CN1895457A - Preparation of Japanese beauty-berry and its inspection - Google Patents
Preparation of Japanese beauty-berry and its inspection Download PDFInfo
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- CN1895457A CN1895457A CN 200610010951 CN200610010951A CN1895457A CN 1895457 A CN1895457 A CN 1895457A CN 200610010951 CN200610010951 CN 200610010951 CN 200610010951 A CN200610010951 A CN 200610010951A CN 1895457 A CN1895457 A CN 1895457A
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- ethanol
- callicarpae formosanae
- folium callicarpae
- dry powder
- extract
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Abstract
A process for preparing the extract of Folium callicarpae formosanae includes such steps as cutting short, decocting three times, collecting decoction, filtering, concentrating, drying, adding alcohol and water, thermal reflux extracting twice, filtering, removing deposit, recovering alcohol, and drying. It can be used for preparing medicine, cosmetics and other products. Its test method is also disclosed.
Description
Technical field: the preparation method and the method for inspection thereof that the invention belongs to a kind of Chinese medicine Folium Callicarpae Formosanae extract.
Background technology: the composition characteristic of Folium Callicarpae Formosanae plant (Folium Callicarpae Formosanae): leaf contains flavonoid, saccharide, tannin, phenols, aminoacid, organic acid.Folium Callicarpae Formosanae nature and flavor hardship, flat; Nontoxic, drug safety has no side effect.Chinese patent CN200410023049.5 discloses a kind of Folium Callicarpae Formosanae extracting method: get Callicarpa nudiflora, decoct with water twice, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is condensed into the thick paste shape, is dried to dry extract, and dried cream powder is broken into dried cream powder and adds appropriate amount of auxiliary materials, make granule, drying, gained granule filling capsule.Contain tannin and polysaccharide in the resulting Folium Callicarpae Formosanae extract of this extracting method, and the contained flavonoid of its leaf, phenols active ingredient extract not, remain and be in the ethanol liquid.
Summary of the invention: the present invention proposes a kind of preparation method and method of inspection thereof of Folium Callicarpae Formosanae extract, with behind broken section of the Chinese medicine Folium Callicarpae Formosanae (Folium Callicarpae Formosanae), decoct with water three times, collecting decoction filters, and filtrate is concentrated into the thick paste shape, dry, obtain thick water extract dry powder, what dry powder added 95% ethanol and suitable quantity of water is adjusted to ethanol content between the 30%-95%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly; Method with percolation or reflux is extracted 2 times, filters, and precipitation is abandoned it, merges ethanol liquid, reclaims ethanol to the thick paste shape, and this step has been removed the impurity except that flavonoid, phenols; Resulting thick paste shape Folium Callicarpae Formosanae ethanol extract adds 3-8 and doubly measures 95% dissolve with ethanol; With 0.2% charcoal treatment once, this step will be removed through the pigment impurity partly that extraction is brought into again; Reclaim ethanol at last, be drying to obtain under the dry heat condition below 60 ℃.
With the Folium Callicarpae Formosanae extract that method of the present invention is extracted, it is hemorrhage to control the intestines and stomach; The spitting of blood that various diseases causes, hematemesis, epistaxis, gingival hemorrhage, hematuria, have blood in stool, dysfunctional uterine hemorrhage, traumatic hemorrhage, acute conjunctivitis, and various surgical wound surface oozings of blood etc.
Description of drawings: Fig. 1 is a technological process of production sketch of the present invention.
The specific embodiment:
1, with behind broken section of the Folium Callicarpae Formosanae (Herb), decoct with water three times, collecting decoction filters, and filtrate is concentrated into the thick paste shape, dry, obtain thick water extract dry powder, resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol and an amount of water, and to be adjusted to ethanol content be 30%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly, perhaps
Resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol and an amount of water, and to be adjusted to ethanol content be 40%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly, perhaps,
Resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol and an amount of water, and to be adjusted to ethanol content be 50%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly, perhaps,
Resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol and an amount of water, and to be adjusted to ethanol content be 60%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly, perhaps,
Resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol and an amount of water, and to be adjusted to ethanol content be 70%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly, perhaps,
Resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol and an amount of water, and to be adjusted to ethanol content be 80%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly, perhaps,
Resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol and an amount of water, and to be adjusted to ethanol content be 90%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly, perhaps,
Resulting Folium Callicarpae Formosanae dry powder adds 95% ethanol, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly.
2, extract 2 times with the method for percolation or reflux, filter, precipitation is abandoned it, merges ethanol liquid, reclaims ethanol to the thick paste shape.
3, resulting Folium Callicarpae Formosanae ethanol extract adding 3-8 doubly measures 95% dissolve with ethanol, reclaims ethanol.
4, the exsiccant condition of thick paste: xeothermic drying below 60 ℃.
A kind of method of inspection of Folium Callicarpae Formosanae extract, step is as follows:
[discriminating]
(1) get this product 2g, add water 20ml, reflux 30 minutes filters, and gets filtrate 2ml, adds 2～3 of ferric chloride test solutions, promptly shows blackish green; Other gets filtrate 2ml, adds 2～3 of 1% gelatin solutions and promptly takes place muddy.
(2) get this product 2g, add water 20ml, reflux 1 hour filters, and filtrate is concentrated into dried, adds methanol 2ml dissolving, filters, as need testing solution.Other gets Folium Callicarpae Formosanae control medicinal material 1g, shines medical material solution in pairs with legal system.Draw each 10 μ l of above-mentioned two kinds of solution, put on same filter paper respectively, put under the ultra-violet lamp (365nm) and observe, show the fluorescence speckle of same color.
(3) get [discriminating] (2) item remaining need testing solution down, add 5% sodium nitrite solution and 10% aluminum nitrate solution each 3 and 4% sodium hydroxide solution 1ml, promptly show red.
Add medicinal adjuvant with the Folium Callicarpae Formosanae ethanol extraction, make tablet, electuary, capsule, injection, aerosol, nasal drop, suppository, external preparation and cosmetics, or daily chemical product such as toothpaste, collutory or the like, after packing, check, put in storage or dispatch from the factory.
Claims (3)
1, a kind of preparation method of Folium Callicarpae Formosanae extract, with behind broken section of the Chinese medicine Folium Callicarpae Formosanae (Folium CallicarpaeFormosanae), decoct with water three times, collecting decoction filters, and filtrate is concentrated into the thick paste shape, dry, obtain thick water extract dry powder, what dry powder added 95% ethanol and suitable quantity of water is adjusted to ethanol content between the 30%-95%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly; Method with percolation or reflux is extracted 2 times, filters, and precipitation is abandoned it, merges ethanol liquid, reclaims ethanol to the thick paste shape, and this step has been removed the impurity except that flavonoid, phenols; Resulting thick paste shape Folium Callicarpae Formosanae ethanol extract adds 3-8 and doubly measures 95% dissolve with ethanol; With 0.2% charcoal treatment once, this step will be removed through the pigment impurity partly that extraction is brought into again; Reclaim ethanol at last, be drying to obtain under the dry heat condition below 60 ℃.
2, the preparation method of Folium Callicarpae Formosanae extract as claimed in claim 1 is characterized in that dry powder adds ethanol and adjusts ethanol content between the 30%-95%, and make total amount be Folium Callicarpae Formosanae dry powder amount 3-8 doubly.
3, a kind of method of inspection of Folium Callicarpae Formosanae extract, step is as follows:
(1) get this product 2g, add water 20ml, reflux 30 minutes filters, and gets filtrate 2ml, adds 2～3 of ferric chloride test solutions, promptly shows blackish green; Other gets filtrate 2ml, adds 2～3 of 1% gelatin solutions and promptly takes place muddy.
(2) get this product 2g, add water 20ml, reflux 1 hour filters, and filtrate is concentrated into dried, adds methanol 2ml dissolving, filters, as need testing solution.Other gets Folium Callicarpae Formosanae control medicinal material 1g, shines medical material solution in pairs with legal system.Draw each 10 μ l of above-mentioned two kinds of solution, put on same filter paper respectively, put under the ultra-violet lamp (365nm) and observe, show the fluorescence speckle of same color.
(3) get [discriminating] (2) item remaining need testing solution down, add 5% sodium nitrite solution and 10% aluminum nitrate solution each 3 and 4% sodium hydroxide solution 1ml, promptly show red.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100109512A CN100509018C (en) | 2006-06-12 | 2006-06-12 | Preparation of Japanese beauty-berry and inspection method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100109512A CN100509018C (en) | 2006-06-12 | 2006-06-12 | Preparation of Japanese beauty-berry and inspection method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1895457A true CN1895457A (en) | 2007-01-17 |
| CN100509018C CN100509018C (en) | 2009-07-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100109512A Expired - Fee Related CN100509018C (en) | 2006-06-12 | 2006-06-12 | Preparation of Japanese beauty-berry and inspection method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104693312A (en) * | 2015-02-06 | 2015-06-10 | 南昌航空大学 | Method for simultaneously extracting various effective constituents from callicarpa cathayana and application thereof |
| CN105194108A (en) * | 2014-06-18 | 2015-12-30 | 海南国瑞堂中药制药有限公司 | Preparation method of callicarpa nudiflora extract |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1307979C (en) * | 2005-03-04 | 2007-04-04 | 北京正大绿洲医药科技有限公司 | Hemostatic beautyberry dripping pill and its preparing method |
-
2006
- 2006-06-12 CN CNB2006100109512A patent/CN100509018C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194108A (en) * | 2014-06-18 | 2015-12-30 | 海南国瑞堂中药制药有限公司 | Preparation method of callicarpa nudiflora extract |
| CN104693312A (en) * | 2015-02-06 | 2015-06-10 | 南昌航空大学 | Method for simultaneously extracting various effective constituents from callicarpa cathayana and application thereof |
| CN104693312B (en) * | 2015-02-06 | 2017-01-04 | 南昌航空大学 | Method that in Folium Callicarpae Formosanae, plurality of active ingredients is extracted simultaneously and application |
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| Publication number | Publication date |
|---|---|
| CN100509018C (en) | 2009-07-08 |
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Owner name: DALI BAI AUTONOMOUS PREFECTURE TCM PHARMACEUTICAL Free format text: FORMER NAME: DALI BAI-NATIONALITY AUTONOMOUS PREFECTURE CHINESE MEDICINE PHARMACY CO., LTD. |
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Address after: 672400 No. 66 East Road, Nanzhao Town, Weishan County, Yunnan Patentee after: Dali Bai Autonomous Prefecture Traditional Chinese Medicine Pharmaceutical Co., Ltd. Address before: 672400 No. 66 East Road, Nanzhao Town, Weishan County, Yunnan Patentee before: Dali Bai-Nationality Autonomous Prefecture Chinese Medicine Pharmacy Co., Ltd. |
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Granted publication date: 20090708 Termination date: 20140612 |
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