CN1861057A - Soft capsule contg. lecithin complex iodine and its prepn. method - Google Patents
Soft capsule contg. lecithin complex iodine and its prepn. method Download PDFInfo
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- CN1861057A CN1861057A CNA2006100122748A CN200610012274A CN1861057A CN 1861057 A CN1861057 A CN 1861057A CN A2006100122748 A CNA2006100122748 A CN A2006100122748A CN 200610012274 A CN200610012274 A CN 200610012274A CN 1861057 A CN1861057 A CN 1861057A
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- soft capsule
- iodine
- lecithin
- chelated iodine
- lecithin chelated
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Abstract
A soft capsule of the lecithin-iodine complex is prepared from lecithin-iodine complex and one or more of diluents, solubilizer, suspending aid, surfactant and iodine release inhibitor through mixing, preparing soft capsules, solidifying in cold air, drying, washing with proper solvent, and drying.
Description
Invention field
The present invention relates to a kind of active component is medicinal composition soft capsule preparation of lecithin chelated iodine and preparation method thereof.
Background technology
Lecithin chelated iodine is brown yellow granule or powder, and special odor is arranged, and is soluble in chloroform, carbon tetrachloride and the benzene; be insoluble to ether and ethanol, in water, form colloid solution, amount of iodine 6.5-7.0%; stable in non-polar solven, but in polar solvent, decompose gradually and discharge iodine.Clinical treatment vasospasm retinitis, hemorrhagic retinitis, vitreous hemorrhage, vitreous opacity, central vein closure retinitis and infantile asthma, bronchitis, goiter due to iodine deficiency, the iodine deficiency hypothyroidism of being mainly used in.Behind the po 600 μ g, major part becomes inorganic iodine and is absorbed in blood, is discharged by urine in the 1h peaking after the administration, 24h, and output is below 10% in the excrement.
Domestic main peroral dosage form has tablet at present, and tablet blood drug level in vivo can not show a kind of feature of steady state release stably; And lecithin chelated iodine has special odor, and inconvenient patient takes; Decompose gradually in polar solvent and discharge iodine, it is stable to be hard to keep during preparation is preserved.
Summary of the invention
The present invention is intended to improve the stability of lecithin chelated iodine, guarantees that medicine discharges in vivo and smooth absorption, thereby can reach metastable bioavailability, improves curative effect of medication; The soft capsule good airproof performance can be covered the special odor of lecithin chelated iodine, and adopts nonpolar content substrate or add iodine release inhibitor, makes lecithin chelated iodine keep stable in formulation preparation and storage, and iodine is not released; Reduce simultaneously dust from flying aborning with the healthy and environment of protection staff, we have proposed the lecithin chelated iodine soft capsule.
Another object of the present invention provides the preparation method of lecithin chelated iodine.
Lecithin chelated iodine soft capsule of the present invention can prepare by the various appropriate method of soft capsule preparation, its preferred for preparation method is as follows: lecithin chelated iodine and diluent, cosolvent, suspending agent, surfactant, iodine are discharged a plurality of mixed content in the inhibitor, promptly get glue with the abundant mixing of gelatin, water, glycerol and/or sorbitol, it is standby to regulate the adhesive tape that is compressed to 0.5～2.0mm thickness by press; Adopt the recognized techniques method to prepare soft capsule liquid mixture, solidifying by cooling in wind, drying are washed ball, are done eventually, promptly with appropriate solvent.
Described lecithin chelated iodine soft capsule is characterized in that content comprises active component lecithin chelated iodine and the suitable carrier of making soft capsule.
Described lecithin chelated iodine soft capsule is characterized in that described carrier comprises diluent, cosolvent, suspending agent, surfactant, iodine and discharges in the inhibitor one and/or a plurality of.
Described lecithin chelated iodine soft capsule is characterized in that described diluent comprises the vegetable and animals oils of the Polyethylene Glycol series of Macrogol 200-600 liquid state, fish oil, soybean oil, refining Oleum Arachidis hypogaeae semen, Semen Maydis oil, Radix Oenotherae erythrosepalae oil, Herba Silybi mariani oil, Oleum Vitis viniferae, Oleum Helianthi, safflower oil, Oleum Hippophae, the suitable preparation of Fructus Canarii albi wet goods soft capsule content.
Described lecithin chelated iodine soft capsule is characterized in that described cosolvent comprises the lower alcohol of C3-C8 or its mixture, polyoxyethylene castor oil, polyoxyethylene hydrogenated Oleum Ricini, zein, hydrogenated palm oil, triglycerides, glycerol diacid fat, glycerol list acid fat, soybean lecithin, lecithin, polyglycerol ester, sucrose fat.
Described lecithin chelated iodine soft capsule is characterized in that described suspending agent comprises PEG4000 or solid-state Polyethylene Glycol, aerosil, liquid paraffin, lanoline, Cera Flava, glyceryl monostearate, the high fatty alcohol of PEG6000.
Described lecithin chelated iodine soft capsule is characterized in that described surfactant package tween 80, polysorbate60, polysorbas20, sodium lauryl sulphate, pluronic-68, neutral liquid fat.
The described lecithin chelated iodine soft capsule of claim 1 is characterized in that described iodine discharges inhibitor and comprises ascorbic acid, sodium ascorbate, calcium ascorbate, different-sodium ascorbate, ascorbyl palmitate.
Described lecithin chelated iodine preparation of soft capsule method is characterized in that active component lecithin chelated iodine and diluent, cosolvent, suspending agent, surfactant, iodine are discharged in the inhibitor one and/or a plurality of, mixed content; Promptly get glue with the abundant mixing of gelatin, water, glycerol and/or sorbitol, it is standby to regulate the adhesive tape that is compressed to 0.5～2.0mm thickness by press; Adopt the recognized techniques method to prepare soft capsule liquid mixture, solidifying by cooling in wind, drying are washed ball, are done eventually, promptly with appropriate solvent.
The specific embodiment
Lecithin chelated iodine soft capsule of the present invention can prepare by the various appropriate method of soft capsule preparation, preferably makes by being prepared as follows method:
The preparation of content: get lecithin chelated iodine, diluent (the Polyethylene Glycol series that comprises Macrogol 200-600 liquid state, fish oil, soybean oil, refining Oleum Arachidis hypogaeae semen, Semen Maydis oil, Radix Oenotherae erythrosepalae oil, Herba Silybi mariani oil, Oleum Vitis viniferae, Oleum Helianthi, safflower oil, Oleum Hippophae, the vegetable and animals oils of the suitable preparation of Fructus Canarii albi wet goods soft capsule content), cosolvent (lower alcohol or its mixture that comprise C3-C8, polyoxyethylene castor oil, polyoxyethylene hydrogenated Oleum Ricini, zein, hydrogenated palm oil, triglycerides, glycerol diacid fat, glycerol list acid fat, soybean lecithin, lecithin, polyglycerol ester, sucrose fat), suspending agent (comprises the solid-state Polyethylene Glycol of PEG4000 or PEG6000, aerosil, liquid paraffin, lanoline, Cera Flava, glyceryl monostearate, high fatty alcohol), surfactant (comprises Tween 80, polysorbate60, polysorbas20, sodium lauryl sulphate, pluronic-68, neutral liquid fat), iodine discharges inhibitor and (comprises ascorbic acid, sodium ascorbate, calcium ascorbate, different-sodium ascorbate, ascorbyl palmitate) a plurality of mixed content that gets in, standby.
The softgel shell preparation: promptly get glue with gelatin, water, glycerol and/or the abundant mixing of sorbitol proper proportion, it is standby to regulate the adhesive tape that is compressed to 0.5～2.0mm thickness by press.
Soft capsule molding preparation: adopt the recognized techniques method to prepare soft capsule liquid mixture, solidifying by cooling in wind, drying are washed ball, are done eventually, promptly with appropriate solvent.
The following examples are to further specify of the present invention, but the present invention does not mean and only is confined to following embodiment.
Specific embodiment is as follows:
Embodiment 1,
Lecithin chelated iodine 1.5g
Cera Flava 10g
Soybean oil 200g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol=1: 0.8: 0.5
Embodiment 2,
Lecithin chelated iodine 3.0g
Olive oil 350g
Aerosil 10g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol=1: 0.9: 0.4
Embodiment 3,
Lecithin chelated iodine 0.75g
Soybean oil 150g
Polyoxyethylene hydrogenated Oleum Ricini 30g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol=1: 0.8: 0.5
Embodiment 4,
Lecithin chelated iodine 1.5g
PEG400 160g
PEG6000 10g
Ascorbic acid 3g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol: sorbitol=1: 0.7: 0.5: 0.1
Embodiment 5,
Lecithin chelated iodine 4.5g
Semen Maydis oil 400g
Lecithin 10g
Polyoxyethylene castor oil 50g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol=1: 0.7: 0.6
Embodiment 6,
Lecithin chelated iodine 3.0g
PEG400 320g
Aerosil 10g
Ascorbyl palmitate 4.5g
Tween 80 6g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol: sorbitol=1: 0.7: 0.5: 0.1
Embodiment 7,
Lecithin chelated iodine 4.5g
Cera Flava 15g
Lecithin 8g
Refining Oleum Arachidis hypogaeae semen 400g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol=1: 0.7: 0.6
Embodiment 8,
Lecithin chelated iodine 3.0g
PEG600 280g
PEG6000 10g
Sodium ascorbate 4.5g
Glycerol 10g
Make 1000
Glue prescription: gelatin (dry weight): purified water: glycerol=1: 0.9: 0.4
Claims (8)
1, a kind of lecithin chelated iodine soft capsule is characterized in that content comprises active component lecithin chelated iodine and the suitable carrier of making soft capsule.
2, the described lecithin chelated iodine soft capsule of claim 1 is characterized in that described carrier comprises diluent, cosolvent, suspending agent, surfactant, iodine and discharges in the inhibitor one and/or a plurality of.
3, the described lecithin chelated iodine soft capsule of claim 1 is characterized in that described diluent comprises liquid Polyethylene Glycol series, vegetable and animals oils.
4, the described lecithin chelated iodine soft capsule of claim 1 is characterized in that described cosolvent comprises the lower alcohol of C3-C8 or its mixture, polyoxyethylene castor oil, polyoxyethylene hydrogenated Oleum Ricini, zein, hydrogenated palm oil, triglycerides, glycerol diacid fat, glycerol list acid fat, soybean lecithin, lecithin, polyglycerol ester, sucrose fat.
5, the described lecithin chelated iodine soft capsule of claim 1 is characterized in that described suspending agent comprises PEG4000 or solid-state Polyethylene Glycol, aerosil, liquid paraffin, lanoline, Cera Flava, glyceryl monostearate, the high fatty alcohol of PEG6000.
6, the described lecithin chelated iodine soft capsule of claim 1 is characterized in that described iodine discharges inhibitor and comprises ascorbic acid, sodium ascorbate, calcium ascorbate, different-sodium ascorbate, ascorbyl palmitate.
7, the described lecithin chelated iodine soft capsule of claim 1 is characterized in that described surfactant package tween 80, polysorbate60, polysorbas20, sodium lauryl sulphate, pluronic-68, neutral liquid fat.
8, the described lecithin chelated iodine preparation of soft capsule of claim 1 method, it is characterized in that active component lecithin chelated iodine and diluent, cosolvent, suspending agent, surfactant, iodine are discharged in the inhibitor one and/or a plurality of mixed content; Promptly get glue with the abundant mixing of gelatin, water, glycerol and/or sorbitol, it is standby to regulate the adhesive tape that is compressed to 0.5～2.0mm thickness by press; Adopt the recognized techniques method to prepare soft capsule liquid mixture, solidifying by cooling in wind, drying are washed ball, are done eventually, promptly with appropriate solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100122748A CN1861057A (en) | 2006-06-15 | 2006-06-15 | Soft capsule contg. lecithin complex iodine and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100122748A CN1861057A (en) | 2006-06-15 | 2006-06-15 | Soft capsule contg. lecithin complex iodine and its prepn. method |
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| CN1861057A true CN1861057A (en) | 2006-11-15 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204894A (en) * | 2011-05-16 | 2011-10-05 | 西安力邦制药有限公司 | Iodized lecithin enteric capsule preparation and preparation method thereof |
| CN105920060A (en) * | 2016-06-26 | 2016-09-07 | 钟志敏 | Medicine composition containing iodized lecithin and preparation method thereof |
| CN108113003A (en) * | 2017-12-15 | 2018-06-05 | 浙江康诺邦健康产品有限公司 | A kind of probiotics soft capsule of suitable infant and preparation method thereof |
-
2006
- 2006-06-15 CN CNA2006100122748A patent/CN1861057A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204894A (en) * | 2011-05-16 | 2011-10-05 | 西安力邦制药有限公司 | Iodized lecithin enteric capsule preparation and preparation method thereof |
| CN102204894B (en) * | 2011-05-16 | 2013-04-10 | 西安力邦制药有限公司 | Iodized lecithin enteric capsule preparation and preparation method thereof |
| CN105920060A (en) * | 2016-06-26 | 2016-09-07 | 钟志敏 | Medicine composition containing iodized lecithin and preparation method thereof |
| CN108113003A (en) * | 2017-12-15 | 2018-06-05 | 浙江康诺邦健康产品有限公司 | A kind of probiotics soft capsule of suitable infant and preparation method thereof |
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Open date: 20061115 |