CN1820750A - Amoxycillin preparation suitable for child administration and its preparing method - Google Patents
Amoxycillin preparation suitable for child administration and its preparing method Download PDFInfo
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- CN1820750A CN1820750A CN 200610200266 CN200610200266A CN1820750A CN 1820750 A CN1820750 A CN 1820750A CN 200610200266 CN200610200266 CN 200610200266 CN 200610200266 A CN200610200266 A CN 200610200266A CN 1820750 A CN1820750 A CN 1820750A
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Abstract
The present invention relates to a kind of Amoxycillin preparation suitable for children to take and its preparation process. The Amoxycillin preparation has less bitter and is suitable for children to take. It has simple production process, convenient taking, fast acting and high bioavailability.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation, particularly relate to the Wymox its preparation method that is fit to child administration.
Background technology
The amoxicillin has another name called amoxicillin, amoxicillin, woods again, the amoxicillin is a Penicillin antibiotics, to Streptococcus such as streptococcus pneumoniae, Hemolytic streptococcuss, do not produce aerobic gram positive coccus such as penicillinase staphylococcus, enterococcus faecalis, aerobic gram-negative bacterias such as escherichia coli, proteus mirabilis, Salmonella, hemophilus influenza, Diplococcus gonorrhoeae do not produce the beta lactamase bacterial strain and helicobacter pylori has good antibacterial activity.Bacteria cell wall is synthetic brings into play bactericidal action by suppressing in the amoxicillin, can make antibacterial become spheroid rapidly and dissolves, breaks.Be mainly used in respiratory tract infection (as bronchitis, pneumonia), typhoid fever, urinary tract infection, skin soft-tissue infection and biliary tract infection etc. due to the sensitive organism clinically.The pathogen that causes children respiratory, urinary tract infection is had the height antibacterial activity, and curative effect is stronger than penicillin, is the medicine commonly used of childrens respiratory tract infection etc.At present, Wymox has dosage forms such as tablet, capsule, granule on the domestic market.The deficiency of existing preparation is:
1, the children's dress pharmaceutical quantities waits to determine according to body weight, age usually.The specification of existing Wymox has two kinds (0.125g, 0.25g), is difficult to satisfy all kinds of children's needs on specification.Old family's length often needs that a slice tablet, a capsules or a bag granule are divided into two parts, three parts and does not wait, and takes to child again.And the process of above-mentioned divided dose is generally weighed in the hand and is carried out by range estimation, hands, and divided dose is difficult to accurately.
2, amoxicillin sheet, capsule need water to swallow, and granule also need be used mixing in water for oral taking, and is very inconvenient to swallowing inconvenient patient, especially children's.
3, amoxicillin sheet, capsule, when granule is taken, need use water delivery service, so in no drinking water supply and the inconvenient occasion of the drinking water certain difficulty of having taken medicine.
4, above-mentioned conventional formulation does not fully take into account the characteristics of children, fails to solve child's difficulty of taking medicine, and is afraid of a difficult problem of taking medicine, and taking medicine needs the adult to advise repeatedly often, and drug compliance is poor.
Child patient is hated the very difficult clinical application that cooperates to detesting of medicine, use suitable correctives, coloring agent etc. and can cover and correct the cacogeusia of medicine and the outward appearance of beautifying medicament to a certain extent, make patient, particularly the child is glad takes, this guarantees that to alleviating patient's misery treatment normally is very significant.Sugar pill is a kind of dosage form that liked by patient (especially child), has many advantages:
1, medicine mostly is bitterness, liking sweet is child's nature, the sugar pill taste is fragrant and sweet, and shape such as confection have fully taken into account the characteristics of children, the child is easy to accept, do not have psychology and fear sense, pleased cooperation is taken, and can well solve the medicine bitter in the mouth, the child fears and dislikes taking medicine the difficult problem of taking medicine and needing the adult to advise repeatedly often.
2, specification can be determined according to the dosage that the child takes medicine, and takes corresponding grain number according to child's situation when taking medicine and gets final product, so tool is accurate with taking dose, the advantage that the head of a family is convenient to grasp can well solve the inaccurate difficult problem of divided dose that occurs when the child takes medicine.
3, sugar pill take various informative, can buccal, chew clothes, be different from conventional tablet, capsule, granule, need water to swallow or take after mixing it with water, under anhydrous situation, just can cause the difficulty of taking medicine.In addition, swallow inconvenient patient and also can take sugar pill easily, children's is particularly suitable.
4, sugar pill is chewed in mouth or buccal, and no conventional tablet, the required disintegrating procedue of capsule have rapid-action, bioavailability advantages of higher.
Summary of the invention
The objective of the invention is to overcome deficiencies such as the inconvenience of swallowing, drug compliance that amoxicillin sheet in the prior art, capsule exist are poor, divided dose is inaccurate, and the need that exist of amoxicillin granules are with mixing in water for oral taking, deficiency such as divided dose is inaccurate, supplementary product consumption is big, provide a kind of taste fragrant and sweet, the child is willing to take, drug compliance is good, divided dose is accurate, and onset is rapid, amoxicillin sugar pill that bioavailability is high and preparation method thereof.To enrich this medicine kind, give full play to the unique advantage of this dosage form of sugar pill.
The technical solution used in the present invention is:
A kind of amoxicillin sugar pill is made up of active constituents of medicine amoxicillin and adjuvant, and wherein the weight ratio of amoxicillin and adjuvant is: amoxicillin 25-250 weight portion, adjuvant 25-2000 weight portion.
Described adjuvant comprises filler, correctives, binding agent and wetting agent, disintegrating agent, lubricant, food coloring etc., can select wherein one or more for use.
Described amoxicillin sugar pill can be composed of the following components: amoxicillin 25-250 weight portion, filler 25-2000 weight portion, correctives 0-100 weight portion, binding agent 0-100 weight portion, disintegrating agent 0-100 weight portion, lubricant 0-100 weight portion, food coloring 0-100 weight portion.
Icing Sugar is one of traditional sugar pill adjuvant commonly used, is used as filler, and the effect of flavoring is arranged.As the adjuvant Icing Sugar commonly used of the tradition in the sugar pill is replaced with sorbitol, xylitol, maltol, lactose, lactose or other suitable adjuvant, then can be made into a kind of sugar pill of no cane sugar type, the patient who is fit to very much diabetics, adiposis patient, the child that dental caries is arranged or other inedibility sugar takes.
Described filler can be selected sucrose, lactose, glucose, maltose, dextrin, maltodextrin, magnesium oxide, mannitol, xylitol, sorbitol, maltol, lactose, microcrystalline Cellulose, erithritol, starch, amylum pregelatinisatum, pregelatinized Starch, microcrystalline Cellulose or other suitable filler for use.Can select wherein one or more for use.Wherein preferably sucrose, lactose, mannitol, sorbitol, xylitol.
Described correctives is used for correcting the poor taste that principal agent or adjuvant bring, and makes made sugar pill have pleasant taste, and described correctives comprises sweeting agent, flavoring agent, effervescent, regulating acid agent, enclose material etc.Add an amount of sweeting agent, flavoring agent can make the sugar pill that makes have suitable fragrant and sweet flavor; Add an amount of effervescent, can make the sugar pill that makes have much local flavor and be imbued with temperament and interest; Add an amount of regulating acid agent, can increase tasty and refreshing sensation; Enclose is carried out with suitable enclose material in the amoxicillin, and prepared clathrate refabrication becomes sugar pill, can reduce the bitterness of amoxicillin, and can increase the stability of principal agent.
Sweeting agent can be selected cyclamate, aspartame, glycyrrhizin, saccharin sodium (calcium), steviosin, protein sugar, cyclohexane sulfamic acid (sodium) or other suitable sweeting agent for use, can select wherein one or more for use, wherein preferred aspartame, steviosin, cyclamate; Aromatic can be selected vanillin, Mentholum, various essence, Cortex Cinnamomi and various fruity material for use, preferred vanillin, Herba Menthae essence, fruity flavor; Effervescent can be selected citric acid, lactic acid, tartaric acid, fumaric acid, malic acid, water-soluble amino acid, acid salt (citric acid potassium dihydrogen, potassium hydrogen tartrate, fumaric acid sodium etc.) or other suitable acid source for use, can select sodium carbonate, sodium bicarbonate, potassium bicarbonate, sodium glycine carbonate or other suitable alkali source for use, can select wherein one or more for use, acid source preferably citric acid, tartaric acid, the preferred sodium bicarbonate of alkali source; The acid agent can be selected acid used in the effervescent acid source, vitamin C or other suitable regulating acid agent, wherein preferably citric acid, vitamin C for use; Described enclose material can be selected the cyclodextrin or derivatives thereof for use, can select for use beta-schardinger dextrin-, HP-, hydroxyethyl-, methyl-beta-schardinger dextrin-, iodic acid group-beta-cyclodextrin etc. as the enclose material, preferred beta-schardinger dextrin-, HP-.The weight ratio of amoxicillin and cyclodextrin or derivatives thereof is: 1: any ratio in the 1-30 scope.
Described binding agent, wetting agent can be selected water, Different concentrations of alcohol, cellulose derivative, polyvinylpyrrolidone, Polyethylene Glycol, gelatin, xanthan gum, syrup, starch slurry or other suitable binding agent for use, can select wherein one or more for use.Wherein preferred alcohol, hydroxypropyl emthylcellulose, polyvinylpyrrolidone.
Described disintegrating agent can be selected low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, microcrystalline Cellulose, gas-producing disintegrant or other suitable disintegrating agent for use.Can select wherein one or more for use.Wherein preferred low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium.
Described lubricant is used for increasing the flowability of medicine, reduce the frictional force between medicine and the punch die, can select micropowder silica gel, magnesium trisilicate, Pulvis Talci, Polyethylene Glycol, sodium laurylsulfate, magnesium stearate, stearic acid, gel aluminum hydroxide or other suitable lubricant for use.Can select wherein one or more for use.Wherein preferred micropowder silica gel, magnesium stearate.
In order to make the outward appearance of sugar pill more beautiful, can add an amount of food coloring, as coloring agent, be used for improving the outward appearance of this preparation.Can adopt natural colorant or synthetic food color.
Methods such as described amoxicillin sugar pill can adopt general method for making, pressing, moulds method for making, hard sugar method for making prepare.Above-mentioned pressing, mould method for making, the hard sugar method for making is the improvement of the present invention to traditional sugar pill method for making.
Existing sugar pill method for making can be called general method for making; be that sugar grain or basic ball with suitable size is core; as the dusting material, select suitable adhesive or wetting agent pill with the mixture of Icing Sugar and other adjuvants for use, and principal agent is wrapped in the sugar pill with suitable method gradation and makes.Weak points such as there is complex procedures in this method, and the amount of labour is big, and the production cycle is long, and the production environment dust from flying is unfavorable for that labor protection, medicament contg instability, drug exposure time outside are long, easily pollutes, and yield rate is low.
Described pressing is meant the amoxicillin sugar pill in forming process, and the moulding process of reference for modern tablet adopts pellet press, and amoxicillin and adjuvant are pressed into sugar pill.This method can overcome the deficiency of general method for making, and technology is simple, is suitable for suitability for industrialized production, is beneficial to labour protection, and it is accurate that yield rate height, prepared product have dosage, good stability, plurality of advantages such as the molten diffusing time is short.Repress is made ball method or other suitable method after can adopting direct powder to be pressed into ball method, granulation.Granulation can be adopted wet granulation, dry granulation, one-step palletizing or other method of granulating.Described pellet press can be special pellet press, and also can adopting more by common tablet machine, method transformation such as mold exchange forms.
The described method for making of moulding is meant the amoxicillin sugar pill in forming process, earlier with amoxicillin and auxiliary materials and mixing, makes plasticity ball piece, and divided dose is made the method for sugar pill again.
Described hard sugar method for making is meant the amoxicillin sugar pill in forming process, adopts the preparation technology of hard sugar, through molten sugar, stir off into the cooling of cream, massecuite appropriateness after, add amoxicillin and other adjuvant, stir evenly, make candy batch, make sugar pill again, or adopt the moulding method of forming to make the method for sugar pill.Sugar cook can be adopted methods such as normal pressure sugar cook, continous vacuum sugar cook and the sugar cook of continous vacuum thin film, preferred continous vacuum thin film sugar cook method.
Preferred pressing in the above-mentioned sugar pill preparation method.Preferred granulation pelleting method in the pressing.
But prepared sugar pill coating is coating not also.Prepared sugar pill can be common spherical pellet, also can be other shape except that sphere, as ellipse, pagoda shape, cylindrical, key shape, circle/special-shaped lamellar etc.Be shaped as circle or the flaky sugar-tablet that also can be described as of abnormity.
Above-mentioned preparation contains pressing that the medicine sugar pill adopted, moulds method for making, hard sugar method for making, is not only applicable to amoxicillin provided by the present invention sugar pill, is applicable to also that simultaneously other contain the medicine sugar pill.
Described amoxicillin sugar pill more preferably component is made (is example to make 1000 balls) according to following prescription:
Amoxicillin 25-250g
Icing Sugar 150-1000g
Mannitol 7-700g
Aspartame 0.1-5g
Powder essence 0.1-5g
Magnesium stearate 0.1-5g
Food coloring 0.1-5g
The heavy 0.1-2.0g of every ball.
Preferred prescription is (is example to make 1000 balls) in the sugar pill proportioning of above-mentioned amoxicillin:
Amoxicillin 50g
Icing Sugar 120g
Mannitol 75g
Aspartame 1g
Powder essence 2g
Magnesium stearate 1g
Food coloring 1g
Above-mentioned amoxicillin sugar pill is characterized in that, can be made by following method:
Auxiliary materials and mixing during method 1:a. gets the amoxicillin and writes out a prescription; B. direct pelleting.
Method 2:a. gets amoxicillin, filler, sweeting agent mixing, granulates drying; B. add lubricant, mixing, pelleting.
Method 3.a. gets amoxicillin, sweeting agent, partially filled dose of mixing, granulates drying; B. with remaining filler, lubricant mixing, pelleting.
Above-mentioned method for making as having added food coloring in the prescription, then can add in step a; As having added flavoring agent such as powder essence in the prescription, add flavoring agent when then can before pelleting, add lubricant.
Prepared tablet can coating also coating not.
The beneficial effect of amoxicillin of the present invention sugar pill and preparation method thereof is mainly reflected in:
1, the amoxicillin sugar pill taste of making is fragrant and sweet, and shape such as confection have fully taken into account the characteristics of children, the child is easy to accept, and does not have psychology and fears sense, and pleased cooperation is taken, can well solve the medicine bitter in the mouth, the child fears and dislikes taking medicine the difficult problem of taking medicine and needing the adult to advise repeatedly often.
2, can well solve the inaccurate problem of divided dose that occurs when the child takes medicine.Medicining condition according to the child when amoxicillin sugar pill prepares is determined every granule amount, takes corresponding grain number according to child's situation when taking medicine and gets final product, so tool is accurate with taking dose, and the advantage that the head of a family is convenient to grasp.
3, the amoxicillin sugar pill take various informative, can buccal, chew clothes, be different from conventional tablet, capsule, granule, need water to swallow or take after mixing it with water, under anhydrous situation, just can cause the difficulty of taking medicine.In addition, swallow inconvenient patient and also can take the amoxicillin sugar pill easily, children's is particularly suitable.
4, the amoxicillin sugar pill is chewed in mouth or buccal, and no conventional tablet, the required disintegrating procedue of capsule have rapid-action, bioavailability advantages of higher.
5, the amoxicillin sugar pill that is provided can enrich the amoxicillin medicine variety, satisfies patient's demand.
The preparation method of the amoxicillin sugar pill that 6, is provided, technology is simple, is beneficial to labour protection, the yield rate height, cost is low, is suitable for suitability for industrialized production, prepared amoxicillin sugar pill medicament contg good uniformity, good stability.
The specific embodiment
Following embodiment is used to further specify the present invention, but does not limit the scope of the invention (is example to make 1000 balls) thus.
Embodiment 1
1, prescription
Amoxicillin 125g
Icing Sugar 200g
Mannitol 75g
Citric acid 3g
Vanillin 2g
The plain 1g of leaf green
Magnesium stearate 0.5g
2, method for making
Get amoxicillin, Icing Sugar, amylum pregelatinisatum, mannitol, citric acid, the plain mixing of leaf green, granulate with 5%PVP ethanol liquid, drying adds vanillin, magnesium stearate, and mixing is pressed into sugar pill, coating.
Amoxicillin and above-mentioned adjuvant are all crossed 120 mesh sieves.During mixing, after elder generation adopts the equivalent incremental method with the basic mixing of material, put into fully mixing of ball mill.Also can adopt 50% ethanol during granulation, exsiccant temperature is controlled at 40-60 ℃.The uniformity of dosage units of measuring obtained sugar pill is good.
Embodiment 2
1, prescription
Amoxicillin 50g
Icing Sugar 150g
Pregelatinized Starch 50g
Aspartame 1g
Micropowder silica gel 1g
Magnesium stearate 1g
Fructus Citri tangerinae essence 2g
2, method for making
Get amoxicillin, Icing Sugar, pregelatinized Starch, aspartame mixing, granulate with 4%PVP ethanol liquid, drying adds Fructus Citri tangerinae essence, micropowder silica gel, magnesium stearate, and mixing is pressed into sugar pill.
Amoxicillin and above-mentioned adjuvant are all crossed 120 mesh sieves.During mixing, after elder generation adopts the equivalent incremental method with the basic mixing of material, put into fully mixing of ball mill.Also can adopt 80% ethanol during granulation, exsiccant temperature is controlled at 40-60 ℃.The uniformity of dosage units of measuring obtained sugar pill is good.
Embodiment 3
1, prescription
Amoxicillin 50g
Icing Sugar 120g
Mannitol 75g
Aspartame 1g
Strawberry essence 2g
Magnesium stearate 1g
Monascorubin 1g
2, method for making
Get amoxicillin, Icing Sugar, mannitol, aspartame, monascorubin mixing, granulate with 4%PVP ethanol liquid, drying adds strawberry essence, magnesium stearate, and mixing is pressed into sugar pill.
Amoxicillin and above-mentioned adjuvant are all crossed 120 mesh sieves.During mixing, after elder generation adopts the equivalent incremental method with the basic mixing of material, put into fully mixing of ball mill.Also can adopt 80% ethanol during granulation, exsiccant temperature is controlled at 40-60 ℃.The uniformity of dosage units of measuring obtained sugar pill is good.
Embodiment 4
1, prescription
Amoxicillin 25g
Icing Sugar 100g
Lactose 250g
Aspartame 1g
Micropowder silica gel 1g
Magnesium stearate 1g
Cream flavour 2g
Vanillin 1g
2, method for making
Get amoxicillin and above-mentioned auxiliary materials and mixing, directly be pressed into sugar pill.
Amoxicillin and above-mentioned adjuvant are all crossed 100 mesh sieves.During mixing, after elder generation adopts the equivalent incremental method with the basic mixing of material, put into fully mixing of ball mill.The uniformity of dosage units of measuring obtained sugar pill is good.
Embodiment 5
1, prescription
Amoxicillin 25g
Sucrose 200g
Glucose 70g
Citric acid 3g
Honey peach essence 2g
2, method for making
Get sucrose and add suitable quantity of water, heating makes dissolves, and adds glucose, stirs evenly to make and dissolves, filter, filtrate sugar cook makes into massecuite, is cooled to 80 ℃, add amoxicillin, citric acid, honey peach essence, be in harmonious proportion and turn when the hard soft appropriateness of candy batch has good plasticity, carry out punch forming.
Embodiment 6
1, prescription
Amoxicillin 25g
Sucrose 200g
Glucose 70g
Citric acid 3g
Vanillin 1g
Chocolate essence 2g
2, method for making
Get amoxicillin and above-mentioned adjuvant, add 50% an amount of ethanol, make soft material, pill, 50 ℃ of dryings are made sugar pill.
Embodiment 7
1, prescription
Amoxicillin 250g
Icing Sugar 150g
Pregelatinized Starch 100g
Aspartame 2g
Fructus Citri tangerinae essence 2g
2, method for making
Being to be core to cross 20 purposes sugar grain, as the dusting material, is wetting agent general ball with 50% ethanol with amoxicillin, Icing Sugar, pregelatinized Starch, aspartame, Fructus Citri tangerinae essence mixture, and 50 ℃ of dryings are selected ball, promptly.The ball of obtained ball heavily is 0.5g.
Embodiment 8
1, prescription
Amoxicillin 50g
Lactose 200g
Amylum pregelatinisatum 50g
Aspartame 1g
Green apple essence 2g
Fructus Gardeniae blue pigment 1g
2, method for making
Get amoxicillin and above-mentioned auxiliary materials and mixing, directly be pressed into sugar pill, the bag film-coat.
Amoxicillin and above-mentioned adjuvant are all crossed 100 mesh sieves.During mixing, after elder generation adopts the equivalent incremental method with the basic mixing of material, put into fully mixing of ball mill.Measure the uniformity of dosage units of obtained sugar pill
Embodiment 9
1, prescription
Amoxicillin 50g
Beta-schardinger dextrin-100
Icing Sugar 120g
Mannitol 50g
Cyclamate 1g
Fructus Citri Limoniae essence 2g
Magnesium stearate 1g
2, method for making
Get beta-schardinger dextrin-, amoxicillin adding suitable quantity of water, ground 5 hours with colloid mill, cold preservation 48 hours filters, vacuum drying (40-60 ℃), the powder of gained and Icing Sugar, mannitol, cyclamate mixing are used the 5%PVP alcohol granulation, drying, add Fructus Citri Limoniae essence, magnesium stearate, mixing is pressed into sugar pill, the bag film-coat.
Claims (10)
1. an amoxicillin sugar pill is made up of active constituents of medicine amoxicillin and adjuvant, and wherein the weight ratio of amoxicillin and adjuvant is: amoxicillin 25-250 weight portion, adjuvant 25-2000 weight portion.
2. the described amoxicillin of claim 1 sugar pill is characterized in that, described adjuvant comprises filler, correctives, binding agent, wetting agent, disintegrating agent, lubricant, food coloring etc., can select wherein one or more for use.
3. the described amoxicillin of claim 1 sugar pill, it is characterized in that described amoxicillin sugar pill can be composed of the following components: amoxicillin 25-250 weight portion, filler 25-2000 weight portion, correctives 0-100 weight portion, binding agent 0-100 weight portion, disintegrating agent 0-100 weight portion, lubricant 0-100 weight portion, food coloring 0-100 weight portion.
4. the described adjuvant of claim 2 is characterized in that, described correctives comprises sweeting agent, flavoring agent, effervescent, regulating acid agent, enclose material etc.; Described enclose material can be selected the cyclodextrin or derivatives thereof for use, preferred beta-schardinger dextrin-, HP-.The weight ratio of amoxicillin and cyclodextrin or derivatives thereof is: 1: any ratio in the 1-30 scope.
5. the described amoxicillin of claim 1 sugar pill is characterized in that, the adjuvant Icing Sugar that traditional sugar pill is commonly used can use sorbitol, xylitol, maltol, lactose, lactose or other suitable adjuvant to replace, and makes a kind of sugar pill of no cane sugar type.
6. the preparation method of the described amoxicillin of claim 1 sugar pill is characterized in that, can adopt general method for making, pressing, moulds method for making, method such as hard sugar method for making prepares; Described pressing is meant amoxicillin and adjuvant are pressed into sugar pill, can adopt that direct powder is pressed into the ball method, the back repress of granulating is made ball method or other suitable method; The described method for making of moulding is meant earlier medicine and auxiliary materials and mixing is made plasticity ball piece that divided dose is made the method for sugar pill again; Described hard sugar method for making after being meant through molten sugar, stirring off into the cooling of cream, massecuite appropriateness, adds amoxicillin and other adjuvant, stirs evenly, and makes candy batch, make sugar pill again, or the employing moulding method of forming is made the method for sugar pill; But adopt also coating not of sugar pill coating that said method makes, can be common spherical pellet, also can be other shape except that sphere,, be shaped as the flaky sugar-tablet that also can be described as ellipse, pagoda shape, cylindrical, key shape, lamellar.
7. the preparation method of the described amoxicillin of claim 5 sugar pill is characterized in that, described pressing, mould method for making, the hard sugar method for making is not only applicable to amoxicillin provided by the present invention sugar pill, is applicable to also that simultaneously other contain the medicine sugar pill.
8. the described amoxicillin of claim 1 sugar pill is characterized in that, described amoxicillin sugar pill can be made (is example to make 1000 balls) according to following prescription:
Amoxicillin 25-250g
Icing Sugar 150-1000g
Mannitol 7-700g
Aspartame 0.1-5g
Powder essence 0.1-10g
Magnesium stearate 0.1-5g
Food coloring 0.1-5g
9. the described amoxicillin of claim 1 sugar pill is characterized in that, described amoxicillin sugar pill can be made (is example to make 1000 balls) according to following prescription:
Amoxicillin 50g
Icing Sugar 120g
Mannitol 75g
Aspartame 1g
Powder essence 2g
Magnesium stearate 1g
Food coloring 2g
10. the preparation method of the described amoxicillin of claim 1 sugar pill is characterized in that, can adopt one of following method:
Auxiliary materials and mixing during method 1:a. gets the amoxicillin and writes out a prescription; B. direct pelleting.
Method 2:a. gets amoxicillin, filler, sweeting agent mixing, granulates drying; B. add lubricant, mixing, pelleting.
Method 3:a. gets amoxicillin, sweeting agent, partially filled dose of mixing, granulates drying; B. with remaining filler, lubricant mixing, pelleting.
Above-mentioned method for making as having added food coloring in the prescription, then can add in step a; As having added flavoring agent such as powdered flavor in the prescription, add flavoring agent when then can before pelleting, add lubricant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610200266 CN1820750A (en) | 2006-03-20 | 2006-03-20 | Amoxycillin preparation suitable for child administration and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610200266 CN1820750A (en) | 2006-03-20 | 2006-03-20 | Amoxycillin preparation suitable for child administration and its preparing method |
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| CN1820750A true CN1820750A (en) | 2006-08-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352489A (en) * | 2014-10-15 | 2015-02-18 | 湖南安邦制药有限公司 | Amoxicillin composition and preparation method thereof |
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2006
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352489A (en) * | 2014-10-15 | 2015-02-18 | 湖南安邦制药有限公司 | Amoxicillin composition and preparation method thereof |
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