therapeutic outcome:
3.1, clothes of the water decoction of Radix Scrophulariae potion 250 gram of taking medicine (be Radix Scrophulariae 250 grams water decoction 1/2nd), thoroughly remove focus pain (except the neuropathic pain that oncothlipsis causes), mental status takes a turn for the better, somatosensory is comfortable, and stool is tight, dry and the vexed and hot-tempered phenomenon of xerostomia larynx is all removed.
3.2, result (all patients take back non-evident effect)
Radix Scrophulariae decoct oral 15 routine clinical efficacy such as following tables:
| Treat routine number | Eliminate cancer pain (1 dose) | Eliminate ascites (10 doses) in a small amount | The mental status takes a turn for the better | Recovery is taken care of oneself and is improved the quality of living |
| 15 | 100％ | 100％ | 100％ | 100％ |
Radix Scrophulariae compositions water decoction oral medication result:
With Radix Scrophulariae compositions water decoction oral medication terminal cancer 12 examples, effective percentage 100%, concrete curative effect sees the following form:
| Treat routine number | Eliminate cancer pain (1 dose) | Eliminate ascites (10 doses) in a small amount | The mental status takes a turn for the better | Weight increase quality of life raising |
| 12 | 100％ | 100％ | 100％ | 100％ |
Radix Scrophulariae and Radix Scrophulariae pharmaceutical composition decoct are converted the steamed soup of pig lean meat or decoct boiled egg curative effect such as following table:
| Treat routine number | Potion is eliminated cancer pain % | Eliminate ascites % in a small amount for 10 doses | Mental status improvement % | Weight increase, quality of life are improved % |
| 8 | 100 | 100 | 100 | 100 |
4, discuss
The present invention can treat terminal cancer and soak into, spreads, occurs the cancer patient of cachexia, focus pain late period.Mainly be to pay attention to strengthening life power, strengthen the viable organism energy, adjust life organic whole balance, nourish congenital kidney qi, the health care taste day after tomorrow.Cooperate function of human body work on the one hand, reach focus on the one hand and assault fortified position; Removing burning wood away under the boiler is optimized rehabilitation environment on the one hand, makes the cancerous cell shock on the one hand.Zhang Yuansu said, " Radix Scrophulariae is the agent of important department, about all gas of pipe neck, elimination and not turbid "." detailed outline ": " kidney water is injured, the kidney-Yang fall, and lonely positive unrooted is sent out to fiery sick, and method should be strengthened water to make fire, so the same worker of Radix Scrophulariae and Radix Rehmanniae.The scrofula that disappears also is the fire that looses, and it is that fire is sick that Liu keeps the truth tuberculosis." " medicine justice ": " and the deficiency of five ZANG-organs of kidney is warm and dry then, suitable cool benefits, solely this cool profit nourishing kidney victory know, cypress, specially for the kidney monarch drug." " book on Chinese herbal medicine justice ": " and Radix Scrophulariae is reported the property of Zhiyin, special main calentura, and bitter in the mouth then drop-down is descending, so can control disease such as internal organs accumulation of heat.Flavor is hot again and little salty, leads to blood stasis so straight hemopoietic divides, also can the layman in channel tunnel, and the carbuncle of dissipation stagnation of pathogenic heat.Cold and not high, profit and oiliness-----------comparatively is gentle, and the abuses difference is light." " Records of Tradition Chinese and Western Medicine in Combination ": " also reuse and must assist it with GUISHAO in the SIWU TANG to the YIN nourishing stomach-clearing decoction, this what is called carefully is not mutually exclusive boldly and with confidence yet.”
It is better that Radix Scrophulariae medicine of the present invention and Radix Scrophulariae medicine add the curative effect of steamed lean meat soup or boiled egg soup, and all dosage forms most preferably are decoction.
5, conclusion
Radix Scrophulariae medicine of the present invention and Radix Scrophulariae pharmaceutical composition are thoroughly eliminated cancer pain, and the treatment ache in late cancer is evident in efficacy, effective percentage 100%, and curative effect is rapidly, short treating period, and non-evident effect is the choice drug of quite ideal thorough elimination cancer pain treatment terminal cancer.Yet patient and the organ failure, digestive function depletion person of the present invention after to treatment chemotherapy and interventional therapy is invalid.
6, points for attention
The patient of the body constitution preference explanation of book is as directed normally taken medicine or is omited dosage, and the patient of body constitution deviation can description as directed slightly subtract dosage.The not wound body of suffering from diarrhoea, weak dose heavily has slight dizziness.
7, taboo
Cachexia patient that Radix Scrophulariae medicine of the present invention and Radix Scrophulariae pharmaceutical composition cause chemotherapy and interventional therapy and organ failure, digestive function depletion person forbidding, to the suitable deficiency and coldness of taste, big loose stool and patient's forbidding of rushing down before taking medicine.
Model case 1
Thank * *, the male, 42 years old, hepatocarcinoma lump maximum lump except that a plurality of tuberositys was 165mm * 148mm, and focus pain has the Aranea hemorrhoid unbearably, obviously becomes thin, and with anemia, skin, sclera dye Huang, and stool is tight, ascites.Behind clothes dose one clothes, pain disappears, obey ten doses of medicines after, mental status recovers as healthy people, and is of pink and healthy-looking, the ascites disappearance.
Model case 2
Cao * *, the women, 76 years old, look into and be uterus carcinoma, to have soaked into and be diffused as ovarian cancer, bladder cancer, sign is skinny progressive emaciation, and metrorrhagia appears in the no color of looking pale, and stool is tight, and dry mouth and tougue is vexed and hot-tempered.Sharp ache unbearably, bitterly the time in the soft vendor's stand, defecation can only not played a hole solution in the middle of bed, can not take care of oneself.Behind clothes dose one clothes, pain disappears, and is happy from head to foot, and mental status takes a turn for the better.After obeying ten doses, life can be taken care of oneself, and can wander about the streets and look for the old man to chat.Transference cure originally.
Model case 3
The dragon * *, the male, 43 years old, the renal carcinoma infiltration metastasis was hepatocarcinoma, intestinal cancer, enlarged abdomen such as June the anemia of pregnant woman, double-legged swelling can not be stood, seat must not must not sleep, and can only recline.Acutely unbearably, stool is tight during pain, and the xerostomia larynx is dry, and is vexed and hot-tempered.Hospital notifies in the week and prepares funeral affairs.Take medicine behind potion one clothes, pain disappears, and is conscious from head to foot happy.Free movement of the bowels is taken medicine after ten doses, can take care of oneself, and can eat to sleep can walk.Wrinkle appears in the double-legged epidermis of swelling, and is soft.
The consumption standard of Radix Scrophulariae medicine of the present invention when clinical practice seen as following table:
| Used Radix Scrophulariae dosage | 250g | 400g | 500g | 600g | 700g | 800g | 900g | 1000g |
| Adapted lean meat weight | 0 | 200g | 300g | 400g | 500g | 600g | 700g | 800g |
| Use the egg number during without lean meat | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Consumption standard during Radix Scrophulariae composition of medicine clinical practice of the present invention sees the following form:
| Used Radix Scrophulariae amount | 250g | 400g | 500g | 600g | 700g | 800g | 900g | 1000g |
| Adapted lean meat weight | 0 | 100g | 200g | 300g | 400g | 500g | 600g | 700g |
| Use the egg number during without lean meat | 0 | 0 | 1 | 2 | 3 | 4 | 5 | 6 |
The specific embodiment
Embodiment 1
Radix Scrophulariae decoct of the present invention
Get Radix Scrophulariae 250 gram, collect immersion after adding the constant decocting, add water again and repeat once to fry in shallow oil, immersion mixes bottling, takes for twice after the cancer patient divides three times every day after meal.
Embodiment 2
Radix Scrophulariae oral liquid of the present invention
Get Radix Scrophulariae 250 gram, collect immersion after adding the constant decocting, add water again and repeat once to fry in shallow oil, immersion mixes and concentrates, and makes the oral liquid bottling routinely, takes for twice after the cancer patient divides three times every day after meal.
Embodiment 3
Scrophularia capsule agent of the present invention
Get Radix Scrophulariae 300 gram, collect immersion after adding the constant decocting, add water again and repeat once to fry in shallow oil, immersion mixes and is condensed into extractum, and 20 orders of granulating are encapsulated, make capsule, and every capsules 0.4 gram is crude drug 10 grams.The cancer patient divides clothes every day after meal three times, and each 10, obey at twice every day after meal, each 15.
Embodiment 4
Radix Scrophulariae tablet of the present invention
Get Radix Scrophulariae 300 gram, collect immersion after adding the decocting of constant, add water again and repeat once to fry in shallow oil, immersion mixes and is condensed into extractum, granulate 20 orders, and tabletting is made tablet, and every 0.4 gram restrains for containing crude drug 10.The cancer patient obeys every day after meal at twice, each 15, divides clothes every day after meal three times, each 10.
Embodiment 5
Radix Scrophulariae granule of the present invention
Get Radix Scrophulariae 300 gram, collect immersion after adding the decocting of constant, add water again and repeat once to fry in shallow oil, immersion mixes and is condensed into extractum, and granulate 20 orders become granule.Every bag 10 grams are for containing crude drug 100 grams.Cancer patient is obeyed every day after meal at twice, and each 1.5 bags divide clothes every day three times, each 1 bag.
The implementation and operation mode of Radix Scrophulariae composition oral liquid of the present invention, granule, tablet is the same.
Claims (3)
1. eliminate cancer pain and the medicine for the treatment of terminal cancer for one kind, it is characterized in that preparation: Radix Scrophulariae 100-1000 by following weight portion feedstock production one-tenth, Radix Angelicae Sinensis 10-100, Radix Codonopsis 10-200, Rhizoma Chuanxiong 10-150, Radix Rehmanniae Preparata 5-150, Rhizoma Atractylodis Macrocephalae 5-150, Rhizomadioscoreae 5-150, Semen Coicis 5-150, Nodus Nelumbinis Rhizomatis 5-150, Radix Glycyrrhizae 5-150.
2. according to a kind of medicine of eliminating cancer pain and treatment terminal cancer of claim 1, it is characterized in that described raw material components is following parts by weight of component: Radix Scrophulariae 300, Radix Angelicae Sinensis 50, Radix Codonopsis 50, Rhizoma Chuanxiong 50, Radix Rehmanniae Preparata 50, the Rhizoma Atractylodis Macrocephalae 50, Semen Coicis 50, Rhizomadioscoreae 60, Nodus Nelumbinis Rhizomatis 30, Radix Glycyrrhizae 30.
3. a medicine as claimed in claim 1 or 2 is converted the preparation method of steamed pig lean meat soup or decoct boiled egg, it is characterized in that may further comprise the steps: mix twice back of thing decocting of getting it filled, convert steamed pig lean meat soup every days two clothes or three clothes, or the thing of getting it filled adds twice of egg decocting, the liquid medicine egg of taking after mixing it with water, every days two clothes or three clothes.
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| CN107137517A (en) * | 2017-07-03 | 2017-09-08 | 曹国荣 | Eliminate autonomic drug and pharmaceutical composition of Pain Treatment cancer and preparation method thereof |
| CN107362232A (en) * | 2017-07-19 | 2017-11-21 | 曹国荣 | Treat autonomic drug and pharmaceutical composition of leukemia and preparation method thereof |
| CN110237183A (en) * | 2019-06-13 | 2019-09-17 | 黄金和 | The Chinese medicine composition and preparation method thereof of health and cancer preventing and treating |
| CN113577184A (en) * | 2021-08-25 | 2021-11-02 | 廖兰青 | Anti-cancer traditional Chinese medicine composition and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1634430A (en) * | 2004-10-29 | 2005-07-06 | 李永胜 | Chinese traditional medicine composition for resisting malignant tumor (cancer) |
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| CN1634430A (en) * | 2004-10-29 | 2005-07-06 | 李永胜 | Chinese traditional medicine composition for resisting malignant tumor (cancer) |
Non-Patent Citations (2)
| Title |
|---|
| 张建春等.玄参的化学成分与药理活性研究进展.山东医药工业22 1.2003,22(1),25-16. |
| 张建春等.玄参的化学成分与药理活性研究进展.山东医药工业22 1.2003,22(1),25-16. * |
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