CN1899338A - Chinese medicine composition for supplementing qi and promoting blood circulation - Google Patents
Chinese medicine composition for supplementing qi and promoting blood circulation Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition for supplementing Qi and promoting blood circulation, and belongs to the field of Chinese medicine preparation technology. The Chinese medicine composition consists of sowthistle-leaf ixeris extract and ginseng extract in certain weight ratio, and has the synergistic effects of promoting blood circulation to disperse blood clots and supplementing Qi. It may be prepared into various kinds of preparation for treating cardiac and cerebral vascular diseases and other diseases in blood circulation system.
Description
Affiliated technical field
The invention belongs to the pharmaceutical technology field, relate to a kind of Chinese medicine composition of benefiting QI for activating blood circulation, specifically the pharmaceutical composition of forming by Radix Ginseng extract and Herba Ixeritis Sonchifoliae extract.
Background technology
Modern study proves: cardiovascular and cerebrovascular disease patient and other blood circulation pathological changes patients all show main organs hypofunction in various degree clinically, symptoms such as hemorheology index abnormal change, groundwater increment deficiency because of histiocyte and internal organs, blood viscosity increases unusually, the erythrocyte aggregation sexual abnormality strengthens, thereby produces the blood stasis due to qi deficiency disease.
Motherland's medical science thinks that blood stasis due to qi deficiency disease is mark with the blood stasis, and the deficiency of vital energy is this, " qi being the governor of blood, blood being the material foundation of QI ", the capable then blood of gas is capable, and the deficiency of vital energy is stasis then, and blood operation freely can not have influence on the biochemistry operation of gas yet; In addition, the blood circulation promoting and blood stasis dispelling medicine property of medicine is high violent, damages healthy energy easily, and the compatibility Qi-tonifying drug prevents to hinder positive important function in addition." inrigorating qi and promoting blood circulation " is the basic method of treatment that the traditional Chinese medical science can cause the pathology fact of blood stasis to be formulated at the clinical deficiency of vital energy, so when the treatment relevant disease, general opinion is used Qi-tonifying drug and blood circulation promoting medicine compatibility, to reach the effect that QI and blood is ruled together.
Radix Ginseng is the representative medicine of inrigorating qi and promoting blood circulation, and QI invigorating and do not stay heresy also is the choice drug at the basis of blood stasis due to qi deficiency disease.Radix Ginseng total saponins is the main effective site of Radix Ginseng, has coronary artery dilating, strengthen myocardial contraction, improve cardiac function, dwindle myocardial infarction area, remove interior free yl, increase the brain perfusion, improve the tolerance of body, alleviate cardiac muscle and cerebrum ischemia reperfusion injury hypoxic-ischemic, improve blood rheology parameter, regulate pharmacological actions such as body's immunity.The constituent of Stem and leaf of Radix Ginseng and the contained total saponins of Radix Ginseng is basic identical, and has similar pharmacological action, and the alternative medicine that therefore can be used as Radix Ginseng is used.
Herba Ixeritis Sonchifoliae has another name called Herba Ixeritis Sonchifoliae, is the herb of feverfew Herba Ixeritis Sonchifoliae.Modern study proves: Radix Ginseng extract has expanding cardiovascular, promotes collateral circulation, increases the myocardial nutrition blood flow, reduce myocardial oxygen consumption, improve the cardiac muscle circulation, reduce cerebral vascular resistance, improve cerebral circulation, the cerebral blood flow increasing amount improves effects such as blood-brain barrier permeability; To the remarkable anticoagulant function of blood system energy, obviously increase the activity of fibrinolysin, and these effects are the bases that prevent and treat thrombosis.Herba Ixeritis Sonchifoliae is mainly used in coronary heart disease, angina pectoris, cerebral thrombosis, the cerebral infarction prevention and treatment of diseases of waiting indefinitely.
Present clinical use KUDIEZI ZHUSHEYE treatment cardiovascular and cerebrovascular disease has blood circulation invigorating efficacies preferably, but does not have the QI invigorating effect, uses the Therapeutic Principle who does not meet the traditional Chinese medical science " inrigorating qi and promoting blood circulation " separately, does not reach ideal therapeutic effect as yet.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of benefiting QI for activating blood circulation, this Chinese medicine composition can blood circulation promoting and blood stasis dispelling, again can replenishing qi and promoting blood flow, and QI and blood is ruled together, and produces synergism, raising evident in efficacy.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition of benefiting QI for activating blood circulation, form by Radix Ginseng extract and two kinds of components of Herba Ixeritis Sonchifoliae extract.
The weight proportion of two kinds of components can be 1 part of Radix Ginseng extract, 0.2～15 part of Herba Ixeritis Sonchifoliae extract in the medicine of the present invention.
The optimum ratio of two kinds of components is in the medicine of the present invention: 1 part of Radix Ginseng extract, 0.5～10 part of Herba Ixeritis Sonchifoliae extract.
The more preferably proportioning of two kinds of components is in the medicine of the present invention: 1 part of Radix Ginseng extract, 0.8～5 part of Herba Ixeritis Sonchifoliae extract.
The best proportioning of two kinds of components is in the medicine of the present invention: 1 part of Radix Ginseng extract, 1～3 part of Herba Ixeritis Sonchifoliae extract.
The main component of the Herba Ixeritis Sonchifoliae extract in the medicine of the present invention is ribosidoadenine and Flavonoid substances; Radix Ginseng extract can be the Radix Ginseng root and rhizome extract, also can be extract of Radix Ginseng stem and leaf, and main component is the saponins material.
The expression method of the weight proportion of Herba Ixeritis Sonchifoliae extract and Radix Ginseng extract can also can be explained with the corresponding quality of medicinal material of extract with the quality statement of extract in the medicine of the present invention.
Pharmaceutical dosage form of the present invention can be injection, transfusion, powder pin, drop pill, tablet, slow releasing tablet, capsule, slow releasing capsule, soft capsule, granule, oral liquid, eye drop.Adjuvant is an acceptable corresponding adjuvant on the pharmaceutics.
The indication of medicine of the present invention can be coronary heart disease, angina pectoris, myocardial ischemia, heart failure, arrhythmia, cerebral thrombosis, cerebral infarction, cerebral ischemia, apoplexy and sequela thereof, diabetes hyperamization pipe pathological changes, optical fundus blood vessel pathological changes, vertebral artery type of cervical spondylosis, thromboangiitis obliterans, also can be used for the auxiliary treatment of cancer.
Pharmaceutical composition of the present invention is made various dosage forms by existing preparation process after can adopting conventional method with Radix Ginseng extract and Herba Ixeritis Sonchifoliae extract uniform mixing.Herba Ixeritis Sonchifoliae extract can adopt following method preparation: get the Herba Ixeritis Sonchifoliae medical material, use 0.1%Na earlier
2CO
3Solution immersion, back extracting in water 3 times, amount of water are respectively 10 times of amounts, 8 times of amounts, 8 times of amounts, all decoct 1 hour; Merge decoction liquor, regulating pH value is 5～6, is concentrated into every 1ml and is equivalent to crude drug in whole 1～1.5g, adds ZTCIV type clarifier and handles; High speed centrifugation, supernatant boiled 30 minutes, put coldly, placed 24 hours in 0～4 ℃ of cold preservation again, filtered the dam Hollow Fiber Ultrafiltration of molecular weight 50,000 of filtrate reuse with microporous filter membrane; Ultrafiltrate adsorbs with polyamide column, washes with water to effluent colourlessly earlier, and reuse 85%～90% ethanol elution is colourless to effluent, decompression recycling ethanol, and the residue vacuum drying obtains the Herba Ixeritis Sonchifoliae purified extract.Radix Ginseng extract can adopt following method preparation: get ginseng crude drug or Stem and leaf of Radix Ginseng medical material, extracted 5 hours with 70% ethanol circulating reflux, decompression recycling ethanol was placed 24 hours in 0～4 ℃ of cold preservation, filtered; The filtrate adjusted volume is equivalent to crude drug in whole 1～1.5g to every 1ml, and adding ZTCIV type clarifier is handled; High speed centrifugation, the supernatant absorption with macroporous adsorbent resin, first water or 5～20% low-concentration ethanol eluting discard, and the high concentration ethanol eluting of reuse 40～95% is collected this high concentration ethanol eluent, reclaims ethanol; Residue is with 3～5 times of amounts neutrality or alkali alumina mix homogeneously, drying, and the back is with 95% high concentration ethanol backflow eluting; Collect this eluent, reclaim ethanol, drying promptly gets the Radix Ginseng purified extract.
Compared with prior art, the invention has the beneficial effects as follows: this Chinese medicine composition is made up of Radix Ginseng extract and two kinds of components of Herba Ixeritis Sonchifoliae extract, the power of ginseng qi-tonifying is first of all medicines, and there is not the fraud of staying heresy, be equipped with the Herba Ixeritis Sonchifoliae blood circulation promoting and blood stasis dispelling, the realization QI and blood is ruled together, and synergism is remarkable, than singly using effect all obviously to improve, prove that through pharmacodynamics test it is evident in efficacy with dosage KUDIEZI ZHUSHEYE and Radix Ginseng total saponins injection.
The curative effect of medicine of the present invention is proved by following pharmacodynamics test:
1. the dirty perfusion experiment of guinea-pig heart
Test material: the medicine of the different proportionings of Herba Ixeritis Sonchifoliae extract (15: 1,10: 1,5: 1,3: 1,1: 1) with Radix Ginseng extract; Radix Ginseng total saponins injection, Shuangding Pharmaceutical Co., Ltd., Shenyang produces; KUDIEZI ZHUSHEYE: Shuangding Pharmaceutical Co., Ltd., Shenyang produces; Cavia porcellus, Britain's kind, male and female dual-purpose, Mus May in age, body weight 350～400g.
Test method: get Cavia porcellus and prepare isolated heart, the Krebs nutritional solution fills O
2, 37 ± 0.5 ℃, the constant voltage perfusion writes down coronary flow behind the balance 15min.Difference constant speed gasing injection normal saline, test sample liquid, Radix Ginseng total saponins injection, KUDIEZI ZHUSHEYE, be 0.35ml, the record coronary flow, after treating that every recovery is stable, continue to give respectively each medicine 0.35ml, be that total amount is 0.7ml, meanwhile (final concentration is 1.67 * 10 to the constant speed gasing injection pituitrin
-2U/ml), record 0.5,5,10, each time point index of 15min.An isolated heart is only given a kind of a kind of concentration of reagent that is subjected to.The paired t-test of difference rate of change the results are shown in Table 1 before and after adopting.
Table 1 shows, the medicine of Radix Ginseng extract and the different proportionings of Herba Ixeritis Sonchifoliae extract respectively can be significantly or is extremely significantly increased the dirty coronary flow of guinea-pig heart (P＜0.01 and P＜0.001), and the coronary flow that obviously or significantly resists due to the lobus posterior hypophyseos reduces (P＜0.05 and P＜0.01), and the strong and weak degree of this effect is relevant with the proportioning of medicine.
2. the influence of the Acute Myocardial Ischemia in Rats that isoproterenol is brought out test
Test material: the medicine of the different proportionings of Herba Ixeritis Sonchifoliae extract (15: 1,10: 1,5: 1,3: 1,1: 1) with Radix Ginseng extract; Radix Ginseng total saponins injection, Shuangding Pharmaceutical Co., Ltd., Shenyang produces; KUDIEZI ZHUSHEYE: Shuangding Pharmaceutical Co., Ltd., Shenyang produces; SD kind rat, male and female half and half.
Test method: with the rat random packet, quiet notes 10% glucose of matched group.Be subjected to reagent thing and matched group all to be mixed with desired concn with 10% glucose, the administration volume is 10ml/kg, injection speed 2ml/min.Administration every day 1 time, successive administration 7 days.The 30min animal subject is with urethane intraperitoneal injection of anesthesia (1.2g/kg) after the last administration, and back of the body position is fixing, links to each other with RM6240 bio signal record analysis system to write down with pin type electrode and marks II and lead.Subcutaneous injection isoproterenol, dosage are 2mg/kg.Observe after the administration 3,5,10,20, the height of ST field offset baseline in the 30min electrocardiogram.With total drift value average serves as to weigh the observation index (sensitivity 1mv=20mm) that cardiac muscle damages.Add up and significance test between each administration group and matched group.The results are shown in Table 2.
Table 2 shows that the medicine of Radix Ginseng extract and the different proportionings of Herba Ixeritis Sonchifoliae extract can be obviously or significantly improved isoproterenol and bring out Acute Myocardial Ischemia in Rats (P＜0.05 and P＜0.01), and the strong and weak degree of this effect is relevant with the proportioning of medicine.
3. the influence of rat cerebral ischemia is tested
Test material: the medicine of the different proportionings of Herba Ixeritis Sonchifoliae extract (15: 1,10: 1,5: 1,3: 1,1: 1) with Radix Ginseng extract; Radix Ginseng total saponins injection, Shuangding Pharmaceutical Co., Ltd., Shenyang produces; KUDIEZI ZHUSHEYE: Shuangding Pharmaceutical Co., Ltd., Shenyang produces; SD kind rat, body weight 215～280g, male and female half and half.
Test method: get SD kind rat, random packet, every day lumbar injection once, continuous three days, the 4th day lumbar injection 1g/kg urethane anesthetized rat, back of the body position is fixing, cervical incision separates bilateral common carotid arteries.Not ligation of sham operated rats tremulous pulse, intravenously administrable is ligation bilateral carotid arteries immediately after 5 minutes, broken end is got brain and is weighed after 3 hours, calculate cerebral index (heavy * 100/ body weight of cerebral index=brain), put then in 110 ℃ of baking ovens to constant weight, calculate brain water content [brain water content %=(weight in wet base-dry weight)/weight in wet base * 100%].Result of the test sees Table 3.
Show by table 3; the medicine of Radix Ginseng extract and the different proportionings of Herba Ixeritis Sonchifoliae extract compares cerebral index, brain water content and the model group of acute cerebral ischemia rat; obvious or significant difference (P＜0.05 and P＜0.01) are all arranged; show that the medicine of Radix Ginseng extract and the different proportionings of Herba Ixeritis Sonchifoliae extract can obviously alleviate the edema phenomenon of acute cerebral ischemia in rats; damage has direct protective action to cerebrum ischemia, and the strong and weak degree of this effect is relevant with the proportioning of medicine.
4. improve the rheology test of blood stasis model rat blood
Test material: the medicine of the different proportionings of Herba Ixeritis Sonchifoliae extract (15: 1,10: 1,5: 1,3: 1,1: 1) with Radix Ginseng extract; Radix Ginseng total saponins injection, Shuangding Pharmaceutical Co., Ltd., Shenyang produces; KUDIEZI ZHUSHEYE: Shuangding Pharmaceutical Co., Ltd., Shenyang produces; The adrenalin hydrochloride injection, Yongkang, Beijing pharmaceutical factory produces; SD kind rat, body weight 220～240g, male and female half and half.
Test method: get SD kind rat, random packet, tail vein injection administration, 1 time/day, continuous 7 days.10min after the last administration, except that the normal control group, the equal subcutaneous injection 10mg/ml of all the other each treated animals adrenalin hydrochloride 0.08ml/100g body weight behind the 2h immerses rat 5min in 4 ℃ of frozen water of dark 10cm; The same again method injection adrenalin hydrochloride behind the 2h.Water is can't help in experiment fasting on the same day, in inferior morning femoral artery get blood, use the 80u/ml anticoagulant heparin, on NEX-1 type viscometer, measure.The results are shown in Table 4.
Table 4 shows, the medicine of Radix Ginseng extract and the different proportionings of Herba Ixeritis Sonchifoliae extract can be obviously or is significantly improved blood stasis model rat height and cut whole blood viscosity, plasma viscosity and erythrocyte aggregation index (P＜0.05 and P＜0.01), and the strong and weak degree of this effect is relevant with the proportioning of medicine.
Experimental result proves: Radix Ginseng extract and Herba Ixeritis Sonchifoliae extract compatibility can produce synergism, and drug effect all is significantly improved than singly using with dosage KUDIEZI ZHUSHEYE or Radix Ginseng total saponins injection; The different proportionings of Radix Ginseng extract and Herba Ixeritis Sonchifoliae extract are influential to drug effect, and from interpretation, the best proportioning of Radix Ginseng extract and Herba Ixeritis Sonchifoliae extract is: 1 part of Radix Ginseng extract, 1～3 part of Herba Ixeritis Sonchifoliae extract.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
Embodiment one: Radix Ginseng-Herba Ixeritis Sonchifoliae soft capsule
Radix Ginseng extract 60g (or being equivalent to ginseng crude drug 10kg)
Herba Ixeritis Sonchifoliae extract 6g (or being equivalent to Herba Ixeritis Sonchifoliae medical material 1kg)
Vegetable oil 125g
Preparation technology: get Radix Ginseng extract, Herba Ixeritis Sonchifoliae extract and vegetable oil mixing, make capsule casing material, adopt existing soft capsule preparation technology to make 1000 soft capsules, promptly get the soft capsule dosage form that contains 10 parts of Radix Ginseng extracts and 1 part of Herba Ixeritis Sonchifoliae extract with gelatin.
Embodiment two: Radix Ginseng-Herba Ixeritis Sonchifoliae sheet
Radix Ginseng extract 12g (or being equivalent to ginseng crude drug 2kg)
Herba Ixeritis Sonchifoliae extract 180g (or being equivalent to Herba Ixeritis Sonchifoliae medical material 30kg)
Dextrin 80g
Starch 100g
Preparation technology: get Radix Ginseng extract, Herba Ixeritis Sonchifoliae extract, dextrin and starch mix homogeneously, granulate, sieve, drying is pressed into 1000, promptly makes the tablet that contains 1 part of Radix Ginseng extract and 15 parts of Herba Ixeritis Sonchifoliae extracts.
Embodiment three: Radix Ginseng-Ixers sonchifolia freeze-dried powder
Radix Ginseng extract 30g (or being equivalent to ginseng crude drug 5kg)
Herba Ixeritis Sonchifoliae extract 60g (or being equivalent to Herba Ixeritis Sonchifoliae medical material 10kg)
Mannitol 300g
Preparation technology: get Radix Ginseng extract, Herba Ixeritis Sonchifoliae extract and mannitol and dissolve with 2000ml water for injection, filter, be packed as 1000 bottles, adopt existing freeze-dried powder preparation technology lyophilization, promptly get the freeze-dried powder that contains 1 part of Radix Ginseng extract and 2 parts of Herba Ixeritis Sonchifoliae extracts.
Embodiment four: Radix Ginseng-Herba Ixeritis Sonchifoliae infusion solutions
Radix Ginseng extract 30g (or being equivalent to ginseng crude drug 5kg)
Herba Ixeritis Sonchifoliae extract 120g (or being equivalent to Herba Ixeritis Sonchifoliae medical material 20kg)
Sodium chloride 900g
Preparation technology: Radix Ginseng extract, Herba Ixeritis Sonchifoliae extract and sodium chloride are added in an amount of water for injection, be stirred to dissolving fully, regulate pH to 6.0～7.5, add the injection water to 100000ml, filter, be packed as 1000 bottles, pressure sterilizing promptly gets the infusion solutions that contains 1 part of Radix Ginseng extract and 4 parts of Herba Ixeritis Sonchifoliae extracts.
Embodiment five: Radix Ginseng-Herba Ixeritis Sonchifoliae injection
Radix Ginseng extract 12g (or being equivalent to ginseng crude drug 2kg)
Herba Ixeritis Sonchifoliae extract 60g (or being equivalent to Herba Ixeritis Sonchifoliae medical material 10kg)
Preparation technology: Radix Ginseng extract and Herba Ixeritis Sonchifoliae extract are added in an amount of water for injection, be stirred to dissolving fully, regulate pH to 6.0～7.5, add the injection water to 5000ml, filter, be packed as 1000, pressure sterilizing promptly makes the injection that contains 1 part of Radix Ginseng extract and 5 parts of Herba Ixeritis Sonchifoliae extracts.
The dirty coronary flow of table 1 pair guinea-pig heart and to pituitrin cause the influence that arteria coronaria shrinks (X ± SD, n=10)
| Group | The isolated heart coronary flow | Give the variation (%) of pituitrin | |||||
| Before the medicine (ml/min) | 3min changes (%) after the administration | Before the medicine (ml/min) | 0.5min | 5min | 10min | 15min | |
| Physiological saline group Radix Ginseng total saponins injection organized 3: 1 ixeri sonhifolia extracts of 5: 1 ixeri sonhifolia extracts of 10: 1 ixeri sonhifolia extracts of 15: 1 ixeri sonhifolia extracts of Ixeris Sonchifolia Hance injection group ixeri sonhifolia extract-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group 1: 1 | 7.31 ±0.90 6.88 ±0.94 7.14 ±0.78 6.91 ±0.80 6.97 ±0.82 7.10 ±1.08 7.04 ±0.93 6.95 ±1.05 | 1.20 ±1.72 3.58** ±1.22 3.79** ±2.15 3.88** ±1.84 4.01** ±1.46 4.83*** ±1.75 4.96*** ±2.28 4.92*** ±2.09 | 6.86 ±0.94 7.22 ±0.80 7.04 ±0.72 6.92 ±0.68 7.11 ±0.97 7.12 ±1.03 6.82 ±0.87 6.94 ±0.93 | -44.32 ±7.43 -40.12 ±4.34 -40.86 ±6.97 -39.14 ±5.90 -37.53* ±7.36 -37.21* ±6.96 -35.81* ±5.72 -36.64* ±6.29 | -32.25 ±6.12 -24.86* ±6.38 -25.18* ±5.75 -24.28* ±5.60 -23.41* ±4.82 -22.08** ±3.95 -21.23** ±7.77 -21.76** ±6.19 | -23.25 ±5.83 -16.75* ±4.41 -16.90* ±6.32 -16.52* ±5.11 -16.38* ±5.29 -15.49* ±4.04 -14.26** ±3.24 -13.94** ±5.48 | -17.13 ±3.76 -15.02 ±3.82 -14.76 ±4.47 -13.80 ±3.73 -13.58 ±4.65 -12.92 ±4.17 -12.06* ±3.84 -12.23* ±5.46 |
Annotate: each administration group and normal saline group be * P＜0.05 * * P＜0.01 * * * P＜0.001 relatively
Table 2 pair isoproterenol bring out Acute Myocardial Ischemia in Rats influence (X ± SD, n=10)
| Group | The mark II S-T total drift average (mv) of leading |
| Model control group Radix Ginseng total saponins injection organized 3: 1 ixeri sonhifolia extracts of 5: 1 ixeri sonhifolia extracts of 10: 1 ixeri sonhifolia extracts of 15: 1 ixeri sonhifolia extracts of Ixeris Sonchifolia Hance injection group ixeri sonhifolia extract-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group 1: 1 | 0.10±0.03 0.08±0.04* 0.09±0.01* 0.08±0.03* 0.08±0.01* 0.07±0.03* 0.06±0.02** 0.06±0.01** |
Annotate: compare * P＜0.05, * * P＜0.01 with matched group
The influence of table 3 pair acute cerebral ischemia in rats (X ± SD, n=10)
| Group | Mus number (only) | Cerebral index | Brain water content (%) |
| Sham-operation group model contrast Radix Ginseng total saponins injection organized 3: 1 ixeri sonhifolia extracts of 5: 1 ixeri sonhifolia extracts of 10: 1 ixeri sonhifolia extracts of 15: 1 ixeri sonhifolia extracts of Ixeris Sonchifolia Hance injection group ixeri sonhifolia extract-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group 1: 1 | 10 10 10 10 10 10 10 10 10 | 0.647±0.053 0.756±0.062 ▲▲ 0.722±0.047 0.708±0.053* 0.719±0.040 0.704±0.032* 0.694±0.053* 0.682±0.046** 0.676±0.050** | 77.858±1.104 80.874±0.853 ▲▲ 79.041±1.069* 78.124±1.162** 79.012±1.348* 78.125±1.360** 78.239±1.199** 78.019±1.251** 77.822±1.508** |
Annotate: * P＜0.05 * * P＜0.01, compare with model group;
▲ ▲Compare with sham operated rats P＜0.01.
The influence of table 4 pair blood stasis rat blood rheological characteristic (x ± SD)
| Group | Whole blood viscosity (mPaS) | Packed cell volume (%) | Plasma viscosity (mPaS) | Erythrocyte aggregation index (Lb) | Fibrinogen (g/L) | |
| 300l/S | 1l/S | |||||
| Normal group model control group Radix Ginseng total saponins injection organized 3: 1 ixeri sonhifolia extracts of 5: 1 ixeri sonhifolia extracts of 10: 1 ixeri sonhifolia extracts of 15: 1 ixeri sonhifolia extracts of Ixeris Sonchifolia Hance injection group ixeri sonhifolia extract-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group-ginseng extract group 1: 1 | 3.81 ±0.44 5.84 ▲▲▲ ±0.60 5.28* ±0.68 5.14* ±0.52 5.08* ±0.63 4.97** ±0.36 4.98** ±0.72 4.84** ±0.57 4.80** ±0.43 | 5.28 ±0.48 6.01 ▲▲ ±0.52 5.93 ±0.78 5.80 ±0.64 5.82 ±0.53 5.71 ±0.35 5.63 ±0.55 5.34* ±0.74 5.41* ±0.57 | 44.19 ±1.57 45.64 ±4.72 44.56 ±3.67 44.38 ±4.10 44.03 ±3.01 44.40 ±5.21 44.35 ±3.11 43.97 ±4.42 43.87 ±4.50 | 1.24 ±0.10 1.51 ▲▲▲ ±0.13 1.46 ±0.08 1.42 ±0.06 1.39* ±0.10 1.38* ±0.07 1.34* ±0.12 1.31* ±0.06 1.33* ±0.11 | 1.57 ±0.15 1.84 ▲▲▲ ±0.14 1.74* ±0.10 1.70* ±0.15 1.66* ±0.09 1.65* ±0.13 1.63* ±0.08 1.60** ±0.06 1.61** ±0.12 | 2.70 ±0.64 3.63 ▲▲ ±0.66 3.52 ±0.68 3.52 ±0.59 3.50 ±0.84 3.52 ±0.80 3.46 ±0.61 3.40 ±0.77 3.43 ±0.65 |
Annotate: 1. model group matched group and normal control group are relatively
▲P＜0.05
▲ ▲P＜0.01
▲ ▲ ▲P＜0.001
2. each administration group and normal control group compare * P＜0.05 * * P＜0.01
Claims (9)
1, a kind of Chinese medicine composition of benefiting QI for activating blood circulation is characterized in that being made up of Herba Ixeritis Sonchifoliae extract and two kinds of components of Radix Ginseng extract.
2, the Chinese medicine composition of benefiting QI for activating blood circulation according to claim 1 is characterized in that the weight proportion of described two kinds of components is: 1 part of Radix Ginseng extract, 0.2～15 part of Herba Ixeritis Sonchifoliae extract.
3, the Chinese medicine composition of benefiting QI for activating blood circulation according to claim 2 is characterized in that the weight proportion of described two kinds of components is: 1 part of Radix Ginseng extract, 0.5～10 part of Herba Ixeritis Sonchifoliae extract.
4, the Chinese medicine composition of benefiting QI for activating blood circulation according to claim 3 is characterized in that the weight proportion of described two kinds of components is: 1 part of Radix Ginseng extract, 0.8～5 part of Herba Ixeritis Sonchifoliae extract.
5, the Chinese medicine composition of benefiting QI for activating blood circulation according to claim 4 is characterized in that the weight proportion of described two kinds of components is: 1 part of Radix Ginseng extract, 1～3 part of Herba Ixeritis Sonchifoliae extract.
6, according to the Chinese medicine composition of claim 1 or 2 or 3 or 4 or 5 described benefiting QI for activating blood circulation, it is characterized in that: the main component of described Herba Ixeritis Sonchifoliae extract is ribosidoadenine and Flavonoid substances; Described Radix Ginseng extract can be the Radix Ginseng root and rhizome extract, also can be extract of Radix Ginseng stem and leaf, and main component is the saponins material.
7, according to the Chinese medicine composition of claim 2 or 3 or 4 or 5 described benefiting QI for activating blood circulation, it is characterized in that: the expression method of the weight proportion of Herba Ixeritis Sonchifoliae extract and Radix Ginseng extract can also can be explained with the corresponding quality of medicinal material of extract with the quality statement of extract.
8, according to the Chinese medicine composition of claim 1 or 2 or 3 or 4 or 5 described benefiting QI for activating blood circulation, it is characterized in that: add acceptable corresponding adjuvant on the pharmaceutics, dosage form can be injection, transfusion, powder pin, drop pill, tablet, slow releasing tablet, capsule, slow releasing capsule, soft capsule, granule, oral liquid, eye drop.
9, the Chinese medicine composition of benefiting QI for activating blood circulation according to claim 8, it is characterized in that indication can be coronary heart disease, angina pectoris, myocardial ischemia, heart failure, arrhythmia, cerebral thrombosis, cerebral infarction, cerebral ischemia, apoplexy and sequela thereof, diabetes hyperamization pipe pathological changes, optical fundus blood vessel pathological changes, vertebral artery type of cervical spondylosis, thromboangiitis obliterans, also can be used for the auxiliary treatment of cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN106074866A (en) * | 2016-07-05 | 2016-11-09 | 江苏苏南药业实业有限公司 | The Chinese medicine preparation of a kind of resisting cardiovascular disease and application |
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| CN106074866A (en) * | 2016-07-05 | 2016-11-09 | 江苏苏南药业实业有限公司 | The Chinese medicine preparation of a kind of resisting cardiovascular disease and application |
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