CN1814310A - Disposable viral inactivating blood transfusion filting device - Google Patents
Disposable viral inactivating blood transfusion filting device Download PDFInfo
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- CN1814310A CN1814310A CN 200510042085 CN200510042085A CN1814310A CN 1814310 A CN1814310 A CN 1814310A CN 200510042085 CN200510042085 CN 200510042085 CN 200510042085 A CN200510042085 A CN 200510042085A CN 1814310 A CN1814310 A CN 1814310A
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- blood
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- photosensitizer
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Abstract
This invention is a one-off virus inactivate blood transfusion filter unit, it belongs to blood processing unit technique field. It includes photosensitizer addition machine, fluorescence irradiation bag and adsorption filtration unit, and they are connected by pipe. Its feature is that the pipe communicates the three unit and blood storage bag in order. Cavernous body that can absorb virus inactivator is set at middle part of the addition machine, fiber membrane filter layer and active carbon absorbed layer is set in absorbing filter. In this invention, methylene orchid is equally added, inactivate efficiency is high, and the equipment structure is simple and reasonable. Its operation is convenient, and blood plasma pollution of each one will not happened, it can be used for medical blood filtering or blood processing in blood station.
Description
Technical field
The invention belongs to blood processor technical field, relate in particular to a kind of defecator that blood plasma is carried out viral inactivation treatment blood.
Background technology
Blood transfusion is one of important means of clinical treatment, and blood plasma is a kind of blood constituent, is the main blood constituent of clinical blood transfusion treatment.Present blood station in all parts of the country is single part of blood plasma for the blood plasma of clinical use, contains and contains lipid envelope virus and other unsettled albumen, thrombin in a large number, and donee healthy had harm.In order to eliminate this harm, must carry out inactivation of virus to blood plasma.Serge blue (Methylene Blue) is the intravenous drug that state-promulgated pharmacopoeia is included, can combine with the genomic nucleic acids of virus and the lipid envelope of virus according to foreign literature report serge blue, the nucleic acid of virus can rupture under the effect of visible light oxidative damage, the peplos breakage makes most lipid envelope virus and non-lipid envelope inactivation of virus.Should theory be used for the deactivation of single bag of plasma viral in recent years, and have no side effect, be safe and reliable and effective inactivation of virus technology.
The dosage of the used serge blue of blood-plasma virus killing is micro-, it is generally acknowledged comparison safety, but consider that blood plasma that frequent infusion contains serge blue can cause the chronic accumulation of serge blue in the body, function of human body is formed potential influence, and employing can absorb serge blue and filter out leukocytic device and can effectively reduce serge blue and leukocytic content in the blood plasma.On April 12nd, 2000, disclosed Chinese patent application 98121328.6 provided a kind of method and device thereof of blood-plasma virus killing, and the device of the deactivation plasma viral that it uses comprises that blood taking needle, blood taking bag, conduit, transfering bag, conduction type photosensitizer easy to break add assembly, fluorescence irradiation bag, leucocyte-removing absorption photosensitizer device and blood plasma reservoir bag.Conduction type photosensitizer easy to break adds assembly and comprises conduction type catheter adapter easy to break, photosensitizer liquid-feeding tube, liquid storage pipe and closed head easy to break.Though the device of this disclosure of the Invention can be removed 85% serge blue and 99.9% above leukocyte, it is very inhomogeneous to exist serge blue to add, and deactivation efficient is poor during illumination, the shortcoming of filter plant complexity.
The utility model content
The purpose of this invention is to provide a kind of disposable viral inactivating plasma filtering device, can add photosensitizer uniformly and effectively filter out photosensitizer, leukocyte and virus, structure is also fairly simple.
The technical scheme that the present invention takes is: disposable viral inactivating blood transfusion filting device, comprise the photosensitizer adder, fluorescence irradiation bag and the adsorption filter that link to each other by conduit, it is characterized in that conduit is communicated with photosensitizer adder, fluorescence irradiation bag, adsorption filter and storage blood bag successively, the spongy body that is adsorbed with photosensitizer is placed in the hollow part of photosensitizer adder, and fiber filter rete and activated carbon adsorption layer are set in the adsorption filter.
Conduit is provided with one and has exhaustor and the adsorption filter parallel connection that aerofluxus is pressed from both sides, and is filtering the air that can get rid of with it when finishing in the blood plasma reservoir bag.In order to control the filter of blood plasma, on the conduit between fluorescence irradiation bag and the slash pocket pin, flow-stopping clip is set, between fluorescence irradiation bag and blood plasma reservoir bag, flow-stopping clip is set also.
The amount of spongy body absorption photosensitizer is certain in the photosensitizer adder, is standard plasma bags blood plasma deactivation required dosage, and general 200ml blood plasma deactivation needs serge blue 148～184 μ g.Spongy body is made by polyester fiber, and serge blue can be that solution also can be solid preparation.Blood plasma adds element by photosensitizer, and serge blue is brought in the fluorescence irradiation bag uniformly, and the illumination bag gets final product deactivation through 30 minutes under certain temperature and illuminance condition, and middle the needs carried out other mechanical mixing operation to the blood plasma of fluorescence irradiation bag.
The fiber rete that is provided with in the adsorption filter is the microporous fiber membranes in two-layer different apertures, and the aperture of the microporous fiber membranes of intake chamber's side is greater than the aperture of the microporous fiber membranes of liquid outtake chamber's side, two fibrous membrane interlayer filling activated carbon adsorption layers.Can fractionatedly filter out the source of infection in any antibacterial, the filtering amount of serge blue is more than 85%, and leukocytic surplus is less than 1.0 * 10
4, the blood plasma total protein response rate can reach more than 80%.
In order to protect microporous fiber membranes and guarantee that the pore size filter of microporous fiber membranes is unlikely to change in filter process; the filter membrane outside in the adsorption filter is respectively equipped with splitter box; be distributed with above it much larger than the through hole of hemocyte diameter, blood plasma can enter microporous fiber membranes by the through hole of splitter box.
When blood plasma was filtered, closeall flow-stopping clip inserted the slash pocket pin in the interlayer conduit of the plasma bags that needs filtration blood plasma earlier; Open the flow-stopping clip between fluorescence irradiation bag and the plasma bags, overstock plasma bags, blood plasma flows into fluorescence irradiation bag through the photosensitizer adder, heat seal fluorescence irradiation bag advance blood conduit, illumination deactivation plasma viral; With high the putting of fluorescence irradiation bag, open the flow-stopping clip between adsorption filter and the fluorescence irradiation bag, blood plasma flows through intake chamber, splitter box, large aperture microporous fiber membranes, activated carbon filtration film, small-bore microporous fiber membranes, splitter box and the liquid outtake chamber of adsorption filter successively, filtering leukocyte and photosensitizer serge blue, after filtering end, open the aerofluxus of aerofluxus folder, the conduit of heat seal blood plasma reservoir bag is stand-by in subzero 20 ℃ of storages then.
Beneficial effect of the present invention is that serge blue adds evenly, deactivation efficient height during illumination, and apparatus structure is simple, reasonable, easy to operate, disposable safe and reliable, can not cause the pollution between each single part of blood plasma.
Description of drawings
The present invention is further illustrated below in conjunction with drawings and Examples.
Fig. 1 is a structural representation of the present invention;
Fig. 2 is that the section A at I position among Fig. 1 is to zoomed-in view.
The specific embodiment
The conduit that embodiment 1 transparent nontoxic macromolecular material is made is communicated with photosensitizer adder 2 successively, fluorescence irradiation bag 1, adsorption filter 7 and storage blood bag 10, the polyester fiber spongy body that is adsorbed with the virus inactivating agent serge blue is placed in the hollow part of photosensitizer adder 2, adsorption filter 7 is flat type cylinder, shell 14 is made for transparent non-toxic high molecular material, in be provided with micropore polyester fiber film 12 and 18, the centre is an activated carbon adsorption layer 13, inlet 20 and liquid outlet 15 lay respectively at the both sides of filter membrane, are respectively equipped with the splitter box 11 and 17 that the polyester woven is made in the outside of two-layer micropore polyester fiber film.When blood plasma to be filtered passes through adsorption filter 7, must pass through inlet 20, intake chamber 19, splitter box 17, microporous fiber membranes 12, activated carbon adsorption layer 13, microporous fiber membranes 18, splitter box 11 and liquid outtake chamber 16 successively, flow out by liquid outlet 15.The conduit of viral inactivating blood transfusion filting device is provided with an exhaustor 6 and adsorption filter 7 parallel connections that have an aerofluxus folder 8, between slash pocket pin 4 and photosensitizer adder 2, be provided with flow-stopping clip 3, be provided with flow-stopping clip 5 between adsorption filter 7 and the fluorescence irradiation bag 1, between adsorption filter 7 and blood plasma reservoir bag 10, be provided with flow-stopping clip 9.
Claims (6)
1, disposable viral inactivating blood transfusion filting device, comprise the photosensitizer adder, fluorescence irradiation bag and the adsorption filter that link to each other by conduit, it is characterized in that conduit is communicated with photosensitizer adder (2), fluorescence irradiation bag (1), adsorption filter (7) and storage blood bag (10) successively, the spongy body of viral adsorption inactivator is placed in the hollow part of photosensitizer adder (2), and adsorption filter is provided with fiber filter rete and activated carbon adsorption layer in (7).
2, disposable viral inactivating blood transfusion filting device according to claim 1 is characterized in that conduit is provided with the exhaustor (6) and adsorption filter (7) parallel connection of band aerofluxus folder (8).
3, disposable viral inactivating blood transfusion filting device according to claim 1 is characterized in that on the conduit between fluorescence irradiation bag (1) and the slash pocket pin (4) flow-stopping clip (3) being set.
4, disposable viral inactivating blood transfusion filting device according to claim 1 is characterized in that between fluorescence irradiation bag (1) and blood plasma reservoir bag (10) flow-stopping clip (5) being set.
5, disposable viral inactivating blood transfusion filting device according to claim 1, it is characterized in that the fiber rete that is provided with in the adsorption filter (7) is microporous fiber membranes (12) and (18) in two-layer different apertures, the aperture of the microporous fiber membranes (12) of intake chamber (19) side is greater than the aperture of the microporous fiber membranes (18) of liquid outtake chamber (16) side, two fibrous membrane interlayer filling activated carbon adsorption layers (13).
6, disposable viral inactivating blood transfusion filting device according to claim 1 is characterized in that the filter membrane outside in the adsorption filter is respectively equipped with splitter box (11) and (17).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510042085 CN1814310A (en) | 2005-02-06 | 2005-02-06 | Disposable viral inactivating blood transfusion filting device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510042085 CN1814310A (en) | 2005-02-06 | 2005-02-06 | Disposable viral inactivating blood transfusion filting device |
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| Publication Number | Publication Date |
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| CN1814310A true CN1814310A (en) | 2006-08-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 200510042085 Pending CN1814310A (en) | 2005-02-06 | 2005-02-06 | Disposable viral inactivating blood transfusion filting device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548932B (en) * | 2008-04-02 | 2012-05-23 | 上海输血技术有限公司 | Disposable photophobic photosencitizer storage and release member and production method thereof |
| US8556085B2 (en) | 2010-11-08 | 2013-10-15 | Stuart Bogle | Anti-viral device |
| CN104399135A (en) * | 2014-11-20 | 2015-03-11 | 上海市血液中心 | Processing device for plasma virus inactivation |
| CN108721961A (en) * | 2018-06-12 | 2018-11-02 | 广州市雷德生物科技有限公司 | A kind of filter device of blood |
-
2005
- 2005-02-06 CN CN 200510042085 patent/CN1814310A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548932B (en) * | 2008-04-02 | 2012-05-23 | 上海输血技术有限公司 | Disposable photophobic photosencitizer storage and release member and production method thereof |
| US8556085B2 (en) | 2010-11-08 | 2013-10-15 | Stuart Bogle | Anti-viral device |
| CN104399135A (en) * | 2014-11-20 | 2015-03-11 | 上海市血液中心 | Processing device for plasma virus inactivation |
| CN108721961A (en) * | 2018-06-12 | 2018-11-02 | 广州市雷德生物科技有限公司 | A kind of filter device of blood |
| CN108721961B (en) * | 2018-06-12 | 2021-01-01 | 广州市雷德生物科技有限公司 | Blood filtering device |
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