CN1911333A - Process for extraction of peel of banana - Google Patents
Process for extraction of peel of banana Download PDFInfo
- Publication number
- CN1911333A CN1911333A CN 200610088459 CN200610088459A CN1911333A CN 1911333 A CN1911333 A CN 1911333A CN 200610088459 CN200610088459 CN 200610088459 CN 200610088459 A CN200610088459 A CN 200610088459A CN 1911333 A CN1911333 A CN 1911333A
- Authority
- CN
- China
- Prior art keywords
- extraction
- pericarpium musae
- blood pressure
- administration
- musae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An extract of banana peel for treating hypertension is prepared from dried banana peel through extracting in water or alcohol 1-3 times, collecting the liquid extract, filtering, and concentrating.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to the extraction process of Chinese crude drug Pericarpium Musae.
Background technology
Pericarpium Musae is the crust of banana fruit, abandons it as refuse usually, but there have report can be used as to be medicinal.Put down in writing according to " national Chinese herbal medicine compilation " (volume two): " Pericarpium Musae or fruit stem: 1～4 liang of the bright root of hypertension consumption "." attached side's 1. hypertension: 1～2 liang on Pericarpium Musae or fruit stem, fry in shallow oil the soup clothes.Banana flowers is decocted in water for oral dose again, can prevent and treat cerebral hemorrhage and apoplexy.”
The hypotensive activity of Fructus Musae has the research report abroad, through online access, " research worker of India Ka Situ Bhujerba medical college reports that they show some volunteers' observation: eat two Fructus Musaes continuous every day in a week, can make blood pressure reduce by 10%.The India scientist delivers research report and says on India's " modern science " medical journal, naturalization compound contained in the Fructus Musae is to play a role with the similar mode of antihypertensive medicine; " they think that Fructus Musae all contains angiotensin-convertion enzyme inhibitor, and ripe Fructus Musae is bigger than the effect of immaturity Fructus Musae performance.
Our result of study shows that Pericarpium Musae also has good antihypertensive activity, and the ripe Pericarpium Musae of different cultivars all has good antihypertensive activity, but the antihypertensive activity of immaturity Pericarpium Musae is very little.Pericarpium Musae is better than spontaneously hypertensive the hypotensive effect of renal hypertension, show as in the experiment under the identical dosage to the blood pressure lowering amplitude of renal hypertensive rat and hypotensive effect persistent period all greater than being the effect of spontaneous hypertensive rat to SHR (Spontaneously HypertensiveRats), this result is to coincide with thinking that the hypotensive effect of Fructus Musae mainly contains angiotensin converting enzyme inhibitor class depressor substance.Experimental result shows that also the antihypertensive activity of Pericarpium Musae has long-lasting characteristics, and the hypotensive effect of keeping of long period can be arranged after the drug withdrawal of continuous use a period of time, and this is the distinguishing feature of this medicine.
Fructus Musae is stated from " detailed outline is picked up any lost article from the road " in China beginning, and " Gui Haiyu weigh will ", " book on Chinese herbal medicine is asked the source " are all on the books.At present domestic existing a large amount of cultivations, and Pericarpium Musae is gurry, so the stock number of Pericarpium Musae is big.Now its extraction is developed as new Chinese medicine, both can economizes on resources, more new Chinese crude drug also is provided for China is clinical, promote the well-being of mankind.
Summary of the invention
The extraction process that the purpose of this invention is to provide a kind of Chinese crude drug Pericarpium Musae.
The objective of the invention is to realize by following measures:
Dried Pericarpium Musae is 40%～80% with aqueous solvent or ethanol extraction, concentration of ethanol, and solvent load is 4～10 times of medical material amount, extraction time is 1～3 time, and extraction time is each 1～3 hour, merge extractive liquid,, filter, be concentrated into relative density 1.00～1.20g/ml, make extractum.
Wherein, more preferably extraction process is: dried Pericarpium Musae extracts with etoh solvent, concentration of ethanol is 60%～80%, solvent load is 5～8 times of medical material amount, and extraction time is 1～3 time, and extraction time is each 1～3 hour, merge extractive liquid,, filter, be concentrated into relative density 1.00～1.20g/ml, make extractum.
Preferred extraction process is: dried Pericarpium Musae extracts with etoh solvent, solvent strength is 80%, solvent load is 7 times of medical material amount, extraction time is 3 times, and extraction time is each 2 hours, merge extractive liquid,, filter, be concentrated into relative density 1.12g/ml, make extractum, obtain total extractives 23.30%.
Process for extraction of peel of banana simple possible provided by the invention is suitable for industrialized great production; The pericarp of Fructus Musae extract drug effect of gained is clear and definite, can be used for hypertensive treatment.
The specific embodiment
Embodiment 1: the evaluation of medical material and pre-treatment:
Dried Pericarpium Musae is the dry peel of Musaceae plant plantain or Fructus Musae
Identify: be the black peel, about long 10cm, wide 1cm, simply, Fructus Musae fragrance slightly.
Pre-treatment: take from the golden yellow peel of ripe Fructus Musae, placed under 80 ℃ of temperature dry 24 hours, cooling is collected.Remove impurity such as handle stalk, be ground into the long sheet piece of 1～2cm.
Embodiment 2: extraction process
Dried Pericarpium Musae water extraction, the consumption of water are 7 times of medical material amount, and extraction time is 3 times, and extraction time is each 3 hours, and merge extractive liquid, filters, and is concentrated into relative density 1.11g/ml, makes extractum, obtains total extractives 14.68%.
Embodiment 3: extraction process
Dried Pericarpium Musae ethanol extraction, solvent strength are 40%, and solvent load is 4 times of medical material amount, and extraction time is 1 time, and extraction time is each 1 hour, and merge extractive liquid, filters, and is concentrated into relative density 1.12g/ml, makes extractum, obtains total extractives 15.10%.
Embodiment 4: extraction process
Dried Pericarpium Musae ethanol extraction, solvent strength are 40%, and solvent load is 10 times of medical material amount, and extraction time is 3 times, extraction time is each 3 hours, and merge extractive liquid, filters, be concentrated into relative density 1.20g/ml, make extractum, obtain total extractives 30.00%.
Embodiment 5: extraction process
Dried Pericarpium Musae ethanol extraction, solvent strength are 60%, and solvent load is 7 times of medical material amount, and extraction time is 2 times, and extraction time is each 1 hour, and merge extractive liquid, filters, and is concentrated into relative density 1.13g/ml, makes extractum, obtains total extractives 17.03%.
Embodiment 6: extraction process
Dried Pericarpium Musae ethanol extraction, solvent strength are 60%, and solvent load is 10 times of medical material amount, and extraction time is 2 times, extraction time is each 2 hours, and merge extractive liquid, filters, be concentrated into relative density 1.13g/ml, make extractum, obtain total extractives 18.57%.
Embodiment 7: extraction process
Dried Pericarpium Musae ethanol extraction, solvent strength are 80%, and solvent load is 7 times of medical material amount, and extraction time is 3 times, and extraction time is each 1 hour, and merge extractive liquid, filters, and is concentrated into relative density 1.00g/ml, makes extractum, obtains total extractives 22.35%.
Embodiment 8: extraction process
Dried Pericarpium Musae ethanol extraction, solvent strength are 80%, and solvent load is 10 times of medical material amount, and extraction time is 1 time, extraction time is each 1 hour, and merge extractive liquid, filters, be concentrated into relative density 1.12g/ml, make extractum, obtain total extractives 16.97%.
Embodiment 9: extraction process
Dried Pericarpium Musae ethanol extraction, solvent strength are 80%, and solvent load is 7 times of medical material amount, and extraction time is 3 times, and extraction time is each 2 hours, and merge extractive liquid, filters, and is concentrated into relative density 1.12g/ml, makes extractum, obtains total extractives 23.30%.
Embodiment 10: pharmacodynamic study
The Pericarpium Musae that the foregoing description 2 and 9 described technologies are made extracts extractum and carries out pharmacodynamic study, can find that the pericarp of Fructus Musae extract that technology of the present invention makes has good antihypertensive activity to renal hypertensive rat, SHR rat.
Acute drop test result shows: p.o. Pericarpium Musae 80% ethanol extraction extractum (ethanol extraction) high (10.0g (crude drug amount)/kg), in (5.0g/kg), low (2.5g/kg) dosage renal hypertensive rat is had good acute hypotensive effect, the maximum reducing amplitude is (X ± SD): SAP:11.6 ± 4.0%, 8.5 ± 3.3%, 5.8 ± 2.0%, DAP:11.3 ± 4.8%, 9.9 ± 3.2%, 4.2 ± 3.4% relatively has significant difference (P＜0.01) with the feedwater group.The hypotensive effect persistent period was above 11 hours.
P.o. the high, medium and low dosage of Pericarpium Musae ethanol extraction has good hypotensive effect to SHR, the maximum reducing amplitude is (X ± SD): SAP:12.8 ± 3.4%, 7.8 ± 2.2%, 5.0 ± 3.3%, DAP:13.2 ± 4.6%, 7.7 ± 1.9%, 4.9 ± 1.6% relatively has significant difference (P＜0.01) with the feedwater group.High, the middle dosage group hypotensive effect persistent period was above 11 hours.
The therapeutic drop test is the result show: every day, p.o. was administered once, successive administration 15 days, the Pericarpium Musae ethanol extraction has good hypotensive effect to renal hypertensive rat, blood pressure promptly obviously descends after the administration in first day, blood pressure has been reduced to floor level and has been in steady after the administration in the 5th～7 day, maximum reducing amplitude high, middle dosage is respectively (X ± SD): SAP:22.6 ± 3.0%, 18.5 ± 3.3%, DAP:22.9 ± 2.7%, 17.0 ± 4.3% relatively has notable difference (P＜0.01) with the feedwater group.Can keep 9～15 days hypotensive effect after the drug withdrawal.
Every day, p.o. was administered once, successive administration 15 days, the Pericarpium Musae ethanol extraction has good hypotensive effect to SHR, blood pressure promptly obviously descends after the administration in first day, blood pressure has been reduced to floor level and has been in steady after the administration in the 5th～7 day, the maximum reducing amplitude of high, medium and low dosage is respectively (X ± SD): SAP:20.3 ± 5.0%, 18.6 ± 3.7%, 11.4 ± 2.4%, DAP:23.2 ± 4.0%, 19.5 ± 3.5%, 11.1 ± 1.7% relatively has notable difference (P＜0.01) with the feedwater group.Can keep 9～15 days hypotensive effect after the drug withdrawal.
The Pericarpium Musae ethanol extraction has certain influence to the heart rate of two kinds of animal models, no matter be that acute administration or therapeutic administration all have the slight heart rate function of falling, but intensity is less.
Conclusion: the ripe Fructus Musae severe edema due to hypofunction of the spleen or 80% ethanol extraction have good antihypertensive activity to clear-headed kidney and two kinds of experimental hypertension animal models of SHR rat.Acute hypotensive effect intensity to two kinds of models is less, but the hypotensive effect time is longer; Therapeutic administration experimental result also shows, two kinds of hypertension animal models all had good antihypertensive activity, the blood pressure lowering amplitude is big and have long-lasting characteristics, under 15 days situation of successive administration, p.o.2.5,5.0,10.0g/kg can make after the drug withdrawal that the blood pressure of animal still remains on reduced levels more than 9 days.
The extract obtained drug effect difference of two kinds of extracting method is not obvious: the blood pressure lowering amplitude does not have notable difference, blood pressure lowering persistent period difference not obvious yet.But therapeutic test pressure decay rate ethanol extraction may be faster than water extract.Two kinds of extracting method all can extract the antihypertensive active substance of Pericarpium Musae effectively, but more reasonable with 80% ethanol extraction method.
The table 1. Fructus Musae severe edema due to hypofunction of the spleen carry or alcohol-extracted extract to the acute blood pressure lowering experimental result of renal hypertensive rat
| Medicine | Dosage (g/Kg) | Number of animals | (X ± SD) (kPa orBPM) before the administration | Blood pressure and changes in heart rate percentage rate after the administration (% X ± SD) | |||||
| Blood pressure and heart rate writing time after the administration (hour) | |||||||||
| 2 | 4 | 6 | 8 | 11 | |||||
| Water | 1.0 ml/100g | 9 | SAP DAP HR | 27.8±2.3 22.8±1.8 356±51 | 5.3±5.9 5.8±5.9 2.3±6.1 | 4.4±3.9 4.4±4.0 -0.4±6.7 | 1.8±4.0 0.4±3.7 -0.9±7.1 | 2.0±5.6 2.5±4.2 -3.3±10.5 | -0.2±5.3 0.2±4.8 -5.7±7.1 |
| Pericarpium Musae (alcohol extraction) | 2.5 | 9 | SAP DAP HR | 27.8±2.3 22.8±1.8 356±51 | -5.1±3.3 ** -4.9±5.1 ** -0.5±5.1 | -5.8±2.0 ** -4.2±3.4 ** -2.9±4.5 | -2.0±2.8 * -2.2±2.8 -1.1±3.8 | -1.7±3.9 -1.8±4.9 -3.8±6.8 | -3.0±5.7 -2.1±5.2 -4.1±4.9 |
| Pericarpium Musae (alcohol extraction) | 5.0 | 9 | SAP DAP HR | 27.9±1.8 23.0±1.6 341±43 | -3.2±6.3 ** -3.8±5.8 ** -0.1±3.0 | -5.8±3.9 ** -7.1±3.8 ** -3.3±7.5 | -8.5±3.3 ** -9.9±3.2 ** -7.2±8.6 | -10.0±5.7 ** -7.7±4.3 ** -9.1±11.0 | -5.6±6.5 * -6.9±6.9 ** -7.7±10.9 |
| Pericarpium Musae (alcohol extraction) | 10.0 | 9 | SAP DAP HR | 28.2±3.0 26.6±2.7 365±33 | -7.3±5.0 ** -7.7±5.7 ** 2.5±6.3 | -10.8±3.3 ** -11.1±3.4 ** 3.8±6.7 | -11.6±4.0 ** -11.3±4.8 ** 3.3±4.8 | -104±3.4 ** -10.1±3.0 ** 5.4±7.0 | -10.1±4.0 ** -11.0±3.8 ** 2.9±5.3 |
| Pericarpium Musae (water is carried) | 5.0 | 8 | SAP DAP HR | 28.2±2.4 23.4±2.4 342±44 | -2.5±4.4 ** -3.1±5.0 ** 1.9±5.8 | -5.2±3.8 ** -3.6±5.0 ** 1.3±8.4 | -6.9±2.1 ** -5.1±4.1 ** -3.6±5.6 | -5.7±2.3 ** -6.0±3.1 ** -1.1±5.2 | -7.4±4.8 ** -7.7±5.1 ** -0.9±6.1 |
Annotate: (1)
*-P＜0.05,
*-P＜0.01; Compare with matched group
(2) blood pressure or heart rate * 100% before blood pressure and heart rate decline percentage rate=(preceding blood pressure of blood pressure or heart rate-administration or heart rate after the administration)/administration
(3) SAP: systolic arterial pressure; DAP: diastolic pressure; HR: heart rate; Down together.
The table 2. Fructus Musae severe edema due to hypofunction of the spleen carry or alcohol-extracted extract to the acute blood pressure lowering experimental result of SHR rat
| Medicine | Dosage (g/kg) | Number of animals | (X ± SD) (kPa or BPM) before the administration | Blood pressure and changes in heart rate percentage rate after the administration (% X ± SD) | |||||
| Blood pressure and heart rate writing time after the administration (hour) | |||||||||
| 2 | 4 | 6 | 8 | 11 | |||||
| Water | 1.0 ml/100g | 9 | SAP DAP HR | 27.0±2.4 22.0±2.2 328±41 | -0.0±4.4 1.3±4.8 1.3±7.7 | 0.7±4.1 3.7±4.8 -0.1±4.7 | -0.7±2.8 1.3±5.3 -0.0±7.1 | -0.5±4.1 0.9±6.3 -2.4±5.7 | 1.5±5.2 2.7±6.1 -1.5±7.2 |
| Pericarpium Musae (alcohol extraction) | 2.5 | 9 | SAP DAP HR | 26.3±1.8 21.2±1.6 344±31 | -4.1±3.3 * -7.4±1.7 ** 0.3±5.0 | -5.0±3.3 ** -4.9±1.6 ** -0.4±5.1 | -4.1±2.5 * -4.7±2.2 ** 0.1±4.0 | -3.7±2.7 -3.4±2.5 -0.7±5.9 | -2.6±3.8 -2.1±3.7 -1.9±3.8 |
| Pericarpium Musae (alcohol extraction) | 5.0 | 9 | SAP DAP HR | 27.2±3.2 22.0±2.8 333±29 | -6.3±1.7 ** -5.7±2.2 ** 2.7±7.1 | -7.8±2.2 ** -7.7±1.9 ** -2.2±8.8 | -6.6±3.3 ** -6.7±2.4 ** -2.6±8.1 | -4.4±2.4 * -5.7±2.1 ** -3.3±8.3 | -3.3±2.4 * -3.2±2.4 * 0.5±6.9 |
| Pericarpium Musae (alcohol extraction) | 10.0 | 10 | SAP DAP HR | 26.4±1.2 22.3±1.1 344±29 | -11.2±2.4 ** -11.8±4.0 ** -1.8±5.4 | -12.8±3.4 ** -13.2±4.6 ** -4.2±4.5 | -12.5±3.5 ** -12.5±3.9 ** -5.7±5.7 | -10.7±3.2 ** -10.3±2.9 ** -5.8±5.5 | -5.7±4.1 ** -6.2±4.4 ** -6.0±5.2 |
| Pericarpium Musae (water is carried) | 5.0 | 8 | SAP DAP HR | 29.0±2.1 23.5±2.0 348±32 | -7.8±1.6 ** -8.7±2.5 ** -4.4±6.4 | -7.2±2.6 ** -7.1±2.0 ** -4.5±5.4 | -8.5±1.6 ** -8.0±2.0 ** -5.0±5.3 | -5.2±2.7 * -7.2±2.3 ** -6.3±6.4 | -3.6±2.3 * -3.9±2.5 * -3.8±4.3 |
Annotate: (1)
*: P＜0.05,
*: P＜0.01; Compare with matched group
(2) blood pressure or heart rate * 100% before blood pressure and heart rate decline percentage rate=(preceding blood pressure of blood pressure or heart rate-administration or heart rate after the administration)/administration
The table 3. Fructus Musae severe edema due to hypofunction of the spleen carry or alcohol-extracted extract to the therapeutic hypotensive effect experimental result of renal hypertensive rat
| Medicine | Dosage (g/Kg) | Number of animals | (X ± SD) (kPa or BPM) before the administration | Administration phase blood pressure and changes in heart rate percentage rate (% X ± SD) | ||||||||
| Administration phase blood pressure and heart rate writing time (my god) | ||||||||||||
| 1 | 3 | 5 | 7 | 9 | 11 | 13 | 15 | |||||
| Water | 1.0ml /100g | 9 | SAP DAP HR | 26.1±3.4 21.3±2.7 360±29 | 5.1±2.4 5.2±3.3 1.3±3.8 | 1.6±3.6 1.4±3.7 0.0±4.6 | 1.6±5.2 2.9±4.5 0.7±6.4 | 3.7±5.2 4.3±6.4 2.4±7.0 | 1.2±4.5 4.4±6.4 2.9±7.7 | 2.7±5.5 3.6±6.3 1.4±5.9 | 2.3±6.7 4.6±6.0 0.7±6.9 | 2.8±5.8 3.8±6.2 0.3±7.8 |
| Pericarpium Musae (alcohol extraction) | 5.0 | 10 | SAP DAP HR | 26.6±.2.7 21.7±2.7 386±40 | -9.2±5.1 ** -9.2±2.7 ** -2.3±4.8 | -13.9±2.8 ** -13.9±2.2 ** -0.2±4.2 | -15.0±3.1 ** -16.6±2.7 ** -4.1±6.26 | -18.5±3.3 ** -16.7±3.5 ** -1.6±3.8 | -16.9±3.8 ** -16.7±4.2 ** -3.4±4.7 * | -17.9±4.6 ** -17.0±4.3 ** -4.8±6.3 * | -18.4±2.7 ** -16.6±4.7 ** -2.5±5.6 | -16.8±4.1 ** -16.1±5.1 ** -6.3±8.0 |
| Pericarpium Musae (alcohol extraction) | 10.0 | 8 | SAP DAP HR | 28.9±2.1 23.9±2.2 367.3±55.1 | -7.7±5.8 ** -8.2±7.5 ** -0.1±3.1 | -19.9±4.4 ** -18.3±4.2 ** -1.7±6.0 | -19.4±4.4 ** -21.1±2.4 ** -1.8±4.6 | -20.8±3.0 ** -20.1±2.2 ** -2.7±5.9 | -20.8±5.3 ** -22.2±3.5 ** -4.7±5.9 * | -22.6±3.0 ** -22.1±3.4 ** -0.8±5.6 | -20.9±2.8 ** -22.9±2.7 ** 1.4±4.1 | -21.2±3.7 ** -21.90±4.3 ** 1.4±7.2 |
| Pericarpium Musae (water is carried) | 5.0 | 10 | SAP DAP HR | 26.1±2.2 20.7±2.7 381±27 | 3.4±10.1 3.7±9.9 -1.2±6.2 | -12.0±4.4 ** -14.5±2.9 ** -3.3±6.4 | -15.4±4.5 ** -17.3±4.7 ** -3.7±5.0 | -16.7±3.7 ** -17.3±4.2 ** -3.2±7.7 | -18.5±3.7 ** -18.6±3.0 ** -5.4±6.7 * | -17.9±3.8 ** -18.9±3.9 ** -7.1±6.0 ** | -19.7±4.1 ** -18.0±5.0 ** -4.7±9.6 | -16.3±6.5 ** -17.4±5.6 ** -3.8±3.9 |
Annotate: (1)
*: P＜0.05,
*: P＜0.01; Compare with matched group
(2) blood pressure or heart rate * 100% before blood pressure and heart rate decline percentage rate=(preceding blood pressure of blood pressure or heart rate-administration or heart rate after the administration)/administration
Continuous table 3
| Medicine | Blood pressure and changes in heart rate percentage rate after the drug withdrawal (% X ± SD) | |||||||
| Blood pressure and heart rate writing time after the drug withdrawal (my god) | ||||||||
| 1 | 3 | 5 | 7 | 9 | 12 | 15 | ||
| Water | SAP DAP HR | 1.5±5.3 2.0±6.8 -0.2±6.7 | 0.7±6.7 2.0±6.2 -1.6±5.5 | 0.5±4.8 1.9±4.8 -0.8±6.3 | 2.4±4.5 2.7±7.0 -0.1±6.6 | 3.3±5.9 3.5±4.5 -1.4±6.4 | 1.1±4.6 2.6±5.7 -0.1±6.2 | 2.8±4.1 4.5±6.4 0.6±6.5 |
| Pericarpium Musae (alcohol extraction) (5.0g/kg) | SAP DAP HR | -18.1±2.6 ** -15.8±4.7 ** -4.9±5.7 | -13.7±4.9 ** -14.5±3.8 ** -7.1±7.1 | -12.1±4.1 ** -11.7±3.2 ** -5.1±9.0 | -7.8±5.3 ** -8.0±2.7 ** -4.8±8.1 | -2.8±4.3 * -0.7±4.6 -5.2±9.2 | 4.2±6.2 5.78±5.9 -3.4±8.9 | 4.3±4.5 6.4±5.4 -3.2±8.4 |
| Pericarpium Musae (alcohol extraction) (10.0g/kg) | SAP DAP HR | -19.1±4.4 ** -21.4±2.7 ** -1.6±7.8 | -18.7±5.1 ** -18.0±3.4 ** 1.5±7.9 | -15.6±4.0 ** -17.6±4.7 ** -4.2±5.4 | -13.9±5.1 ** -14.1±4.2 ** -2.7±7.8 | -10.3±6.2 ** -11.1±4.1 ** -2.4±7.2 | -0.5±10.2 -1.1±9.4 -3.4±5.0 | 2.2±11.6 1.9±10.0 -0.5±6.2 |
| Pericarpium Musae (water is carried) (5.0g/kg) | SAP DAP HR | -15.2±4.6 ** -16.0±5.1 ** -4.5±10.1 | -11.8±4.8 ** -12.3±4.9 ** -7.3±8.6 | -8.5±5.2 ** -6.9±4.1 ** -7.3±6.8 * | -4.4±4.9 ** -2.7±4.9 -6.9±7.5 | 0.8±3.4 2.4±5.3 -6.6±7.9 | 4.1±5.8 9.7±10.8 -5.0±8.4 | 5.8±8.5 11.0±14.4 -3.8±6.7 |
The table 4. Fructus Musae severe edema due to hypofunction of the spleen carry or alcohol-extracted extract to the therapeutic hypotensive effect experimental result of SHR rat
| Medicine | Dosage (g/Kg) | Number of animals | (X ± SD) (kPa or BPM) before the administration | Blood pressure and changes in heart rate percentage rate during the administration (% X ± SD) | ||||||||
| Blood pressure and heart rate writing time during the administration (my god) | ||||||||||||
| 1 | 3 | 5 | 7 | 9 | 11 | 13 | 15 | |||||
| Water | 1.0ml /100g | 9 | SAP DAP HR | 26.7±1.8 21.7±1.5 362±68 | 5.3±6.3 7.7±9.2 3.7±6.0 | 1.4±5.5 3.5±7.8 1.7±7.7 | 3.1±3.7 4.2±6.5 3.3±7.5 | -0.2±3.6 0.9±5.9 -0.7±7.3 | 2.4±6.4 4.0±7.8 0.3±3.4 | 2.6±4.7 2.7±6.0 1.4±6.4 | 1.6±4.4 1.0±5.9 0.5±6.4 | 2.1±5.2 1.8±6.0 1.5±7.1 |
| Pericarpium Musae (water is carried) | 5.0 g/kg | 9 | SAP DAP HR | 26.1±1.8 21.3±1.5 344±32 | -3.9±8.0 * -4.6±9.1 * -4.7±4.4 ** | -15.9±5.3 ** -17.2±5.0 ** -5.1±2.7 * | -16.2±3.0 ** -18.3±5.3 ** -9.8±2.5 ** | -18.7±3.0 ** -20.9±3.9 ** -7.9±2.9 * | -16.3±2.6 ** -21.5±3.6 ** -4.5±4.3 * | -17.4±3.7 ** -22.8±4.3 ** -4.6±2.9 * | -17.8±3.7 ** -20.1±4.2 ** -5.6±4.3 * | -18.9±3.6 ** -20.9±5.2 ** -5.0±3.1 * |
| Pericarpium Musae (alcohol extraction) | 10.0 g/kg | 8 | SAP DAP HR | 27.9±2.3 22.6±2.2 406±64 | -11.2±8.2 ** -11.9±6.3 ** -1.2±4.7 | -18.3±3.4 ** -19.6±3.3 ** -2.0±5.1 | -18.9±4.1 ** -19.8±4.6 ** 2.3±6.5 | -19.9±3.2 ** -20.9±3.7 ** 1.7±5.7 | -18.4±3.8 ** -23.2±4.0 ** 3.5±4.7 | -20.3±5.0 ** -20.1±4.1 ** 1.2±8.5 | -19.8±3.8 ** -22.2±4.3 ** 0.8±6.3 | -19.5±4.6 ** -19.9±3.6 ** -3.1±5.2 |
| Pericarpium Musae (alcohol extraction) | 5.0 g/kg | 9 | SAP DAP HR | 27.9±3.5 22.9±3.3 328±38 | -13.2±6.0 ** -10.6±6.9 ** 2.6±4.7 | -15.8±2.7 ** -17.0±2.4 ** 1.0±2.9 | -18.6±3.7 ** -19.5±2.5 ** 2.3±4.8 | -18.4±2.3 ** -19.2±3.2 ** 2.5±4.0 | -17.4±2.9 ** -18.8±2.6 ** -1.3±2.2 | -18.0±3.7 ** -19.5±3.5 ** 1.4±3.5 | -16.8±3.5 ** -18.5±2.6 ** 1.7±6.3 | -17.6±2.6 ** -18.4±2.9 ** -0.4±3.2 |
| Pericarpium Musae (alcohol extraction) | 2.5 g/kg | 10 | SAP DAP HR | 26.7±1.9 21.6±1.7 357±32 | -2.8±5.1 ** -2.2±7.0 * -3.6±3.2 ** | -8.4±3.7 ** -7.7±3.3 ** -5.2±2.6 * | -10.2±2.8 ** -10.5±2.9 ** -3.5±4.3 * | -9.8±2.3 ** -10.8±2.4 ** -3.1±3.2 | -10.8±2.8 ** -10.7±2.3 ** -3.2±5.3 | -10.5±2.5 ** -10.6±2.4 ** -1.3±4.6 | -10.6±2.0 ** -10.9±2.0 ** -4.2±4.6 | -11.4±2.4 ** -11.1±1.7 ** -5.0±4.5 * |
Annotate: (1)
*: P＜0.05,
*: P＜0.01; Compare with matched group
(2) blood pressure or heart rate * 100% before blood pressure and heart rate decline percentage rate=(preceding blood pressure of blood pressure or heart rate-administration or heart rate after the administration)/administration
Continuous table 4
| Medicine | Blood pressure and changes in heart rate percentage rate after the drug withdrawal (% X ± SD) | |||||||
| Blood pressure and heart rate writing time after the drug withdrawal (my god) | ||||||||
| 1 | 3 | 5 | 7 | 9 | 12 | 15 | ||
| Water | SAP DAP HR | 0.8±4.1 2.5±6.9 0.6±7.7 | 1.0±5.2 2.4±5.4 0.2±10.2 | 1.4±2.8 2.1±3.4 0.3±10.7 | 3.1±4.7 2.1±3.5 0.6±9.5 | 3.9±6.2 5.8±7.7 1.7±9.8 | 4.2±5.7 3.8±6.8 3.3±7.0 | 4.2±6.4 3.3±5.6 0.7±8.7 |
| Pericarpium Musae (water is carried) (5.0g/kg) | SAP DAP HR | -18.1±2.8 ** -20.9±4.0 ** -6.3±3.3 * | -18.1±4.8 ** -19.4±4.4 ** -5.2±4.9 | -17.4±5.2 ** -17.8±5.8 ** -4.9±3.8 | -14.1±4.7 ** -15.8±4.3 ** -6.1±4.7 | -12.4±6.8 ** -13.7±5.2 ** -6.5±6.4 | -0.4±4.9 -11.9±7.1 ** -3.2±6.1 | -0.4±5.8 0.7±4.3 -5.3±5.7 |
| Pericarpium Musae (alcohol extraction) (10.0g/kg) | SAP DAP HR | -18.1±3.2 ** -19.1±4.2 ** -2.7±8.6 | -16.7±3.6 ** -18.3±4.1 ** -0.3±7.7 | -16.2±3.3 ** -15.6±1.7 ** 1.0±9.0 | -12.1±2.6 ** -14.6±1.9 ** 2.3±5.4 | -12.2±3.7 ** -10.6±5.3 ** -0.7±6.6 | -4.1±3.2 ** -4.5±3.7 ** 5.0±8.1 | 4.4±5.2 8.7±5.6 0.8±7.1 |
| Pericarpium Musae (alcohol extraction) (5.0g/kg) | SAP DAP HR | -16.7±2.7 ** -18.1±3.1 ** -2.0±6.1 | -17.1±2.5 ** -16.6±2.6 ** -3.1±4.3 | -13.7±3.3 ** -14.6±4.3 ** -4.7±7.3 | -14.0±4.5 ** -14.2±2.8 ** -2.5±8.8 | -12.8±4.6 ** -12.3±3.6 ** -5.2±7.3 | -0.9±5.0 * -1.0±4.3 * -3.6±6.8 | 1.7±4.8 -0.7±4.2 -1.9±6.3 |
| Pericarpium Musae (alcohol extraction) (2.5g/kg) | SAP DAP HR | -10.5±2.3 ** -10.6±2.6 ** -4.9±5.9 | -9.8±2.32 ** -10.6±2.9 ** -4.5±4.9 | -8.2±4.2 ** -8.1±3.6 ** -5.3±4.2 | -6.0±3.1 ** -5.9±3.7 ** -4.1±6.0 | -2.6±3.5 * -3.4±4.5 ** -3.8±6.3 | 1.1±3.1 -0.3±5.0 -1.6±5.0 | 3.1±3.8 3.7±3.0 -0.7±5.0 |
Annotate: (1)
*: P＜0.05,
*: P＜0.01; Compare with matched group
(2)
##: p＜0.01; With with dosage Pericarpium Musae administration group relatively
(3) blood pressure or heart rate * 100% before blood pressure and heart rate decline percentage rate=(preceding blood pressure of blood pressure or heart rate-administration or heart rate after the administration)/administration
Claims (3)
1, a kind of extraction process of Chinese crude drug Pericarpium Musae, it is characterized in that described process for extraction of peel of banana is: dried Pericarpium Musae is with aqueous solvent or ethanol extraction, concentration of ethanol is 40%～80%, solvent load is 4～10 times of medical material amount, and extraction time is 1～3 time, and extraction time is each 1～3 hour, merge extractive liquid,, filter, be concentrated into relative density 1.00～1.20g/ml, make extractum.
2, process for extraction of peel of banana as claimed in claim 1, it is characterized in that described extraction process is: dried Pericarpium Musae extracts with etoh solvent, concentration of ethanol is 60%～80%, solvent load is 5～8 times of medical material amount, and extraction time is 1～3 time, and extraction time is each 1～3 hour, merge extractive liquid,, filter, be concentrated into relative density 1.00～1.20g/ml, make extractum.
3, process for extraction of peel of banana as claimed in claim 1 or 2, it is characterized in that described extraction process is: dried Pericarpium Musae extracts with etoh solvent, solvent strength is 80%, solvent load is 7 times of medical material amount, and extraction time is 3 times, and extraction time is each 2 hours, merge extractive liquid,, filter, be concentrated into relative density 1.12g/ml, make extractum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610088459 CN1911333A (en) | 2006-08-24 | 2006-08-24 | Process for extraction of peel of banana |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610088459 CN1911333A (en) | 2006-08-24 | 2006-08-24 | Process for extraction of peel of banana |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1911333A true CN1911333A (en) | 2007-02-14 |
Family
ID=37720497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610088459 Pending CN1911333A (en) | 2006-08-24 | 2006-08-24 | Process for extraction of peel of banana |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1911333A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102640935A (en) * | 2012-05-24 | 2012-08-22 | 中华全国供销合作总社济南果品研究院 | Method for extracting dietary fiber in banana skin by adopting enzymic method |
| CN108261481A (en) * | 2018-02-06 | 2018-07-10 | 南京博彩生物工程有限公司 | It is a kind of that there is active material for continuing buck functionality and its preparation method and application |
-
2006
- 2006-08-24 CN CN 200610088459 patent/CN1911333A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102640935A (en) * | 2012-05-24 | 2012-08-22 | 中华全国供销合作总社济南果品研究院 | Method for extracting dietary fiber in banana skin by adopting enzymic method |
| CN108261481A (en) * | 2018-02-06 | 2018-07-10 | 南京博彩生物工程有限公司 | It is a kind of that there is active material for continuing buck functionality and its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101129673A (en) | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis | |
| CN100345558C (en) | Extract product of general flavone of kudzuvine root, preparation method and application | |
| CN1911333A (en) | Process for extraction of peel of banana | |
| CN104523930B (en) | A kind of Pericarpium Citri Reticulatae Rhizoma Atractylodis Macrocephalae compositions reducing emesis of chemotherapy | |
| CN101791336A (en) | Extract from long pepper and preparation method and application thereof | |
| CN1850148A (en) | Medicine for increasing bird's immunity and treating immunity-inhibiting diseases, and preparing medicine therefor | |
| CN1108310C (en) | Algae polysaccharide and its preparation and use | |
| CN104940272A (en) | Trichosanthes seed oil oral liquid | |
| CN1520831A (en) | Health-preserving liver-protecting drug and method for making same | |
| CN1943620A (en) | Chinese medicine composition for treating cardio-cerabral vascular diseases and its preparing method | |
| CN1264506C (en) | Pharmaceutical combination containing red sage root element and preparation method thereof | |
| CN101084937A (en) | Ginkgo leaves freezing-dried powder injection and preparation method thereof | |
| CN1237991C (en) | Medicine for treating amnesia and dementia | |
| CN1283230C (en) | Freeze-dried girald daphne powder injection and its preparing method | |
| CN1634537A (en) | Glossy ganoderma extract and preparation method and use thereof | |
| CN1156287C (en) | A pharmaceutical composition for treating myocardial diseases | |
| CN1559469A (en) | Prepn. method for freezing-drying powder injection for treating cardiovascular disease | |
| CN1557824A (en) | Silkworm excrement total alkaloid and its preparation method | |
| CN101062108A (en) | Medicinal composition for treating dysmenorrhea and preparation process thereof | |
| CN1148182C (en) | Application of tea polyphenol in preparing medicine to suppress beta-amyloid aggregation and fibroplasia | |
| CN1093416C (en) | Plant Medicine for treating cardiovascular medicine and its preparing process | |
| Ramachandra et al. | Cardio protective effect of aegle marmelos on isoproterenol induced myocardial infarction in rats | |
| CN1778336A (en) | Preparation of compound Danshen Root dropping ball | |
| CN105663969A (en) | Application of dried tangerine or orange peel and rhizoma galangae composition to preparation of chemotherapy-vomit resisting drug | |
| CN1947729A (en) | Traditional Chinese medicine composition for anti-inflammation, preparing method and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |