CN1836686A - Chinese traditional effective part compound preparation for promoting organic body immune function, and its preparation method - Google Patents
Chinese traditional effective part compound preparation for promoting organic body immune function, and its preparation method Download PDFInfo
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Abstract
The present invention is compound Chinese medicine preparation comprising effective Chinese medicine parts for raising body's immunity and its preparation process. The compound Chinese medicine preparation of the present invention is Jade Screen Powder comprising effective Chinese medicine parts of astragalus root in 12 weight portions, white atractylodes rhizome in 12 weight portions and ledebouriella root in 6 weight portions. It is superior to corresponding traditional medicine and has determined quality and stable clinical effect in raising body's immunity and treating relevant diseases.
Description
Technical field:
The present invention relates to effective ingredient in Chinese compound preparation of a kind of human body immunity improving function and preparation method thereof.
Background technology:
The clinical practice in hundreds of years shows the determined curative effect of many Chinese medicine patent medicine, but that traditional Chinese patent medicine exists is big such as taking dose, decocts and takes inconvenience, and active ingredient is indeterminate, the difficult quality control of medical material and patent medicine and cause shortcoming such as clinical drug effect instability.For reaching Chinese medicine preparation safety, controlled, effective aim, national Bureau of Drugs Supervision vigorously advocates the modernization of Chinese medicine always.In existing Chinese patent medicine kind, record various Chinese medicine oral liquid in the latest edition Chinese Pharmacopoeia, its extraction and preparation technique still is better simply water decoction-alcohol sedimentation, reflected internal and international research expansion as yet of going up to the active substance basis of classical prescription kind, the level of its preparation process was still located than the primary stage, the research that reaches separation and Extraction of determining to chemical effective parts in this patent medicine also lacks very much, this will inevitably cause in this patent medicine production process and the quality control target of finished product is failed to understand, can't guarantee stable clinical efficacy.
Summary of the invention:
The purpose of this invention is to provide a kind of Chinese medicine by the human body immunity improving function, the pharmaceutical composition that effective site that extraction separation obtains is formed, i.e. modern Chinese medicine compound recipe, and the preparation method of this medicine is proposed.
The object of the present invention is achieved like this:
The effective ingredient in Chinese compound preparation of human body immunity improving function, the Chinese medicine composition that described compound preparation is made up of the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, its ratio of weight and number are the Radix Astragali 12, the Rhizoma Atractylodis Macrocephalae 12, Radix Saposhnikoviae 6.
The effective ingredient in Chinese compound preparation of above-mentioned human body immunity improving function, what adopt in the described compound preparation is the effective site of Chinese medicine, described compound formulation is to add corresponding adjuvant in above-mentioned described compositions, makes tablet, slow releasing agent, drop pill, granule, capsule, slow-release micro-pill, syrup, mixture, medicinal tea or oral formulations.
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, the Radix Astragali in the described Chinese medicine composition, the boiling water extraction method of the effective site of the Rhizoma Atractylodis Macrocephalae two flavor Chinese medicines, 15 times in water is more than the amount, decoct more than 2 times, each 90～120 minutes, obtain repeatedly water boiling and extraction liquid, merge, being concentrated into medical material weight and volume ratio is 1: 1, slowly add ethanol while stirring, order contains amount of alcohol and reaches 80%, places more than 24 hours, gets supernatant, reclaim ethanol, be concentrated into suitable concentration, by by ratio being the macroporous resin column of filling in 1: 1, earlier with the deionized-distilled water eluting than adsorbance amount of resin and medical material amount, again with 25% ethanol elution, continue with 50% ethanol elution, collect 50% ethanol, reclaim ethanol, aqueous solution after concentrating is transferred pH value to 2 with hydrochloric acid, utilizing the liquid-liquid extraction tower, is the active ingredient of extracting in the solvent extraction acid solution with the n-butyl alcohol, promptly gets any composition effective site in the Chinese medicine composition behind the recovery solvent.
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, the effective site extracting method of the Radix Astragali also comprises in the described Chinese medicine composition, described with behind 25% ethanol elution, continue with 50% ethanol elution, collect 50% alcoholic acid eluent, after with the n-butyl alcohol being the active ingredient of extracting in the solvent extraction acid solution again, collect n-butanol extracting liquid.
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, the effective site extracting method of the Rhizoma Atractylodis Macrocephalae also comprises in the described Chinese medicine composition, described with 25% ethanol elution after, collect 25% ethanol elution, reclaim ethanol, aqueous solution concentrates back hydrochloric acid adjust pH to 2, behind n-butanol extraction, acid solution is transferred pH value to 10 with sodium hydroxide, again with n-butanol extraction, the alkali liquor after the extraction transfers pH value to neutral with hydrochloric acid, remove the residual solvent in the aqueous solution after, concentrate, promptly get the effective site of the Rhizoma Atractylodis Macrocephalae.
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, give as one thinks fit described Radix Saposhnikoviae medical material cataclasm, steam distillation extracts volatile oil, and the volatile oil of extraction wraps up with beta-schardinger dextrin-, gets the volatile oil effective site of Radix Saposhnikoviae, get the aqueous solution after the distillation, being concentrated into medical material weight and volume ratio is 1: 1, by macroporous resin column, with 10 times of deionized-distilled water eluting more than the column volume, collect eluent, promptly get the water boiling and extraction effective site of Radix Saposhnikoviae after concentrating.
The invention has the advantages that:
1. it is QI invigorating, consolidating superficial resistance, hidroschesis that the function of the Chinese medicine compound of human body immunity improving function of the present invention cures mainly.Be used for the empty susceptible ailment said due to cold or exposure person of exterior deficiency, spontaneous perspiration aversion to wind or body.The empty spontaneous perspiration of body, cold easily, particularly chronic disease such as chronic nephritis, hepatitis flu person is especially suitable to the easy patient that catches a cold; For chronic bronchitis patient, can obviously reduce flu, influenza sickness rate after taking, prevent that chronic bronchitis from showing effect repeatedly and increase the weight of, increase resistance against diseases.
2. the Chinese medicine compound of chemical effective parts combination, because the Chinese patent medicine that the chemical constituent that is contained is made than traditional handicraft is wanted much less, and the effective ingredient of its composition is studied clear easily, thereby can guarantee in the patent medicine production process and the clear and easy control of the quality control target of finished product, help guaranteeing stable clinical efficacy, finally reach the purpose that the national medicine of being advocated is answered " safe, controlled, effective ".Simultaneously, from medical material, extract effective site, help avoiding the unsettled shortcoming of patent medicine quality that the height difference of quality causes between the different batches medical material in the production process, and help the saving and the protection of Chinese crude drug plantation resource.
3. make a general survey of the discovering of Chinese medicine of many and human body immunity improving function: preliminary study work such as the relevant side of tearing open, compatibility rule, forefathers have made a lot of accumulation; Simultaneously, Xiang Guan pharmacology and pharmacodynamic study have also possessed suitable basis.Great majority research concentrates on observes the full side of medicine to immunoregulatory influence, especially is that object of study person is in the majority with the water decoction.Be seen in report with the correlational study of effective substance, have the research of its each single medicinal material effective substance of forming only, in fact the effective part group of compound recipe is not the simple addition that is equal to the single medicinal material effective substance, determines or checking and should screen by pharmacological experiment.And this patent has found the chemistry of each medical material in the Chinese medicine patent medicine to imitate the position, and then makes up and make modern Chinese medicine effective site patent medicine, has filled up the aforementioned blank of relevant Chinese medicine research both at home and abroad, and has had originality and advance.
The specific embodiment of the present invention:
Embodiment 1:
The effective ingredient in Chinese compound preparation of human body immunity improving function, described compound preparation is formed Chinese medicine composition by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, and its ratio of weight and number is the Radix Astragali 12, the Rhizoma Atractylodis Macrocephalae 12, Radix Saposhnikoviae 6.
Embodiment 2:
The effective ingredient in Chinese compound preparation of above-mentioned human body immunity improving function, what adopt in the described compound preparation is the effective site of Chinese medicine, described compound formulation is to add corresponding adjuvant in above-mentioned described compositions, makes tablet, slow releasing agent, drop pill, granule, capsule, slow-release micro-pill, syrup, mixture, medicinal tea or oral formulations.
Embodiment 3:
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, the Radix Astragali in the described Chinese medicine composition, the boiling water extraction method of the effective site of the Rhizoma Atractylodis Macrocephalae two flavor Chinese medicines, 15 times in water is more than the amount, decoct more than 2 times, each 90～120 minutes, obtain repeatedly water boiling and extraction liquid, merge, being concentrated into medical material weight and volume ratio is 1: 1, slowly add ethanol while stirring, order contains amount of alcohol and reaches 80%, places more than 24 hours, gets supernatant, reclaim ethanol, be concentrated into suitable concentration, by by ratio being the macroporous resin column of filling in 1: 1, earlier with the deionized-distilled water eluting than adsorbance amount of resin and medical material amount, again with 25% ethanol elution, continue with 50% ethanol elution, collect 50% ethanol, reclaim ethanol, aqueous solution after concentrating is transferred pH value to 2 with hydrochloric acid, utilizing the liquid-liquid extraction tower, is the active ingredient of extracting in the solvent extraction acid solution with the n-butyl alcohol, promptly gets any composition effective site in the Chinese medicine composition behind the recovery solvent.
The effective site extracting method of the Radix Astragali also comprises in the described Chinese medicine composition, describedly continue with 50% ethanol elution, collect 50% ethanol with behind 25% ethanol elution, after with the n-butyl alcohol being the active ingredient of extracting in the solvent extraction acid solution, collect n-butanol extracting liquid.
Embodiment 4:
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, the effective site extracting method of the Radix Astragali also comprises in the described Chinese medicine composition, described with behind 25% ethanol elution, continue with 50% ethanol elution, collect 50% alcoholic acid eluent, after with the n-butyl alcohol being the active ingredient of extracting in the solvent extraction acid solution again, collect n-butanol extracting liquid.
Embodiment 5:
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, the effective site extracting method of the Rhizoma Atractylodis Macrocephalae also comprises in the described Chinese medicine composition, described with 25% ethanol elution after, collect 25% ethanol elution, reclaim ethanol, aqueous solution concentrates back hydrochloric acid adjust pH to 2, behind n-butanol extraction, acid solution is transferred pH value to 10 with sodium hydroxide, again with n-butanol extraction, the alkali liquor after the extraction transfers pH value to neutral with hydrochloric acid, remove the residual solvent in the aqueous solution after, concentrate, promptly get the effective site of the Rhizoma Atractylodis Macrocephalae.
Embodiment 6:
The Chinese medicinal preparation method of above-mentioned human body immunity improving function, give as one thinks fit described Radix Saposhnikoviae medical material cataclasm, steam distillation extracts volatile oil, and the volatile oil of extraction wraps up with beta-schardinger dextrin-, gets the volatile oil effective site of Radix Saposhnikoviae, get the aqueous solution after the distillation, being concentrated into medical material weight and volume ratio is 1: 1, by macroporous resin column, with 10 times of deionized-distilled water eluting more than the column volume, collect eluent, promptly get the water boiling and extraction effective site of Radix Saposhnikoviae after concentrating.
The effective ingredient in Chinese compound preparation of embodiment 1 described human body immunity improving function, what adopt in the described compound preparation is the effective site of Chinese medicine, described compound formulation is to add corresponding adjuvant in above-mentioned described compositions, makes granule or capsule or slow-release micro-pill or syrup or mixture or medicinal tea or oral formulations.
Obtain the technology of the effective site of Chinese medicine, be summarized as follows:
Radix Astragali 12g Rhizoma Atractylodis Macrocephalae 12g Radix Saposhnikoviae 6g.Select the pharmacological action of raise immunity to attach most importance to during its function cures mainly, determine that cleaning up result of experiment with mice carbon is the contrast index.
Mice 20-26g/, male and female half and half.Experiment is divided into 10 every group by body weight, removes L
9(3
4) outside 9 groups of orthogonal experiment, other establishes matched group, normal group and model group.
Matched group for specimen preparation: three flavor medical material pulverize separately are become fine powder,, add the entry certain volume, face the time spent to shake up and make into suspension, extract the volume number of conversion and give mouse stomach by the recipe quantity back mixing of weighing.When other confession sample was prepared, each extracted the part that obtains by different routes, is converted to the amount that is equivalent to crude drug separately and prepares.
Model group adopts lumbar injection hydrocortisone 30mg/kg/ day, and successive administration finishes to experiment, cycle 8-10 day.Each administration group in injection hydrogen can began to irritate stomach in second day and supply sample, inject parallel every day simultaneously hydrogen can, clean up index determining until final carbon, specifically experimental implementation sees list of references for details.
The Radix Astragali adds 15 times in water more than the amount, decoct more than 2 times, each 90～120 minutes, obtain repeatedly water boiling and extraction liquid, merge, being concentrated into medical material weight and volume ratio is 1: 1, slowly adds ethanol while stirring, and order contains amount of alcohol and reaches 80%, place more than 24 hours, get supernatant, reclaim ethanol, be concentrated into suitable concentration, by the ratio than adsorbance amount of resin and medical material amount is 1: 1, by macroporous resin column, earlier with the deionized-distilled water eluting, again with 25% ethanol elution, continue with 50% ethanol elution, collect 50% alcoholic acid eluent, reclaim ethanol, concentrate; The Rhizoma Atractylodis Macrocephalae with deionized-distilled water, 25% ethanol elution after, collect 25% ethanol elution, reclaim ethanol, concentrate.Get above-mentioned two kinds of concentrated solutions respectively, equally as follows preparation: concentrated solution extracts 4 times with dilute hydrochloric acid adjust pH to 2, water-saturated n-butanol, merges n-butanol extracting liquid, and evaporate to dryness obtains " acidity " part alleged in the following table.Aqueous solution reuse ammonia solution adjust pH to 10, water-saturated n-butanol extraction 4 times merges n-butanol extracting liquid, and evaporate to dryness obtains " alkalescence " part alleged in the following table.Remaining aqueous solution to neutral, obtains " remainder " part alleged in the following table with the dilute hydrochloric acid adjust pH.The Radix Saposhnikoviae medical material is given as one thinks fit cataclasm, and steam distillation extracts volatile oil, and the volatile oil of extraction wraps up with beta-schardinger dextrin-, gets the volatile oil effective site of Radix Saposhnikoviae, claims in the following table by " volatile oil "; Get the aqueous solution after the distillation, being concentrated into medical material weight and volume ratio is 1: 1, by macroporous resin column, with 10 times of deionized-distilled water, 25% ethanol elutions more than the column volume, collects eluent, concentrates, and claims in the following table " washing " and " 25% ethanol ".
Experimental result:
Normal group 3.9, matched group 3.7.
| The Radix Astragali | The Rhizoma Atractylodis Macrocephalae | Radix Saposhnikoviae | ||
| Acid | 4.3 | Remaining | 4.2 | Washing+volatile oil 4.3 |
| Alkalescence | 3.8 | Alkalescence | 4.0 | 25% ethanol+volatile oil 3.9 |
| Remaining | 3.9 | Acid | 3.9 | Volatile oil 3.9 |
The stronger live part of immunity pharmacological action is determined: according on average planting of each test group result, determine that finally the Radix Astragali is acidic moiety (4.3).The Rhizoma Atractylodis Macrocephalae is remaining part (4.2).Radix Saposhnikoviae is (washing+volatile oil) partly (4.3).
As can be seen, the immunological enhancement of nearly all experimental group all is better than undressed matched group (3.7), explanation is under the identical situation of medical material consumption, compare with traditional undressed matched group mode of taking, after medicinal material extract being separated, is got rid of the composition of part useless (even playing negative interaction), taking dose can significantly reduce, and drug effect still can be kept simultaneously, even is strengthened.
The effective ingredient in Chinese compound preparation of human body immunity improving function, described compound preparation is formed Chinese medicine composition by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, and its ratio of weight and number is 12 kilograms of the Radixs Astragali, 12 kilograms of the Rhizoma Atractylodis Macrocephalaes, 6 kilograms of Radix Saposhnikoviaes.Mix the back and makes tablet or slow releasing agent or drop pill according to conventional Chinese medicinal preparation method, such as under the situation of above-mentioned each medical material inventory, finally make 3000, promptly every is equivalent to crude drug totally 10 grams, and then taking dose is every day 2 times, each 1-2 sheet.
Claims (6)
1. the effective ingredient in Chinese compound preparation of a human body immunity improving function, it is characterized in that: described compound preparation is formed Chinese medicine composition by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, and its ratio of weight and number is the Radix Astragali 12, the Rhizoma Atractylodis Macrocephalae 12, Radix Saposhnikoviae 6.
2. the effective ingredient in Chinese compound preparation of human body immunity improving function according to claim 1, it is characterized in that: what adopt in the described compound preparation is the effective site of Chinese medicine, described compound formulation is to add corresponding adjuvant in above-mentioned described compositions, makes tablet, slow releasing agent, drop pill, granule, capsule, slow-release micro-pill, syrup, mixture, medicinal tea or oral formulations.
3. the Chinese medicinal preparation method of the described human body immunity improving function of claim 2, it is characterized in that: the Radix Astragali in the described Chinese medicine composition, the boiling water extraction method of the effective site of the Rhizoma Atractylodis Macrocephalae two flavor Chinese medicines, 15 times in water is more than the amount, decoct more than 2 times, each 90～120 minutes, obtain repeatedly water boiling and extraction liquid, merge, being concentrated into medical material weight and volume ratio is 1: 1, slowly add ethanol while stirring, order contains amount of alcohol and reaches 80%, places more than 24 hours, gets supernatant, reclaim ethanol, be concentrated into suitable concentration, by by ratio being the macroporous resin column of filling in 1: 1, earlier with the deionized-distilled water eluting than adsorbance amount of resin and medical material amount, again with 25% ethanol elution, continue with 50% ethanol elution, collect 50% ethanol, reclaim ethanol, aqueous solution after concentrating is transferred pH value to 2 with hydrochloric acid, utilizing the liquid-liquid extraction tower, is the active ingredient of extracting in the solvent extraction acid solution with the n-butyl alcohol, promptly gets any composition effective site in the Chinese medicine composition behind the recovery solvent.
4. the Chinese medicinal preparation method of human body immunity improving function according to claim 3, it is characterized in that: the effective site extracting method of the Radix Astragali also comprises in the described Chinese medicine composition, described with behind 25% ethanol elution, continue with 50% ethanol elution, collect 50% alcoholic acid eluent, after with the n-butyl alcohol being the active ingredient of extracting in the solvent extraction acid solution again, collect n-butanol extracting liquid.
5. the Chinese medicinal preparation method of human body immunity improving function according to claim 3, it is characterized in that: the effective site extracting method of the Rhizoma Atractylodis Macrocephalae also comprises in the described Chinese medicine composition, described with 25% ethanol elution after, collect 25% ethanol elution, reclaim ethanol, aqueous solution concentrates back hydrochloric acid adjust pH to 2, behind n-butanol extraction, acid solution is transferred pH value to 10 with sodium hydroxide, again with n-butanol extraction, the alkali liquor after the extraction transfers pH value to neutral with hydrochloric acid, remove the residual solvent in the aqueous solution after, concentrate, promptly get the effective site of the Rhizoma Atractylodis Macrocephalae.
6. the Chinese medicinal preparation method of the described human body immunity improving function of claim 2, it is characterized in that: give as one thinks fit described Radix Saposhnikoviae medical material cataclasm, steam distillation extracts volatile oil, the volatile oil that extracts wraps up with beta-schardinger dextrin-, get the volatile oil effective site of Radix Saposhnikoviae, get the aqueous solution after the distillation, being concentrated into medical material weight and volume ratio is 1: 1, pass through macroporous resin column, with 10 times of deionized-distilled water eluting more than the column volume, collect eluent, promptly get the water boiling and extraction effective site of Radix Saposhnikoviae after concentrating.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951418B (en) * | 2006-09-30 | 2010-11-10 | 山西大学 | Chewing tablet of 'Yu Ping Feng' and preparation method thereof |
| CN1985875B (en) * | 2006-12-14 | 2011-07-20 | 天津科技大学 | Preparing process of Jade-screen total polyose |
| CN102133336A (en) * | 2010-01-21 | 2011-07-27 | 常州善美药物研究开发中心有限公司 | Traditional Chinese medicine composite, and preparation method and application thereof |
| CN101411743B (en) * | 2007-11-16 | 2012-05-23 | 安徽医科大学 | Use of Chinese medicine jade screen powder as medicament for preventing and treating liver damage |
| CN104473956A (en) * | 2014-12-12 | 2015-04-01 | 南京大学 | Yupingfeng powder active ingredient composition and preparation method and application thereof |
-
2005
- 2005-03-23 CN CN 200510009846 patent/CN1836686A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951418B (en) * | 2006-09-30 | 2010-11-10 | 山西大学 | Chewing tablet of 'Yu Ping Feng' and preparation method thereof |
| CN1985875B (en) * | 2006-12-14 | 2011-07-20 | 天津科技大学 | Preparing process of Jade-screen total polyose |
| CN101411743B (en) * | 2007-11-16 | 2012-05-23 | 安徽医科大学 | Use of Chinese medicine jade screen powder as medicament for preventing and treating liver damage |
| CN102133336A (en) * | 2010-01-21 | 2011-07-27 | 常州善美药物研究开发中心有限公司 | Traditional Chinese medicine composite, and preparation method and application thereof |
| CN102133336B (en) * | 2010-01-21 | 2014-06-11 | 常州善美药物研究开发中心有限公司 | Traditional Chinese medicine composite, and preparation method and application thereof |
| CN104473956A (en) * | 2014-12-12 | 2015-04-01 | 南京大学 | Yupingfeng powder active ingredient composition and preparation method and application thereof |
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