CN1846720A - Making process of high activity red ginseng prepn - Google Patents
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Abstract
The present invention discloses high activity red ginseng treating process. By means of controlling the steaming temperature and time of ginseng and making full use of saponin enzyme and other active matters in ginseng, the treating process converts the diol type saponins Ra, Rb1, Rb2, Rb3, Rc and Rd in high contents in ginseng into Rg3, Rg5, Rh2, Rh3 and other rare saponins, converts triol type saponins Re, Rg1, Rf, etc into Rg2, Rg4, Rh1, Rh4 and other active components, and raises the contents of rare saponins greatly. The present invention is suitable for processing Korean ginseng, American ginseng, notoginseng, etc.
Description
Technical field:
The present invention relates to a kind of manufacture method of Radix Ginseng Rubra, especially a kind of saponin enzyme and other material effects that utilize Radix Ginseng self, make glycols saponin Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd in the Radix Ginseng be converted into the rare saponin of Radix Ginseng such as Rg3, Rg5, Rh2, Rh3 more, make triol saponins Re, Rg1, Rf etc. be converted into the manufacture method of the high activity red ginseng of Rg2, Rg4, Rh1, Rh4 isoreactivity composition more.
Background technology:
Radix Ginseng (Panax ginseng C.A.Meryer) is the Chinese medicine that has won fame both at home and abroad, and Chinese take the history in existing 4000 of Radix Ginseng, a genus in the panax species Araliaceae (Araliceae), and mass-market in the market Radix Ginseng has:
Panax gingeng.C.A.Meyer (P.schinseng Nees), koryo insam is referred to as common Radix Ginseng in China, another name: Radix Ginseng Sativus (cultivation product), SHANSHEN (wild product), wooden club (popular name, northeast).
P.quinguefolus L. U.S. ginseng, Radix Panacis Quinquefolii, Radix Panacis Quinquefolii.
P.pseudonginseng Radix Notoginseng, Radix Notoginseng ginseng (Yunnan, Guizhou, Sichuan cultivation).
P.japanicus C.A.Meyer, Rhizoma Panacis Japonici, Japanese Rhizoma Panacis Japonici.
The Radix Ginseng main active is ginsenoside's (Saponin).Ginsenoside's compounds can be divided into three types: a class is the oleanane type pentacyclic triterpene saponin, and its sapogenin is oleanolic acid (Oleanonic acid), and two classes are tetracyclic triterpene saponins of dammarane type in addition: protopanoxadiol and Protopanaxatriol's class.Protopanoxadiol (Protopanaxadiol) saponins comprises Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rg5, Rh2, Rh3, F2, C-K etc.; Protopanaxatriol's saponins (Protopanaxatriol) comprises ginsenoside Re, Rf, Rg1, Rg2, Rg4, Rh1, Rh4 etc.
Though ginsenoside's (Saponin) kind is kind surplus in the of 40 nearly, have rare saponin such as Rg3, Rg5, Rh2, Rh3 and Rg2, Rg4, Rh1 only, saponin that the Rh4 isoreactivity is high is just more valuable.Have anticancer, cancer cell-apoptosis, metastasis, raising immunity, anti-radical action as Rh2 (comprising Rh3); That Rh1 (comprising Rh4) has is anticancer, protect the liver, anti-radical action; Rg3 (comprising Rg5) have antithrombotic, anticancer, improve memory, anti-radical action; Rg2 (comprising Rg4) has the protection heart, improves memory, antithrombotic, anti-radical action.
Because that content is higher in the Radix Ginseng mainly is glycols saponin Rb1, Rb2, Rb3, Rc, Rd and triol saponins Re, Rg1, Rf etc., Radix Ginseng is difficult for preserving in addition, so people are processed into Radix Ginseng Radix Ginseng Rubra now mostly and are preserved and eat.The processing method of tradition Radix Ginseng Rubra is that Radix Ginseng is steamed 1～2 hour after drying down at 95～100 ℃, though the method can make the diol segment saponins in the Radix Ginseng change into active higher Rg3, Rg5, rare saponin such as Rh2, Rh3; Part triol saponins changes into saponin such as active higher Rg2, Rg4, Rh1, Rh4 and becomes Radix Ginseng Rubra, but its rare saponin content is extremely low, as Rh2 content have only 100,000/, Rg3 content has only 3/100000ths.Up to now, also do not have a kind of content that can improve rare saponin, improve its physiologically active, improve the manufacture method of the high activity red ginseng of its use value.
Summary of the invention:
The present invention is in order to solve the few technical problem of rare saponin content in the existing in prior technology Radix Ginseng Rubra, a kind of effect that utilizes Radix Ginseng self saponin enzyme and other materials is provided, make glycols saponin Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd in the Radix Ginseng be converted into the rare saponin of Radix Ginseng such as Rg3, Rg5, Rh2, Rh3 more, make triol saponins Re, Rg1, Rf etc. be converted into the manufacture method of the high activity red ginseng of Rg2, Rg4, Rh1, Rh4 isoreactivity composition more.
Technical solution of the present invention is: a kind of manufacture method of high activity red ginseng, utilize the effect of other Radix Ginsengs self materials such as Radix Ginseng self saponin enzyme in the high activity Radix Ginseng course of processing, and improve the rare saponin content in its product.Get fresh Radix Ginseng, handled 1-10 minute with 95～100 ℃ the washing back, the stranger is joined reach both disorganizes, but Radix Ginseng self saponin enzymatic activity preserves 70～80%; 60～90 ℃ of reactions 0.5～1 hour; After being warming up to the processing of 100-130 ℃ of processing conversion in 0.5～3 hour enzyme denaturing again, drying obtains goods.
Available whole water is participated in the worker, also can utilize whole water to join the processing of cutting into slices.
In the specific Radix Ginseng Rubra course of processing, make glycols saponin Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd be converted into the rare saponin of Radix Ginseng such as Rg3, Rg5, Rh2, Rh3 more, make triol saponins Re, Rg1, Rf etc. be converted into Rg2, Rg4, Rh1, Rh4 more, these active component contents are brought up to several times to tens times of traditional Radix Ginseng Rubra, improve its activity greatly, the extraordinary Radix Ginseng Rubra of preparation high activity also makes groups of people's composition triol saponins of getting angry be converted into highly active rare saponin.
Powder, its extractum can be cut into slices, be dried to the high activity red ginseng that described method obtains, and is used to do other goods.
Described Radix Ginseng comprises panax species root processing such as Radix Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng ginseng, Rhizoma Panacis Japonici.
The present invention is processed in the process of Radix Ginseng Rubra at Radix Ginseng, by the boiling temperature and the time of control Radix Ginseng, give full play to Radix Ginseng self the saponin enzyme that the Radix Ginseng root contains and the effect of other materials, do not add any foreign substance, make glycols saponin Ra, Rb1, Rb2, Rb3, Rc, Rd be converted into the rare saponin of Radix Ginseng such as Rg3, Rg5, Rh2, Rh3 more, make triol saponins Re, Rg1, Rf etc. be converted into Rg2, Rg4, Rh1, Rh4 isoreactivity composition more, can prepare the high activity specific Radix Ginseng Rubra of rare saponin content than high several times to tens times of traditional Radix Ginseng Rubra.Can be suitable for the processing of panax species such as Korean Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng ginseng, Rhizoma Panacis Japonici.
Description of drawings:
Fig. 1 is the embodiment of the invention, traditional Radix Ginseng Rubra and raw material Radix Ginseng saponin content thin layer chromatography (TLC) figure.
Fig. 2 is the high performance liquid chromatogram-mass spectrum of the embodiment of the invention and traditional Radix Ginseng Rubra.
The specific embodiment:
Embodiment 1:
Get fresh cultivation koryo insam root, washing, empty water steamed 1-10 minute with 95～100 ℃; The stranger is joined reach both disorganizes, publish paper (Chem.Pharm.Bull., 49,795-798,2001 according to the inventor; Process Biochem., 37,793-798,2002) method extraction and determination, Radix Ginseng self saponin enzymatic activity preserve 70～80%, the stranger was joined become the enzyme state that works; 60～90 ℃ of reactions 0.5～1 hour; Handle 0.5～3 hour conversion enzyme denaturing at 100-130 ℃, be drying to obtain the given activity Radix Ginseng Rubra.
Its goods are according to state-promulgated pharmacopoeia (Pharmacopoeia of People's Republic of China version in 2005, Chemical Industry Press, p7, p105) Radix Ginseng of regulation and the assay method of red ginseng saponin measure the embodiment of the invention, raw materials used---the saponin analysis result of the Radix Ginseng Rubra of Radix Ginseng, traditional handicraft made such as Fig. 1, table 1, shown in Figure 2.
Among Fig. 11, Rb1; 2, Rc; 3, Rd; 4, Re; 5, Rg1; 6, Rg2; 7, Rg3; 8, Rh1; 9, Rh2; 10, the raw material Radix Ginseng; 11, the traditional handicraft Radix Ginseng Rubra; 12, the embodiment of the invention.From Fig. 1 thin-layer chromatogram (TLC), can see almost not having the saponin speckle above the raw material Radix Ginseng Rg1 point, illustrate that rare saponin content is very low; The tradition Radix Ginseng Rubra has some rare saponin speckles; The embodiment of the invention has rare saponin series speckle clearly; Rare saponin content is apparently higher than traditional Radix Ginseng Rubra.
Measure this product given activity Radix Ginseng Rubra, raw material Radix Ginseng and traditional Radix Ginseng Rubra saponin content, its result such as table 1, shown in Figure 2 with high performance liquid chromatography (HPLC).
Table 1, given activity Radix Ginseng Rubra, raw material Radix Ginseng and traditional Radix Ginseng Rubra saponin content are relatively
| Embodiment | The raw material Radix Ginseng | The traditional handicraft Radix Ginseng Rubra | ||
| Saponin content (%) | Rb1 | 0.28 | 0.37 | 0.37 |
| Rb2 | 0.05 | 0.10 | 0.09 | |
| Rc | 0.14 | 0.19 | 0.18 | |
| Rd | 0.03 | 0.10 | 0.08 | |
| Re | 0.11 | 0.14 | 0.14 | |
| Rg1 | 0.14 | 0.25 | 0.24 | |
| Rf | 0.04 | 0.04 | 0.04 | |
| Rg2 * | 0.06 | - | 0.003 | |
| Rg4 | 0.04 | - | + | |
| Rg3 * | 0.09 | - | 0.002 | |
| Rg5 | 0.03 | - | 0.002 | |
| Rh1 * | 0.08 | - | 0.007 | |
| Rh4 | 0.06 | - | 0.004 | |
| Rh2 * | 0.006 | - | 0.0005 | |
| C-K | 0.003 | - | + |
Annotate: in the table-, do not detect; +, trace contains; *, 20 (S)-types and 20 (R)-saponin total amounts
Can see that from table 1 the rare saponin Rg3 of the embodiment of the invention, Rg5, Rh2, Rh3, Rg2, Rg4, Rh1, Rh4 equal size improve several times to tens times than traditional Radix Ginseng Rubra.
Measure the embodiment of the invention and traditional red ginseng saponin as shown in Figure 2 with high performance liquid chromatography-mass spectrum logotype instrument (HPLC-MS).
The experimental apparatus of Fig. 2 and reagent: Waters2690 separative element, Waters996 diode array detector, Waters Millennium 32 chromatographic work stations, three grades of level Four bars of Finnigan TSQ mass spectrograph, WatersODS2 chromatographic column (2.0 * 150mm).Tedia company trifluoroacetic acid aqueous solution, isopropyl alcohol, Millipore company ultra-pure water.Experiment condition: 35 ℃ of liquid-phase chromatographic analysis column temperatures, flow velocity 0.2ml/min.The liquid-phase condition of Radix Ginseng extract is: with acetonitrile/water such as degree such as grade (20: 80v/v) flushing 30min, in 5min, jump to acetonitrile concentration 28% then, with acetonitrile/water such as degree such as grade (28: 72v/v) flushing 25min, in 20min, make acetonitrile concentration reach 31% then, in 46min, make acetonitrile concentration reach 100% again, acetonitrile flushing 20min with 100%.Mass spectrum APCI interface ion source, chuck gas 30.0psi assists gas 5.0AU, spray point voltage 4.0mA, 250 ℃ of capillary tube heating-up temperatures.500 ℃ of vapourizing temperatures.
Rare saponin peak area ratio tradition such as the Rg3 of given activity Radix Ginseng Rubra, Rg5, Rh2, Rh3, Rg2, Rg4, Rh1, Rh4 Radix Ginseng Rubra is high tens times as can see from Figure 2.
Learn thus; Of the present invention---utilize saponin enzyme and other materials of Radix Ginseng self, do not add any foreign substance, the content of the rare saponin Rg3 of prepared specific Radix Ginseng Rubra, Rg5, Rh2, Rh3, Rg2, Rg4, Rh1, Rh4 etc. improves very big.
Embodiment 2:
Get fresh Radix Panacis Quinquefolii root, handle obtaining the high high activity Radix Panacis Quinquefolii of rare saponin content according to the method for embodiment 1.Through high-performance liquid chromatogram determination, the content of rare saponin Rg3 that content is very low in the raw material Radix Panacis Quinquefolii and Rg5 is up to 0.05% as a result; The content of Rg2 and Rg4 is more than 0.01%; The content of Rh1 and Rh4, Rh2 and Rh3 is more than 0.003%.
Embodiment 3:
Get fresh Radix Notoginseng root washing, be cut into 1.5 millimeters sheet, handle obtaining the high high activity Radix Notoginseng of rare saponin content according to the method for embodiment 1.Through high-performance liquid chromatogram determination, the content of Rg3 that does not almost have in the raw material Radix Notoginseng and Rg5 is more than 0.02% as a result; The content of Rg2 and Rg4 is more than 0.01%; The content of the content of Rh1 and Rh4 more than 0.01%, Rh2 and Rh3 is more than 0.002%.
Get fresh Rhizoma Panacis Japonici root washing, be cut into 1.5 millimeters sheet, handle obtaining the high specific Rhizoma Panacis Japonici of rare saponin content according to the method for embodiment 1.Through high-performance liquid chromatogram determination, the content of Rg3 that does not almost have in the raw material Rhizoma Panacis Japonici and Rg5 is up to 0.01% as a result; The content of Rg2 and Rg4 is more than 0.008%; The content of Rh1 and Rh4 content more than 0.01%, Rh2 and Rh3 is more than 0.001%.
Claims (6)
1. the manufacture method of a high activity red ginseng is characterized in that: utilize the effect of other Radix Ginsengs self materials such as Radix Ginseng self saponin enzyme in the high activity Radix Ginseng course of processing, improve the rare saponin content in its product.
2. the manufacture method of high activity red ginseng according to claim 1 is characterized in that: get fresh Radix Ginseng, handled 1-10 minute with 95～100 ℃ after the washing, the stranger is joined reach both disorganizes, but Radix Ginseng self saponin enzymatic activity preserves 70～80%; 60～90 ℃ of reactions 0.5～1 hour; After being warming up to the processing of 100-130 ℃ of processing conversion in 0.5～3 hour enzyme denaturing again, drying obtains goods.
3. the manufacture method of high activity red ginseng according to claim 1 and 2 is characterized in that: available whole water is participated in the worker, also can utilize the processing of cutting into slices of whole water ginseng.
4. the manufacture method of high activity red ginseng according to claim 1 and 2, it is characterized in that: in the specific Radix Ginseng Rubra course of processing, make glycols saponin Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd is converted into Rg3 more, Rg5, Rh2, the rare saponin of Radix Ginsengs such as Rh3, make triol saponins Re, Rg1, Rf etc. is converted into Rg2 more, Rg4, Rh1, Rh4, these active component contents are brought up to several times to tens times of traditional Radix Ginseng Rubra, improve its activity greatly, the extraordinary Radix Ginseng Rubra of preparation high activity also makes groups of people's composition triol saponins of getting angry be converted into highly active rare saponin.
5. the manufacture method of high activity red ginseng according to claim 1 and 2 is characterized in that: the high activity red ginseng that described method obtains, can cut into slices, be dried to powder, its extractum, and be used to do other goods.
6. the manufacture method of high activity red ginseng according to claim 1 and 2 is characterized in that: described Radix Ginseng comprises panax species roots processing such as Radix Ginseng, Radix Panacis Quinquefolii, Radix Notoginseng ginseng, Rhizoma Panacis Japonici.
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