CN1919271A - Gynecological inflammation treating medicine composition and uses thereof - Google Patents
Gynecological inflammation treating medicine composition and uses thereof Download PDFInfo
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- CN1919271A CN1919271A CN 200610052241 CN200610052241A CN1919271A CN 1919271 A CN1919271 A CN 1919271A CN 200610052241 CN200610052241 CN 200610052241 CN 200610052241 A CN200610052241 A CN 200610052241A CN 1919271 A CN1919271 A CN 1919271A
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- angelicae sinensis
- rhizoma atractylodis
- fructus kochiae
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Abstract
The invention relates to a pharmaceutical composition for treating gynaecologic inflammation and process for preparation, wherein the raw materials include herba solidaginis, broom cypress fruit, flavescent sophora root, white atractylodes rhizome and Chinese angelica root. The preparing process comprises the steps of proportioning, watering and boiling, concentrating, charging ethanol, precipitating, reclaiming ethanol, concentrating into concrete, mixing concentrated extracts, drying, sieving, granulating. The composition can be prepared into any of the pharmacologically acceptable dose forms.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of gynecological inflammation, particularly a kind of pharmaceutical composition of pure natural treatment gynecological inflammation.
Background technology
Gynecological inflammation is women's commonly encountered diseases and a frequently-occurring disease, brings many miseries to the patient, has a strong impact on the healthy of numerous women.At present, how western medical treatment is used for the treatment of gynecological inflammation with nitre imidazoles antimicrobial drug such as metronidazole suppository, Metrogel and econazole nitrate and miconazole nitrate etc.Although therapeutic effect still can, prolonged and repeated use certainly will cause the imbalance and the drug resistance of flora in patient's vagina.This just needs to recover the normal microbial environment of patient's vagina, rather than simultaneously anaerobe, aerobe, fungus etc. is all killed.Because can further destroy microecological environment so on the contrary.Therefore, the present invention is directed to the deficiency of above-mentioned technology, adopt natural Chinese medicines, through scientific composition and development meticulously, can benefiting QI and nourishing blood, heat-clearing and toxic substances removing, again can heat clearing and damp drying to keep normal microbial environment, for further satisfying the medication demand of vast female patient, provide a Chinese medicine preparation that anti-inflammation is satisfied.
Summary of the invention
The objective of the invention is further to satisfy the medication demand of vast female patient, a kind of scalable, good effect that has is provided, side effect is little, the pharmaceutical composition of the treatment gynecological inflammation of compliance advantages of higher,
Purpose of the present invention can take following method to realize:
A kind of pharmaceutical composition for the treatment of gynecological inflammation is characterized in that: it forms tablet, capsule, suppository, foam, gel, ointment (weight portion) by following raw materials according and pharmaceutically acceptable additives:
Herba Veronicae 50-500 Fructus Kochiae 50-500 Radix Sophorae Flavescentis 25-500 Rhizoma Atractylodis Macrocephalae 25-500
Radix Angelicae Sinensis 25-500
Its formula optimization is: (weight portion)
Herba Veronicae 200, the Fructus Kochiae 150 Radix Sophorae Flavescentiss 100 Rhizoma Atractylodis Macrocephalaes 100 Radix Angelicae Sinensis 150
Described pharmaceutically acceptable additives are following one or more:
Stearic acid, semi-synthetic fatty acid ester, vaseline, liquid Paraffin, Arlacel-80, tween 80, lecithin, sodium lauryl sulphate, dimethyl sulfoxine, azone, glycerol, gelatin, Polyethylene Glycol, Polyethylene Glycol-32 glycerol monolaurate (gelucire44/14), HPMC, CMC-Na, ethylparaben, Oleum Sesami, soybean oil, Oleum Arachidis hypogaeae semen, tartaric acid, citric acid, sodium bicarbonate, propylene glycol, carbomer, PVA, alginate, tragcanth.
Described tablet can be common tablet, vagina effervescence or other various suitable tablets, can be with suitable coating material coating also coating not.
Described capsule can be common capsule, soft capsule, effervescent capsule, controlled release vaginal capsule or other various suitable capsules.
Described suppository can be common bolt, type of effervescent suppository, soft capsule suppository or other various suitable suppositorys.
The present invention has produced synergism with above drug matching, and range of application enlarges, the side effect such as dysbacteriosis of having avoided the Western medicine broad-spectrum sterilization to cause again simultaneously.Also can be widely used in the treatment of gynecological inflammation such as trichomonal vaginitis, colpitis mycotica, bacterial vaginitis and mixed vaginitis.
The specific embodiment
Embodiment 1:
(1) get following raw material by weight percentage ready:
Herba Veronicae 200 grams, the Fructus Kochiae 150 gram Radix Sophorae Flavescentiss 100 gram Rhizoma Atractylodis Macrocephalaes 100 gram Radix Angelicae Sinensis 150 grams
(2) get that the Fructus Kochiae, Radix Sophorae Flavescentis decoct with water, concentrate, add ethanol precipitation, reclaim ethanol, to be condensed into the extractum shape standby;
(3) get that Herba Veronicae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis add alcohol reflux, to filter, be condensed into the extractum shape standby:
(4) above-mentioned spissated respectively two kinds of extractum are mixed, dry, sieve, granulate, make suitable preparation (woman is scorching fixed).
(5) getting above-mentioned two kinds of extract powders, to be broken into fine powder standby; 60 ℃ of dryings 2 hours, citric acid was 105 ℃ of dryings 1 hour with sodium bicarbonate, porphyrize respectively, and it is standby to cross 100 mesh sieves; With the Myrj 45 heating and melting, after the anhydrous calcium chloride dehydration, filtering calcium chloride is standby; After getting the Myrj 45 heating and melting, under agitation add above-mentioned metronidazole, miconazole nitrate, sodium bicarbonate, citric acid fine powder respectively, fully stir evenly, injection molding, cooling, demoulding, packing promptly gets woman's inflammation and decides type of effervescent suppository.
Embodiment 2
Tablet is got following raw material by weight ready:
(1) Herba Veronicae 500 grams, the Fructus Kochiae 450 gram Radix Sophorae Flavescentiss 300 gram Rhizoma Atractylodis Macrocephalaes 300 gram Radix Angelicae Sinensis 300 grams
(2) take by weighing the above-mentioned raw materials medicine and get extractum, be ground into fine powder,, granulate with the appropriate amount of auxiliary materials mixing with example 1 legal system, drying, tabletting promptly gets the scorching stator of woman.
Embodiment 3:
Take by weighing Herba Veronicae 500 gram, the Fructus Kochiae 400 grams, Radix Sophorae Flavescentis 250 grams, the Rhizoma Atractylodis Macrocephalae 250 grams, Radix Angelicae Sinensis 250 grams get extractum with example 1 legal system, and to make fine powder standby; Citric acid, sodium bicarbonate pulverize separately become fine powder standby; Above-mentioned fine powder and appropriate amount of auxiliary materials mixing are that binding agent is granulated with the ethanol solution of PVPK30, drying, and tabletting promptly get woman's inflammation and decides effervescent tablet.
Embodiment 4:
Capsule takes by weighing Herba Veronicae 500 grams by weight, and the Fructus Kochiae 450 restrains, Radix Sophorae Flavescentis 300 grams, and the Rhizoma Atractylodis Macrocephalae 300 grams, Radix Angelicae Sinensis 300 grams get extractum with example 1 legal system and make fine powder and appropriate amount of auxiliary materials mixing, the encapsulating capsule, packing promptly gets woman's inflammation and decides capsule.
Embodiment 5:
Get the extractum fine powder that the same method 1 makes, add liquid Paraffin and stir evenly standby in right amount; Other gets vaseline, lecithin is an amount of, and heat fused, temperature are reduced to about 50 ℃, add above-mentioned spares, fully stir evenly, and are pressed into soft capsule, and packing promptly gets woman's inflammation and decides soft capsule.
Embodiment 6: get an amount of stearic acid, glyceryl monostearate, liquid paraffin, white vaseline, Arlacel-60, Tween-60 heat fused, hold the oil phase temperature at 70～80 ℃; Other gets an amount of glycerol, sorbic acid, water and is heated to 70～80 ℃, under agitation is added in the oil phase, continues to be stirred to about 60 ℃, slowly adds the extractum fine powder that the same method 1 makes, and continues to be stirred to molding, and packing gets promptly that the woman is scorching to decide ointment.
For a better understanding of the present invention, below further set forth medicine of the present invention at clinical action effect, but not to the restriction of effect of the present invention.
Concrete clinical practice is as follows:
1. clinical subjects: 90 examples in the treatment group of the present invention, male 60 examples, women 30 examples.52 examples are organized in treatment, matched group 38 examples, the course of disease 1～3 year.The general use 3 courses of treatment of medicinal tablet of the present invention, 3 months each courses of treatment.Matched group gives Metronidazole Tablet oral, and every day three times, the time is the same with the medication group, takes 9 months continuously.Other matched group situation sees the following form.Clinical test results is as follows: illustrate that treatment group effect is significantly better than matched group (seeing Table 1).
Table 1 liang group clinical effectiveness comparison sheet
| Clinical | The basic healing | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group matched group P value | 19 9 ＜0.01 | 16 10 ＜0.01 | 13 7 | 4 12 | 92.30 68.42 ＜0.01 |
Characteristics of the present invention are:
1. be the All Pure Nature pharmaceutical preparation, have nourishing qi and blood, clearing heat and detoxicating, the merit of heat-clearing and damp-drying drug, its in clinical use good effect, the cycle is short, price is low, without strict indication and toxic and side effect;
2. the employing peroral dosage form is easy to use, and mouthfeel is good, and the patient easily accepts;
3. treat both principal and secondary aspect of disease, evident in efficacy, and can keep normal microbial environment;
4. medical expense is low, but than the conventional therapy cost saving more than 50%.
Claims (5)
1, a kind of pharmaceutical composition for the treatment of gynecological inflammation, it is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials: the consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
Herba Veronicae 50-500 Fructus Kochiae 50-500 Radix Sophorae Flavescentis 25-500 Rhizoma Atractylodis Macrocephalae 25-500
Radix Angelicae Sinensis 25-500
2, pharmaceutical composition according to claim 1, the optimised quantity that it is characterized in that filling a prescription is:
Herba Veronicae 200, the Fructus Kochiae 150 Radix Sophorae Flavescentiss 100 Rhizoma Atractylodis Macrocephalaes 100 Radix Angelicae Sinensis 150
3, preparation of drug combination method according to claim 1 is characterized in that comprising the steps:
(1) taking by weighing each raw material such as Herba Veronicae, the Fructus Kochiae, Radix Sophorae Flavescentis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis by formula proportion gets ready by weight;
(2) get that the Fructus Kochiae, Radix Sophorae Flavescentis decoct with water, concentrate, add ethanol precipitation, reclaim ethanol, to be condensed into the extractum shape standby;
(3) get that Herba Veronicae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis add alcohol reflux, to filter, be condensed into the extractum shape standby:
(4) above-mentioned spissated respectively two kinds of extractum are mixed, dry, sieve, granulate, make tablet or make any medicament on the pharmaceutics.
4, pharmaceutical composition according to claim 1 is characterized in that: described pharmaceutically acceptable additives are following one or more: citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate, glycerol, gelatin, Polyethylene Glycol, glycerol monolaurate (gelucire44/14), propylene glycol, dextrin, ethanol, dried starch etc.
5, described Chinese medicine preparation of the present invention is any one in tablet, granule, the capsule, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; Preferred tablet for oral administration, the preferred effervescent suppository of external.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610052241 CN1919271A (en) | 2006-06-30 | 2006-06-30 | Gynecological inflammation treating medicine composition and uses thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610052241 CN1919271A (en) | 2006-06-30 | 2006-06-30 | Gynecological inflammation treating medicine composition and uses thereof |
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| Publication Number | Publication Date |
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| CN1919271A true CN1919271A (en) | 2007-02-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200610052241 Pending CN1919271A (en) | 2006-06-30 | 2006-06-30 | Gynecological inflammation treating medicine composition and uses thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2343065A1 (en) * | 2008-09-11 | 2011-07-13 | Qingdao Qiyuan Bio-technologies Co., Ltd. | The pharmaceutical composition containing ferulic acid and matrine compounds, the preparation and the use thereof |
-
2006
- 2006-06-30 CN CN 200610052241 patent/CN1919271A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2343065A1 (en) * | 2008-09-11 | 2011-07-13 | Qingdao Qiyuan Bio-technologies Co., Ltd. | The pharmaceutical composition containing ferulic acid and matrine compounds, the preparation and the use thereof |
| EP2343065A4 (en) * | 2008-09-11 | 2012-09-19 | Qingdao Qiyuan Bio Technologies Co Ltd | The pharmaceutical composition containing ferulic acid and matrine compounds, the preparation and the use thereof |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20090109 Address after: Zhejiang city of Ningbo province Yinzhou District Yinxian Avenue East Zhejiang Pharmaceutical College No. 888 post encoding: 315100 Applicant after: Yang Xiong Zhi Co-applicant after: Yang Yijie Address before: 21, 4 floor, 293 South Rainbow Road, Jiangdong District, Zhejiang, Ningbo, China: 315040 Applicant before: Yang Yijie |
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Owner name: YANG XIONGZHI Free format text: FORMER OWNER: YANG YIKAI Effective date: 20090109 |
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Open date: 20070228 |