CN1915227A - Method for preparing drop pills - Google Patents
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- CN1915227A CN1915227A CNA200610115808XA CN200610115808A CN1915227A CN 1915227 A CN1915227 A CN 1915227A CN A200610115808X A CNA200610115808X A CN A200610115808XA CN 200610115808 A CN200610115808 A CN 200610115808A CN 1915227 A CN1915227 A CN 1915227A
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Abstract
A process for preparing dripping pills features use of quantitative injection moulding method, resulting in high roundness, high qualified rate and high granularity.
Description
Technical field
The present invention relates to the method that quantitative injection molding prepares drop pill.
Background technology
Drop pill is with medicine dissolution, emulsifying or is suspended in the suitable molten matrix, splashes in the not miscible liquid coolant by suitable dropper, because that capillary effect is shrunk to drop is spherical, and cooled and solidified and the pill made.
The drop pill beginning sees 1933, and the Denmark pharmaceutical factory prepares vitamin A, D drop pill in this way; Useful PEG4000 in 1956 is a substrate, preparation phenobarbital drop pill; There was human dropping preparation method trial-production antimony potassium tartrate drop pill in China in 1958.Chinese Pharmacopoeia records drops from version in 1977.
Drop pill is particularly suitable for containing liquid medicine and principal agent volume medicine pill little or excitatory; can increase stability of drug; reduce zest; cover bad smell etc., have that workshop health and labor protection are good, the production cycle is shorter, can increase medicine stability; improve insoluble drug dissolution rate and dissolution, both can make the characteristics that rapid release also can be made slow releasing preparation; therefore, drop pill has large development in recent years, and having developed one is new varieties.
Though drop pill has above-mentioned advantage, also there are some problems in process of production.For example the drop pill machine of using in commercial production at present mainly is the drop pill machine that medicinal liquid borrow energy and gravity are oozed naturally by the water dropper mouth of pipe, the different thickness by the dropper bore of the ball method of double differences is controlled, the mouth of pipe crosses that medicinal liquid is not fully filled when thick, make the different increase of the ball method of double differences, ball is heavily controlled the rerum natura that also is subjected to medicinal liquid with the roundness of pill, temperature, the selection of liquid coolant and the temperature of liquid coolant, water dropper and the distance of cooling off liquid level, the size of drop, the interfacial tension of medicinal liquid and liquid coolant, the surface tension of medicinal liquid, the influence of the factors such as thickness of dropper tube wall, make drop pill in commercial production, have the different and uppity problem of roundness pill of the ball method of double differences, accepted product percentage is lower, the production cost height, and can only produce ball and focus on the following drop pill of 70mg, restricted further developing of drop pill.
Goal of the invention
The present invention is directed to dropping preparation method and prepare the problem that pill exists, adopt quantitative injection molding to produce drop pill, the characteristics that not only keep the drop pill of current methods preparation, but also do not need dropper and liquid coolant, make the ball method of double differences different more easy to control with roundness pill, simplify production process, improve certified products, reduce production costs, and can produce the drop pill that ball heavily surpasses 70mg.
Summary of the invention
For achieving the above object, the present invention adopts following method to prepare drop pill: with 1 weight portion medicine dissolution, emulsifying or be suspended in 1～20 suitable weight portion molten matrix, stir evenly, make uniform medicinal liquid, with dosing pump medicinal liquid is injected spherical mold under 70 ℃～95 ℃ heat-retaining conditions, be cooled to ball, the demoulding, drying, the sieve ball selects ball, counting packaging, promptly.
Substrate of the present invention is Polyethylene Glycol and/or poloxamer and/or stearic acid and/or sodium lauryl sulphate; The diameter range of spherical mold of the present invention is 2mm～10mm; The ball that is cooled to of the present invention is degree of passing cooling, and degree of passing chilling temperature is 45 ℃～0 ℃; Baking temperature of the present invention is that 15 ℃～30 ℃, relative humidity are 20%～50%, the time is 30 minutes～60 minutes.
Method for preparing drop pills of the present invention and dropping preparation method relatively have following beneficial effect:
1. the present invention has cancelled dropper and liquid coolant, has overcome the influence to ball weight and pill roundness of dropper and liquid coolant, has simplified production process.
2. the present invention adopts quantitative injection molding to produce drop pill, not only can effectively control the different and pill roundness of the ball method of double differences, improve accepted product percentage, and it is great in the drop pill of 70mg to produce ball.
3. the present invention has increased drying process, helps further improving the stability of drop pill.
The specific embodiment
Embodiment 1
The preparation of WUZHI DIWAN is got 1 weight portion Fructus Schisandrae Sphenantherae ethanol extractum and is added in the fused polyethylene glycol 6000 substrate of 1～10 weight portion, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～10mm, 45 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of WUZHI DIWAN of the present invention's preparation improves 12%, and average production cost descends 21%, under equal conditions preserves shelf-life prolongation 12 months.
Embodiment 2
The preparation of liver-benefiting dropping pill is got 1 weight portion silymarin and is added in the fused polyethylene glycol 6000 substrate of 1～5 weight portion, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 50% the condition dry 45 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of liver-benefiting dropping pill of the present invention's preparation improves 6%, and average production cost descends 17%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 3
The preparation of dripping pills of andrographolide is got 1 weight portion andrographolide and is added in the fused polyethylene glycol 6000 substrate of 2～8 weight portions, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～8mm, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 30 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of dripping pills of andrographolide of the present invention's preparation improves 11%, and average production cost descends 23%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 4
The preparation of Flunarizine hydrochloride pills is got 1 weight portion flunarizine hydrochloride and is added in the fused polyethylene glycol 6000 substrate of 5～20 weight portions, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～5mm, 45 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 45 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of Flunarizine hydrochloride pills of the present invention's preparation improves 13%, and average production cost descends 18%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 5
The preparation of phosphoric ligustrazine drop is got 1 weight portion ligustrazine phosphate and is added in the substrate of 2～5 weight portion Macrogol 4000s and 1～5 weight portion polyethylene glycol 6000 mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～8mm, 45 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of phosphoric ligustrazine drop of the present invention's preparation improves 39%, and average production cost descends 42%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 6
The preparation of breviscapine drop pills is got 1 weight portion breviscapine and is added in the substrate of 2～5 weight portion Macrogol 4000s and 1～6 weight portion polyethylene glycol 6000 mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～10mm, 35 ℃～6 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of breviscapine drop pills of the present invention's preparation improves 27%, and average production cost descends 36%, under equal conditions preserves shelf-life prolongation 12 months.
Embodiment 7
The preparation of schizandrol drop pill is got 1 weight portion schizandrol extractum and is added in the fused polyethylene glycol 6000 substrate of 1.5～6 weight portions, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm, 25 ℃～10 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of schizandrol drop pill of the present invention's preparation improves 19%, and average production cost descends 20%, under equal conditions preserves shelf-life prolongation 12 months.
Embodiment 8
The preparation of drop pills of paeonol is got 1 weight portion paeonol and is added in the fused polyethylene glycol 6000 substrate of 2～9 weight portions, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～5mm, 40 ℃～2 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 40% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of paeonol of the present invention's preparation improves 16%, and average production cost descends 23%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 9
The preparation of drop pills of sodium ferulic acid is got 1 weight portion sodium ferulate and is added in the substrate of 1～5 weight portion polyethylene glycol 6000,2～6 weight portion Macrogol 4000s and 1～5 weight portion poloxamer mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm with dosing pump, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of the drop pills of sodium ferulic acid that the present invention prepares improves 32%, and average production cost descends 27%, preserves shelf-life prolongation 6 months under equal bar.
Embodiment 10
The preparation of Olea acid dropping balls is got 1 weight portion oleanolic acid and is added in the substrate of 1～9 weight portion polyethylene glycol 6000 and 0.1～2 weight portion sodium lauryl sulphate mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～8mm, 45 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 40% the condition dry 30 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of Olea acid dropping balls of the present invention's preparation improves 9%, and average production cost descends 13%, under equal conditions preserves shelf-life prolongation 3 months.
Embodiment 11
The preparation of drop pills of total saponin of gen-seng haulms is got 1 weight portion stem and leaf of Radix Ginseng total saponins and is added in the substrate of 1～5 weight portion polyethylene glycol 6000,1～3 weight portion Macrogol 4000 and 0.1～1 weight portion sodium lauryl sulphate mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm with dosing pump, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding, in temperature is that 26 ℃, relative humidity are under 40% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of total saponin of gen-seng haulms of the present invention's preparation improves 25%, and average production cost descends 30%, under equal conditions preserves shelf-life prolongation 12 months.
Embodiment 12
The preparation of retrandrine drop pill is got 1 weight portion retrandrine and is added in the fused polyethylene glycol 6000 substrate of 1～5 weight portion, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm, 40 ℃～2 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of retrandrine drop pill of the present invention's preparation improves 17%, and average production cost descends 21%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 13
The preparation of drop pills of coumarin acetic acid is got 1 weight portion coumarin acetic acid and is added in the fused polyethylene glycol 6000 of 1～7 weight portion, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～5mm, 35 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 26 ℃, relative humidity are under 40% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of coumarin acetic acid of the present invention's preparation improves 11%, and average production cost descends 10%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 14
The preparation of huperzine dropping pills is got in the substrate of 1 weight portion huperzine A and 1～5 weight portion polyethylene glycol 6000,1～3 weight portion poloxamer and 0.5～3 weight portion stearic acid mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～8mm with dosing pump, 40 ℃～2 ℃ temperature degree of passing coolings, the demoulding, in temperature is that 26 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of huperzine dropping pills of the present invention's preparation improves 10%, and average production cost descends 16%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 15
The preparation of drop pills of lentinan is got 1 weight portion lentinan and is added in the fused polyethylene glycol 6000 substrate of 1～6 weight portion, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm, 35 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 40% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of lentinan of the present invention's preparation improves 12%, and average production cost descends 8%, under equal conditions preserves shelf-life prolongation 3 months.
Embodiment 16
The preparation of drop pills of centella total glycoside is got 1 weight portion Herba Centellae total glycosides and is added in the fused polyethylene glycol 6000 substrate of fused 1～5 weight portion, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～5mm, 40 ℃～10 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 25 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of centella total glycoside of the present invention's preparation improves 14%, and average production cost descends 7%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 17
The preparation of Gypenosides dropping pills is got 1 weight portion Herb Gynostemmae Pentaphylli total glycosides and is added in the fused polyethylene glycol 6000 substrate of fused 1～5 weight portion, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～5mm, 40 ℃～2 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 25 ℃, relative humidity are under 50% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of Gypenosides dropping pills of the present invention's preparation improves 19%, and average production cost descends 13%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 18
The preparation of gastrodine drop pill is got 1 weight portion gastrodine and is added in the substrate of 1～5 weight portion polyethylene glycol 6000,1～5 weight portion stearic acid and 1～3 weight portion poloxamer mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～9mm, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 23 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of gastrodine drop pill of the present invention's preparation improves 15%, and average production cost descends 11%, under equal conditions preserves shelf-life prolongation 3 months.
Embodiment 19
The preparation of drop pills of soybean aglycone is got 1 weight portion daidzein and is added in fused 1～5 weight portion polyethylene glycol 6000 substrate, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～8mm, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of soybean aglycone of the present invention's preparation improves 16%, and average production cost descends 17%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 20
The preparation of drop pills of hemsleyadin is got 1 weight portion hemsleyadin and is added in fused 1～5 weight portion polyethylene glycol 6000 substrate, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～7mm, 45 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 50% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of gastrodine drop pill of the present invention's preparation improves 9%, and average production cost descends 6%, under equal conditions preserves shelf-life prolongation 3 months.
Embodiment 21
The preparation of drop pills of agrimophol is got 1 weight portion strand agrimophol and is added in the fused polyethylene glycol 6000 substrate of fused 3～9 weight portions, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～8mm, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 40% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of agrimophol of the present invention's preparation improves 18%, and average production cost descends 24%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 22
The preparation of polyactin drop pill is got 1 weight portion polyactin and is added in fused 2～8 weight portion polyethylene glycol 6000 substrate, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～8mm, 40 ℃～2 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of polyactin drop pill of the present invention's preparation improves 11%, and average production cost descends 13%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 23
The preparation of Fibrauretin dripping pill is got 1 weight portion fibrauretin and is added in fused 3～9 weight portion polyethylene glycol 6000 substrate, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～7mm, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of Fibrauretin dripping pill of the present invention's preparation improves 20%, and average production cost descends 31%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 24
The preparation of drop pills of cucurbitacine is got 1 weight portion cucurbitacin and is added in the substrate of 2～6 weight portion polyethylene glycol 6000s and 1～5 weight portion Macrogol 4000 mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm, 40 ℃～5 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 40% the condition dry 30 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of cucurbitacine of the present invention's preparation improves 12%, and average production cost descends 13%, under equal conditions preserves shelf-life prolongation 12 months.
Embodiment 25
The preparation of drop pills of lysionotin is got 1 weight portion lysionotin and is added in the substrate of 1～3 weight portion polyethylene glycol 6000 and 1～7 weight portion Macrogol 4000 mixed melting, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～10mm, 45 ℃～3 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 45% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of drop pills of cucurbitacine of the present invention's preparation improves 19%, and average production cost descends 23%, under equal conditions preserves shelf-life prolongation 6 months.
Embodiment 26
The preparation of rorifone drop pill is got 1 Chong Liang Fen rorifone and is added in fused 1～6 weight portion polyethylene glycol 6000 substrate, stir evenly, make uniform medicinal liquid, under 70 ℃～90 ℃ heat-retaining conditions, medicinal liquid is injected the spherical mold that diameter is 2mm～6mm, 40 ℃～2 ℃ temperature degree of passing coolings, the demoulding with dosing pump, in temperature is that 30 ℃, relative humidity are under 40% the condition dry 60 minutes, the sieve ball selects ball, counting packaging, promptly.
Compare with dropping preparation method, the average accepted product percentage of Fibrauretin dripping pill of the present invention's preparation improves 8%, and average production cost descends 11%, under equal conditions preserves shelf-life prolongation 3 months.
Claims (5)
1. method for preparing drop pills, it is characterized in that it is that 1 weight portion medicine is added in 1～20 suitable weight portion molten matrix, stir evenly, make uniform medicinal liquid, with dosing pump medicinal liquid is injected spherical mold under 70 ℃～95 ℃ heat-retaining conditions, be cooled to ball, the demoulding, drying, the sieve ball selects ball, and counting packaging is made.
2. the substrate in the described method for preparing drop pills of claim 1 is Polyethylene Glycol and/or poloxamer and/or stearic acid and/or sodium lauryl sulphate.
3. the spherical mold in the described method for preparing drop pills of claim 1, its diameter range is 2mm～10mm.
4. be cooled to ball in the described method for preparing drop pills of claim 1 and be degree of passing cooling means, degree of passing chilling temperature is 45 ℃～0 ℃.
5. the baking temperature in the described method for preparing drop pills of claim 1 is that 15 ℃～30 ℃, relative humidity are 20%～50%, and be 30 minutes～60 minutes drying time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610115808XA CN100431528C (en) | 2006-08-16 | 2006-08-16 | Method for preparing drop pills |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610115808XA CN100431528C (en) | 2006-08-16 | 2006-08-16 | Method for preparing drop pills |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1915227A true CN1915227A (en) | 2007-02-21 |
| CN100431528C CN100431528C (en) | 2008-11-12 |
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| CNB200610115808XA Active CN100431528C (en) | 2006-08-16 | 2006-08-16 | Method for preparing drop pills |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1552313A (en) * | 2003-12-19 | 2004-12-08 | 北京正大绿洲医药科技有限公司 | Process for preparing drops or other drop agents |
| CN2696631Y (en) * | 2004-01-08 | 2005-05-04 | 北京长征天民高科技有限公司 | Equipment for preparing dropping pills and other dropping dosage forms |
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| CN100431528C (en) | 2008-11-12 |
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Assignee: Nanchang Helioeast Pharmaceutical Co., Ltd. Assignor: Hongyi Science and Technology Co., Ltd., Nanchang Contract fulfillment period: 2009.1.20 to 2026.1.20 Contract record no.: 2009360000015 Denomination of invention: Method for preparing Yueshu dripping pills to treat dysmenorrhea Granted publication date: 20081112 License type: Exclusive license Record date: 20090318 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.1.20 TO 2026.1.20; CHANGE OF CONTRACT Name of requester: NANCHANG HONGYI DRUG INDUSTRY CO., LTD. Effective date: 20090318 |
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Assignee: NANCHANG HELIOEAST PHARMACEUTICAL Co.,Ltd. Assignor: HELIOEAST SCIENCE & TECHNOLOGY Co.,Ltd. NANCHANG Contract record no.: 2009360000015 Date of cancellation: 20200619 |
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Application publication date: 20070221 Assignee: NANCHANG HELIOEAST PHARMACEUTICAL Co.,Ltd. Assignor: HELIOEAST SCIENCE & TECHNOLOGY Co.,Ltd. NANCHANG Contract record no.: X2020980004274 Denomination of invention: Method for preparing Yueshu dripping pills to treat dysmenorrhea Granted publication date: 20081112 License type: Exclusive License Record date: 20200722 |