CN1857519A - Chinese medicine for improving memory - Google Patents
Chinese medicine for improving memory Download PDFInfo
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- CN1857519A CN1857519A CN 200610065626 CN200610065626A CN1857519A CN 1857519 A CN1857519 A CN 1857519A CN 200610065626 CN200610065626 CN 200610065626 CN 200610065626 A CN200610065626 A CN 200610065626A CN 1857519 A CN1857519 A CN 1857519A
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Abstract
The memory improving Chinese medicine is developed based on Chinese medicine theory and through combining with modern chemical and pharmacologic base and referring clinical experience. It is prepared with desert cistanche, roasted fleeceflower root, wolfberry fruit and Chuanxiong rhizome in certain weight proportion. The animal experiments show that the medicine can improve mouse's memory impairment, raising SOD level inside brain tissue, inhibit cholinesterase activity and promote learning memory function.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly relate to a kind of improvement memory herbal mixture.
Background technology
Along with aged tendency of population, the sickness rate of senile dementia (AD) also increases thereupon, is the fourth-largest cause of disease that causes old people's death after tumor, heart disease, cerebrovascular.The medicine of treatment senile dementia mainly contains cholinesterase inhibitor at present, cerebral vasodilator, and calcium antagonists prevents A β deposition medicine, suppresses β, gamma secretase medicine and anti-inflammatory agent etc.AD cause of disease complexity, the morbidity link is more, and up to now, western medicine AD effect is relatively poor, and the patient often has marked difference to the reaction of certain certain drug, and is prone to drug resistance and side effect and fails extensive use clinically.
The senile dementia disease is changed into basic Clinical symptoms with forgetful, slow-witted and stupid and disposition that carrying out property increases the weight of." the brain being the house of mentality " is so the sick position of primary disease is at brain.Theory of Chinese medical science is thought: kidney storing essence, the smart marrow of giving birth to, brain are marrow unit sea.Kidney brain relation is particularly important.Prolonged illness consume or old deficiency of the kidney, deficiency of kidney-essence can not be given birth to marrow and be filled brain, and marrow subtracts brain and disappears, and refreshing machine apraxia causes primary disease then.Modern pharmacological research also shows, kidney-nourishing tcm drug can significantly improve the performance of intellectual deteriorations such as ability of learning and memory decline that AD causes, cognitive dysfunction, and for the every pathological index of AD and gene expression role of correcting arranged unusually all.
Summary of the invention
The purpose of this invention is to provide a kind of effective improvement memory medicine, it can remedy the above-mentioned deficiency of existing medicine.
A kind of Chinese medicine that improves memory, it is characterized in that its effective ingredient that contains made by following raw materials according: Herba Cistanches, baked polygonum capitatum, Fructus Lycii, Rhizoma Chuanxiong, the ratio of their parts by weight is: 75-100: 50-75: 40-60: 25-50.
Above-mentioned improvement memory preparation method of Chinese medicine, it is characterized in that each Chinese medicine component is pulverized is coarse powder, 40 ℃ of-60 ℃ of reflux, extract, of ethanol with 8-12 times of weight, filter, the water of 8-12 times of weight of medicinal residues reuse is carried, ethanol and aqueous extract cryoconcentration, concentrated solution respectively merge spray drying, obtain brown powder shape medicine, add to compose and expect to make granule.
Process for preparing medicine of the present invention is simple to operate, the cycle is short, active constituent content is high, and cost of manufacture is low; This medicine can obviously improve mouse memory acquired disturbance, direction identification obstacle, improves SOD level in the cerebral tissue, suppresses cholinesterase activity, promotes the effect of learning and memory of little mouse function.
The specific embodiment
Below by embodiment the present invention is described.
Take by weighing Herba Cistanches 15g, baked polygonum capitatum 10g, Fructus Lycii 10g, Rhizoma Chuanxiong 5g, it is coarse powder (20-80 order) that each Chinese medicine component is pulverized, with twice of the ethanol 40-60 ℃ reflux, extract, of 10 times of weight, filter, 80 ℃ of water-baths of the water of 8-12 times of weight of medicinal residues reuse extract twice, merge ethanol and aqueous extract, concentrating under reduced pressure, merge concentrated solution, spray drying, adding dextrin, Icing Sugar excipient are made granule.The preparation of making is an index with the content of active ingredient echinacoside, adopts high-efficient liquid phase technique to carry out quality control standard.
Chinese medicine of the present invention is formed by the principle of Chinese traditional treatment senile dementia.Motherland's medical science thinks, the people is to old age or prolonged illness, the QI of five ZANG-organs degradation, the QI and blood seminal fluidization is given birth to not enough, damage of essence is in down, can not on fill in brain.The brain sky declines, and refreshing mistake of unit supported, and gods are become deaf, and is the dull-witted main pathomechanism that takes place.At the pathological characteristic of traditional Chinese medical science senile dementia, suitable kidney-tonifying sperm-generating in treatment, invigorating the spleen and benefiting QI, nourshing blood and promoting blood circulation.Based on the Herba Cistanches of kidney tonifying, essence replenishing, simultaneously, the treatment senile dementia had good curative effect with the composition of prescription such as ministerial drug of invigorating the spleen and benefiting QI, nourshing blood and promoting blood circulation.
Monarch drug in the side: Herba Cistanches, sweet saltiness temperature is gone into kidney and large intestine channel, can kidney-replenishing and benefiting essence-blood; Ancients' cloud: kind control cloudy person, guiding QI in YANG meridians to expel the pathogen in YIN meridian, kidney yang is able to temperature compensation, then can spermatogenesis benefit marrow, marrow is abundant, and brain must be filled, and brain god must support the effect that then can give full play to its memory gods, so be monarch drug.Ministerial drug: baked polygonum capitatum, sweet puckery tepor is gone into Liver and kidney two warps, can invigorating the liver and kidney and benefiting essence-blood, can strengthen the effect that Herba Cistanches spermatogenesisization benefit marrow is supported brain.Adjuvant drug: Fructus Lycii, sweet flat, go into Liver and kidney two warps, have the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity can assist monarch, ministerial drug to strengthen its kidney invigorating and essence nourishing, gives birth to the effect that marrow is supported brain.Messenger drug: Rhizoma Chuanxiong, Xin Wen goes into liver and gall and pericardium channel, energy blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; Rhizoma Chuanxiong is done good works and is wandered away, and is " the gas medicine in the blood " energy of forefathers' meaning: " the up head, the descending sea of blood ", so but blood stasis dispelling blood leads to the brain network and qi and blood circulation promotion, support brain god.And its merit of wandering away can make monarch, all medicine tonifys without causing stagnation of minister.All medicine phases 5, the spermatogenesis that gathers altogether nourishes blood, and mends the merit that marrow fills brain, so the treatment senile dementia is had good effect.
Improve the pharmacodynamics requirement of memory effect by the treatment by Chinese herbs senile dementia, for observing the influence of YINAO JIAONANG to the learning and memory of little mouse function, this experimentation adopts animal models such as learning memory disorder mice due to the scopolamine hydrobromide, the direction identification obstacle mice due to the pentobarbital sodium, aged mouse, has carried out the mensuration of experimental index such as the experiment of mice diving tower, Y type water labyrinthine test, brain superoxide dismutase (SOD) level, brain acetylcholine esterase (AchE) activity.
1 laboratory sample and experimental technique
Being tried thing YINAO JIAONANG content is brown powder, is provided lot number by Chinese Marine University's medicine: 20041101.
Animal Kunming kind healthy mice, male and female half and half, body weight 20 ± 2g.Kunming kind aged mouse, female, 10 months ages of Mus, body weight: 36 ± 2g.Provide by Shandong University's Experimental Animal Center.No. 20030004, animal production licence number: scxk (Shandong).Experimental situation temperature: 20-24 ℃; Relative humidity: 50-70%.
Instrument and reagent mice diving tower instrument, Y type water maze instrument are this institute and make by oneself.721 spectrophotometers, Shanghai the 3rd analytical tool factory produces.SHG-1 type biochemiluminescence measuring instrument, Weights and Measures Bureau trial (demonstration) plant, Shanghai City produces.80-2B centrifuge: Anting Scientific Instrument Factory, Shanghai.Scopolamine hydrobromide injection is Shanghai Hefeng Pharmaceutical Co., Ltd.'s product, lot number: 020901.Piracetam Tablet is that SHANDONG LUOXIN PHARMACY STOCK Co., LTD. produces, and lot number 040326 is with before using dissolved in distilled water.Xanthine, U.S. Sigma company product.
YINAO JIAONANG is to the influence (diving tower method) of memory acquisition disturbance learning and memory of little mouse function
Kunming kind healthy mice, body weight 20 ± 2g is divided into blank group, model control group, piracetam group and 3 dosage groups of YINAO JIAONANG, every group of 20 mices, male and female half and half at random by body weight.Control animals gives distilled water.Piracetam group and YINAO JIAONANG group give piracetam 0.4g/kg, YINAO JIAONANG 0.625,1.25,2.5g/kg respectively.Tried thing per os filling stomach and give experimental animal, 30d tests in 31d continuously.
Experiment divides training and tests two stages.Except that the blank treated animal, all the other are respectively organized mice and set up model respectively at the preceding 10min lumbar injection scopolamine 2mg/kg of training.Earlier mice was put into the reaction chamber endoadaptation 3 minutes during training, pass to the 36V alternating current then immediately, the rebound platform was a correct response to hide electric shock after animal was subjected to shocking by electricity, and was shocked by electricity as jumping to once more on the copper grid, was wrong reaction.So training is 5 minutes, writes down the wrong reaction number of times of every Mus, as school grade.The recast test steadily is placed on mice on the diving tower during test after 24 hours, writes down wrong reaction number of times in the incubation period and 5 minutes of jumping off platform for the first time, as the memory hold facility of animal.
YINAO JIAONANG is to the influence of mouse brain activity of cholinesterase
The mice sacrificed by decapitation is got brain and is adopted improvement Ellman method
[2]Measure the full brain cholinesterase of mice vigor.
YINAO JIAONANG is distinguished the influence (water maze method) of obstacle learning and memory of little mouse function to direction
Grouping and medication 1.4.1.The 31st day begins training after administration, and all the other respectively organize mice ip injection nembutal 15g/kg respectively except that the blank group to train preceding 30 minutes.During training mice is put down gently the entry " Y " type prong from long arm end, arriving at platform with it in 15min is correct response, and repetition training behind the rest 15min is trained 10 every day, continuous 5 days.Mice correct response every day number of times respectively organized in record.
YINAO JIAONANG is to the influence of mouse brain SOD level
The healthy aged mouse of Kunming kind, 10 months ages of Mus, body weight 36 ± 2g.Be divided into blank group, piracetam group and 3 dosage groups of YINAO JIAONANG at random by body weight, control animals gives distilled water.Piracetam group and YINAO JIAONANG group give piracetam 0.4g/kg, YINAO JIAONANG 0.625,1.25,2.5g/kg respectively.Tried thing per os filling stomach and give experimental animal, gastric infusion is 30 days continuously, and after 24 hours, broken end is got brain in the last administration, adopts xanthine---luminol chemiluminescence method
[4]Measure SOD.
2 experimental results
YINAO JIAONANG is to the influence (diving tower method) of memory acquisition disturbance learning and memory of little mouse function
Table 1 YINAO JIAONANG is to the influence of memory acquisition disturbance learning and memory of little mouse function (X ± SD)
| Group | Dosage (g/kg) | Number of animals (n) | Learning capacity | Memory ability | |
| Errors number in the 5min | Incubation period (s) | Errors number in the 5min | |||
| Blank group model matched group piracetam YINAO JIAONANG YINAO JIAONANG YINAO JIAONANG | -- -- 0.4 2.5 1.25 0.625 | 20 20 20 20 20 20 | 1.4±1.1 4.2±2.3 2.8±1.6* 2.7±2.0* 2.9±1.9* 3.3±2.1 | 195.1±93.5 88.3±69.5 167.4±81.1** 148.9±78.2* 151.6±100.5* 139.1±87.2* | 1.3±1.2 3.1±1.8 1.9±1.0* 2.1±1.6 2.0±1.4* 2.3±1.8 |
Annotate: compare with model control group: *: P＜0.05 * *: P＜0.01
YINAO JIAONANG is to the influence of mouse brain activity of cholinesterase
Table 2 YINAO JIAONANG is to the influence of mouse brain activity of cholinesterase (X ± SD)
| Group | Dosage (g/kg) | Number of animals (n) | Activity of cholinesterase (U/g cerebral tissue) |
| Blank group model matched group piracetam group YINAO JIAONANG YINAO JIAONANG YINAO JIAONANG | -- -- 0.4 2.5 1.25 0.625 | 20 20 20 20 20 20 | 75.9±6.4 91.1±10.5 80.6±9.5** 82.4±12.7* 79.7±14.3** 84.3±12.2 |
Annotate: compare with model control group: *: P＜0.05 * *: P＜0.01
YINAO JIAONANG is distinguished the influence (water maze method) of obstacle learning and memory of little mouse function to direction
Table 3 YINAO JIAONANG is to the influence of distinguishing obstacle learning and memory of little mouse function (X ± SD)
| Group | Dosage (g/kg) | Number of animals (n) | The correct response number of times | ||||
| The 1st day | The 2nd day | The 3rd day | The 4th day | The 5th day | |||
| Blank group model matched group piracetam YINAO JIAONANG YINAO JIAONANG YINAO JIAONANG | -- -- 0.4 2.5 1.25 0.625 | 20 20 20 20 20 20 | 6.1±1.7 3.2±2.0 5.4±2.9* 5.2±2.8* 4.3±1.9 4.8±2.1* | 7.5±2.1 4.6±2.4 7.3±2.9** 6.7±2.8* 6.4±1.9* 6.4±2.2* | 8.4±1.1 6.9±1.7 8.3±1.5* 8.2±1.4* 8.6±1.1** 7.9±1.3* | 9.0±1.2 7.6±1.6 8.7±1.1* 8.6±1.0* 8.9±1.0** 8.3±1.4* | 8.9±1.0 7.9±1.4 8.4±1.1 8.6±1.2 9.0±1.0* 8.5±1.2 |
Annotate: compare with model control group: *: P＜0.05 * *: P＜0.01
YINAO JIAONANG is to the influence of mouse brain SOD level
Table 4 YINAO JIAONANG is to the influence of mouse brain SOD (X ± SD)
| Group | Dosage (g/kg) | Number of animals (n) | SOD (U/ml) |
| Blank group piracetam YINAO JIAONANG YINAO JIAONANG YINAO JIAONANG | -- 0.4 2.5 1.25 0.625 | 16 16 16 16 16 | 251.2±13.9 264.7±15.1* 270.6±23.0** 266.4±18.9* 257.7±19.5 |
Annotate: compare with the blank group: *: P＜0.05 * *: P＜0.01
3. experiment conclusion
The result shows: YINAO JIAONANG can obviously be improved mouse memory acquired disturbance, direction identification obstacle, improves SOD level in the cerebral tissue, suppresses cholinesterase activity.YINAO JIAONANG has the effect that promotes the learning and memory of little mouse function, its mechanism may with influence brain in factors such as cholinesterase activity and anti-radical action relevant.
Claims (2)
1. Chinese medicine that improves memory is characterized in that its effective ingredient that contains made by following raw materials according, Herba Cistanches, baked polygonum capitatum, Fructus Lycii, Rhizoma Chuanxiong, and the ratio of their parts by weight is: 75-100: 50-75: 40-60: 25-50.
2. improvement memory preparation method of Chinese medicine according to claim 1, it is characterized in that each Chinese medicine component is pulverized is coarse powder, 40 ℃ of-60 ℃ of reflux, extract, of ethanol with 8-12 times of weight, filter, the water of 8-12 times of weight of medicinal residues reuse is carried, ethanol and aqueous extract cryoconcentration, concentrated solution respectively merge spray drying, obtain brown powder shape medicine, add to compose and expect to make granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2397144A1 (en) * | 2010-06-16 | 2011-12-21 | Sinphar Tian-li Pharmaceutical Co., Ltd. (Hangzhou) | Use of Isoacteoside in Preventing or Treating Amyloid Beta Peptide-Associated Diseases or Conditions, and Method for Inhibiting Formation, Accumulation or Aggregation of Amyloid Beta Peptides |
| CN105396026A (en) * | 2014-09-15 | 2016-03-16 | 北京创盈科技产业集团有限公司 | Traditional Chinese medicine preparation containing cistanche deserticola, and preparation method thereof |
-
2006
- 2006-03-21 CN CNB2006100656266A patent/CN100446792C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2397144A1 (en) * | 2010-06-16 | 2011-12-21 | Sinphar Tian-li Pharmaceutical Co., Ltd. (Hangzhou) | Use of Isoacteoside in Preventing or Treating Amyloid Beta Peptide-Associated Diseases or Conditions, and Method for Inhibiting Formation, Accumulation or Aggregation of Amyloid Beta Peptides |
| CN105396026A (en) * | 2014-09-15 | 2016-03-16 | 北京创盈科技产业集团有限公司 | Traditional Chinese medicine preparation containing cistanche deserticola, and preparation method thereof |
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| CN100446792C (en) | 2008-12-31 |
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