CN1842340A - Oral skin care composition - Google Patents
Oral skin care composition Download PDFInfo
- Publication number
- CN1842340A CN1842340A CNA200480024427XA CN200480024427A CN1842340A CN 1842340 A CN1842340 A CN 1842340A CN A200480024427X A CNA200480024427X A CN A200480024427XA CN 200480024427 A CN200480024427 A CN 200480024427A CN 1842340 A CN1842340 A CN 1842340A
- Authority
- CN
- China
- Prior art keywords
- bacterium
- kefir
- lactobacillus
- orally administered
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Skin care means which even when orally administered regularly, does not cause side effects and is capable of exerting systemic effects, whose effects would not be deteriorated by perspiration or friction. In particular, there is provided an oral skin care composition comprising a kefir fungus fermented milk. There are further provided a food or medical product comprising this composition.
Description
Technical field
The present invention relates to a kind of oral skin care composition, and the purposes as food and medicine of said composition.
Background technology
Nowadays,, following in the society for whitening or the care of skin Caring improves, various with whiten/skin Caring etc. is that the skin protection of purpose is developed with goods.These skin protections are directly used in skin mostly with goods.
But, when outside when being used for skin, the effect of skin protection can only embody to some extent in the local part that has been coated with, is not suitable for for the people that needs carry out the whole body skin protection.And then when the face etc. of special concern in beauty treatment was partly implemented skin protection, perspire or physical friction etc. can cause the reduction or the disappearance of skin effect, so need just repeat coating every one period short time, this is very inconvenient.So,, also be developed by the oral goods that carry out skin protection as beauty food, health food or functional food.
Kefir grain (being also referred to as kefir grain) is a kind of kind bacterium (introduction (starter)) that is called as the traditional zymotic breasts such as Caucasus region of kefir (Kefir).In recent years, the cosmetics that utilize this kefir have been developed.For example, in patent documentation 1, put down in writing a kind of cosmetics, it is characterized in that, cooperated from the isolating newborn lactobacillus of the kefir grain thalline extract of (ラ Network ト バ チ Le ス belongs to lactobacillus) with skin-whitening effect and oxygen scavenging activity effect.In addition, in patent documentation 2, a kind of cosmetics have been put down in writing with skin-whitening effect and safety, it is characterized in that, inoculation belongs to yeast and cultivates from the isolating yeast of kefir (Kefir) grain (Saccharomyces), remove yeast from the culture fluid that obtains, modulate fermentation liquid thus, cooperate the fermentation liquid of so making to form.In patent documentation 3, put down in writing a kind of cosmetics of removing spot, freckle, melanotic nevus etc., it is characterized in that, cooperate the culture supernatant of kefir grain.
But these cosmetics directly apply to skin, and it is not clear whether can to reach good skin effect by oral kefir.
Patent documentation 1: the spy opens flat 5-163134 communique
Patent documentation 2: the spy opens flat 7-10734 communique
Patent documentation 3: international the 01/019324th trumpeter's volume that discloses
Summary of the invention
The objective of the invention is to, a kind of skin protection measure is provided,, can bring into play the whole body effect, and perspire or friction can not make effect reduce even this skin protection measure also has no side effect by oral frequent use.
The inventor etc. concentrate on studies, and found that can bring into play by oral kefir bacterium fermentation milk to whiten/the skin Caring effect, thereby have finished the present invention.
That is, the present invention relates to a kind of oral skin care composition that contains kefir bacterium fermentation milk and said composition purposes as food and medicine.
In addition, the invention still further relates to a kind of method of using above-mentioned Orally administered composition for skin protection.
And then, the invention still further relates to a kind of in order to make method oral skin care composition, that use the kefir fermentation milk.
By the present invention, can obtain oral skin care composition.The kefir bacterium fermentation milk that the present invention uses eats in itself owing to be the natural origin product, so can often use safely by oral.In addition, compositions of the present invention be owing to can orally use, thus can obtain the whole body effect, and perspire or friction can not make its effect reduce.
The specific embodiment
The kefir bacterium fermentation milk of Shi Yonging is meant kefir and kefir sample fermentation milk and their mixture in the present invention.The kefir bacterium fermentation milk of Shi Yonging is preferably kefir in the present invention.
The kefir of Shi Yonging is meant the fermentation milk that the kefir grain is obtained as kind of bacterium use in the present invention.
The kefir grain is meant lactobacillus and the symbiotic truffles of yeast, is natural immobilized microorganism homobium.Symbiosis is meant that heterogeneity biological keeps stable close relation aspect position/geographical and the phenomenon of living.
With regard to the kefir grain that uses in the present invention,, just be not particularly limited so long as be used as the kefir grain of the kind bacterium of kefir.For example, use is got final product by the kind bacterium of the kefir of extensive diet at Caucasus region.
The kefir grain of Shi Yonging is lactobacillus and zymic homobium in the present invention, and in this, situation about mixing simply with lactobacillus and yeast is different.
Kefir grain of the present invention except bacterium, for example can also contain viscous polysaccharide class (kefiran etc.) and its content and be the kefir grain total amount 50～55%.
In addition, the symbiotic bacterium of kefir intragranular by being subjected to each other to the effect of materials such as the excretory bacteriocin of the other side etc., with separately or the bacterium of the same race that mixes compare, vitality and effective ingredient secretion capacity are good.
Can be by following method, the bacterium that difference mixes the symbiotic bacterium of kefir intragranular of the present invention, with lactobacillus and yeast.
In being suitable for the test that is generally used for dish (disc) method that the antibiotic to the Ruzhong detects or cup envelope (cup) method etc., compare with yeast with the lactobacillus that mixes simply, demonstrate good antibacterial activity at relative coli-group of the symbiotic bacterium of kefir intragranular of the present invention etc.Above-mentioned dish rule is as being described in McGroarty, J.A. and Reid, and of alactobacillus substance that inhibits Escherichia coli.Can.J.Microbiol G.1988.Detection is among the 34:974-978.
The kefir grain of Shi Yonging for example can obtain from ラ イ セ Application ス イ Application ト Le グ company (Russia) etc. in the present invention.In the present invention, for example preferred the use according to special opened the method put down in writing among the clear 62-83842 and activatory kefir grain.
In addition, in the present invention, also can be used as the kefir grain with utilizing method commonly used to separate for example cultivation powder (culture powder) that obtains from kefir.Such cultivation powder etc. are on sale in ウ イ ズ バ イ company (Germany), リ ョ one サ Application company (Canada) and ロ one ゼ Le company (Canada) etc.
Kefir of the present invention, the kefir that can use Japanese Kefir company to sell.Perhaps, kefir also can be opened the method for putting down in writing in clear 62-83842 communique and the Te Kai 2000-166467 communique and makes according to method commonly used is for example special.For example, can make animal milk, soyabean milk or rice breast or their mixture with the kefir grain as kind of a bacterium, perhaps their skimmed milk, modified milk, blending milk or milk product etc. obtained at 25 ℃ of bottom fermentations in 24 hours.
In the manufacturing of above-mentioned kefir,, for example can use breast with cattle, Babalus bubalis L., horse, sheep or goat etc. as animal milk, as soyabean milk, for example can use tunning or the emulsion of Semen sojae atricolor etc.,, for example can use rice breast or unpolished rice breast etc. as the rice breast.
In addition, the present invention also can use and add for example caseic enzyme analyte of fermentation assistant and derive from the kefir that newborn mineral makes its fermentation form again in soyabean milk.Perhaps, the tunning that obtains by method as follows is also preferably as kefir of the present invention.
Operation 1) germ-resistant relatively soyabean milk coordination compound 100g, inoculation kefir grain 0.15～15g (is preferably 0.3～10g, more preferably 0.5～4.5g);
Operation 2) makes it 5～30 ℃ of (being preferably 15～25 ℃, more preferably 18 ℃～23 ℃) bottom fermentations 8～27 hours, and/or reach 0.55～1.50 (be preferably 0.60～1.20, more preferably 0.65～0.90) until acidity.
Wherein, in this fermentation, also can use the kind bacterium of handling the kefir grain in the manner as described below and obtaining.
Operation is germ-resistant relatively Lac Bovis seu Bubali 100g a), and inoculation 0.15～15g (is preferably 0.3～10g, more preferably 0.5～4.5g) kefir grain;
Operation b) cultivates modulation kind of bacterium down 5～30 ℃ (being preferably 15～25 ℃, more preferably 18 ℃～23 ℃).
When claiming " acidity " in this manual, except special circumstances, be meant lactic acid acidity.This lactic acid acidity can by with 1% phenolphthalein solution as indicator, carry out acid-base titration with 1/10N NaOH, the acid that contains in the food be converted into lactic acid production and try to achieve by the 1/10NNaOH of needs.
If pass through the necessary time or reach necessary acidity, then be cooled to 5～2 ℃, stop the carrying out of fermenting.
Except soyabean milk or added the soyabean milk of water, the soyabean milk coordination compound that uses in above-mentioned operation 1 also comprises fermentation assistant.By this auxiliary agent, make composition the consisting of of soyabean milk coordination compound near Lac Bovis seu Bubali.As the auxiliary agent that uses in the present invention, can be used alone or in combination the fermentation assistant that commercially available fermentation assistant for example uses when making Yoghurt (yogurt), cheese etc., preferably contain the composition from Ca, P, Fe, Na, K, Mg, Cl, phosphate and lactose, selected 1 or more than 2 kind, more preferably contain P, Fe, K, Cl and lactose at least or all contain this 7 kinds of compositions.The addition of each composition can be according to the composition of soyabean milk coordination compound, the strain class that is used to ferment etc., and set in various scopes, and the preferred approximate content (g) among the soyabean milk coordination compound 100g is respectively: Ca is more than 0.005, more preferably below 0.5; P (as Phos) is more than 0.009, more preferably below 0.9; Fe is more than 0.001, more preferably below 1; Na is more than 0.006, more preferably below 0.6; More than the K0.001, more preferably below 1; Mg is more than 0.0007, more preferably below 0.07; Cl is more than 0.008, more preferably below 0.8; Lactose is more than 0.01, more preferably below 50.
Can be used for auxiliary agent of the present invention, also can contain milk surum (whey) (for example milk surum that when making cheese, produces) concentrate.The example of table 1 expression fermentation assistant.
Table 1.
The example of fermentation assistant
| Ca | P | Fe | Na | K | Lactose |
| 312mg | 267mg | 0.3mg | 144mg | 450mg | 13.5g |
The soyabean milk coordination compound can contain animal protein as required, preferred peptone; Proteolysis hangs down molecule mixture.As animal protein and peptone, can use commercially available material.
The kefir sample fermentation milk of the Shi Yonging product that lactobacillus and yeast can be mixed replaces the kefir grain as kind of a bacterium in the present invention, makes by the method identical with above-mentioned kefir grain.This lactobacillus and yeast can obtain from the segregation/cultivation of kefir grain, also can use the lactobacillus and the yeast that are not to derive from the kefir grain.
With regard to kefir bacterium fermentation milk of the present invention,, also can use above-mentioned kefir grain and non-lactobacillus, yeast or the acetic acid bacteria that derives from the kefir grain to carry out product of mixing as kind of a bacterium.
In the present invention, kefir bacterium fermentation milk is not particularly limited on form, can use aqueous fermentation milk, but also can use particularly powder of solid.Especially under the situation that is powder,, be under the situation of the composition of directly keeping fermentation milk, to be concentrated, so be favourable with the kefir that lyophilization method for making commonly used obtains.
As above-mentioned lactobacillus, for example can enumerate lactobacillus (Lactobacillus) or lactic acid coccus etc.
As lactobacillus, for example can enumerate lactobacillus kefiranofaciens (Lactobacilluskefiranofaciens), lactobacillus casei (Lactobacillus casei), Lactobacillus kefir (Lactobacillus kefiri) or Lactobacillus brevis (Lactobacillus brevis) etc.
In addition, as the lactic acid coccus, for example can enumerate lactococcus lactis (Lactococcus lactis), enterococcus faecalis (Enterococcus faecalis), Streptococcus lactis (Lister) Lohnis 1909.554. (Streptococcus lactis), Streptococcus cremoris (Streptococcus cremoris), biacetyl Streptococcus lactis (Lister) Lohnis 1909.554. (Streptococcusdiacetylactis), Leuconostoc mesenteroides (Leuconostoc mesenteroides), particularly Leuconostoc mesenteroides dextranicum (Leuconostoc mesenteroides subsp dextranicum), perhaps leuconostoc mesenteroides sub species cremoris (Leuconostoc cremoris) etc.
As above-mentioned yeast, for example can enumerate the non-saccharomyces fermentati of lactose fermentation yeast or lactose.
As the lactose fermentation yeast, for example can enumerate yeast Kluyveromyces marxianus (Kluyveromyces marxianus), particularly yeast Kluyveromyces marxianus Marx mutation (Kluyveromyces marxianus var.marxianus) or yeast Kluyveromyces marxianus lactic acid mutation (Kluyveromyces marxianus var.Lactis), candida kefyr (Candita kefyr), perhaps Brettanomyces anomalus etc.
In addition, as the non-saccharomyces fermentati of lactose, for example can enumerate saccharomyces unisporus (Saccharomyces uniporous), saccharomyces cerevisiae (Saccharomyces cerevisiae), candida holmii (Candita holmii) or Saccharomyces unisporaqs etc.
Kind bacterium when kefir grain in the present invention or manufacturing are used for kefir sample fermentation milk can contain above-mentioned bacterium with combination in any, preferably contains 6～10 kinds in 10～15 kinds of lactobacilluss and yeast, more preferably contains 10 kinds in 7 kinds of lactobacilluss and yeast.Kind bacterium when kefir grain of the present invention or manufacturing kefir sample fermentation milk can further contain 7 kinds in lactic acid coccus.
Wine kefir grain of the present invention or the kind bacterium when making kefir sample fermentation milk as lactobacillus, preferably contain 4 kinds of lactobacillus kefiranofaciens, Lactobacillus kefir, Lactobacillus brevis and Leuconostoc mesenteroides; As yeast, contain among candida kefyr, candida holmii or the Saccharomycesunisporaqs more than a kind, particularly 3 kinds.
Kind bacterium when kefir grain of the present invention or manufacturing kefir sample fermentation milk can according to circumstances further contain acetic acid bacteria.
Being used for the above-mentioned bacterium that kefir bacterium fermentation milk of the present invention contains, can be viable bacteria, also can be dead bacterium.In addition, kefir bacterium fermentation milk of the present invention also can contain viable bacteria and dead bacterium both sides.
Compositions of the present invention can contain the composition that can be used in skin protection, for example phospholipid such as vegetable oil, carotenoid, antioxidant, vitamin, aminoacid, mineral, collagen, chrondroitin, chondroitin sulfate, elastin laminin, hyaluronic acid, glycosamine, oligosaccharide, eicosapentaenoic acid, docosahexenoic acid, linoleic acid, linolenic acid, arbutin, kojic acid, Placenta Hominis (placenta), Rucinol, the flower acid of mixing, autonomic nerve amide and Squalene, and anti-inflammatory agent etc.Be preferably collagen, chrondroitin, hyaluronic acid, Placenta Hominis and phospholipid such as autonomic nerve amide and Squalene.
These compositions can be composite or natural origin product, in addition, when being natural origin, can be crude extract, also can be refining thing.
In addition, in the present invention, can use the composition shown in above-mentioned separately, also two or more kinds may be used.
The vegetable oil that uses among the present invention can wait from the seed of plant by squeezing to obtain.For example American Avocado Tree oil, Semen Lini oil, almond oil, perilla oil, olive oil, safflower oil, Semen Tritici aestivi germ oil, Oleum sesami, Testa oryzae oil, perilla oil, Oleum sesami, soybean oil, Semen Maydis oil, almond oil, Petiolus Trachycarpi oil, Oleum Helianthi, Jojoba oil, Oleum Gossypii semen, Oleum Vitis viniferae and Radix Oenotherae erythrosepalae wet goods.Be preferably safflower oil, Semen Tritici aestivi germ oil and Semen sojae atricolor wet goods.In the present invention, extracting method and the process for purification to vegetable oil is not particularly limited.In addition, vegetable oil of the present invention can be crude extract, also can be refining thing.And then in the present invention, above-mentioned vegetable oil can use separately, and also two or more kinds may be used.
As being used for carotenoid of the present invention, for example can enumerate carotenoid hydrocarbon and carotenol (phylloxanthin class) etc.
Above-mentioned carotenoid hydrocarbon for example is beta-carotene and lycopin (lycopene) etc., is preferably beta-carotene.In addition, above-mentioned carotenol for example is phylloxanthin, cryptoxanthin, cryptoxanthine, canthaxanthin, capsanthin, α-doradexanthin (α-De ラ デ キ サ Application チ Application), echinenone, crustaxanthin and tunaxanthin (Star Na キ サ Application チ Application) etc., be preferably phylloxanthin, cryptoxanthin, be preferably phylloxanthin especially.
In addition, these carotenoid are preferably the natural origin product.For example preferably contain the Flos Tagetis Erectae extract of phylloxanthin, be preferably the extract of the petal that comes from Flos Tagetis Erectae especially.
In the present invention, these carotenoid can use separately, also can for example can and use beta-carotene and phylloxanthin also with two or more.
As above-mentioned antioxidant, can enumerate vitamin C, vitamin E, anthocyanin and polyphenyl phenol etc.Be preferably vitamin C and vitamin E.
These polyphenoils are preferably the natural origin product.The soybean extract that for example preferably contains vitamin E, the special soybean oil that preferably contains vitamin E.
In the present invention, these polyphenoils can use separately, also can be also with two or more.
As said vitamin, for example can enumerate vitamin A oil, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotiamide, calcium pantothenate, vitamin C, vitamin D2, vitamin E and vitamin K etc., be preferably vitamin B2 etc.Compositions of the present invention can contain these vitamin separately, also can contain two or more.
As above-mentioned mineral, can enumerate copper, zinc, selenium, calcium, manganese, potassium and ferrum etc.Compositions of the present invention can contain these vitamin separately, also can contain two or more.
As above-mentioned aminoacid, can enumerate tryptophan, threonine and methionine etc.Compositions of the present invention can contain these vitamin separately, also can contain two or more.
With regard to compositions of the present invention, only otherwise damage effect of the present invention, also can contain excipient, sweet flavoring agent, sour flavoring agent, viscosifier, spice, pigment, emulsifying agent and other normally used raw material in food.
With regard to compositions of the present invention,, can be used for the finishing of skin as skin protection usefulness.For example can be used to whiten with and skin Caring use etc.
The use-case of whitening does not bleach as being meant for skin is beautified, and specifically, does not promptly have spot, freckle in order there to be mottle, and is gloomy, the colour of skin is fine and use.Thereby compositions of the present invention for example can be used to burn prevents/improves or the preventing/treating of spot/freckle etc.
The skin Caring use-case is as being meant in order to bring tension force, gloss, softness, smooth, transparent feel to skin, makes skin texture careful and neat and use.Thereby, with regard to compositions of the present invention, for example can be used to prevent/improve cause the wrinkle that produces or lax by the variation of aging, uv light exposure, incretion balance and active oxygen damage etc., improve skin elasticity, skin moisture-keeping, prevent/improve acne or goose pimples, also be used to prevent/improve skin roughening etc. in addition.
In the present invention, also can be presented at main body, packing, description or the propaganda thing etc. of Orally administered composition of the present invention, distinguish with kefir bacterium fermentation milk in the past by the content that will be used for above-mentioned skin protection purposes.Here, main body is meant the container that Orally administered composition of the present invention is directly packed into, packing is meant parcel paper of this container or chest etc., and description is meant the document of explanation Orally administered composition of the present invention, and the propaganda thing is meant the document that is used for sales promotion Orally administered composition of the present invention.
Compositions among the present invention can be used as food, particularly can be as being health food, functional food, healthy accesary foods, specific food for health care, beauty food and the dietary supplement (replenishing) of purpose with skin protection etc.These food for example can be drinking waters such as tea and juice; Forms such as ice cream, fruit jelly, maltose, chocolate and chewing gum.In addition, also can be forms such as liquor, powder, granule, capsule or tablet.
In addition, the compositions among the present invention can for example can be used for prevention or treatment spot/freckle as medicine.These medicines are for example with the form oral administration of tablet, coated tablet, coated tablet, hard or Gelseal, liquor, emulsion agent or suspending agent.
Intake to the compositions among the present invention is not particularly limited, and can suitably select according to dosage form and user or patient's age, body weight and symptom.Be kefir 0.3g～9g for example, be preferably 2～6g, more preferably the oral uptake of 4g～6g as adult's effective ingredient amount every day.In addition, can be during the picked-up according to user or patient's age, symptom arbitrary decision.
Show embodiments of the invention below, but the present invention is not limited by these embodiment.
Embodiment
Antibacterial activity at coli-group
Use contains the kefir grain (buying from Japanese Kefir company) of lactobacillus kefiranofaciens, Lactobacillus kefir, Lactobacillus brevis, yeast Kluyveromyces marxianus, candida kefyr, candida holmii and Saccharomyces unisporaqs.
According at McGroarty, J.A. and Reid, G 1988.Detection of a lactobacillussubstance that inhibits Escherichia coli.Can.J.Microbiol, the method of putting down in writing among the 34:974-978, the relatively antibacterial activity of the bacterium that survives in the kefir grain and the non-kefir relative coli-group of bacterium of originating.At first, use sterilization swab (swab) 1 platinum loop amount of 18 hours culture fluid of cropping pattern kind (Escherichia coli) equably on BYE plate culture medium.Then, the bacteria culture fluid 5 μ l of the object of check antibacterial activity are penetrated in the filter paper disk (diameter 6mm).This dish is placed on substantial middle portion on the above-mentioned BYE plate culture medium.Then, by under 4 ℃, hatching this BYE plate culture medium 3 hours, the bacteria culture fluid that penetrates in the dish is diffused in the culture medium.Then, after 37 ℃ are cultivated 18 hours down, the prevention band of monitor desk periphery.
The result as seen, symbiotic bacterium is compared with the bacterium of the same race in non-kefir grain source in the kefir grain, suppresses the fertility of coli-group more consumingly, demonstrates outstanding antibacterial activity.
The modulation of kefir MSL
The blending milk that interpolation defatted milk powder allotment in Lac Bovis seu Bubali is formed sterilizes, and cooling is inoculated into above-mentioned kefir grain wherein as kind of a bacterium then, makes its fermentation 24 hours under 25 ℃, obtains fermentation milk.With this fermentation milk lyophilization, obtain the powder body of kefir MSL.
The modulation of kefir MSD
Except after lyophilization, carrying out sterilization processing, the same with above-mentioned kefir MSL, obtain the powder body of kefir MSD.
With regard to above-mentioned kefir MSL and kefir MSD, total total solids composition is 96～98%, and protein is 22～25%, lipid is 9.0～11%, sugar is 54～55%, ash is 5.2～5.8%, energy is 390～417kcal.In addition, in the viable count that contains in kefir MSL, lactobacillus is 10
8Individual/more than the g, yeast is 10
5Individual/more than the g.
Soya-bean milk fermentation product modulation example 1
Soyabean milk (マ Le サ Application corporate system) 1013g is sterilized reaching under 80 ℃ the temperature.Inoculate kefir grain (buying) 50g therein, cultivate down at 20 ℃ from Japanese Kefir company.Form softish card after 19 hours in inoculation, acidity is 0.40.Inoculate after 24 hours, acidity is 0.50.
Soya-bean milk fermentation product modulation example 2
(1) modulation of the kind bacterium of use kefir grain
Reach in the warm germ-resistant Lac Bovis seu Bubali at 90 ℃, the kefir grain of inoculation Caucasus region (buying from Japanese Kefir company) 1.5% (weight ratio) cultivated 20 hours down at 20 ℃, obtained kind of a bacterium.
(2) modulation of soyabean milk fermented product
Soyabean milk (Japanese Beans corporate system) 900g is sterilized cooling (10 ℃) reaching under 70 ℃ the temperature.On the other hand, auxiliary agent 34g, peptone 2g with the composition of table 1 are dissolved in the product that water 64g forms sterilize, be added in the soyabean milk after the sterilization.Inoculate the kind bacterium 1.5% (weight ratio) that above-mentioned modulation obtains, cultivate down at 20 ℃.
Inoculate after 14 hours, form adamantine card.Inoculate 22 hours postcooling.Table 2 shows the variation of acidity.
Table 2
| After 14 hours | After 20 hours | After 22 hours | After 1 evening | |
| Soya-bean milk fermentation product modulation example 1 | 0.50 | |||
| Soya-bean milk fermentation product modulation example 2 | 0.70 | 0.85 | 0.87 | 0.92 |
Soya-bean milk fermentation product modulation example 3
(1) modulation of kind bacterium
Among each Lac Bovis seu Bubali 160g after 90 ℃ reach temperature sterilization, inoculate 2.5g kefir grain (buying) respectively, 20 ℃ of cultivations 20 hours down from Japanese Kefir company.Form card well.Inoculate 24 hours postcooling.
(2) modulation of soyabean milk fermented product
Under 75 ℃ to soyabean milk (the Japanese PVC one Application ズ corporate system after adding water with table 3,4 ratio; BX 13.1) sterilized 5 minutes.On the other hand, auxiliary agent (forming identical with table 1) and commercially available peptone are sterilized respectively, add in the aquation soyabean milk, inoculate each 1.5% (weight ratio) of kind bacterium that above-mentioned modulation forms down, cultivate down at 20 ℃ at 17 ℃.
Table 3 cooperates A: total amount 2kg deal
| Soyabean milk water | 1600g 200g(BX11.5) |
| Peptone auxiliary agent water | 4g 34g 162g(200g) |
Table 4 cooperates B: total amount 2kg deal
| Soyabean milk water | 1400g 400g(BX 10.2) |
| Peptone auxiliary agent water | 4g 34g 162g(200g) |
Inoculate after 19 hours, all form card separately, but all soft than the card that in soya-bean milk fermentation product modulation example 3, obtains.Inoculate 24 hours postcooling.Each acidity of table 5 expression.
Table 5
| After 20 hours | After 24 hours | After+1 evening | |
| Cooperate A | 0.65 | 0.80 | |
| Cooperate B | 0.65 | 0.73 | 0.78 |
Soya-bean milk fermentation product modulation example 4
With usual way the coordination compound of the soyabean milk (unmodulated, the BX 10.6 of マ Le サ Application corporate system) that contains table 6 is carried out sterilization processing.
Table 6 coordination compound (BX 11.0)
| The auxiliary agent peptone water of soyabean milk table 1 | 1000g 11g 2g 50g |
Inoculation and soya-bean milk fermentation product modulation example 3 be the same modulates the kind bacterium 1.5% that forms, 21 ℃ of cultivations down.
After inoculation 19 hours, form soft and good card.This moment, acidity was 0.75.
The tunning that obtains is heated, and in heating process, liquid level from all directions rises, and swells to about 1.5 times of liquid measure, solidifies.But, different with solidifying of lactoprotein, can disappear by cooling.Liquid level also recovers.Even it is be not in addition aquation soyabean milk and liquid additive to be sterilized, also out of question.
Soya-bean milk fermentation product modulation example 5 (manufacturing of soyabean milk fermented product 180kg)
(1) modulation of kind bacterium
1) to 90 ℃ of kefir grains that reach warm germ-resistant Lac Bovis seu Bubali inoculation Caucasus region (buying), 1.5% (weight ratio) from Japanese Kefir company.
2) cultivate 20 hours (acidity 0.78) down at 20 ℃.
(2) modulation of soyabean milk fermented product
1) in soyabean milk (Japanese PVC one Application ズ corporate system BX12.8) 150kg, adds water 20kg (BX11.1).Sterilized 5 minutes down at 80 ℃.
2) on the other hand, auxiliary agent 1.9kg (final concentration 1.1%), peptone 0.36kg (final concentration 0.2%) with table 1 are dissolved in the product that water 10kg forms and carry out 80 ℃ of sterilizations 5 minutes.
3) soyabean milk/water-mixture is cooled to after 25 ℃, is adding auxiliary agent/peptone/water-mixture, and then inoculate the above-mentioned kind bacterium 3kg that is modulated into, beginning to cultivate (24 ℃).
4) inoculation forms good card after 18 hours (23.5 ℃).This is slightly harder than the card that forms in soya-bean milk fermentation product modulation example 4.Stir (22 ℃).
After inoculating 19 hours, acidity is 0.60, inoculate 20 hours after, acidity is 0.72.The tunning that obtains is carried out 85 ℃ of sterilizations 5 minutes.
By usual way lyophilization tunning, obtain flaxen powder.The taste of complete imperceptible soyabean milk uniqueness in powder.
The modulation of test food 1
According to composition modulation test food 1 and 2 as shown in table 7.
Table 7
| Composition | Content (weight %) | |
| Test food 1 | Test food 2 | |
| Kefir MSL | 95.7 | - |
| Kefir MSD | - | 95.7 |
| Excipient (constituting) by fructo-oligose and loose fiber (pine fibre) | 4.3 | 4.3 |
Effect test to people's skin
1. testee
The testee is 31～40 years old 10 of healthy womens, as subjective symptoms, and xerosis cutis and skin roughening or the acne skin is arranged.At duration of test, the testee do not use overtesting food 1 and 2 beyond to the resultful medicine of skin, medicine for external use, health food.
2. test method
(1) acquisition method of test food
Make the testee absorb in test food 1 or the test food 2 any one simultaneously, 1 2g of test food, 1 day 3 times, picked-up 28 days with water.
(2) the Pigmented detection of ultraviolet induction
At first, to the inboard ultraviolet that shines minimal erythema dose of testee's a upper arm parts, it measures melanin value, erythema (erythema) value and L-value with Megusa (メ グ ザ) meter and colour difference meter after 14 days and after 28 days.Then, begin to absorb test food, and continue picked-up 28 days.In test food when beginning picked-up, to the ultraviolet of the minimal erythema dose identical with last time with the different inboard irradiation of upper arm parts of irradiation ultraviolet radiation last time, after they 14 days and after 28 days with Megusameter and colour difference meter mensuration melanin value, erythema value and L-value.
In addition, even the ultraviolet irradiation amount is identical, because the appearance form of erythema varies with each individual, so at irradiation ultraviolet radiation the previous day on-test, judge that when second day on-test the testee goes out the irradiation dose of erythema, its 1.5 times of amounts are made as above-mentioned minimal erythema dose.
(3) mensuration of wrinkle
Before the picked-up test food, the wrinkle on the tail of the eye as duplicate (replica), then, is begun to absorb test food, continue picked-up 28 days, at its 28th day once more with the wrinkle on the tail of the eye as duplicate.To the parallel light of this duplicate irradiation, the shade that produces is carried out Flame Image Process from certain orientation (30 ℃), calculate shaded area and its length thus.Calculate shaded area and its length, the numerical value of revisal tail of the eye wrinkle duplicate from standard scale (scale) equally.Calculate wrinkle area occupation ratio, maximum wrinkle mean depth and maximum wrinkle depth capacity from these numerical value.
As above-mentioned standard scale, the duplicate that use is made from the mold of each degree of depth of 0.2mm, 0.4mm, 0.6mm, 0.8mm, 1.0mm.
(4) mensuration of the viscoelasticity of skin (cutaneous protuberance mechanical characteristic)
Before the test food picked-up, the probe driving fit that makes Cutometer by applying certain negative pressure, is measured the viscoelasticity of skin in the skin surface of forethiga inboard with the variation that attracted to the skin in the probe.Then, begin to absorb test food, continue picked-up 28 days, measured the viscoelasticity of skin at its 28th day once more as described above.
(5) mensuration of cutin water quantities
Before the picked-up test food, probe driving fit by making Comeometer is in the skin surface of forethiga inboard, microprocessor in the device reads the mobile minute of interior switching information of probe and electricity, estimate with the correction data of having logined these information, thereby measure the cutin water quantities.Then, begin to absorb test food, continue picked-up 28 days, measured the cutin water quantities at its 28th day once more as described above.
(6) intestinal bacterium is checked
Before the picked-up of test food and picked-up finish after (begin to absorb the 28th day), measure the bacterium number of the bacillus bifidus in the stool according to usual way.
(7) investigation method
When on-test, the testee is carried out investigation about living habit, then, before beginning to absorb test food, the investigation carried out about skin in the 28th day of picked-up back the 14th day and picked-up back.
(8) daily record
To the testee, will be logged in the daily record in the picked-up of diet, health and the test food of the every day of picked-up during the test food etc.
(9) condition determination
Said determination all be under certain indoor conditions (20 ℃ of temperature, humidity are below 60%), the back that washes one's face carries out after about 1 hour.
3. result
(1) whitening effect (the Pigmented inhibition effect of ultraviolet induction)
To the results are shown in table 8.
Melanin:
About during before the picked-up test food and in the picked-up each, the melanin value before the ultraviolet radiation is made as 100 o'clock melanin INDEX value (10 routine testees' mean+SD), at the 14th day, show 101.74 ± 1.33% during before the picked-up test food, show 99.74 ± 1.40% during in the picked-up test food, owing to the picked-up test food has reduced by 2.0%.At the 28th day, picked-up before the test food during show 101.24 ± 1.02%, show 99.21 ± 1.02% during in the picked-up test food because the picked-up test food reduces by 2.03%, there were significant differences (p＜0.01, t check).
Erythema:
About during before the picked-up test food and in the picked-up each, the erythema value before the ultraviolet radiation is made as 100 o'clock erythema INDEX value (10 routine testees' mean+SD), at the 14th day, show 102.39 ± 1.52% during before the picked-up test food, show 101.50 ± 1.52% during in the picked-up test food, owing to the picked-up test food has reduced by 0.89%.At the 28th day, picked-up before the test food during show 102.64 ± 3.02%, show 101.51 ± 1.89% during in the picked-up test food reduce by 1.13% owing to absorb test food.
L-value:
About during before the picked-up test food and in the picked-up each, the L-value before the ultraviolet radiation is made as 100 o'clock L-INDEX value (10 routine testees' mean+SD), at the 14th day, show 97.74 ± 1.97% during before the picked-up test food, show 113.69 ± 3.51% during in the picked-up test food, owing to the picked-up test food increases by 15.95%, there were significant differences (p＜0.01, t check).At the 28th day, picked-up before the test food during show 97.23 ± 2.57%, show 102.00 ± 3.33% during in the picked-up test food because the picked-up test food increases by 4.77%, there were significant differences (p＜0.01, t check).
Table 8
| Pilot project | The 14th day | The 28th day | |
| Melanin INDEX value | In absorbing before the picked-up | 101.74±1.33 99.74±1.40 ** | 101.24±1.02 99.21±1.02 ** |
| Erythema INDEX value | In absorbing before the picked-up | 102.39±1.52 101.50±1.52 | 102.64±3.02 101.51±1.89 |
| L-INDEX value | In absorbing before the picked-up | 97.74±1.97 113.69±3.51 ** | 97.23±2.57 102.00±3.33 ** |
Measured value is represented 10 routine testees' mean+SD.
*Expression p＜0.01.
(2) anti-wrinkle effect
The wrinkle area occupation ratio:
The wrinkle area occupation ratio has 3 examples as seen to reduce by 3.2～11.8% by the picked-up test food in 10 routine testees, on average reduces by 7.83%.
Maximum wrinkle mean depth:
With regard to maximum wrinkle mean depth owing to be difficult to measure the wrinkle of little wrinkle and so on, so can measure have only 6 examples among the 10 routine testees.The improvement that the 4 visible picked-up of example test food wherein cause, the maximum 135.3 μ m that improve on average improve 47.7 μ m.
Maximum wrinkle depth capacity:
As seen 5 examples in can measuring 6 examples of maximum wrinkle mean depth absorb the improvement that test food causes, maximum is improved as 70.7 μ m, on average improve 45.98 μ m.
(3) viscoelasticity of skin improves effect
Face:
Relatively absorb before the test food and after the picked-up, visible what improve is 4 examples among the 10 routine testees.
Arm:
Relatively absorb before the test food and after the picked-up, visible what improve is 4 examples among the 10 routine testees.
(4) moistening effect (cuticlar water divides the result of quantitative determination)
Face:
Relatively absorb before the test food and after the picked-up, visible what improve is 7 examples among the 10 routine testees.With regard to the cuticlar water component (mean+SD) of 10 examples, with respect to 51.83 ± 63.87 μ s before the picked-up, after the picked-up 63.87 ± 10.68 μ s, improved 12.04 μ s, rise meaningful (p＜0.05, t check).
Arm:
Relatively absorb before the test food and after the picked-up, what as seen improve is 10 examples among the 10 routine testees, with regard to the cuticlar water component (mean+SD) of 10 examples, with respect to 33.93 ± 6.76 μ s before the picked-up, after the picked-up 40.33 ± 7.64 μ s, 6.4 μ s have been improved, rise meaningful (p＜0.01, t check).
(5) result of intestinal bacterium inspection
Bacillus bifidus in the stool (Bifidobacterium spp.):
Relatively absorb before the test food and after the picked-up, the increases of the visible bacillus bifidus bacterium of 5 examples are arranged in 10 routine testees, maximum from 6.0 * 10
8Be increased to 4.1 * 10
9Individual/the g stool, increase by 6.8 times, the bacterium number (mean+SD) of 10 examples is from 3.4 * 10
9Be increased to 6.4 * 10
9Individual/the g stool, increase by 2.12 times.
(6) Tiao Cha result
According to feeling of testee, the state of the skin relevant with wrinkle with moist, tension force, elasticity, skin texture, transparent feel is estimated.The situation that can not feel each state is estimated with the mark between-5～-1 minutes, and the situation of each state that can feel is estimated with the mark between 1～5 minute.Table 9 expression 10 routine testees' meansigma methods.When observing with the meansigma methods of 10 examples, comparing under any state with before the picked-up test food, the mark of picked-up back the 14th day and the 28th day all increases, there are significant difference (p＜0.05, sign test) in moist (before the picked-up and after the picked-up the 28th day), the tension force of skin (before the picked-up and after the picked-up the 14th day), skin texture (before the picked-up and after the picked-up the 14th day), transparent feel (before the picked-up and after the picked-up before the 14th day, picked-up and after the picked-up the 28th day).
Table 9 is based on the mark of the state of my skin that feels
| The state of skin | Before the picked-up | Picked-up the 14th day afterwards | Picked-up the 28th day afterwards | (the 14th day mark after the picked-up)-(mark before the picked-up) | (the 28th day mark after the picked-up)-(mark before the picked-up) |
| Moist | -2.0 | -0.7 | -0.4 | 1.3 | 1.6 * |
| Tension force | -2.7 | -0.8 | -0.9 | 1.9 * | 1.8 |
| Elastic force | -2.2 | -0.7 | -0.5 | 1.5 | 1.7 |
| Skin texture | -2.6 | -1.2 | -1.8 | 1.4 * | 0.8 |
| Transparent feel | -2.9 | -1.2 | -1.4 | 1.7 * | 1.5 * |
| Wrinkle | -2.4 | -0.4 | -0.7 | 2.0 * | 1.7 * |
*Expression p＜0.05 (sign test).
(7) generaI investigation after drinking
The impression of testee after picked-up comprise " exsiccant skin occur moist ", " it is very unobstructed that stool becomes; the anesthesia of abdominal distention ", " daughter says that my skin has had gloss ", " number of times of stool has increased ", " with compare before the picked-up, the state of skin has improved " etc.
4. sum up
For the whitening effect of test food 1 and 2, visible Pigmented inhibition/early stage improvement the, also improvement of visible wrinkle.For the viscoelasticity of skin, as seen face improves.For moisture-keeping functions (cuticlar water component), as seen face, arm all improve.Particularly moistening effect is outstanding.
In addition, for intestinal bacterium, as seen be called as the increase of the bacillus bifidus of probiotics.
In test food 1, visible outstanding whitening effect and wrinkle improves effect.On the other hand, in test food 2, visible outstanding moistening effect.
In addition, the viscoelasticity aspect of the also visible whitening effect of the soya-bean milk fermentation product that forms of above-mentioned modulation, skin improve effect, moisture-keeping functions (cuticlar water component) aspect improve effect, the bacillus bifidus bacterium increases effect.
Claims (17)
1. oral skin care composition, wherein,
Contain kefir bacterium fermentation milk.
2. Orally administered composition according to claim 1, wherein
Kefir bacterium fermentation milk is the fermentation milk that the kefir grain is obtained as kind of bacterium use.
3. Orally administered composition according to claim 2, wherein
The kefir grain is the symbiotic truffle of lactobacillus and yeast.
4. according to claim 2 or 3 described Orally administered compositions, wherein,
The kefir grain contains the viscous polysaccharide class.
5. Orally administered composition according to claim 4, wherein,
Containing the viscous polysaccharide class is 50～55% of total amount.
6. according to claim 4 or 5 described Orally administered compositions, wherein,
The viscous polysaccharide class is a kefiran.
7. Orally administered composition according to claim 1, wherein,
Kefir bacterium fermentation milk is that lactobacillus and yeast are mixed the fermentation milk that the product that forms obtains as kind of bacterium.
8. according to any described Orally administered composition in the claim 3～7, wherein,
Lactobacillus is the bacterium of selecting from lactobacillus and lactic acid coccus more than a kind.
9. Orally administered composition according to claim 8, wherein,
Lactobacillus is more than one the bacterium of selecting from lactobacillus kefiranofaciens, lactobacillus casei, Lactobacillus kefir and Lactobacillus brevis.
10. according to Claim 8 or 9 described Orally administered compositions, wherein,
The lactic acid coccus is more than one the bacterium of selecting from lactococcus lactis, enterococcus faecalis, Streptococcus lactis (Lister) Lohnis 1909.554., Streptococcus cremoris, biacetyl Streptococcus lactis (Lister) Lohnis 1909.554., Leuconostoc mesenteroides and leuconostoc mesenteroides sub species cremoris.
11. according to any described Orally administered composition in the claim 3～10, wherein,
Yeast is more than one the bacterium of selecting from lactose fermentation yeast and the non-saccharomyces fermentati of lactose.
12. Orally administered composition according to claim 11, wherein,
The lactose fermentation yeast is more than one the bacterium of selecting from yeast Kluyveromyces marxianus, candida kefyr and Brettanomyces anomalus.
13. according to claim 11 or 12 described Orally administered compositions, wherein,
The non-saccharomyces fermentati of lactose is more than one the bacterium of selecting from saccharomyces unisporus, saccharomyces cerevisiae, candida holmii or Saccharomyces unisporaqs.
14. according to any described Orally administered composition in the claim 3～7, wherein,
Lactobacillus is lactobacillus kefiranofaciens, Lactobacillus kefir, Lactobacillus brevis, 4 kinds of bacterium of Leuconostoc mesenteroides, and yeast is more than one the bacterium of selecting from candida kefyr, candida holmii and Saccharomycesunisporaqs.
15. according to any described Orally administered composition in the claim 1～14, wherein,
Further use acetic acid bacteria as kind of a bacterium.
16. according to any described Orally administered composition in the claim 1～15, wherein,
Kefir bacterium fermentation milk is the fermentation milk that soya-bean milk fermentation is obtained.
17. according to any described Orally administered composition in the claim 1～15, wherein,
Kefir bacterium fermentation milk is the fermentation milk that the Lac Bovis seu Bubali fermentation is obtained.
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| CN102056489B (en) * | 2008-06-10 | 2012-08-01 | 株式会社妃丝 | Novel fermented milk product and use thereof |
| CN103025338A (en) * | 2010-05-21 | 2013-04-03 | 株式会社明治 | Composition for improving condition of skin |
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| RS50695B (en) * | 2005-04-01 | 2010-06-30 | Hamlet Protein A/S. | Fermented protein product |
| JP2007000750A (en) * | 2005-06-23 | 2007-01-11 | Spring:Kk | Active oxygen dissipating agent, and method for producing active oxygen dissipating agent |
| JP2008179601A (en) * | 2006-12-28 | 2008-08-07 | Suntory Ltd | Cosmetic composition containing bacterium of genus lactobacillus |
| WO2010021117A1 (en) * | 2008-08-18 | 2010-02-25 | 日本ケフィア株式会社 | Internal preparation for achieving beautiful skin containing milk serum kefir as the active ingredient |
| US9439933B2 (en) | 2010-06-28 | 2016-09-13 | Kabushiki Kaisha Yakult Honsha | Skin properties improving agent for oral administration |
| JP2019118281A (en) * | 2017-12-28 | 2019-07-22 | ハイドロックス株式会社 | Substance produced by bacteria composing kefir grains |
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| JPS6283842A (en) * | 1985-10-08 | 1987-04-17 | Sennosuke Tokumaru | Freeze-dried yogurt and production thereof |
| FR2622797B1 (en) * | 1987-11-05 | 1991-02-01 | Oreal | COSMETIC COMPOSITION BASED ON YOGURT OR KEFIR |
| JP2911199B2 (en) * | 1990-09-14 | 1999-06-23 | 三省製薬株式会社 | External preparation |
| JPH05163134A (en) * | 1991-12-18 | 1993-06-29 | Dowa Mining Co Ltd | Cosmetic |
| JPH0710734A (en) * | 1993-06-21 | 1995-01-13 | Dowa Mining Co Ltd | Cosmetic |
| JPH09191852A (en) * | 1996-01-19 | 1997-07-29 | Sennosuke Tokumaru | Healthy food |
| JPH0838046A (en) * | 1994-07-28 | 1996-02-13 | Nakagaki Gijiyutsushi Jimusho:Kk | Spawn for fermented milk and fermented milk prepared from the same spawn |
| JPH0937711A (en) * | 1995-07-28 | 1997-02-10 | Sennosuke Tokumaru | Health food |
| JP2000032909A (en) * | 1998-07-21 | 2000-02-02 | Bio Health:Kk | Food for improving digestion and absorption by environmental improvement caused by enteric microbe |
| JP2000166467A (en) * | 1998-12-10 | 2000-06-20 | Nippon Kefia Kk | Health food containing fermented milk product and herbs |
| IL139853A0 (en) * | 1999-04-13 | 2002-02-10 | Sigma Tau Healthscience Spa | Dietary supplement derived from fermented milks for the prevention of osteoporosis |
| JP3533427B2 (en) * | 1999-09-14 | 2004-05-31 | 株式会社応微研 | Cosmetics |
| JP3619185B2 (en) * | 2001-06-22 | 2005-02-09 | 株式会社ナリス化粧品 | Cosmetics |
| JP4207477B2 (en) * | 2001-07-06 | 2009-01-14 | 不二製油株式会社 | Composition for improving bowel movement |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102056489B (en) * | 2008-06-10 | 2012-08-01 | 株式会社妃丝 | Novel fermented milk product and use thereof |
| CN103025338A (en) * | 2010-05-21 | 2013-04-03 | 株式会社明治 | Composition for improving condition of skin |
| CN103025338B (en) * | 2010-05-21 | 2015-01-28 | 株式会社明治 | Composition for improving condition of skin |
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| WO2005018653A1 (en) | 2005-03-03 |
| CN100534446C (en) | 2009-09-02 |
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