CN1876068A - Process and application of Chinese medicinal preparation containing belamcanda - Google Patents
Process and application of Chinese medicinal preparation containing belamcanda Download PDFInfo
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- CN1876068A CN1876068A CN 200610076700 CN200610076700A CN1876068A CN 1876068 A CN1876068 A CN 1876068A CN 200610076700 CN200610076700 CN 200610076700 CN 200610076700 A CN200610076700 A CN 200610076700A CN 1876068 A CN1876068 A CN 1876068A
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Abstract
The invention relates to a preparation containing belamcanda rhizome and method for preparing same, wherein the preparation is made from belamcanda rhizome powder with a content higher than 0.5%, or the mixture of belamcanda rhizome extract or belamcanda rhizome powder and extract, the belamcanda rhizome powder is the coarse powder, ultramicro powder and nano powder prepared from leaves or overground portions with leaves of belamcanda or iris through disintegrating.
Description
Affiliated technical field: the present invention relates to a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation, particularly relate to the development processing and the application aspect the treatment diabetes thereof that contain the Rhizoma Belamcandae Chinese medicine preparation.The manufacture field that belongs to Chinese medicine.
Background technology: diabetes are one group of clinical syndromes that caused by the nature-nurture factor interaction, it is one group of common metabolism endocrinopathy, cause hyperglycemia with insulin secretion or effect defective or both common defects, it has long, the difficult radical cure of ill cycle, necessary long-term prescription, and the characteristics that very easily lead to complications.Along with the raising of people's living standard, the change of dietary structure, the reduction of labor intensity, the aggravation of aged tendency of population, the sickness rate of diabetes is the trend that rises gradually, and the city is significantly higher than the rural area.Interrelated data shows, the mortality rate that is caused by diabetes is higher at present, is only second to cardiovascular, and diseases such as cerebrovascular and tumor become and threaten human " No. three killer ", serious harm people's health.The diabetes clinical manifestation is polydipsia, polyphagia, polyuria, loses weight etc., promptly so-called " three-many-one-little " symptom, and the later stage can be caused multiple syndrome, and patient is very painful.The medicine of treatment diabetes is more at present, can be divided into Western medicine and Chinese medicine two big classes basically.The most blood sugar lowering of Western medicine are very fast, but are prone to side effect such as hypoglycemic reaction, lactic acidosis, gastrointestinal reaction.The symptom of the most energy of Chinese medicine diabetes-alleviating, toxic and side effects is little, but blood sugar lowering is slow.It is that relapse rate is very high after the drug withdrawal that existing medicine also has a shortcoming.Rhizoma Belamcandae is the leaf of irides Rhizoma Belamcandae Belamcanda chinensis (L.) DC. or the aerial parts of band leaf, contains compositions such as flavone, triterpene, phenolic acid, polysaccharide.Still do not have the ancient books record and the bibliographical information that are applied to treat the diabetes aspect, do not have relevant patent report yet.
Summary of the invention: the object of the present invention is to provide a kind of Blackberrylily Rhizome that contains, or the Chinese medicine preparation made of the mixture of Rhizoma Belamcandae extract or Blackberrylily Rhizome and its extract, said preparation can significantly reduce the blood glucose of diabetics, improve its sugared tolerance situation, improve hepatic glycogen content, significantly improve " three-many-one-little " symptom, and can activate islet cells, promote the islet cells excreting insulin, reach the purpose of treatment diabetes, provide Rhizoma Belamcandae to be used for the treatment of a kind of new purposes of diabetes.
For achieving the above object, the Rhizoma Belamcandae preparation that contains of the present invention is a Blackberrylily Rhizome by (dry weight percentage ratio) more than 0.5%, or the mixture of Rhizoma Belamcandae extract or Blackberrylily Rhizome and extract thereof, or add some and help strengthening hypoglycemic activity, reduction or eliminate toxic and side effects and untoward reaction, improve chemicals, Chinese medicine and the natural drug of diabetes patient's clinical " three-many-one-little " symptom and the auxiliary components of extract thereof, the suitable additives that add 0-99.5% again, and the preparation of the suitable clinical practice of making through corresponding preparation technology.
The Rhizoma Belamcandae that is used as raw material among the present invention can be leaf of Rhizoma Belamcandae fresh harvesting or exsiccant or band leaf aerial parts.Rhizoma Belamcandae can be ground into the powder of suitable size particles by common pulverizer, also can become superfine powder or be ground into nano level powder by suitable way by micronizing.The thickness of powder depends on dosage form and preparation technology's needs.The bright leaf of Rhizoma Belamcandae can directly adopt the composition in the milling process extraction leaf, or pushes the extraction of squeezing the juice by adding an amount of water.Extract of the present invention be meant from Blackberrylily Rhizome or/and the Rhizoma Belamcandae extract separation and purification to total flavones, total alkaloids, total phenolic acid, total polysaccharides.Extract also refers to further to separate from total flavones, total alkaloids, total phenolic acid, total polysaccharides and the single chemical constituent that obtains.
Rhizoma Belamcandae extract of the present invention is meant and adopts water extraction, decoction and alcohol sedimentation technique, alcohol extracting method, ethanol extract from water precipitation, percolation, supercritical carbon dioxide extraction method, the resulting Rhizoma Belamcandae extract of macroporous adsorbent resin method, also comprise squeezing the juice of bright leaf, and concentrate, dry thing.
The technology that water extraction of the present invention is produced Rhizoma Belamcandae extract is meant Blackberrylily Rhizome or coarse granule under the condition more than 50 ℃, percentage by weight by medical material and water is 1: 6-1: 25 extracting in waters are more than 0.5 hour, and extracting solution merges, and concentrate, drying, promptly.
The technology that decoction and alcohol sedimentation technique of the present invention is produced Rhizoma Belamcandae extract is meant Blackberrylily Rhizome or coarse granule under 50-100 ℃ condition, percentage by weight by medical material and water is 1: 6-1: 25 extracting in waters are more than 0.5 hour, and extracting solution merges, and is condensed into thick paste, add ethanol to remove macromolecule impurity, add alcoholic acid amount for containing the alcohol amount to medicinal liquid, staticly settle, filter for 50%-85%, behind the alcohol deposit fluid decompression recycling ethanol, concentrate, drying, promptly.
The technology that alcohol extracting method of the present invention is produced Rhizoma Belamcandae extract is meant Blackberrylily Rhizome or coarse granule under 70-100 ℃ condition, by medical material and alcoholic acid percentage by weight is 1: 6-1: 25 added the 50%-85% ethanol extraction more than 0.5 hour, extracting solution merges, behind the decompression recycling ethanol, concentrate, drying, promptly.
The technology that ethanol extract from water precipitation of the present invention is produced Rhizoma Belamcandae extract is meant Blackberrylily Rhizome or coarse granule under 50-100 ℃ condition, by medical material and alcoholic acid percentage by weight is 1: 6-1: 25 added the 50%-85% ethanol extraction more than 0.5 hour, extracting solution merges, behind the decompression recycling ethanol, staticly settle, filter, filtrate concentrates, drying, promptly.
The technology that percolation of the present invention is produced Rhizoma Belamcandae extract is meant in the percolator of packing into after Blackberrylily Rhizome or the coarse granule moistening, by medical material and alcoholic acid percentage by weight is 1: 6-1: 30 add the 50%-85% ethanol percolation, percolate merges, behind the decompression recycling ethanol, medicinal liquid concentrates, drying, promptly.
The technology that supercritical carbon dioxide extraction method of the present invention is produced Rhizoma Belamcandae extract is meant packs Blackberrylily Rhizome or coarse granule in the extraction kettle into, with supercritical carbon dioxide extraction method (can add an amount of entrainer, pH value regulator as required) effective ingredient in the medical material is extracted, decompress(ion) is removed carbon dioxide again, residue is collected, concentrate, drying, promptly.
The technology that macroporous adsorbent resin legal system of the present invention is got Rhizoma Belamcandae extract is meant the Rhizoma Belamcandae extracting solution of said method gained, concentrating under reduced pressure, concentrated solution adsorbs effective ingredient through macroporous adsorptive resins, discard effluent, continue, make till the absorption complete eluting of effective ingredient quilt thereon with 10%-80% ethanol elution macroporous adsorptive resins, behind the eluent decompression recycling ethanol, reconcentration, drying, promptly.
The preparation that contains Rhizoma Belamcandae of the present invention comprises various types of pills, tablet, capsule, granule, powder, oral liquid, injection, and suitable clinically dosage form.
Additive of the present invention comprises but is not limited to filler, wetting agent, binding agent, disintegrating agent, lubricant, pH regulator agent, flavoring agent, coloring agent.Contain percentage by weight shared in the Rhizoma Belamcandae preparation and be respectively described: filler 0-98%, lubricant 0-30%, binding agent 0-50%, disintegrating agent 0-50%, and wetting agent, pH regulator agent, flavoring agent, coloring agent can be according to dosage form, the required flexible interpolation of preparation technology.
The invention has the advantages that extraction process without organic solvent, with low cost, safe and effective, production technology is simple, is suitable for pharmaceutical factory large-scale production.Experimental study shows that Rhizoma Belamcandae mainly contains flavone, alkaloid, phenolic acid, polysaccharide component.The preparation that Blackberrylily Rhizome or extract are made can significantly reduce the blood glucose of diabetics, improve its sugared tolerance, improve hepatic glycogen content, significantly improve " three-many-one-little " symptom and prolong the diabetes rat swimming time, and can significantly promote the islet cells excreting insulin of In vitro culture to have multiple hypoglycemic mechanism; And do not find obvious toxic and side effects.Disease to cardiovascular and hormonal system has adjusting and protective effect simultaneously.Show the preparation that contains Rhizoma Belamcandae of the present invention, it not only has good hypoglycemic activity clinically, can prevent and treat diabetic complication again simultaneously, becomes a kind of newtype drug that has treatment diabetes and complication thereof concurrently.
Embodiment
The invention will be further described below in conjunction with specific embodiment.
Embodiment 1:
Get the leaf 1000g of leaf of Rhizoma Belamcandae or band twig, clean, after the drying, be ground into 20-400 purpose powder, use water pill, make the piller of the heavily about 1g of per 20 balls, promptly get the Rhizoma Belamcandae water pill with pulverizer to remove impurity.
Embodiment 2:
Get Rhizoma Belamcandae granule 1000g, add 10 liters in water, decoct and extracted 2 hours, extracting solution concentrates, and drying with ethanol system soft material, is crossed 60 mesh sieves and granulated, 65 ℃ of dryings, and granulate, encapsulated, promptly get the Rhizoma Belamcandae capsule, every capsules dress Rhizoma Belamcandae extract 0.3g.
Embodiment 3:
Get Rhizoma Belamcandae granule 1000g, add 10 liters of 80% ethanol, decoct and extracted 2 hours, filter, behind the decompression filtrate recycling ethanol, concentrate, drying with ethanol system soft material, is crossed 60 mesh sieves and is granulated 65 ℃ of dryings, granulate, tabletting, bag film-coat or sugar-coat promptly get the Rhizoma Belamcandae sheet, and every contains Rhizoma Belamcandae extract 0.3g.
Embodiment 4:
Get Rhizoma Belamcandae granule 1000g, add 10 liters in water, decoct and extracted extracting solution 2 hours, be condensed into thick paste, adding ethanol is 70% to making medicinal liquid contain the alcohol amount, staticly settles, filter, behind the decompression filtrate recycling ethanol, concentrate, drying with ethanol system soft material, is crossed 60 mesh sieves and is granulated, 65 ℃ of dryings, granulate, tabletting, bag film-coat or sugar-coat promptly get the Rhizoma Belamcandae sheet, and every contains Rhizoma Belamcandae extract 0.3g.
Embodiment 5:
Get Rhizoma Belamcandae granule 1000g, add 10 liters of 80% ethanol, decoct and extracted 2 hours, filter, behind the decompression filtrate recycling ethanol, add water to 50 liters, staticly settle, filter, filtrate is condensed into 1000ml, put coldly, adjust pH 6-8 leaves standstill more than the 24h, filter, filtrate is used microporous filter membrane, ultrafiltration membrance filter more successively, and filtrate is sub-packed in the ampoule, 105 ℃ of pressure sterilizing 45min promptly get the Rhizoma Belamcandae injection.
Embodiment 6:
Get Rhizoma Belamcandae granule 1000g, in the extraction kettle of packing into, fed supercritical carbon dioxide extraction 3 hours, decompress(ion) is removed carbon dioxide, residue is collected, concentrated, drying adds water 1000ml heating for dissolving, put coldly, adjust pH 6-8 leaves standstill more than the 24h, filters, filtrate is with mannitol 300g, heating for dissolving, and mixing is put cold, adjust pH 6-8 leaves standstill more than the 24h, filters, and uses microporous filter membrane, ultrafiltration membrance filter more successively, filtrate is sub-packed in the ampoule, and lyophilization promptly gets the injection Rhizoma Belamcandae.
Embodiment 7:
Get Rhizoma Belamcandae granule 1000g, add 10 liters of 80% ethanol, decoct and extracted 2 hours, filter, behind the decompression filtrate recycling ethanol, add water to 50 liters, staticly settle, filter, filtrate is by AB-8 type macroporous adsorptive resins absorption effective ingredient, discard effluent, continue and use 70% ethanol elution, collect 70% ethanol elution, behind the decompression recycling ethanol, be condensed into 1000ml, put cold, adjust pH 6-8 leaves standstill more than the 24h, filters, filtrate is with mannitol 300g, heating for dissolving, mixing, put coldly, adjust pH 6-8 leaves standstill more than the 24h, filter, use microporous filter membrane more successively, ultrafiltration membrance filter, filtrate are sub-packed in the ampoule, lyophilization promptly gets the injection Rhizoma Belamcandae.
But any collocation combination in any among the above embodiment.
Claims (12)
1, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation, it is characterized in that: said preparation is by the Blackberrylily Rhizome of (in dry matter weight) 0.5%-100%, or penetrate in the mixture of extract or Blackberrylily Rhizome and extract thereof, add necessary additives composition, and make the preparation that is suitable for clinical use through corresponding preparation technology, wherein, Blackberrylily Rhizome is the leaf of Rhizoma Belamcandae or Rhizoma Iridis Tectori or is with the leaf aerial parts through pulverizing coarse powder, ultra-micro powder and the nanometer powder of gained; Rhizoma Belamcandae extract be meant the leaf of Rhizoma Belamcandae or Rhizoma Iridis Tectori or band leaf aerial parts with The suitable solvent through extracting, concentrating or/and dry gained, and comprise effective site and effective ingredient through further separation and purification gained.
2, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: Blackberrylily Rhizome and Rhizoma Belamcandae extract mixture are to be mixed by the Blackberrylily Rhizome of 0.5%-100% and the Rhizoma Belamcandae extract of 0.5%-100%.
3, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: the Rhizoma Belamcandae extract preparation method can adopt water extraction, decoction and alcohol sedimentation technique, alcohol extracting method, ethanol extract from water precipitation, percolation, supercritical carbon dioxide extraction method, macroporous adsorbent resin method in the said preparation.
4, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1 is characterized in that: effective site be meant from Blackberrylily Rhizome or/and the Rhizoma Belamcandae extract separation and purification to total flavones, total alkaloids, total phenolic acid, total polysaccharides.Effective ingredient is meant the single chemical constituent of further separating and obtaining from total flavones, total alkaloids, total phenolic acid, total polysaccharides.
5, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: the Blackberrylily Rhizome that is contained in the said preparation or/and Rhizoma Belamcandae extract also can be mixed with auxiliary components, described auxiliary components strengthens hypoglycemic activity, reduction or eliminates toxic and side effects and untoward reaction for helping, and improves chemicals, Chinese medicine and natural drug and the extract thereof of diabetes patient's clinical " three-many-one-little " symptom.
6, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: the Blackberrylily Rhizome that is contained in the said preparation is or/and Rhizoma Belamcandae extract also can be mixed with auxiliary components, and described auxiliary components is chemicals, Chinese medicine and natural drug and the extract thereof that helps resisting cardiovascular disease, reduction or eliminate toxic and side effects and untoward reaction.
7, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: the Blackberrylily Rhizome that is contained in the said preparation or/and Rhizoma Belamcandae extract also can be mixed with auxiliary components, described auxiliary components is inhibited for helping inflammatory reaction, immunoreation is had chemicals, Chinese medicine and natural drug and the extract thereof of inhibition or enhancing and regulating action, reduction or elimination toxic and side effects and untoward reaction.
8, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: the dosage form of said preparation comprises various types of pills, tablet, capsule, granule, powder, oral liquid, injection, and other suitable clinically dosage form.
9, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: said preparation contains the additives that are necessary, comprises filler, wetting agent and binding agent, disintegrating agent, lubricant, pH regulator agent.
10, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: said preparation is used for the treatment of diabetes and complication thereof clinically, comprises heart, brain, kidney, nerve, blood vessel, lungs, liver, gallbladder, pancreas, esophagus gastrointestinal, genitals, bone, joint, skin, oral cavity, eye, ear and blood complication because of diabetes cause.
11, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: said preparation possesses clinically and significantly resists myocardial ischemia and the antiarrhythmic effect, the pharmacological action result shows cardiovascular disease from antioxidation, microcirculation improvement, coronary artery dilator, the blood flow increasing aspect plays a role simultaneously.
12, a kind of processing and application that contains the Rhizoma Belamcandae Chinese medicine preparation according to claim 1, it is characterized in that: no matter said preparation is early stage to inflammatory clinically, or inflammatory all has the obvious suppression effect late period, and has certain refrigeration function.Rhizoma Belamcandae can significantly suppress the increasing of mouse skin capillary permeability due to the histamine, can obviously suppress the development of rat hyaluronidase foot edema.Can also obviously suppress inflammatory exudation and hypertrophy due to the Oleum Tiglii in addition, the increasing with rat granuloma hamartoplasia of abdominal cavity capillary permeability due to the Dichlorodiphenyl Acetate all has inhibitory action.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610076700 CN1876068A (en) | 2006-04-29 | 2006-04-29 | Process and application of Chinese medicinal preparation containing belamcanda |
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| CN 200610076700 CN1876068A (en) | 2006-04-29 | 2006-04-29 | Process and application of Chinese medicinal preparation containing belamcanda |
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| CN1876068A true CN1876068A (en) | 2006-12-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301258A (en) * | 2013-05-31 | 2013-09-18 | 安徽源和堂药业股份有限公司 | Blackberrylily rhizome medicinal slice processing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301258A (en) * | 2013-05-31 | 2013-09-18 | 安徽源和堂药业股份有限公司 | Blackberrylily rhizome medicinal slice processing method |
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