CN111000249A - Weight-losing and blood sugar-reducing compound plant polypeptide oral liquid and preparation method thereof - Google Patents

Weight-losing and blood sugar-reducing compound plant polypeptide oral liquid and preparation method thereof Download PDF

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Publication number
CN111000249A
CN111000249A CN201911197176.XA CN201911197176A CN111000249A CN 111000249 A CN111000249 A CN 111000249A CN 201911197176 A CN201911197176 A CN 201911197176A CN 111000249 A CN111000249 A CN 111000249A
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polypeptide
oral liquid
weight
compound plant
reducing
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许驰名
王忠长
朱海亮
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Nanjing Divio Pharmaceutical Technology Co ltd
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Nanjing Divio Pharmaceutical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention discloses a compound plant polypeptide oral liquid for losing weight and reducing blood sugar and a preparation method thereof; the raw materials comprise main materials, auxiliary materials and purified water; every 100 milliliters of the compound plant polypeptide oral liquid comprises 1 to 10 grams of quinoa polypeptide, 0.1 to 0.5 gram of bitter gourd polypeptide, 1 to 5 grams of micromolecule soybean polypeptide and auxiliary materials, wherein the auxiliary materials mainly comprise: the health-care food is obtained by dissolving 0.5-1 g of polygonatum sibiricum extract, 0.1-0.2 g of momordica grosvenori extract and 1-5 g of L-arabinose in water.

Description

Weight-losing and blood sugar-reducing compound plant polypeptide oral liquid and preparation method thereof
Technical Field
The invention relates to a compound plant polypeptide oral liquid for losing weight and reducing blood sugar and a preparation method thereof.
Background
In recent years, diabetes has become one of 3 chronic non-infectious diseases threatening human health worldwide. The fifth edition of the international diabetes union states that diabetes has become a major killer of current threats to human health. The research in 2002 finds that the prevalence rate of urban diabetes in China is about 4.5 percent; a survey of diabetes mellitus for more than 9 million people aged 18 years in 31 province and city in 2010 shows that the rate of diabetic patients is as high as 9.65%. Along with the improvement of living standard, the increase of nutrient intake and the acceleration of working rhythm of people, the prevalence rate of diabetes rises year by year, and the development trend is not optimistic.
Disclosure of Invention
Aiming at the defects of the prior art, the invention solves the problems that: provides a weight-losing and sugar-reducing compound plant polypeptide oral liquid with the functions of small intestine digestion and absorption, auxiliary regulation of blood fat, blood sugar and blood pressure, fatigue relief, liver protection and organism immunity improvement and a preparation method thereof.
In order to solve the problems, the technical scheme adopted by the invention is as follows:
a compound plant polypeptide oral liquid for reducing weight and lowering blood sugar is prepared from main material, adjuvant and purified water; every 100 milliliters of the compound plant polypeptide oral liquid comprises 1 to 10 grams of quinoa polypeptide, 0.1 to 0.5 gram of bitter gourd polypeptide, 1 to 5 grams of micromolecule soybean polypeptide and auxiliary materials, wherein the auxiliary materials mainly comprise: 0.5-1 g of polygonatum extract, 0.1-0.2 g of momordica grosvenori extract and 1-5 g of L-arabinose.
Furthermore, the main materials of the compound plant polypeptide oral liquid per 100 ml comprise 8 g of quinoa polypeptide, 0.2g of balsam pear polypeptide and 2g of micromolecular soybean polypeptide.
Furthermore, the auxiliary materials in each 100 ml of the compound plant polypeptide oral liquid comprise 1g of rhizoma polygonati extract, 0.15 g of fructus momordicae extract and 3.5g of L-arabinose.
Furthermore, the quinoa polypeptide, the momordica charantia polypeptide and the small molecular soybean polypeptide are small molecular peptides with the molecular weight of below 2000.
Furthermore, the molecular weight of the small-molecular soybean polypeptide is 180-2000.
Furthermore, the molecular weight of the small-molecular soybean polypeptide is 180-1000.
Furthermore, the molecular weight of the small-molecular soybean polypeptide is 250-1000.
A preparation method of a compound plant polypeptide oral liquid for losing weight and reducing blood sugar comprises the following steps:
s1, mixing the main materials according to the mixture ratio of the components, and then adding purified water to dissolve;
s2, adding auxiliary materials into the main materials dissolved in the step S1 for dissolving;
s3, performing damp-heat sterilization on the solution of the main material and the auxiliary material in the step S2 to obtain the compound plant polypeptide oral liquid.
The invention has the advantages of
1. Compared with the prior art, the invention takes a plurality of plant active polypeptides as nitrogen sources, is easy to be absorbed in the small intestine, is beneficial to the quick and efficient utilization of the organism, can effectively improve the negative nitrogen balance of the organism, and the food-borne polypeptides can improve the structure and the function of epithelial cells of the intestinal mucosa and improve the absorption capacity of the intestinal mucosa.
2. The compound plant polypeptide oral liquid is rich in various amino acids and polypeptides, has high bioavailability, is easy to be absorbed by human bodies, and can effectively improve the health states of patients with obesity, hyperglycemia, hyperlipidemia and the like; is helpful for regulating sub-health state of organism, such as improving sleep, coordinating intestine and stomach, regulating immunity, enhancing resistance, etc.; the health-care food can promote muscle recovery and protein synthesis after operation, improve protein balance, accelerate postoperative rehabilitation, increase glycogen synthesis and other effects, can be used as a formula food with special medical application for sub-health people, operation patients, tumor patients and the like, meets the special nutritional requirements of the patients, improves the nutritional status of the patients, promotes the overall health level of the patients, and provides a good basis for the treatment and recovery of diseases.
Detailed Description
The present invention will be described in further detail below.
Example 1
Weighing 8 g of quinoa polypeptide, 0.2g of bitter gourd polypeptide and 2g of micromolecular soybean polypeptide respectively, mixing uniformly, adding purified water for dissolving, adding 1g of rhizoma polygonati extract, 0.15 g of fructus momordicae extract and 3.5g of L-arabinose for preparing 100 mL solution, subpackaging, and carrying out moist heat sterilization to obtain the compound plant polypeptide oral liquid.
Example 2
Weighing 4 g of quinoa polypeptide, 0.2g of bitter gourd polypeptide and 0.5g of micromolecular soybean polypeptide respectively, mixing uniformly, adding purified water for dissolving, adding 1g of rhizoma polygonati extract, 0.15 g of fructus momordicae extract and 0.5g of L-arabinose for preparing 100 mL solution, subpackaging, and carrying out damp-heat sterilization to obtain the compound plant polypeptide oral liquid.
Example 3
Weighing 1g of quinoa polypeptide, 0.1 g of bitter gourd polypeptide and 2g of micromolecular soybean polypeptide respectively, mixing uniformly, adding purified water for dissolving, adding 1g of rhizoma polygonati extract, 0.15 g of fructus momordicae extract and 0.5g of L-arabinose for preparing 100 mL solution, subpackaging, and carrying out moist heat sterilization to obtain the compound plant polypeptide oral liquid.
Example 4
Weighing 1g of quinoa polypeptide, 0.05 g of bitter gourd polypeptide and 0.5g of micromolecular soybean polypeptide respectively, mixing uniformly, adding purified water for dissolving, adding 1g of rhizoma polygonati extract, 0.15 g of fructus momordicae extract and 0.5g of L-arabinose for preparing 100 mL solution, subpackaging, and carrying out damp-heat sterilization to obtain the compound plant polypeptide oral liquid.
Comparative example 1
The procedure is as in example 1 except that quinoa polypeptide is not contained.
Comparative example 2
The same procedure as in example 1 was followed, except that Momordica charantia polypeptide was not included.
Comparative example 3
The procedure is as in example 1 except that the soybean polypeptide is not included.
Comparative example 4
The same procedure as in example 1 was repeated, except that quinoa polypeptide, momordica charantia polypeptide and small soybean polypeptide were not included.
Experimental example 1 Effect of different compositions on weight loss
The invention observes 50 obese cases, the effective rate is 95 percent, wherein: over a month, 91% of these were lost, accounting for 5-7 kg. The weight-losing effect of the invention is remarkable, no toxic or side effect exists during taking, the invention proves that the invention can be taken for a long time, the satiety after taking is generally reflected during taking is good, the fat and protein metabolism in the body is adjusted and consumed, the toxin is rapidly decomposed to be discharged, the toxin expelling and beautifying effects are achieved, meanwhile, the nutrition supplement is comprehensive, the invention adopts a unique formula and an advanced technology, the taking is convenient, the absorption is rapid, and the rebound is avoided after the weight-losing.
The clinical curative effect is summarized as follows:
1. case selection
The invention takes the cases of severe obesity, moderate obesity and mild obesity as the selection standard: according to the calculation method recommended by the world health organization, the standard weight of a male is calculated by multiplying 70 percent by cm-80, the standard weight of a female is calculated by multiplying 60 percent by cm-70, the plus or minus 10 percent of the standard weight is the normal weight, the plus or minus 10 to 20 percent of the standard weight is overweight or underweight, and the plus or minus 20 percent of the standard weight is obese or underweight. By taking the weight as the standard, selecting the mild obesity when the weight exceeds the standard weight by 20-30%, the moderate obesity when the weight exceeds the standard weight by 30-40%, and the severe obesity when the weight exceeds the standard weight by more than 40%. A total of 60 observations were made for mildly 20, moderately obese 20, and severely obese 20.
2. Determination of therapeutic effect
The effect is shown: the body weight is reduced by more than 5 kg per month.
The method has the following advantages: the body weight is reduced by 1-4.9 kg per month.
And (4) invalidation: body weight was not reduced.
3. Method of treatment
The method is suitable for people: people with excessive weight due to unbalanced nutrition.
The taking method comprises the following steps: 50ml is taken 30 minutes before three meals each day. The dosage of the composition is doubled for patients with overweight standard weight above 40%.
Note that: reduced appetite is a normal phenomenon during administration; after the product is taken, warm and plain boiled water or mineral water is needed to be drunk more because the excessive fat in the body is consumed and toxin is decomposed.
4. Clinical results
Table 1 shows the effect of different compositions on weight loss.
Figure DEST_PATH_IMAGE002
TABLE 1
As can be seen from the above table, the weight-reducing effect of example 1 is the best, and the blood sugar-reducing effect of example 4 is relatively poor due to the low content of quinoa polypeptide, momordica charantia polypeptide and small-molecule soybean polypeptide. The quinoa polypeptide, the momordica charantia peptide and the small molecular soybean polypeptide are respectively lacked in the comparative example 1, the comparative example 2 and the comparative example 3, the weight-losing effect is obviously reduced, and the curative effect is also obviously reduced after the three plant polypeptides are removed in the comparative example 4. Therefore, the weight-reducing plant polypeptide composition provided by the invention has a remarkable weight-reducing effect, and all components play a role in a synergistic manner, so that a good weight-reducing curative effect is realized.
Experimental example 2 hypoglycemic Activity of different polypeptide compositions
2.1 test specimens
Examples 1 to 4, comparative examples 1 to 4.
2.2 Experimental animals
Healthy SD mice (clean grade), male and female halves, body weight (25g-40 g).
2.3 establishment and grouping of diabetic mouse models
Taking 150 mice, each half of the mice is male and female, randomly selecting 10 mice as a blank control group, feeding the rest mice with high-sugar and high-fat feed for one week, injecting a freshly prepared alloxan solution 65mg/kg through tail veins, measuring fasting blood sugar of the mice fasted for 12 hours by using a blood sugar kit after the third day, selecting the mice with the blood sugar higher than 11mmol/l as experimental objects, randomly selecting qualified mice, dividing the mice into 9 groups, and setting a diabetes model group, wherein the groups are shown in examples 1 to 4 and the groups in comparative examples 1 to 4.
2.4 blood sugar lowering experiment method
The blank control group and the model group were gavaged with physiological saline of the same volume as the former, examples 1 to 4 and comparative examples 1 to 4 at a dose of 10mg/kg, respectively, and fasting blood glucose values were measured at weeks 2, 4 and 6, respectively, for 6 consecutive weeks.
2.5 statistical methods
Each index is expressed as x + -s, and the significant difference between means is measured by t-test.
2.6 analysis of hypoglycemic action of oral liquid
Table 2 effect of different compositions on blood glucose in mice.
Figure DEST_PATH_IMAGE004
TABLE 2
Note: the representation of different letters in each column has significant difference (P < 0.05).
As can be seen from the above table, the blood sugar of the mice in the blank group does not change significantly after gastric lavage, and the blood sugar of the model group is significantly different from that of the blank control group (P < 0.05), which indicates that the model is successfully established, and the blood sugar of each group in examples 1-4 and comparative examples 1-4 is significantly different from that of the model group (P < 0.05), wherein the blood sugar reducing effect of example 1 is the best, and the blood sugar reducing effect of example 4 is relatively poor due to the low content of quinoa polypeptide, momordica charantia polypeptide and small-molecule soybean polypeptide. The quinoa polypeptide, the momordica charantia peptide and the small molecular soybean polypeptide are respectively absent in the comparative example 1, the comparative example 2 and the comparative example 3, the blood sugar reducing effect is obviously reduced, and the curative effect is also obviously reduced after the three plant polypeptides are removed in the comparative example 4. Therefore, the hypoglycemic drug composition provided by the invention has a remarkable hypoglycemic effect, and all components play a synergistic role, so that a good hypoglycemic curative effect is realized.
The quinoa polypeptide has a plurality of biological effects beneficial to health, can reduce low-density lipoprotein of triglyceride, promote cholesterol excretion, prevent and treat diabetes, and is beneficial to reducing the occurrence of vascular complications of diabetes; can relax bowels and guide excretion, and is helpful for patients with habitual constipation. The balsam pear polypeptide is a bioactive substance extracted from balsam pear, has obvious hypoglycemic effect, and is a natural health product. Indian scientists found that polypeptide-P in Momordica charantia has a stronger action than the hypoglycemic drug Shenfonylurea, and reported by Indian doctor Hanna, a polypeptide drug extracted from Momordica charantia was used for treating diabetes, and was as effective as insulin. The soybean polypeptide contains peptide segments such as antihypertensive peptide, cholesterol-lowering peptide, antitumor peptide, CPPS and the like, so that the soybean polypeptide can be used in the pharmaceutical industry to produce medicines with corresponding effects, such as antihypertensive drug, powerful calcium supplement, tumor inhibitor and the like which can treat both symptoms and root causes. However, in the pharmaceutical industry, the soybean peptide mixture obtained by the enzymatic hydrolysis or microbial decomposition method must be separated and purified to achieve the desired effect at a smaller dosage, and although the processing cost is increased, the additional value of the drug is also greatly increased. The vegetable protein peptide not only can rapidly provide protein nutrition, but also can improve the digestion and absorption functions of the small intestine, assist in regulating blood fat, blood sugar and blood pressure, relieve fatigue, protect the liver, improve the immunity of the organism and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (8)

1. The compound plant polypeptide oral liquid for losing weight and reducing blood sugar is characterized in that the raw materials comprise main materials, auxiliary materials and purified water; every 100 milliliters of the compound plant polypeptide oral liquid comprises 1 to 10 grams of quinoa polypeptide, 0.1 to 0.5 gram of bitter gourd polypeptide, 1 to 5 grams of micromolecule soybean polypeptide and auxiliary materials, wherein the auxiliary materials mainly comprise: 0.5-1 g of polygonatum extract, 0.1-0.2 g of momordica grosvenori extract and 1-5 g of L-arabinose.
2. The oral liquid of claim 1, wherein the main ingredients of each 100 ml of the oral liquid comprise quinoa polypeptide 8 g, Momordica charantia polypeptide 0.2g, and small-molecule soybean polypeptide 2 g.
3. The weight-reducing and sugar-reducing compound plant polypeptide oral liquid as claimed in claim 1, wherein the auxiliary materials in each 100 ml of the compound plant polypeptide oral liquid comprise 1g of rhizoma polygonati extract, 0.15 g of fructus momordicae extract and 3.5g of L-arabinose.
4. The weight-reducing and sugar-reducing compound plant polypeptide oral liquid as claimed in claim 1, wherein the small molecular soybean polypeptide is a small molecular peptide with a molecular weight below 2000.
5. The weight-reducing and sugar-reducing compound plant polypeptide oral liquid as claimed in claim 4, wherein the molecular weight of the small molecular soybean polypeptide is 180-2000.
6. The weight-reducing and sugar-reducing compound plant polypeptide oral liquid as claimed in claim 4, wherein the molecular weight of the small molecular soybean polypeptide is 180-1000.
7. The weight-reducing and sugar-reducing compound plant polypeptide oral liquid as claimed in claim 4, wherein the molecular weight of the small molecular soybean polypeptide is 250-1000.
8. The preparation method of the weight-losing and sugar-reducing compound plant polypeptide oral liquid according to any one of claims 1 to 7 is characterized by comprising the following steps:
s1, mixing the main materials according to the mixture ratio of the components, and then adding purified water to dissolve;
s2, adding auxiliary materials into the main materials dissolved in the step S1 for dissolving;
s3, performing damp-heat sterilization on the solution of the main material and the auxiliary material in the step S2 to obtain the compound plant polypeptide oral liquid.
CN201911197176.XA 2019-11-29 2019-11-29 Weight-losing and blood sugar-reducing compound plant polypeptide oral liquid and preparation method thereof Pending CN111000249A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106912960A (en) * 2017-03-06 2017-07-04 青岛海大华旗生物科技有限公司 A kind of hypoglycemia healthcare food and preparation method thereof
CN107183696A (en) * 2017-07-19 2017-09-22 北京加康生物技术有限公司 A kind of health food and preparation method thereof
CN108721628A (en) * 2018-07-05 2018-11-02 河北东方韵健康管理股份有限公司 A kind of formula and its preparation process of the complex peptides that can treat fatty liver
CN109234344A (en) * 2018-10-30 2019-01-18 吉林农业大学 A kind of quinoa peptide and its preparation method and application
CN109757734A (en) * 2019-03-01 2019-05-17 上海傅克化学科技有限公司 A kind of polypeptide oral liquor and preparation method thereof
CN109770368A (en) * 2019-04-02 2019-05-21 新疆正生营养研究院(有限公司) A kind of more taste plant polypeptide weight losing meal-replacing powders and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106912960A (en) * 2017-03-06 2017-07-04 青岛海大华旗生物科技有限公司 A kind of hypoglycemia healthcare food and preparation method thereof
CN107183696A (en) * 2017-07-19 2017-09-22 北京加康生物技术有限公司 A kind of health food and preparation method thereof
CN108721628A (en) * 2018-07-05 2018-11-02 河北东方韵健康管理股份有限公司 A kind of formula and its preparation process of the complex peptides that can treat fatty liver
CN109234344A (en) * 2018-10-30 2019-01-18 吉林农业大学 A kind of quinoa peptide and its preparation method and application
CN109757734A (en) * 2019-03-01 2019-05-17 上海傅克化学科技有限公司 A kind of polypeptide oral liquor and preparation method thereof
CN109770368A (en) * 2019-04-02 2019-05-21 新疆正生营养研究院(有限公司) A kind of more taste plant polypeptide weight losing meal-replacing powders and preparation method thereof

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Application publication date: 20200414