CN1833658A - Medicine for treatment of cardio-cerebral blood vessel diseases and diabetes, and its prepn. method - Google Patents
Medicine for treatment of cardio-cerebral blood vessel diseases and diabetes, and its prepn. method Download PDFInfo
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- CN1833658A CN1833658A CNA2006100509106A CN200610050910A CN1833658A CN 1833658 A CN1833658 A CN 1833658A CN A2006100509106 A CNA2006100509106 A CN A2006100509106A CN 200610050910 A CN200610050910 A CN 200610050910A CN 1833658 A CN1833658 A CN 1833658A
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Abstract
A Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases, and diabetes is prepared from 25 minerals including Chinese medical stone, Dragon's bone, feldspar, stalactite, etc. Its preparing process is also disclosed.
Description
[technical field]
The present invention relates to a kind of medicine of preventing and treating cardiovascular and cerebrovascular disease, diabetes and preparation method thereof, belong to the field of Chinese medicines.
[background technology]
Cardiovascular and cerebrovascular disease, diabetes are the world's three big diseases, have become the killer of harm humans health at present.Show according to World Health Organization's statistics, China has had 1.1 hundred million people to suffer from cardiovascular and cerebrovascular disease such as hypertension, arteriosclerosis, people more than 40 years old has 57% people to suffer from various degree cardiovascular and cerebrovascular disease approximately, ten thousand people suffer from diabetes surplus having 600, and there are every day 3000 people to increase progressively approximately, cardiovascular and cerebrovascular disease accounts for 39.4% of human mortality rate, relapse rate 87%, and disability rate 50% all occupies the first place.Three first of is first killer that cardiovascular and cerebrovascular disease becomes harm humans health.The residence is with the harm of this disease to the mankind, present national governments, to heavily prevention, control is gone forward side by side and is changed from the heavily treatment in past for medical institutions and health care personnel, a large amount of research datas prove, can control hypertension effectively, cardiovascular and cerebrovascular disease and grain urine disease incidence rate 80% can be prevented or reduce to hyperlipidemia and hyperglycemia just, at present, be used for controlling respectively hypertension, hyperlipidemia both at home and abroad, the medicine of hyperglycemia emerges in an endless stream, but the bright crude drug that can control " three-hypers " does not simultaneously emerge as yet.
[summary of the invention]
The purpose of this invention is to provide a kind of can prophylaxis of hypertension, hyperlipidemia, hyperglycemia, can treat the medicine of cardiovascular and cerebrovascular disease, diabetes again.
Another object of the present invention provides the preparation method of this medicine.
Medicament selection Maifanitum of the present invention, Ophicalcitum, Terra Flava Usta, Lapis Chloriti, Mirabilitum crystallina, Stalactitum, Cinnabaris, Azuritum, coal, salt alkali, Os Draconis, Anhydrite, Chalcanthitum, Melanteritum, succinum makes up, has tranquillizing the mind by relieving convulsion, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver and subsiding YANG, functions such as dredging the meridian, this drug regimen is behind biofermentation, be rich in aspartic acid, glutamic acid, the cruel propylhomoserin of Radix Asparagi, clean propylhomoserin, histidine, glycine, 19 seed amino acids such as threonine, account for 95% of amino acid needed by human body sum, isoleucine wherein, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine is can not synthesize in the human body or aggregate velocity can not satisfy the body needs, simultaneously, it also contains the main mine material of needed by human body: Ca, Mg, K, S, 14 kinds of secondary element: Si of the needed by human that P and World Health Organization (WHO) announce, F, Zn, Cu, Mn, Cr, Mo, Co, Se, Ni, V, Sn, I, Fe; In addition, it also a distinguishing feature be to contain abundant active cation, after these cationes are closed eventually with anion in human body, effective mediator's yin-yang, the raising human body immunity of enhancing metabolism of human cell.
Drug component consumption of the present invention is to sum up through a large amount of clinical the groping of inventor, and the crude drug effective dose has better curative effect in the following weight parts scope:
Maifanitum 100-200 part, Ophicalcitum 15-40 part, Terra Flava Usta 15-30 part, Lapis Chloriti 15-30 part, Mirabilitum crystallina 15-35 part, Stalactitum 20-50 part, Halloysitum Rubrum 10-25 part, Limonitum 15-35 part, Muscovitum 10-30 part, Dens Draconis 20-80 part, Gypsum Fibrosum 15-35 part, Cinnabaris 5-15 part, Azuritum 15-25 part, coal 10-40 part, salt alkali 15-25 part, Os Draconis 20-100 part, Anhydrite 10-30 part, Chalcanthitum 10-20 part, Melanteritum 15-30 part, succinum 20-40 part.
Be preferably: 150 parts of Maifanitums, 20 parts of Ophicalcitums, 20 parts of Terra Flava Ustas, 20 parts of Lapis Chloriti, 20 parts of Mirabilitum crystallinas, 30 parts of Stalactitums, 15 parts of Halloysitum Rubrums, 30 parts of Limonitum, 15 parts on Muscovitum, 30 parts of Dens Draconiss, 25 parts in Gypsum Fibrosum, 6 parts in Cinnabaris, 15 parts of Azuritum, 15 parts of coals, 20 parts of salt alkali, 50 parts of Os Draconis, 15 parts of Anhydrites, 10 parts in Chalcanthitum, 15 parts of Melanteritum, 30 parts of succinums.
Medicine of the present invention is made solid preparation and liquid preparation according to the preparation method and the biofermentation technique of GMP production management standard, and wherein solid system comprises that tablet, granule, glue assists agent, buccal tablet; Liquid preparation comprises oral liquid, oral close, injection.
In order to make medicine of the present invention bring into play its drug effect better, the preparation method of preferred active constituent of the present invention is as follows:
A) with Maifanitum, Ophicalcitum, Terra Flava Usta, Lapis Chloriti, Mirabilitum crystallina, Stalactitum, Halloysitum Rubrum, Limonitum, Muscovitum, Dens Draconis, Gypsum Fibrosum, Cinnabaris, Azuritum, coal, salt alkali, Os Draconis, Anhydrite, Chalcanthitum, Melanteritum, succinum decontamination;
B: it is standby to take by weighing the above-mentioned raw materials medicine according to weight proportion;
C: each crude drug calcining that will take by weighing is ground into powder, mix homogeneously after the cooling;
D: mixing crude drug powder is added edible hydrochloric acid or edible (acetic acid) and the fermentation of probiotic bacteria kind;
E: the medicinal liquid that will ferment boils after-filtration, has made the active constituent of medicine of the present invention.
The active constituent of medicine of the present invention can place the different dosage form of preparation, existing required adjuvant, according to GMP production management standard, adopt conventional Chinese medicine preparation to make solid preparation and liquid preparation, wherein solid preparation comprises tablet, granule, capsule, buccal tablet, and liquid preparation comprises oral liquid, oral administration syrup, injection.
Medicine of the present invention has tranquillizing the mind by relieving convulsion, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, suppressing the hyperactive liver and subsiding YANG, dredging the meridian, strengthening the body resistance, adjusting nervus centralis regulating YIN and YANG balance, improve vessel wall elasticity, coronary blood flow increasing, blood fat reducing, improve immunity, regulate metabolic function, thereby bring high blood pressure down, blood fat and blood glucose.
[specific embodiment]
Below further set forth the beneficial effect of medicine of the present invention by preliminary clinical trial.
The Preliminary Clinical Observation of [test example 1] hypertension therapy of the present invention.
Medicine of the present invention " the refreshing liquid in a healthy and balanced way of stone " is provided by Shishen Mineral Medicine Inst., Guizhou.
1, physical data
Accept family for medical treatment and suffer from 30 examples, wherein male 9 examples, women 21 examples, 40-50 year 8 examples, 51-60 year 13 examples, 61-70 year 9 examples.
2, diagnostic criteria and the curative effect determinate standard standard of working out with reference to national cardiovascular epidemiology in 1979 and crowd prevention and treatment forum.
3, Therapeutic Method: every day three times, each 30CC-50CC, it is oral to convert mineral water by 1: 2, and period in a medicine is withdrawn other medicines.
4, therapeutic outcome
Take 1 middle of the month of the refreshing liquid in a healthy and balanced way of medicine stone of the present invention, produce effects 25 examples, obvious effective rate 83%, effective 5, effective percentage 17%, total effective rate 100%.
The Preliminary Clinical Observation of [test example 2] drug treatment of diabetic of the present invention.
1, physical data
Accept the patient of family 30 examples for medical treatment, wherein male 17 examples, women 13 examples, 40-50 year 3 examples, 51-60 year 15 examples, 61-70 year 12 examples.
2, diagnostic criteria and curative effect determinate standard are developed and published the clinical research guideline with reference to Ministry of Public Health in 1993.
3, Therapeutic Method: every day three times, each 30CC-50CC, it is oral to convert mineral water by 1: 2, and period in a medicine is withdrawn other medicines.
4, therapeutic outcome
Take medicine of the present invention and fall 1 middle of the month of the refreshing liquid in a healthy and balanced way of stone, produce effects 22 examples, obvious effective rate 73.33%, effective 6 examples, effective percentage 20%, invalid example, total effective rate 93.33%.
Below logical embodiment further sets forth the preparation method of medicine of the present invention.
The preparation of [embodiment 1] medicine oral liquid of the present invention
A) each crude drug is drifted about with clear water, remove the impurity of crude drug;
B) take by weighing 150 parts of Maifanitums, 20 parts of Ophicalcitums, 20 parts of Terra Flava Ustas, 20 parts of Lapis Chloriti, 20 parts of Mirabilitum crystallinas, 30 parts of Stalactitums, 15 parts of Halloysitum Rubrums, 30 parts of Limonitum, 15 parts on Muscovitum, 30 parts of Dens Draconiss, 25 parts in Gypsum Fibrosum, 6 parts in Cinnabaris, 15 parts of Azuritum, 15 parts of coals, 20 parts of salt alkali, 50 parts of Os Draconis, 15 parts of Anhydrites, 10 parts in Chalcanthitum, 15 parts of Melanteritum, 30 parts of succinums;
C) the above-mentioned raw materials medicine is calcined in 500-600 ℃ of stove respectively, the duration and degree of heating is as the criterion with the palm YAOSHI of crumbing;
D) will calcine crude drug and pulverize, go out medicated powder with 150-200 purpose steel sieve vibrosieve;
E) medicated powder and alimentary acetic acid (or edible hydrochloric acid) are prepared in 1: 1000 ratio, other adds an amount of probiotic bacteria kind ferments, and fermentation time is more than 6 days;
F) will ferment medicinal liquid and boil, after the filtration the mother solution of medicine of the present invention, mother solution is oral liquid with mineral water or pure water after by rare erosion in 1: 2.
Claims (6)
1, a kind of medicine of preventing and treating cardiovascular and cerebrovascular disease, diabetes is characterized in that it is to be made by following raw medicaments in portion by weight:
Maifanitum 100-200 part, Ophicalcitum 15-40 part, Terra Flava Usta 15-30 part, Lapis Chloriti 15-30 part, Mirabilitum crystallina 15-35 part, Stalactitum 20-50 part, Halloysitum Rubrum 10-25 part, Limonitum 15-35 part, Muscovitum 10-30 part, Dens Draconis 20-80 part, Gypsum Fibrosum 15-35 part, Cinnabaris 5-15 part, Azuritum 15-25 part, coal 10-40 part, salt alkali 15-25 part, Os Draconis 20-100 part, Anhydrite 10-30 part, Chalcanthitum 10-20 part, Melanteritum 15-30 part, succinum 20-40 part.
2, medicine according to claim 1 is characterized in that the weight portion of above-mentioned raw materials medicine is preferably:
150 parts of Maifanitums, 20 parts of Ophicalcitums, 20 parts of Terra Flava Ustas, 20 parts of Lapis Chloriti, 20 parts of Mirabilitum crystallinas, 30 parts of Stalactitums, 15 parts of Halloysitum Rubrums, 30 parts of Limonitum, 15 parts on Muscovitum, 30 parts of Dens Draconiss, 25 parts in Gypsum Fibrosum, 6 parts in Cinnabaris, 15 parts of Azuritum, 15 parts of coals, 20 parts of salt alkali, 50 parts of Os Draconis, 15 parts of Anhydrites, 10 parts in Chalcanthitum, 15 parts of Melanteritum, 30 parts of succinums.
3,, it is characterized in that this method comprises the following steps: according to the preparation method of claim 1 or 2 medicines
A) with Maifanitum, Ophicalcitum, excellent imperial liver, Lapis Chloriti, Mirabilitum crystallina, Stalactitum, Halloysitum Rubrum, Limonitum, Muscovitum, Dens Draconis, Gypsum Fibrosum, Cinnabaris, Azuritum, coal, salt alkali, Os Draconis, Anhydrite, Chalcanthitum, Melanteritum, succinum decontamination;
B) it is standby to take by weighing the above-mentioned raw materials medicine according to weight proportion;
Each crude drug calcining that c) will take by weighing is ground into powder, mix homogeneously after the cooling;
D) mixing crude drug powder is added edible hydrochloric acid or edible (acetic acid) and the fermentation of probiotic bacteria kind;
E) medicinal liquid that will ferment boils after-filtration, has made the active constituent of medicine of the present invention.
4,, it is characterized in that its active constituent is made solid preparation and liquid preparation according to GMP production management standard according to the preparation method of the described medicine of claim 3.
5, according to the preparation method of the described medicine of claim 4, wherein solid preparation comprises tablet, granule, capsule, buccal tablet.
6, according to the preparation method of the described medicine of claim 4, wherein liquid preparation comprises oral liquid, oral administration syrup, injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100509106A CN100486592C (en) | 2006-01-11 | 2006-01-11 | Medicine for treatment of cardio-cerebral blood vessel diseases and diabetes, and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100509106A CN100486592C (en) | 2006-01-11 | 2006-01-11 | Medicine for treatment of cardio-cerebral blood vessel diseases and diabetes, and its preparation method |
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| CN1833658A true CN1833658A (en) | 2006-09-20 |
| CN100486592C CN100486592C (en) | 2009-05-13 |
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| CNB2006100509106A Expired - Fee Related CN100486592C (en) | 2006-01-11 | 2006-01-11 | Medicine for treatment of cardio-cerebral blood vessel diseases and diabetes, and its preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530424B (en) * | 2008-03-13 | 2011-07-06 | 陆立林 | Preparation of palaeo-oceanographical organism medical stone with muscle-penetrating applying treatment for health preservation, rehabilitation and health care |
| CN104223090A (en) * | 2014-10-14 | 2014-12-24 | 史春艳 | Medicated food preparation for treating diabetes and preparation method thereof |
| CN106747388A (en) * | 2016-11-28 | 2017-05-31 | 广州孟阳辉健康管理有限公司 | A kind of mineral Chinese medicine material compositions for preparing tea set |
| CN110279711A (en) * | 2019-07-29 | 2019-09-27 | 深圳市砾石新配方科技发展有限公司 | A kind of more effect remedies formulas |
| CN110559315A (en) * | 2019-09-24 | 2019-12-13 | 深圳紫石活水之源康世科技有限公司 | Formula of medicinal stone for promoting blood circulation and benefiting spirit |
-
2006
- 2006-01-11 CN CNB2006100509106A patent/CN100486592C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530424B (en) * | 2008-03-13 | 2011-07-06 | 陆立林 | Preparation of palaeo-oceanographical organism medical stone with muscle-penetrating applying treatment for health preservation, rehabilitation and health care |
| CN104223090A (en) * | 2014-10-14 | 2014-12-24 | 史春艳 | Medicated food preparation for treating diabetes and preparation method thereof |
| CN106747388A (en) * | 2016-11-28 | 2017-05-31 | 广州孟阳辉健康管理有限公司 | A kind of mineral Chinese medicine material compositions for preparing tea set |
| CN110279711A (en) * | 2019-07-29 | 2019-09-27 | 深圳市砾石新配方科技发展有限公司 | A kind of more effect remedies formulas |
| CN110559315A (en) * | 2019-09-24 | 2019-12-13 | 深圳紫石活水之源康世科技有限公司 | Formula of medicinal stone for promoting blood circulation and benefiting spirit |
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| Publication number | Publication date |
|---|---|
| CN100486592C (en) | 2009-05-13 |
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Granted publication date: 20090513 Termination date: 20120111 |