CN1872125B - Medicine for treating disease of gstrointestinal tract, and preparation method - Google Patents
Medicine for treating disease of gstrointestinal tract, and preparation method Download PDFInfo
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- CN1872125B CN1872125B CN2005100136021A CN200510013602A CN1872125B CN 1872125 B CN1872125 B CN 1872125B CN 2005100136021 A CN2005100136021 A CN 2005100136021A CN 200510013602 A CN200510013602 A CN 200510013602A CN 1872125 B CN1872125 B CN 1872125B
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- radix aucklandiae
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A medicine for treating gastrointestinal diseases is disclosed. Its advantages are high natural level and safety and low toxic by-effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is medicine of the treatment gastroenteropathy made of raw material and preparation method thereof.
Background technology
The Radix Aucklandiae is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..The bitter in the mouth suffering, warm in nature, fragrance is hot strong, contains and enriches volatile oil, returns spleen, stomach, large intestine, three warmers, gallbladder meridian.This medicine has promoting the circulation of QI to relieve pain, and the function of strengthening the spleen to promote digestion is mainly used in breast gastral cavity distending pain, and heavy behind the dysentery, food stagnation does not disappear, the treatment of symptoms such as anorexia.
At present mostly be pill or the tablet that compound recipe is made about the medicine of Radix Aucklandiae preparation clinically, drug effect is slower.Dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of treatment gastroenteropathy with new type natural substrate adjuvant preparation.
Another object of the present invention provides a kind of preparation method for the treatment of gastroenteropathy pharmaceutical preparation.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, this medicine comprises: Radix Aucklandiae oil, adjuvant, wherein adjuvant comprises filler and plasticity substrate, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
The adjuvant of preferred drug component of the present invention is following one or more the natural adjuvant of plant origin for the filler adjuvant is selected from: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum;
Best substrate adjuvant of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Adjuvant is 1: 0.1～1: 1 with the ratio of the weight of Radix Aucklandiae oil in the pharmaceutical composition of the present invention;
Adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of Radix Aucklandiae oil in the preferred pharmaceutical composition of the present invention;
Adjuvant is 1: 0.2～1: 0.4 with the ratio of the weight of Radix Aucklandiae oil in the best pharmaceutical composition of the present invention.
Medicine mesostroma adjuvant of the present invention and amount of drug are than being the scope that allows on the galenic pharmacy, and medicine described here can be that crude drug also can be the effective ingredient extract.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method; make common any preparation at present; but, preferably adopt following method to be prepared into dropping pill formulation, but this can not limit protection scope of the present invention in order to make each crude drug of this medicine bring into play drug effect better.
The preparation method of medicine of the present invention is as follows:
(a) get Radix Aucklandiae oil, adjuvant is standby;
(b) in appropriate amount of auxiliary materials, add Radix Aucklandiae oil, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Further preferred manufacturing procedure is:
The mixture heated melt temperature is 60～85 ℃ in the step (b), and mixing time is 10～30 minutes, and dripping a system temperature and be 60～85 ℃, dropper bore is 1.1～3.5 millimeters, and condensing agent is 0～18 ℃ liquid paraffin or a methyl-silicone oil.
Best preparation method is:
The mixture heated melt temperature is 64 ℃ in the step (b), and dripping a system temperature and be 64 ℃, dropper bore is 1.2～2.5 millimeters, and condensing agent is 0 ℃ a methyl-silicone oil.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, for example: selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis substrate adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that chronic gastroenteropathy is treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill that this adjuvant is made can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
In order to understand the present invention better, dissolve scattered time limit, weight differential, drop pill soft durometer, the drop pill with FUFANG DANSHEN DIWAN glues test explanation advantages of the present invention such as ball below.
Test example 1: dissolve scattered time limit contrast experiment example
In vitro tests
According to the new substrate Radix Aucklandiae oil of the present invention drop pill of embodiment 1 method preparation,, investigate its good releasing effect by indexs such as mensuration dissolve scattered time limits.
1. test medication: the new substrate Radix Aucklandiae oil of the present invention drop pill.
2. method and result:
Dissolve scattered time limit: by " method is measured result such as table 1 under this item of Chinese pharmacopoeia.
The dissolve scattered time limit of the Radix Aucklandiae oil drop pill that three batches in table 1 is made with the new medium adjuvant, weight differential are relatively
Test data shows, different all being controlled in the pharmacopeia prescribed limit of dissolve scattered time limit, the ball method of double differences of new substrate Radix Aucklandiae oil drop pill.Result of the test explanation, the molten diffusing speed of the Radix Aucklandiae oil drop pill made from novel adjuvant is faster, is more conducive to medicine and plays a role in the shortest time; Different being controlled in the pharmacopeia prescribed limit of the ball method of double differences of new substrate Radix Aucklandiae oil drop pill illustrates that this natural substrates adjuvant is used to prepare drop pill, and can use in industrialization.
Test example 2: the new substrate Radix Aucklandiae oil of the present invention drop pill soft durometer, the sticking ball comparative observation of drop pill
According to 3 batches of the new substrate Radix Aucklandiae oil of the present invention drop pill of embodiment 1 method preparation, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.
Table 2: three batches of Radix Aucklandiae oil drop pill character observations made from the new medium adjuvant relatively
Test data shows that new substrate Radix Aucklandiae oil drop pill soft durometer changes and the sticking ball of drop pill changes little.Result of the test illustrates that the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is used for the preparation of drop pill, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a) get Radix Aucklandiae oil 5.0g, xylitol 25.3g, starch 6.7g is standby;
(b) get xylitol and starch mix homogeneously, adding above-mentioned Radix Aucklandiae oil fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 2
(a) get Radix Aucklandiae oil 20g, lactose 76.9g, starch 23.1g is standby;
(b) get lactose and starch mix homogeneously, adding above-mentioned Radix Aucklandiae oil fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 3
(a) get Radix Aucklandiae oil 40g, xylitol 71.4g, arabic gum 28.g is standby;
(b) get xylitol and arabic gum mix homogeneously, adding above-mentioned Radix Aucklandiae oil fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 4
(a) get Radix Aucklandiae oil 6g, xylitol 80g, starch 20g is standby;
(b) get xylitol and starch mix homogeneously, adding above-mentioned Radix Aucklandiae oil fully mixes, mixture stirs at 45～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～70 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in-10～10 ℃ the methyl-silicone oil, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 5
(a) get Radix Aucklandiae oil 25g, xylitol 62.5g, starch 37.5g is standby;
(b) get xylitol and starch mix homogeneously, add above-mentioned Radix Aucklandiae oil, mixture stirs at 45～115 ℃ of heating and meltings, and mixing time is 1～30 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 5000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 6
(a) get Radix Aucklandiae oil 15g, maltose 100g is standby;
(b) get maltose and add above-mentioned Radix Aucklandiae oil, mixture is at 55～75 ℃ of heating and meltings, stir, mixing time is 5～12 minutes, and insulation is 1.20～3.0 millimeters at 55～75 ℃ of temperature following system, dropper bore, splash in 0～15 ℃ the liquid paraffin, make 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly
Embodiment 7
(a) get Radix Aucklandiae oil 20g, xylitol 80g, cyclodextrin 20g is standby;
(b) get xylitol and cyclodextrin mixing mixing, add above-mentioned Radix Aucklandiae oil, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 5～20 minutes, and insulation is dripped system 58～70 ℃ of insulations, splash in 12 ℃ of liquid paraffin, make 4000 drop pill of drop pill, promptly.
Embodiment 8
(a) get Radix Aucklandiae oil 30g, xylitol 99g, pregelatinized Starch 12g is standby;
(b) get xylitol and pregelatinized Starch mix homogeneously, add above-mentioned Radix Aucklandiae oil, mixture stirs at 60～75 ℃ of heating and meltings, and mixing time is 10～60 minutes, insulation, at 55～65 ℃ of temperature following system, dropper bore is 1.0～3.5 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 9
(a) get Radix Aucklandiae oil 35g, lactose 66g, starch 34g is standby;
(b) get mixing of lactose and starch, add above-mentioned Radix Aucklandiae oil, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the methyl-silicone oil, makes 5000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 10
(a) get Radix Aucklandiae oil 40g, xylitol 62.5g, arabic gum 37.5g is standby;
(b) get the mixing mixing of xylitol and arabic gum, add above-mentioned Radix Aucklandiae oil, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the liquid paraffin, makes 5000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 11
(a) get Radix Aucklandiae oil 45g, xylitol 80g, alginic acid 20g is standby;
(b) get xylitol and alginic acid mixing mixing, add above-mentioned Radix Aucklandiae oil, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.21～3.5 millimeters, splashes in 0～15 ℃ the methyl-silicone oil, makes 3000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 12
(a) get Radix Aucklandiae oil 50g, xylitol 166g, sodium carboxymethyl cellulose 34g is standby;
(b) get xylitol and sodium carboxymethyl cellulose mix homogeneously, add above-mentioned Radix Aucklandiae oil, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～20 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.5～3.5 millimeters, splashes in 10～18 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 13
(a) get Radix Aucklandiae oil 55g, lactose 40g, agar 10g is standby;
(b) get lactose and agar mix homogeneously, add above-mentioned Radix Aucklandiae oil, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 62～67 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 4 ℃ the methyl-silicone oil, makes 3000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 14
(a) get Radix Aucklandiae oil 55g, xylitol 85g, arabic gum 15g is standby;
(b) get xylitol and arabic gum mix homogeneously, add above-mentioned Radix Aucklandiae oil, mixture stirs at 55～85 ℃ of heating and meltings, and mixing time is 5～30 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes .3000 grain drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 15
(a) get Radix Aucklandiae oil 60g, lactose 70g, hydroxypropyl emthylcellulose 20g is standby;
(b) getting lactose and hydroxypropyl emthylcellulose mixes, add above-mentioned Radix Aucklandiae oil, fully mix, mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, make 3000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 16
(a) get Radix Aucklandiae oil 70g, xylitol 60g, methylcellulose 40g is standby;
(b) get xylitol and methylcellulose mixing, adding above-mentioned Radix Aucklandiae oil fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 3000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 17
(a) get Radix Aucklandiae oil 150g, sorbitol 150g, carboxymethyl starch 50g is standby;
(b) get sorbitol and carboxymethyl starch mixing, adding above-mentioned Radix Aucklandiae oil fully mixes, mixture stirs at 58～78 ℃ of heating and meltings, and mixing time is 20～50 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0～10 ℃ the methyl-silicone oil, makes 10000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 18
(a) get Radix Aucklandiae oil 5.5g, xylitol 55g, lactose 5g is standby;
(b) get xylitol and lactose mixing, adding above-mentioned Radix Aucklandiae oil fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 15～25 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0～15 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Claims (4)
1. medicine of controlling gastroenteropathy is characterized in that this medicine consists of: Radix Aucklandiae oil, appropriate amount of auxiliary materials, and wherein adjuvant is xylitol and starch, xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Adjuvant is 1: 0.1～1: 1 with the ratio of the weight of Radix Aucklandiae oil; Get Radix Aucklandiae oil, adjuvant is standby; Add Radix Aucklandiae oil in adjuvant, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
2. the medicine of the described treatment gastroenteropathy of claim 1 is characterized in that the adjuvant and the ratio of the weight of Radix Aucklandiae oil are 1: 0.1～1: 0.6.
3. the medicine of the described treatment gastroenteropathy of claim 1 is characterized in that the adjuvant and the ratio of the weight of Radix Aucklandiae oil are 1: 0.2～1: 0.4.
4. the medicine of the arbitrary described treatment gastroenteropathy of claim 1-3 comprises the steps:
(a) get Radix Aucklandiae oil, adjuvant is standby;
(b) get Radix Aucklandiae oil, adjuvant is standby; Add Radix Aucklandiae oil in adjuvant, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100136021A CN1872125B (en) | 2005-06-01 | 2005-06-01 | Medicine for treating disease of gstrointestinal tract, and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2005100136021A CN1872125B (en) | 2005-06-01 | 2005-06-01 | Medicine for treating disease of gstrointestinal tract, and preparation method |
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| Publication Number | Publication Date |
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| CN1872125A CN1872125A (en) | 2006-12-06 |
| CN1872125B true CN1872125B (en) | 2010-08-25 |
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| CN2005100136021A Expired - Fee Related CN1872125B (en) | 2005-06-01 | 2005-06-01 | Medicine for treating disease of gstrointestinal tract, and preparation method |
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2005
- 2005-06-01 CN CN2005100136021A patent/CN1872125B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 曾志等.中药复方中后下组份化学成分的研究（Ⅰ）木香挥发油.中草药32 8.2001,32(8),683-685. * |
| 王巍.第二军医大学硕士学位论文新基质复方丹参滴丸的研究.2004,全文. * |
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