CN1899516A - Medicine for treating coronary heart disease and arrhythmia caused cardio palmus and preparing method - Google Patents
Medicine for treating coronary heart disease and arrhythmia caused cardio palmus and preparing method Download PDFInfo
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- CN1899516A CN1899516A CN 200610091090 CN200610091090A CN1899516A CN 1899516 A CN1899516 A CN 1899516A CN 200610091090 CN200610091090 CN 200610091090 CN 200610091090 A CN200610091090 A CN 200610091090A CN 1899516 A CN1899516 A CN 1899516A
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Abstract
The Chinese medicine is prepared with ten kinds of Chinese medicinal materials, including honeysuckle, angelica, white peony root, solomoseal rhizome, licorice, etc. The Chinese medicine is used for treating coronary heart disease and arrhythmia caused by deficiency in qi and Yin and with the symptoms of cardio palmus, stuffiness in the chest, night sweat, etc. It has the functions of removing necrosis and promoting tissue regeneration, resolving phlegm, stopping palpitation and others, determined curative effect, fast acting, and no toxic side effect.
Description
Technical field
The present invention relates to coronary heart disease and arrhythmia caused cardiopalmus, uncomfortable in chest, night sweat, spontaneous perspiration, lack of appetite indigestion and loss of appetite, dizzy meet labor what for etc. the deficiency of both qi and yin expectorant stasis of blood wait.This product has promoting tissue regeneration by removing blood stasis, reduces phlegm only to throb with fear regulating liver and qi, the effect of kidney tonifying yin nourishing.
Background technology
Set forth the pathogenesis and the rule of treatment of indication with theory of Chinese medical science: coronary heart disease is the doctor trained in Western medicine name of disease, also claim ischemic heart desease, characteristics according to its clinical manifestation, should belong to Chinese medicine categories such as " precordial pain with cold limbs, the thoracic obstruction ", now unify the called after thoracic obstruction, coronary heart disease and arrhythmia is called thoracic obstruction cardiopalmus through Department of Medical Administration of State Administration of Traditional Chinese Medicine thoracic obstruction emergency case cooperative groups.
Chinese medicine one organic conception is a guiding theory, thinks the sick position of primary disease at the heart, and is in close relations with liver,spleen,kidney, on weakened body resistance basis, expectorant is turbid, blood stasis, cold coagulation, the stagnation of QI hinder in heart arteries and veins and form, and is often because of after the heavy meal, excited, overwork, cold stimulation and bringing out always belongs to the deficiency in origin and excess in superficiality card.We reach constantly summary of experience through clinical observation for many years, think and hinder caused by liver and kidney deficiency, phlegm and blood stasis in heart arteries and veins, are that the mistake of heart arteries and veins is supported, and are the pathogenesis key of primary disease, mainly show as the deficiency of both qi and yin expectorant stasis of blood clinically.How does the deficiency of both qi and yin expectorant stasis of blood form? main duty in the functional disorder of liver spleen kidney.Because eating and drinking without temperance, excessive consumption of alcohol and surfeit delicious food savoury injure spleen the moon, spleen sun, and it is expectorant that spleen the moon is hindered the then bright Tianjin of heat-transformation, and the then strong fortune of spleen sun wound is not normal, accumulatively wet raise phlegm.Chronic dietary does not save, and the spleen negative and positive are all empty, and the source of vital function is gradually not enough.Because feelings will internal injury is mainly anger and think of.Strongly fragrant in the excessive anger impairing the liver, irritability, perverse and unreasonable manner is violated spleen, and spleen fortune is dull, accumulatively wet raise phlegm; Anxiety impairing the spleen, stagnation of spleen-QI, eructation is not stretched, and lifting is obstructed, and fortuneization is dull, accumulatively wet raise phlegm.Long-term feelings will internal injury, stagnation of liver-QI with deficiency of the spleen, the source of vital function are also gradually not enough.
Because above-mentioned diet feelings will is hindered, if things go on like this, insufficiency of vital energy and blood, the heart-yin motive is impaired, and turbid continuous the fortune in heart feeling pulse of expectorant reaches kidney for a long time, the kidney qi degradation, in each function of body, the function of kidney is very important, kidney yang plays warm biochemical action to each internal organs, kidney yin plays nourishing, soft and moist effect to each internal organs, so " non-this of YANG of five ZANG-organs can not be sent out, and non-this of the moon of the five internal organs can not be grown " the saying of (Zhang Jingyue) arranged, kidney yang one void, spleen sun heart-yang is empty thereupon; Kidney yin one is lost, and liver-yin, the heart-yin are also lost thereupon.The liver,spleen,kidney function is further lacked of proper care, and makes motive Yin bivacuity, and expectorant is turbid to be hindered in heart arteries and veins, and arteries and veins film of a specified duration is decreased, and phlegm and blood stasis, heart arteries and veins lose supports, and is cardiopalmus and send out.So aspect the legislation treatment, at first separate resolution feeling pulse phlegm and blood stasis, adjust Liver and kidney simultaneously to control the heart.In line with the principle of opening Bai Yu professor " based on logical ", cure saying of tame Liu Chun " Liu Chun medical science complete or collected works " according to the Ming Dynasty again: " all hearts are fallen ill; must transfer its Liver and kidney two dirty earlier; the ghost of the kidney person heart; the irritability general rule motive and, irritability stagnates, and then the motive is weary, this cardiopathia must be transferred its liver earlier also; ... control its kidney, also by its heresy.Liver and kidney two is dirty all and then the heart is spontaneous, examines its heart man's deficiency and excess then and controls it." just according to mentioned above principle, we establish with promoting tissue regeneration by removing blood stasis, reduce phlegm and only throb with fear, regulating liver and qi, the kidney tonifying yin nourishing is basic rule of treatment, establishes the medicine composition that conversion is protected the flat oral liquid of the heart.And confirm that through modern pharmacological research the activating blood circulation to dissipate blood stasis class medical instrument that eliminates the phlegm has antiplatelet aggregation, and improve the effect of coronary circulation, and nourishing the liver and kidney class medicine has the free radical resisting damage, suppress the effect that LPO generates.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of promoting tissue regeneration by removing blood stasis that has, reduce phlegm and only throb with fear, regulating liver and qi, effect medicine of kidney tonifying yin nourishing and preparation method thereof, this curative effect of medication is definite, and effect has no side effect taking convenience rapidly.
The inventor of Department of Pharmacy of the present invention is according to theory of Chinese medical science and the compound Chinese medicinal preparation that develops through for many years clinical empirical summary, and general conversion by name is protected the flat oral liquid of the heart.Medicine of the present invention is to be prepared from by acceptable excipient on the raw material of Chinese medicine of following weight parts and the pharmaceutics:
Flos Lonicerae 250-340 Radix Angelicae Sinensis 250-340 Radix Paeoniae Alba 50-90
Rhizoma Polygonati 150-240 Radix Glycyrrhizae 150-240 Radix Scrophulariae 80-140
Radix Ophiopogonis 80-140 Radix Bupleuri (processed with vinegar) 15-35 Pericarpium Citri Reticulatae Viride (process with vinegar) 15-35
Radix Dichroae (processed with vinegar) 15-35
Press the monarch principles of formulating prescriptions and analyze prescription compatibility of medicines:
Select Flos Lonicerae sweet cold, nontoxic (Compendium of Materia Medica) in the side for use, heat-clearing and toxic substances removing, tonify deficiency nourish blood (book on Chinese herbal medicine is looked for the truth), stimulate the menstrual flow into network, and all flowers are all diffusing, and Emperor Xuantong's QI and blood is arranged, the Xie Zhigong (book on Chinese herbal medicine is just read) that looses ... it is cold analgesic to get its gas, the tonneau of advocating (book on Chinese herbal medicine is looked for the truth).The sweet temperature of Radix Angelicae Sinensis is the reinforcing the heart valiant general, and promoting tissue regeneration by removing blood stasis (book on Chinese herbal medicine terrible) is supported battalion's pain relieving, and the gas in the treating blood disorders (book on Chinese herbal medicine is just read) and blood enrich blood (Compendium of Materia Medica).Warming middle-JIAO to relieve pain removes plug in the objective blood (not Lu), so two medicines are monarch, Radix Angelicae Sinensis draws Flos Lonicerae and goes into the heart by lung, and this cohabits in also last for cardiopulmonary.Two medicines cooperate, and stimulate the menstrual flow into network a surname's venting QI-blood, blood circulation promoting and blood stasis dispelling, reinforcing the heart benefit battalion.Minister with Radix Paeoniae Alba picric acid, be slightly cold promoting blood circulation, dispelling malignant blood (not Lu), the removing heat from blood of astringing the lung, system liver peace spleen.Heart master blood, removing heat from blood is so reinforcing the heart (book on Chinese herbal medicine is terrible) is moved back battalion's heat with relieving restlessness (book on Chinese herbal medicine is just read).Join the Rhizoma Polygonati sweet in the mouth again, property is flat, and is nontoxic.Invigorating the spleen and replenishing QI, settling five organs (not Lu), the profit cardiopulmonary, replenishing essence marrow (book on Chinese herbal medicine is terrible), essence is filled refreshing solid, profit can nourish blood (book on Chinese herbal medicine is just read).It is sweet flat to get Radix Glycyrrhizae again, goes into cardiopulmonary taste (terrible, the herbal classic of book on Chinese herbal medicine), cures mainly the cold and heat pathogen of the vital organs of the human body ... the logical negative and positive of passing through, thus administer the healthy energy of internal organs negative and positive, with except that the pathogen of cold and heat negative and positive also.Hard muscles and bones, longue meat, times strength person ... heart master's power (book on Chinese herbal medicine is high former), the Radix Glycyrrhizae sweet in the mouth, property is flat, detoxifcation in what ... coordinating the actions of various ingredients in a prescription ... QI invigorating relieving spasm to stop pain (book on Chinese herbal medicine is just read).Three medicines are the minister person, and play sour and sweet drugs can transforme into YIN, and bitter sweet consolidating YIN is then sent out the machine of negative and positive lifting, with the principal drug assistance the meridian dredging, and profit QI and blood, and blood vessels, blood stasis dispelling blood, He Yingwei, beneficial the heart-yin is held up the motive, the peace internal organs.Assistant salty with the hardship of Radix Scrophulariae, be slightly cold (Compendium of Materia Medica), strong kidney water is with system heart-fire (book on Chinese herbal medicine is terrible).Reinforcing YIN-essence benefit is smart, be few cloudy kidney channel monarch drug also, (medicine mirror).Assistant is with Radix Ophiopogonis, and energy reinforcing YIN-essence benefit is smart, and the clear god of the heart pacifies then QI and blood and smooth ... heart system gas is capable, and the trouble of pent-up can be released.The husband says: can answer the arteries and veins person, and is what also? the lid the heart controlling blood vessels, and hundred feeling pulse are clear if lung moistens the heart towards the ancestor in lung, then arteries and veins also is in harmonious proportion, and QI and blood is without hindrance, must be at someone's command to pursue feeling pulse unobstructed also (medicine mirror).Radix Scrophulariae, Radix Ophiopogonis two, medicine was assistant person, and is sweet with its salty-cold hardship, the former kidney nourishing water, latter's lung moistening gold.Gold is clearly then aquatic, and water can help fiery, and this is to mend monarch, minister with restoring normal coordination between the heart and kidney, regulation between water and fire, and then the stasis of blood goes arteries and veins to transfer, and the lung profit heart is clear, then the heart-yin taste, the motive is multiple.Make with Radix Bupleuri (processed with vinegar), bitter in the mouth is put down and is gone into liver, and main cold and heat pathogen pushes away Chen Zhixin (herbal classic), and suppressing the hyperactive liver gallbladder, three warmers, guarantor's network be fire (detailed outline) mutually, delivers rationally, and the yang invigorating of bringing down a fever looses 12 through skin ulcer cellulitis blood clotting gas poly-(Bencao Beiyao).Get cold, the bitter in the mouth of gas of stir-baked PERICARPIUM CITRI RETICULATAE VIRIDE with vinegar again, nontoxic, the cloudy priming of sufficient fault also, shaoyin channel prescribe medicine also (medicine mirror) is controlled chest and diaphragm QI rising in reverse order hypochondriac pain, soothing the liver gallbladder, eliminating the pathogens from the lung gas (detailed outline) again.Two medicated vinegar are processed, and all go into Liver Channel, to strengthen the regulating liver and qi effect.The bitter in the mouth of reuse vinegar Radix Dichroae, cold poisonous (herbal classic) are gone into the heart, lung, liver three through (key medicine is divided agent), the sudden and violent brave kind expulsion of property, must can exempt to tell (medicine mirror) through processed with vinegar, dispersion can be used to remove obstruction, the kind expectorant knot of opening, all expectorant meridians that stagnate, know can under swarm (medicine justice), water the part of the body cavity above the diaphragm housing the heart and lungs then Radix Dichroae can tell it; Water is under coercing, and then Radix Dichroae can be broken it and be warded off and descend its water, but must promoting the circulation of blood medicine assistant help it, must receive perfect merit (Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House).We with its three medicine for making.To help medicine that the monarch and his subjects help, open entire merit to reach the machine of internal organs lifting.Again, Radix Angelicae Sinensis get Radix Dichroae then blood stasis dispelling and eliminating the phlegm only throb with fear, the Radix Paeoniae Alba is joined Radix Bupleuri, Pericarpium Citri Reticulatae Viride, and then easing the affected liver is soothing the liver, transfer to reach mechanism of qi, then the motive can performance and, Radix Scrophulariae, Rhizoma Polygonati, Radix Ophiopogonis, the yin nourishing of Radix Glycyrrhizae kidney tonifying, on help in the heart.The conditioning Liver and kidney so based on logical, hold concurrently in full side is beneficial to the heart, and the stasis of blood is reduced phlegm and disappeared, then through ruton, the motive and.Have promoting tissue regeneration by removing blood stasis, reduce phlegm and only throb with fear, regulating liver and qi, the effect of kidney tonifying yin nourishing.That is on logical basis, " Liver and kidney two dirty all and, and the heart is spontaneous." the weight portion proportion optimization of raw material of Chinese medicine of the present invention:
Flos Lonicerae 250 Radix Angelicae Sinensis 250 Radix Paeoniae Albas 50
Rhizoma Polygonati 150 Radix Glycyrrhizaes 150 Radix Scrophulariaes 80
Radix Ophiopogonis 80 Radix Bupleuri (processed with vinegar), 15 Pericarpium Citri Reticulatae Viride (process with vinegar) 15
Radix Dichroae (processed with vinegar) 15
The weight portion proportioning of above-mentioned raw materials medicine is also preferred:
Flos Lonicerae 303 Radix Angelicae Sinensis 303 Radix Paeoniae Albas 61
Rhizoma Polygonati 202 careless 202 Radix Scrophulariaes 101
(processed with vinegar) 20 skins Radix Ophiopogonis 101 (processed with vinegar) 20
Radix Dichroae (processed with vinegar) 20
The weight portion proportioning of above-mentioned raw materials medicine is also preferred:
Flos Lonicerae 320 Radix Angelicae Sinensis 320 Radix Paeoniae Albas 70
Rhizoma Polygonati 220 Radix Glycyrrhizaes 220 Radix Scrophulariaes 120
Radix Ophiopogonis 120 Radix Bupleuri (processed with vinegar), 25 Pericarpium Citri Reticulatae Viride (process with vinegar) 25
Radix Dichroae (processed with vinegar) 25
The weight portion proportioning of above-mentioned raw materials medicine is also preferred:
Flos Lonicerae 340 Radix Angelicae Sinensis 340 Radix Paeoniae Albas 90
Rhizoma Polygonati 240 Radix Glycyrrhizaes 240 Radix Scrophulariaes 140
Radix Ophiopogonis 140 Radix Bupleuri (processed with vinegar), 35 Pericarpium Citri Reticulatae Viride (process with vinegar) 35
Radix Dichroae (processed with vinegar) 35
Medicine of the present invention can be carried according to the conventional method such as the water of this area, alcohol extraction etc. is prepared into acceptable oral preparation dosage form on any pharmaceutics.Wherein preferred oral liquid, tablet, granule or pill.
Medicine of the present invention also can be made by the method for being prepared as follows:
More than ten flavors, Flos Lonicerae rinsing twice adds 10 times of water gagings, 80 ℃ of warm macerating twice, each 1 hour, immersion merged, and filtered, filtrate device is in addition collected; Radix Angelicae Sinensis, Radix Bupleuri, Pericarpium Citri Reticulatae Viride add 6 times of water gagings, and vapor distillation extracted volatile oil 5 hours, and volatile oil after the distillation and aqueous solution device are in addition collected; Medicinal residues and Rhizoma Polygonati, Radix Glycyrrhizae, Radix Scrophulariae, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Dichroae merge, and add 6 times of water gagings and decoct twice, each 1.5 hours, collecting decoction filters, and filtrate and above-mentioned medicinal liquid merge, be evaporated to relative density 1.10～1.15 (80 ℃), add ethanol and make and contain alcohol amount and reach 65%, fully stir, static 24 hours, filter filtrate recycling ethanol, add water to 1000ml, be heated to and boil, cold preservation 24 hours, centrifugal, supernatant adds volatile oil promptly.Technology is made acceptable oral preparation dosage form on the pharmaceutics, oral liquid, tablet, granule or pill routinely then.
The preparation method of medicine of the present invention is preferred:
More than ten flavors, Flos Lonicerae rinsing twice adds 10 times of water gagings, 80 ℃ of warm macerating twice, each 1 hour, immersion merged, and filtered, filtrate device is in addition collected; Radix Angelicae Sinensis, Radix Bupleuri, Pericarpium Citri Reticulatae Viride add 6 times of water gagings, and vapor distillation extracted volatile oil 5 hours, and volatile oil after the distillation and aqueous solution device are in addition collected; Medicinal residues and Rhizoma Polygonati, Radix Glycyrrhizae, Radix Scrophulariae, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Dichroae merge, and add 6 times of water gagings and decoct twice, each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned medicinal liquid merge, and are evaporated to relative density 1.10～1.15 (80 ℃), adding ethanol makes and contains alcohol amount and reach 65%, fully stir, static 24 hours, filter, filtrate recycling ethanol, add water to 1000ml, be heated to and boil, cold preservation 24 hours, centrifugal, supernatant adds volatile oil, potassium sorbate, steviosin, add water to 1000ml, mixing, packing, 115 ℃ of heat sterilizations 30 minutes, promptly.Promptly get oral liquid formulations method of the present invention and result
One, analgesic activity.
1. the influence of Dichlorodiphenyl Acetate induced mice writhing response.
Get 60 of male mices, be divided into five groups at random by body weight, in 7 days, press gastric infusion every day of dosage shown in the table 1 once, the normal control group is irritated stomach with the volume solvent, the administration volume is all 10ml/kg, after the last administration 1 hour, give o.6% acetic acid 10ml/kg of all ip in mice, observe and respectively organize mice writhing response number of times in 10 minutes.The result shows: conversion is protected the number of times that the flat oral liquid of the heart can obviously reduce acetic acid induced mice writhing response.(seeing Table 1)
2. to the influence of mice hot plate method pain threshold.
Get 50 of the qualified female mices of preliminary election, be divided into five groups at random by body weight, in 7 days, press gastric infusion every day of dosage shown in the table 2 once, the normal control group is irritated stomach and is not had with the volume solvent, and the administration volume is all 10ml/kg, after the last administration 1 and 5 hour, observe the time (s) that hind leg appears licking in mice with the hot plate dolorimeter, be pain threshold, the result shows: conversion is protected the flat oral liquid of the heart can obviously improve mice hot plate method pain threshold, has tangible dose-effect relationship (seeing Table 2)
Two, antiarrhythmic effect.
1. aconitine is brought out ARR influence.
40 rats are divided into five groups at random by body weight, every group of male and female half and half, with 7 days in press gastric infusion every day of dosage shown in the table 3 once, the normal control group is irritated stomach with the volume solvent every day, the administration volume is all 10ml/kg, after the last administration 60 minutes, ip hydronium(ion) aldehyde 0.3g/kg anesthetized rat, trace normal ECG, arrhythmia mostly is ventricular tachycardia and the short paroxysmal tachycardia of polyphyly, writes down each treated animal arrhythmia and holds time, and the result shows, conversion is protected the flat oral liquid of the heart can obviously shorten the ARR time that aconitine brings out, and the various arrhythmia that aconitine is caused also have obvious improvement effect.(seeing Table 3)
2. barium chloride is brought out ARR influence.
4 of rats are divided equally five groups by body weight, every group of male and female half and half, with 7 days in press gastric infusion every day of dosage shown in the table 3 once.Matched group is irritated the gastric solubleness matchmaker, the administration volume is all 10ml/kg, after the last administration 1 hour, ip hydronium(ion) aldehyde 0.3g/kg anesthetized rat, trace normal ECG, inject barium chloride 2mg/kg by the tongue vein then, bring out arrhythmia at once, ventricular bigeminy, sporadic premature beat and two-phase ventricular tachycardia appear, observe electrocardiogram, record transfers the time of sinus rhythm to, as can be seen from Table 3, propafenone and conversion protect three dosage groups of the flat oral liquid of the heart and matched group comparison arrhythmia for this reason the time obviously shorten, and be tangible dose-effect relationship.(seeing Table 3)
3. chloroform is brought out the influence of mice ventricular fibrillation.
70 of male mices, be divided into five groups at random by body weight, irritate gastric solubleness matchmaker 10ml/kg for first group, the 2-5 group irritates stomach propafenone 50mg/kg respectively and conversion is protected the flat oral liquid 40 of the heart, 20 and 10g/kg, with 7 days in every day gastric infusion once, after the last administration 1 hour, mice is put into the inversion 1000ml beaker of the cotton balls (whenever change a Mus later on and add the 0.5ml chloroform) that contains the 2ml chloroform, until respiratory arrest, cut the thoracic cavity at once open, quiver in the observation chamber of having or not, the matched group chamber rate of quivering is 14/14 (100%), propafenone is 4/14 (29%), conversion is protected the flat oral liquid 15 of the heart, 10, the 5ml/kg group is respectively 7/14 (50%), 9/14 (64%), 9/14 (64%), the result shows, compares with matched group, positive drug propafenone and conversion are protected the chamber of the high dose group of the flat oral liquid of the heart and are quivered rate by notable difference P＜0.01, and the chamber rate of quivering with low dose group in the flat oral liquid of while conversion guarantor's heart also has notable difference P＜0.05.
Three, function of resisting myocardial ischemia.
1. to lactate dehydrogenase L DH and the active influence that raises of creatine phosphokinase CK of myocardial ischemia mice due to the isoproterenol.
48 male mices are divided equally six groups by body weight, in 7 days, press gastric infusion every day of dosage shown in the table 4 once, irritate the gastric solubleness matchmaker for the 1st and 2 group, the administration volume is all 10ml/kg, after administration 4-6 days, the 1st group of sc normal saline 10ml/kg, 2-6 group sc isoproterenol 4mg/kg, in last administration isoproterenol after 24 hours, the sacrificed by decapitation animal is got blood, presses document [1,2] and measures LDH and CK in the serum, the result shows, conversion is protected the flat oral liquid of the heart can obviously reduce LDH and the active rising of CK in the little serum of myocardial ischemia that isoproterenol causes.(seeing Table 4)
2. experimental dog blocking-up coronary artery is caused the influence of acute myocardial ischemia.
20 dogs are divided into four groups at random, and matched group gavages solvent, and the administration volume is all 2ml/kg, its excess-three group gavages nifedipine 2ml/kg respectively, conversion is protected flat oral liquid 4 of the heart and 8g/kg, intravenous anesthesia dog (pentobarbital sodium 30mg/kg) tracheal intubation connects respirator, begins to speak to expose heart.Separate 1/3 place on the left anterior descending coronary artery, threading is in order to ligation, seam is put the fixed epicardial lead of multiple spot, connect polygraph, trace epicardial electrogram, as contrasting before the administration, ligation arteria coronaria then, gastric infusion at once, and after administration 30,45,60,120,180,240,300 minutes record epicardial electrogram, and the calculating myocardium degree of ischemia (∑--ST).(seeing Table 5)
5h behind the medicine takes off heart and weighs, and stays left ventricle along coronary sulcus excision atrium, weighs.Below the heart ligature, parallel coronary sulcus is evenly with the cross-section thick myocardium sheet of 1cm that is cut into of ventricle part, place 37 ℃ of temperature of nitro tetrazole orchid (N-BT) dye liquor to incubate dyeing in 15 minutes, infarct is not painted, non-infarct is dyed blueness, cut off the non-infarct that each myocardium sheet is colored, undyed infarct is weighed.Divided by heavy or ventricle heavy whole-heartedly, and the infarction size that obtains accounts for heavy with right ventricle whole-heartedly percentage ratio.(seeing Table 6)
Have table 5 as seen, conversion protect the flat oral liquid of the heart and nifedipine group all have obviously alleviate degree of myocardial ischemia (∑--effect ST), with matched group relatively, 60 minutes conversions are protected the effect that the flat oral liquid of the heart promptly has obvious reduction degree of myocardial ischemia after the administration.Simultaneously with medicine before (before the ligation) self relatively, in the 5h, the degree of myocardial ischemia of matched group significantly strengthens behind the medicine; And conversion is protected two dosage groups of the flat oral liquid of the heart and nifedipine group and degree of myocardial ischemia was obviously strengthened in 30 minutes behind medicine, and obvious reduction effect was arranged after 60 minutes, and along with the prolongation of administration time, and ∑--ST is tending towards normal value before the medicine.(seeing Table 6)
Table 6 explanation, conversion is protected two dosage groups of the flat oral liquid of the heart and nifedipine all has the effect of significantly dwindling myocardial infarct size, and the infarct scope accounts for the difference that heavy whole-heartedly and percentage ratio that ventricle is heavy and matched group more all have highly significant.(P＜0.001) (seeing Table 6)
3. to the influence of cardiac hemodynamics of dogs.
20 dogs are divided into four groups at random, every group of gastric infusion, the administration volume is all 2ml/kg, matched group gavages solvent, its excess-three group gavages nifedipine 2mg/kg respectively, conversion is protected flat oral liquid 4 of the heart and 8g/kg, experimental dog is with the slow injecting anesthetic of pentobarbital sodium 30mg/kg vein, tracheal intubation, the artificial respiration, open breast, expose heart, separate LCA and aortic root, place Electromagnetic Flow machine probe, measure coronary flow (CF) respectively, cardiac output (CO), calculate coronary resistance (CR), cardiac output (SV), cardiac index (CI) and SI (SI), left ventricle tip intubate connects pressure transducer, measures left indoor pressure (LVSP) through carrier amplifier, left side chamber EDP (LVEDP) and left indoor pressure maximum rate (± dp/dtmax), arterial cannulation recording blood pressure (BP), mapping standard I I are led electrocardiogram and are calculated the rhythm of the heart (HR), with all observation index record and polygraph.Separate common carotid artery and external jugular vein and extract arterial blood, extract Coronary vein blood, measure oxygen content, calculating myocardium oxygen consumption with oximeter with external jugular vein intubate to Coronary vein.After treating that These parameters is stable, value, ligation arteria coronaria then before the record administration, and gavage administration at once, with carried out record in 30,45,60,120,180,240,300 minutes behind the medicine, every observation index and derivation parameter are carried out statistical procedures, adopt and relatively t check and variance analysis of matched group.
(1) to the influence of dog coronary flow CF and coronary resistance CR.
Behind the medicine 30 minutes as can be seen from Table 7.Compare with matched group, nifedipine and conversion are protected the effect that two dosage groups of the flat oral liquid of the heart all are significantly increased CF, and CF descends simultaneously, can continue until 300 minutes action time.(seeing Table 7)
(2) to dog left side chamber EDP (LVEDP) and maximum fall off rate (influence dp/dtmax) of left indoor pressure.
The result shows: conversion protects the flat oral liquid of the heart and makes-dp/dtmax has certain rising, and it and nifedipine all effectively prevent the rising of LVEDP simultaneously, thereby have improved left chamber diastolic function and compliance.(seeing Table 8)
(3) to (+dp/dtmax) the influence of the maximum climbing speed of dog left indoor pressure (LVSP) and left indoor pressure.
The result shows: conversion is protected the effect that the flat oral liquid of the heart has obvious rising+dp/dtmax, and LVSP is not had obvious influence.Illustrate that this medical instrument has the effect of certain promotion myocardial contractility.(seeing Table 9)
(4) to dog cardiac output (CO), cardiac output (SV), the influence of total peripheral resistance (TPVR).
As can be seen from Table 10, conversion is protected two dosage groups of the flat oral liquid of the heart and the nifedipine group has increased cardiac output, cardiac output significantly, has reduced total peripheral resistance simultaneously, and the pharmacological action of the flat oral liquid of conversion guarantor's heart is dose dependent.(seeing Table 10)
(5) to the influence of dog cardiac index (CI) and SI (SI).
CI and SI are the indexs of reflection CO and SI.Experimental result proves that conversion is protected the flat oral liquid of the heart has equally obviously increased CI and SI.Illustrate that this medical instrument has the effect that strengthens heart working efficient.(seeing Table 11)
(6) to the influence of dog blood pressure (BP), heart rate (HR) and myocardial oxygen consumption.
Presentation of results: conversion is protected the flat oral liquid of the heart does not all have obvious influence to dog blood pressure and heart rate, but obviously reduces myocardial oxygen consumption.(seeing Table 12)
Discuss
Ischemic heart desease is owing to coronary vasodilator oxygen supply and nutrient substance or eliminates the needs that function such as metabolite can not satisfy cardiomotility and cause [3], can show as that angina pectoris, arrhythmia, pump decline, myocardial infarction or sudden death, above-mentioned experimental result shows: conversion is protected the flat oral liquid of the heart and is had tangible arrhythmia, resists myocardial ischemia and analgesic activity.
The arrhythmia that aconitine, barium chloride, chloroform bring out is the comparatively ideal experimental model of research anti-arrhythmic, and they can influence the ion permeability of myocardial cell membrane directly or indirectly, disturbs Na
+, Ca
2+And K
+Or Ca
2+Interior stream, promoting the depolarization and the process of repolarization of film influence action potential duration, APD (APO) and effective refractory period (ERP), consequently forms arrhythmia [4].Experimental result shows, conversion is protected the flat oral liquid of the heart all has significantly antagonism to above-mentioned dissimilar arrhythmia, and can obviously improve ventricular premature contraction, ventricular tachycardia, ventricular bigeminy, sporadic premature beat and the two-phase ventricular tachycardia of rat due to aconitine and the barium chloride, the prompting conversion protect the flat oral liquid of the heart antiarrhythmic effect may with its prevention myocardial cell Na
+Or Ca
2+Interior stream, stabilized cell membrane interaction relevant [5], in addition, conversion is protected the flat oral liquid of the heart also can reduce the ventricular fibrillation that chloroform causes.This is by the effect that influences catecholamine [6], reduces the irritability of cardiac muscle, prevents ARR generation, prevents ARR generation.
When causing myocardial damage for the injected in mice isoproterenol, but the scope and the order of severity of the active height of LDH and CK reflecting myocardium ischemic injuries in its serum, in this experiment, conversion is protected the flat oral liquid of the heart can obviously reduce LDH and CK activity, and this may be one of mechanism that alleviates ischemic arrhythmia.
The coronary ligation method is to estimate to use the earliest in the myocardial ischemia drug efficacy experiment method and method [7] the most widely.Conversion is protected the flat oral liquid of the heart can obviously alleviate dog acute myocardial ischemia degree, and along with the prolongation of administration time, it is normal that epicardial electrogram is recovered, and can significantly reduce myocardial infarct size simultaneously.
Aspect hemodynamics: it is the main feature of ischemic heart desease that (1) coronary flow reduces.Conversion is protected the flat oral liquid of the heart can obviously increase coronary flow, and coronary resistance is descended, and this medicine energy coronary artery dilating is described, reduces locular wall tension force, alleviates ejection impedance, increases the myocardial nutrition blood flow.(2) left indoor pressure, chamber, left side EDP, with the important indicator that the maximum rate of change of left indoor pressure is evaluation myocardial contraction and diastole, conversion is protected the flat oral liquid of the heart has certain enhancing to myocardial contraction, the more important thing is that it makes the myocardial relaxation function obviously improve simultaneously.Clinical and zoopery shows, multiple heart diseases such as myocardial ischemia, hypertrophic neuropathy, heart failure and tachycardia all can cause the diastolic function infringement of left chamber, compliance reduces and stiffness increases [8], and this medicine makes-dp/dtmax obviously raises, LVEDP significantly reduces, improve coronary circulation, diastolic function, ventricular compliance, reduced the locular wall stiffness simultaneously, thereby improved heart working efficient.(3) cardiac output and cardiac output are the indexs of reflection heart working situation, and conversion is protected the flat oral liquid of the heart obviously increases CO, SV, CI, SI, has reduced TPVR simultaneously, illustrates that this medicine can strengthen the pumping function of heart, and can improve myocardial blood supply state.(4) the flat oral liquid of conversion guarantor's heart can also reduce myocardial oxygen consumption, keeps the myocardial metabolism balance.
In addition, conversion is protected the body of turning round that the flat oral liquid of the heart can also significantly improve mice hot plate pain threshold and suppress mice that acetic acid causes and is reflected incidence rate.The prompting conversion is protected the flat oral liquid of the heart and is also had significant analgesia role, and this is to improving the pain that myocardial damage causes, and for example angina pectoris etc. is very useful.
In sum, it is very remarkable that conversion is protected every pharmacological action of the flat oral liquid of the heart, all obvious than corresponding positive drug, by observing different arrhythmia models, the morphology of myocardial infarction and ischemia model and myocardial ischemia, physiology, biochemical index have proved that it is the important preparation of treatment heart disease obvious results that conversion is protected the flat oral liquid of the heart.
Conversion is protected the flat oral liquid of the heart
Have promoting tissue regeneration by removing blood stasis, reduce phlegm and only throb with fear, regulating liver and qi, the effect of kidney tonifying yin nourishing.
Be used for coronary heart disease and arrhythmia caused cardiopalmus, uncomfortable in chest, night sweat, spontaneous perspiration, lack of appetite indigestion and loss of appetite, dizzy meet labor what for etc. the deficiency of both qi and yin expectorant stasis of blood wait.It is to blood, urine, just conventional, and liver, renal function also have no adverse effects, and do not see obvious adverse reaction.We think that it is a kind of promoting tissue regeneration by removing blood stasis safely and effectively that conversion is protected the flat oral liquid of the heart, reduces phlegm and only throbs with fear, regulating liver and qi, the medicine of kidney tonifying yin nourishing.
Embodiment
Embodiment 1
Flos Lonicerae 250 Radix Angelicae Sinensis 250 Radix Paeoniae Albas 50
Rhizoma Polygonati 150 Radix Glycyrrhizaes 150 Radix Scrophulariaes 80
Radix Ophiopogonis 80 Radix Bupleuri (processed with vinegar), 15 Pericarpium Citri Reticulatae Viride (process with vinegar), 15 Radix Dichroae (processed with vinegar) 15
Can be made into tablet
Embodiment 2
Flos Lonicerae 320 Radix Angelicae Sinensis 320 Radix Paeoniae Albas 70
Rhizoma Polygonati 220 Radix Glycyrrhizaes 220 Radix Scrophulariaes 120
Radix Ophiopogonis 120 Radix Bupleuri (processed with vinegar), 25 Pericarpium Citri Reticulatae Viride (process with vinegar), 25 Radix Dichroae (processed with vinegar) 25
Make granule
Embodiment 3
Flos Lonicerae 340 Radix Angelicae Sinensis 340 Radix Paeoniae Albas 90
Rhizoma Polygonati 240 Radix Glycyrrhizaes 240 Radix Scrophulariaes 140
Radix Ophiopogonis 140 Radix Bupleuri (processed with vinegar), 35 Pericarpium Citri Reticulatae Viride (process with vinegar), 35 Radix Dichroae (processed with vinegar) 35
Make pill
Embodiment 4
Flos Lonicerae 303 Radix Angelicae Sinensis 303 Radix Paeoniae Albas 61
Rhizoma Polygonati 202 Radix Glycyrrhizaes 202 Radix Scrophulariaes 101
(processed with vinegar) 20 skins Radix Ophiopogonis 101 (processed with vinegar) 20 Radix Dichroae (processed with vinegar) 20
Make oral liquid
More than ten flavors, Flos Lonicerae rinsing twice adds 10 times of water gagings, 80 ℃ of warm macerating twice, each 1 hour, immersion merged, and filtered, filtrate device is in addition collected; Radix Angelicae Sinensis, Radix Bupleuri, Pericarpium Citri Reticulatae Viride add 6 times of water gagings, and vapor distillation extracted volatile oil 5 hours, and volatile oil after the distillation and aqueous solution device are in addition collected; Medicinal residues and Rhizoma Polygonati, Radix Glycyrrhizae, Radix Scrophulariae, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Dichroae merge, and add 6 times of water gagings and decoct twice, each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned medicinal liquid merge, and are evaporated to relative density 1.10～1.15 (80 ℃), adding ethanol makes and contains alcohol amount and reach 65%, fully stir, static 24 hours, filter, filtrate recycling ethanol, add water to 1000ml, be heated to and boil, cold preservation 24 hours, centrifugal, supernatant adds volatile oil, potassium sorbate, steviosin, add water to 1000ml, mixing, packing, 115 ℃ of heat sterilizations 30 minutes, promptly.
Claims (9)
1. a medicine for the treatment of coronary heart disease and arrhythmia caused cardio palmus is characterized in that, it is the oral formulations that is prepared from by acceptable excipient on following weight parts Chinese medicinal raw materials and the pharmaceutics:
Flos Lonicerae 250-340 Radix Angelicae Sinensis 250-340 Radix Paeoniae Alba 50-90
Rhizoma Polygonati 150-240 Radix Glycyrrhizae 150-240 Radix Scrophulariae 80-140
Radix Ophiopogonis 80-140 Radix Bupleuri 15-35 Pericarpium Citri Reticulatae Viride 15-35
Radix Dichroae 15-35.
2. a kind of medicine for the treatment of coronary heart disease and arrhythmia caused cardio palmus according to claim 1 is characterized in that, the weight portion proportioning of raw material of Chinese medicine is:
Flos Lonicerae 250 Radix Angelicae Sinensis 250 Radix Paeoniae Albas 50
Rhizoma Polygonati 150 Radix Glycyrrhizaes 150 Radix Scrophulariaes 80
Radix Ophiopogonis 80 Radix Bupleuri, 15 Pericarpium Citri Reticulatae Virides 15
Radix Dichroae 15.
3. a kind of medicine for the treatment of coronary heart disease and arrhythmia caused cardio palmus according to claim 1 is characterized in that, the weight portion proportioning of raw material of Chinese medicine is:
Flos Lonicerae 340 Radix Angelicae Sinensis 340 Radix Paeoniae Albas 90
Rhizoma Polygonati 240 Radix Glycyrrhizaes 240 Radix Scrophulariaes 140
Radix Ophiopogonis 140 Radix Bupleuri, 35 Pericarpium Citri Reticulatae Virides 35
Radix Dichroae 35.
4. a kind of medicine for the treatment of coronary heart disease and arrhythmia caused cardio palmus according to claim 1 is characterized in that, the weight portion proportioning of raw material of Chinese medicine is:
Flos Lonicerae 303 Radix Angelicae Sinensis 303 Radix Paeoniae Albas 61
Rhizoma Polygonati 202 Radix Glycyrrhizaes 202 Radix Scrophulariaes 101
Radix Ophiopogonis 101 Pericarpium Citri Reticulatae Viride 20
Radix Dichroae 20 Radix Bupleuri 20.
5. a kind of medicine for the treatment of coronary heart disease and arrhythmia caused cardio palmus according to claim 1 is characterized in that, the weight portion proportioning of raw material of Chinese medicine is:
Flos Lonicerae 303 Radix Angelicae Sinensis 303 Radix Paeoniae Albas 61
Rhizoma Polygonati 202 Radix Glycyrrhizaes 202 Radix Scrophulariaes 101
Radix Ophiopogonis 101 Pericarpium Citri Reticulatae Viride 20
Radix Dichroae 20 Radix Bupleuri 20.
6. according to each described a kind of medicine for the treatment of coronary heart disease and arrhythmia caused cardio palmus of claim 1-5, it is characterized in that this medicine is oral liquid, tablet, granule or pill.
7. according to each described a kind of medicine for the treatment of coronary heart disease and arrhythmia caused cardio palmus of claim 1-5, it is characterized in that this medicine is an oral liquid formulations.
8. according to each described a kind of preparation method for the treatment of the medicine of coronary heart disease and arrhythmia caused cardio palmus of claim 1-5, it is characterized in that, comprise the following steps:
More than ten flavors, Flos Lonicerae rinsing twice adds 10 times of water gagings, 80 ℃ of warm macerating twice, each 1 hour, immersion merged, and filtered, filtrate device is in addition collected; Radix Angelicae Sinensis, Radix Bupleuri, Pericarpium Citri Reticulatae Viride add 6 times of water gagings, and vapor distillation extracted volatile oil 5 hours, and volatile oil after the distillation and aqueous solution device are in addition collected; Medicinal residues and Rhizoma Polygonati, Radix Glycyrrhizae, Radix Scrophulariae, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Dichroae merge, adding 6 times of water gagings decocts twice, each 1.5 hours, collecting decoction filtered, filtrate and above-mentioned medicinal liquid merge, be evaporated to relative density 1.10～1.15, add ethanol and make and contain alcohol amount and reach 65%, fully stir, static 24 hours, filter, filtrate recycling ethanol adds water to 1000ml, be heated to and boil, cold preservation 24 hours, centrifugal, supernatant adds volatile oil, promptly, technology is made acceptable oral preparation dosage form on the pharmaceutics routinely then, as oral liquid, tablet, granule or pill.
9, a kind of preparation method for the treatment of the medicine of coronary heart disease and arrhythmia caused cardio palmus according to claim 8, it is characterized in that, comprise the following steps, more than ten the flavor, twice of Flos Lonicerae rinsing, add 10 times of water gagings, 80 ℃ of warm macerating twice, each 1 hour, immersion merged, filter, filtrate device is in addition collected; Radix Angelicae Sinensis, Radix Bupleuri, Pericarpium Citri Reticulatae Viride add 6 times of water gagings, and vapor distillation extracted volatile oil 5 hours, and volatile oil after the distillation and aqueous solution device are in addition collected; Medicinal residues and Rhizoma Polygonati, Radix Glycyrrhizae, Radix Scrophulariae, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Dichroae merge, and add 6 times of water gagings and decoct twice, each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned medicinal liquid merge, and are evaporated to relative density 1.10～1.15, adding ethanol makes and contains alcohol amount and reach 65%, fully stir, static 24 hours, filter, filtrate recycling ethanol, add water to 1000ml, be heated to and boil, cold preservation 24 hours, centrifugal, supernatant adds volatile oil, potassium sorbate, steviosin, add water to 1000ml, mixing, packing, 115 ℃ of heat sterilizations 30 minutes promptly get this product oral liquid formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610091090 CN1899516A (en) | 2006-07-13 | 2006-07-13 | Medicine for treating coronary heart disease and arrhythmia caused cardio palmus and preparing method |
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| CN 200610091090 CN1899516A (en) | 2006-07-13 | 2006-07-13 | Medicine for treating coronary heart disease and arrhythmia caused cardio palmus and preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705733A (en) * | 2014-01-17 | 2014-04-09 | 刘镜 | Chinese medicine capsule for treating arrhythmia and preparation method thereof |
| CN103948792A (en) * | 2014-04-23 | 2014-07-30 | 通化万通药业股份有限公司 | Cardioversion and heart-protection medicine and oral liquid |
-
2006
- 2006-07-13 CN CN 200610091090 patent/CN1899516A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705733A (en) * | 2014-01-17 | 2014-04-09 | 刘镜 | Chinese medicine capsule for treating arrhythmia and preparation method thereof |
| CN104784476A (en) * | 2014-01-17 | 2015-07-22 | 刘镜 | Traditional Chinese medicine capsule for treating arrhythmia and preparation method |
| CN103948792A (en) * | 2014-04-23 | 2014-07-30 | 通化万通药业股份有限公司 | Cardioversion and heart-protection medicine and oral liquid |
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Open date: 20070124 |