CN104399135A - Processing device for plasma virus inactivation - Google Patents
Processing device for plasma virus inactivation Download PDFInfo
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- CN104399135A CN104399135A CN201410667647.XA CN201410667647A CN104399135A CN 104399135 A CN104399135 A CN 104399135A CN 201410667647 A CN201410667647 A CN 201410667647A CN 104399135 A CN104399135 A CN 104399135A
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- 230000002779 inactivation Effects 0.000 title abstract description 5
- 241000701370 Plasmavirus Species 0.000 title abstract 4
- 210000004369 blood Anatomy 0.000 claims abstract description 70
- 239000008280 blood Substances 0.000 claims abstract description 70
- 229960000907 methylthioninium chloride Drugs 0.000 claims abstract description 25
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims abstract 4
- 238000005286 illumination Methods 0.000 claims description 44
- 239000000126 substance Substances 0.000 claims description 40
- 210000002381 plasma Anatomy 0.000 claims description 39
- 239000003814 drug Substances 0.000 claims description 28
- 230000007246 mechanism Effects 0.000 claims description 22
- 241000700605 Viruses Species 0.000 claims description 17
- 239000012530 fluid Substances 0.000 claims description 13
- 238000001802 infusion Methods 0.000 claims description 13
- 239000010409 thin film Substances 0.000 claims description 12
- 230000008676 import Effects 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 7
- 230000010355 oscillation Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 abstract 4
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 22
- 238000000034 method Methods 0.000 description 18
- 230000008569 process Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 239000010836 blood and blood product Substances 0.000 description 6
- 229940125691 blood product Drugs 0.000 description 6
- 238000009832 plasma treatment Methods 0.000 description 6
- 230000036770 blood supply Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 210000003677 hemocyte Anatomy 0.000 description 3
- 229940000351 hemocyte Drugs 0.000 description 3
- 238000002616 plasmapheresis Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000011797 cavity material Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 150000002390 heteroarenes Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention relates to the technical field of medical instruments and especially relates to a processing device for plasma virus inactivation. The processing device for plasma virus inactivation provided by the invention comprises a blood separating device and an optical processing device, wherein the blood separating device and the optical processing device are respectively provided with an input port and an output port; the output port of the blood separating device is connected with the input port of the optical processing device through a first catheter; a first conveying pump and a dosing device are arranged on the first catheter; the processing device further comprises a second catheter and a third catheter; the output port of the optical processing device and the input port of the blood separating device are respectively connected with one ends of the second catheter and the third catheter; a second conveying pump is arranged on the second catheter; a third conveying pump is arranged on the third catheter. The plasma processing device provided by the invention is mainly applied to the methylene blue photochemistry plasma virus inactivation, is arranged as a system for real-time processing of plasma according to a plasma-displacing principle, is capable of realizing the real-time feedback while processing and is capable of greatly increasing the handling capacity and processing efficiency.
Description
Technical field
The present invention relates to field of medical technology, particularly relate to a kind of blood processor for blood-plasma virus killing.
Background technology
The Main Function of blood plasma is delivery hemocyte, the material of transport maintenance needed for human life activity and the refuse etc. of the interior generation of body.Blood plasma is equivalent to the intercellular substance of connective tissue.Blood plasma is the important component part of blood, in weak yellow liquid (because of containing bilirubin).In the chemical composition of blood plasma, moisture accounts for 90 ~ 92%, other are 10% based on solute plasma protein, and containing electrolyte, nutrient (nutrients), enzyme (enzymes), hormones (hormones), cholesterol (cholesterol) and other important component parts.
Blood-plasma virus killing, refer to and by physics or chemical means, the structure of virus protein is damaged, allow the virus that may exist in blood plasma lose infection, to cause a disease and fertility, in the past 10 years, blood-plasma virus killing technology has been employed in multiple developed country and China and has promoted.Methylene blue (Methylene blue) photochemistry blood-plasma virus killing, due to its reliable inactivation of virus effect and safety, has become this field and has applied technology the most general in recent years.
Methylene blue Chinese is by name: two (dimethylamino) phenothiazine-5-father-in-law chloride of 3,7-, also known as methylene blue, methylene blue, methylene blue, methylene blue, reddish blue, is a kind of heteroaromatic compound, and No. CAS: 61-73-4.The aqueous solution of methylene blue is blue in oxidative environment, but reducing agent such as chance zinc, ammonia etc. can be reduced into colorless state.Act on rapidly after the quiet note of methylene blue, substantially namely discharge with urine without metabolism, orally can be absorbed under gastrointestinal pH condition, and be reduced to rapidly white methylene blue in tissue.Methylene blue in 6 days 74% by urine discharge, wherein 22% be original shape, and all the other be white methylene blue, and part possibility methylated, a small amount of methylene blue pass through bile, discharged by feces.
Summary of the invention
In view of existing blood-plasma virus killing technology is only applicable to the process of single bag of blood plasma, cannot carry out that patients blood plasma is a large amount of, continuous print process, the object of the present invention is to provide a kind of for clinical viral deactivation treatment, in closed system, continuously, circular treatment patient self blood plasma to be to reach the device of particular treatment object.Plasma treatment device provided by the present invention is mainly used in methylene blue photochemistry blood-plasma virus killing, it is a kind of principle based on plasmapheresis, in airtight system, blood plasma is processed in real time, it can realize real-time feedback while process, greatly improve treating capacity and treatment effeciency, have broad application prospects.
For achieving the above object and other relevant objects, the invention provides a kind of blood processor for blood-plasma virus killing, comprise blood separating mechanism and light processor, described blood separating mechanism and light processor are respectively equipped with input port and delivery outlet, the delivery outlet of blood separating mechanism is connected with the input port of light processor by the first conduit, described first conduit is provided with the first transport pump and chemicals dosing plant, also comprise the second conduit and the 3rd conduit, described light processor delivery outlet is connected with the second conduit one end with the 3rd conduit respectively with the input port of blood separating mechanism, described second conduit is provided with the second transport pump, described 3rd conduit is provided with the 3rd transport pump.
The free end of the second conduit and the 3rd conduit can communicate with blood sample feed system in use simultaneously, and in this case, blood sample feed system can be blood exporter; Second conduit can also be identical with blood collection systems with blood supply system respectively with the free end of the 3rd conduit, and in this case, blood supply system and blood collection systems can be that blood products and the container for collecting blood products are housed respectively.
Preferably, described light processor comprises illumination pipeline, and to the light source that illumination pipeline irradiates, the input port of described illumination pipeline and delivery outlet are respectively input port and the delivery outlet of light processor.
Preferred, described light processor also comprises casing, and described light source and illumination pipeline are all positioned at casing.
Further preferred, described light processor also comprises and carries out temperature controlled attemperating unit to case intracorporeal space.
Preferred, described illumination pipeline comprises illumination container and/or illumination conduit.
Preferred further, described illumination conduit is the roundabout shape with multiple straightway.
Preferred, described illumination pipeline is also provided with oscillation device.
Preferably, described chemicals dosing plant is solid methylene blue or liquid methylene blue chemicals dosing plant.
Preferred, described methylene blue chemicals dosing plant comprises and loads thin film with the medicine container of hollow cavity and medicine, and described medicine loads thin film and is positioned at medicine container, and described medicine container is provided with import and outlet.
Preferred further, described medicine container is made up of the upper base with outlet of going to the bottom and corresponding with import, and described medicine loads the import department that thin film is positioned at hollow cavity.
Described medicine loads that thin film is preferably hemispherical, and medicine is filled in hemispherical formed depression, and the flow direction in hemispheric opening and chemicals dosing plant keeps level.
Preferred, the first conduit between described blood separating mechanism and chemicals dosing plant is provided with stop valve, and the first conduit between described chemicals dosing plant and light processor is provided with stop valve.
Preferred, described first conduit is parallel with multiple described chemicals dosing plant, and the inlet ductwork place of each chemicals dosing plant is equipped with stop valve, and the first conduit between described chemicals dosing plant and light processor is provided with stop valve.
Preferably, the second conduit between the second transport pump and light processor is also provided with buffer unit.
Preferred, the second conduit between described light processor and buffer unit is also provided with stop valve, the second conduit between described buffer unit and the second transport pump is also provided with stop valve.
Preferably, also comprise fluid infusion bag, the delivery outlet of described fluid infusion bag is connected with the second transport pump entrance.
Preferred, the conduit between described fluid infusion bag and the second transport pump is also provided with stop valve.
Preferably, described 3rd transport pump is two-way pump, and described 3rd conduit is two-way conduit.
The main function mode of described 3rd conduit and the 3rd transport pump first the blood sample collected is inputted blood separating mechanism by the 3rd conduit, after blood separating mechanism is centrifugal by blood sample, derived by delivery outlet by blood plasma, remaining part is fed back by the 3rd conduit again.
Preferred, described 3rd conduit is provided with stop valve.
Preferably, described each transport pump and stop valve are all electrically connected with central control system.
In plasma treatment device provided by the present invention, the effect of stop valve and pump is the liquid flow in order to control between each device, each transport pump and stop valve all can independently carry out controlling and operating separately, also by central control system, entirety is carried out to each transport pump and stop valve and controls and operation.
Second aspect present invention provides the purposes of described plasma treatment device in methylene blue photochemistry blood-plasma virus killing field.
As mentioned above, plasma treatment device provided by the present invention is mainly used in methylene blue photochemistry blood-plasma virus killing, it is a kind of system of with the principle of plasmapheresis, blood plasma being carried out to process in real time, it can realize real-time feedback while process, greatly improve treating capacity and treatment effeciency, have broad application prospects.
Accompanying drawing explanation
Fig. 1 is shown as overall structure schematic diagram of the present invention;
Fig. 2 is shown as chemicals dosing plant structural representation of the present invention;
Fig. 3 is shown as light processor structural representation of the present invention.
Element numbers explanation
1 free end
2 the 3rd transport pumps
3 second transport pumps
4 first transport pumps
5 stop valves
6 stop valves
7 stop valves
8 stop valves
9 stop valves
10 stop valves
11 stop valves
12 stop valves
13 stop valves
14 stop valves
15 first conduits
16 second conduits
17 the 3rd conduits
18 buffer units
19 fluid infusion bags
20 blood separating mechanisms
30 light processors
31 illumination pipelines
32 light sources
33 casings
34 attemperating units
35 oscillation devices
40 chemicals dosing plants
41 medicine containers
42 medicines load thin film
43 go to the bottom
44 upper bases
45 medicines
Detailed description of the invention
Below by way of specific instantiation, embodiments of the present invention are described, those skilled in the art the content disclosed by this description can understand other advantages of the present invention and effect easily.The present invention can also be implemented or be applied by detailed description of the invention different in addition, and the every details in this description also can based on different viewpoints and application, carries out various modification or change not deviating under spirit of the present invention.
Notice, in the following example, the concrete process equipment that indicates or device all adopt conventional equipment in this area or device; All force value and scope all refer to absolute pressure.
In addition should be understood that the one or more method steps mentioned in the present invention do not repel and can also to there is additive method step or can also insert additive method step before and after described combination step between these steps clearly mentioned, except as otherwise noted; Will also be understood that, the relation that is connected between the one or more equipment/devices mentioned in the present invention is not repelled and can also to be there are other equipment/devices or can also insert other equipment/devices before and after described unit equipment/device between these two equipment/devices clearly mentioned, except as otherwise noted.And, except as otherwise noted, the numbering of various method steps is only the convenient tool differentiating various method steps, but not be ordering or the enforceable scope of restriction the present invention of restriction various method steps, the change of its relativeness or adjustment, when changing technology contents without essence, when being also considered as the enforceable category of the present invention.
As shown in Figure 1, the invention provides a kind of blood processor for blood-plasma virus killing, comprise blood separating mechanism 20 and light processor 30, blood separating mechanism 20 and light processor 30 are respectively equipped with input port and delivery outlet, the delivery outlet of blood separating mechanism 20 is connected with the input port of light processor 30 by the first conduit 15, described first conduit 15 is provided with the first transport pump 4 and chemicals dosing plant 40, also comprise the second conduit 16 and the 3rd conduit 17, described light processor 30 delivery outlet is connected with the second conduit 16 one end with the 3rd conduit 17 respectively with the input port of blood separating mechanism 20, described second conduit 16 is provided with the second transport pump 3, described 3rd conduit 17 is provided with the 3rd transport pump 2.
The effect of described blood separating mechanism 20 is by centrifugal action, is separated by blood plasma with hemocyte, and hemocyte also will be defeated by patient, and blood plasma fractions carries out subsequent treatment.Those skilled in the art rule of thumb can select blood separation instrument and the separation condition of suitable types, and concrete blood separation instrument applicatory is as the blood cell separator of Baxter company of the U.S. and Haemonalics company, and separation condition can refer to product description.Blood sample enters blood separating mechanism 20 by the 3rd conduit 17, blood plasma fractions is flowed out from delivery outlet by the first conduit 15 after treatment, blood sample remainder is returned into the 3rd conduit 17 by input port, 3rd conduit 17 is two-way conduit, the 3rd transport pump 2 on its pipeline is two-way pump, and the 3rd conduit 17 is provided with stop valve 5.The free end 1 of the second conduit 16 and the 3rd conduit 17 can communicate with blood sample feed system in use simultaneously, and in this case, blood sample feed system can be blood exporter, and the remainder of blood sample can feed back to blood exporter by the 3rd conduit 17; Second conduit 16 can also be identical with blood collection systems with blood supply system respectively with the free end 1 of the 3rd conduit 17, in this case, blood supply system and blood collection systems can be that blood products and the container for collecting blood products are housed respectively, the remainder of blood sample can, by the 3rd conduit 17 input pod, be collected rear for subsequent use in a reservoir.
A chemicals dosing plant 40 can be only set on the first conduit 15 in the present invention, also can on the first conduit 15 multiple chemicals dosing plant 40 in parallel.When only arranging a chemicals dosing plant, the first conduit 15 between blood separating mechanism 20 and chemicals dosing plant 40 is provided with stop valve 6, and the first conduit 15 between chemicals dosing plant 40 and light processor 30 is provided with stop valve 11.When the multiple chemicals dosing plant 40 of parallel connection, its structure as shown in Figure 1, described first conduit 15 is parallel with multiple chemicals dosing plant 40, the inlet ductwork place of each chemicals dosing plant 40 is equipped with stop valve 6,7,8,9,10, and the first conduit 15 between described chemicals dosing plant 40 and light processor 30 is provided with stop valve 11.
Chemicals dosing plant 40 can be solid medicating device, also can be liquid feeding device.As shown in Figure 2, chemicals dosing plant 40 is solid medicating device (film absorption methylene blue chemicals dosing plant), chemicals dosing plant 40 comprises and loads thin film 42 with the medicine container 41 of hollow cavity and medicine, medicine loads thin film 42 and is positioned at medicine container 41, and medicine container 41 is provided with import and outlet.Medicine container 41 by with import go to the bottom 43 and the upper base 44 with outlet that corresponds form, described medicine loads the import department that thin film 42 is positioned at hollow cavity.It is hemispherical that described medicine loads thin film 42, and medicine is filled in hemispherical formed depression, and the flow direction in hemispheric opening and chemicals dosing plant 40 keeps level.
As mentioned above, the free end 1 of the 3rd conduit 17 can directly be connected with the container collecting blood products, and now blood products can be derived from the 3rd conduit 17 by flow velocity faster.But in theory, the blood plasma being processed rear acquisition by light processor 30 can be directly used in feedback, because feedback object may be blood exporter, so the speed of feedback can not be too fast, and in order to raise the efficiency further, so the present invention can also comprise buffer unit 18, as shown in Figure 1, the second conduit 16 between the second transport pump 3 and light processor 40 is also provided with buffer unit 18.During actual operation, the blood plasma that process can be obtained imports and first stores in buffer unit 18, and then feeds back, and light processor 40 can continue on for follow-up plasma treatment.As shown in Figure 1, the second conduit 16 between described light processor 40 and buffer unit 18 is also provided with stop valve 12, the second conduit 16 between described buffer unit 18 and the second transport pump 3 is also provided with stop valve 13.
The present invention also can comprise fluid infusion bag 19, and the effect of fluid infusion bag 19 prevents blood coagulation from blocking syringe needle.As shown in Figure 1, the delivery outlet of fluid infusion bag 19 is connected with the second transport pump 3 entrance, and the conduit between fluid infusion bag 19 and the second transport pump 3 is also provided with stop valve 14.
As shown in Figure 3, light processor 30 comprises illumination pipeline 31, and to the light source 32 that illumination pipeline 31 irradiates, the concrete illumination condition of light source 32 is 30000 ~ 38000Lx, and the input port of described illumination pipeline 31 and delivery outlet are respectively input port and the delivery outlet of light processor 30.Described light processor 30 also comprises casing 33, and in casing 33, temperature controlled attemperating unit 34 is carried out in space, and described light source 32 and illumination pipeline 31 are all positioned at casing 33, and in casing, temperature range is generally 2 ~ 8 DEG C.Described illumination pipeline 31 comprises illumination container and/or illumination conduit, when illumination pipeline 31 is for illumination container, blood plasma can be placed in illumination container and carry out illumination, when illumination pipeline 31 is for illumination conduit, can light source 32 be adopted to irradiate it when flowing through illumination conduit, in order to save space and improve light efficiency, illumination conduit is generally the roundabout shape with multiple straightway.The position of light source 32 should coordinate illumination pipeline 31 as far as possible, to ensure that the light that light source 32 sends can fully be radiated on illumination pipeline 31.Preferably can be provided with multiple light source 32, to ensure that illumination pipeline 31 can be subject to the irradiation of light from multiple directions.No matter which kind of illumination methods, all need the light application time ensureing blood plasma, light application time is generally 30 ~ 60min.Illumination pipeline 31 can also be provided with oscillation device 35, to ensure that the blood plasma in illumination pipeline 31 can accept irradiation equably.
In the present invention, the effect of stop valve and pump is the liquid flow in order to control between each device, and each transport pump and stop valve all can independently carry out controlling and operating separately, also by central control system, carries out entirety control and operation each transport pump and stop valve.As shown in Figure 1, each transport pump and stop valve are all electrically connected with central control system.
The present invention's concrete principle is in use as follows: blood flows in blood separating mechanism 20 through the 3rd conduit 17, after blood separating mechanism 20 is separated, blood plasma fractions enters light processor 30 by the first conduit 15, remainder is fed back by the 3rd conduit 17, when blood plasma is by the first conduit 15, carry out dosing by chemicals dosing plant 40 pairs of blood plasma.Illumination pipeline 31 is for having the illumination conduit of the roundabout shape of multiple straightway, and blood plasma carries out photo-irradiation treatment after entering light processor 30 in the process flowing through illumination conduit, and actual conditions is 2 ~ 8 DEG C, 30000 ~ 38000Lx photo-irradiation treatment, 30 ~ 60min.。Blood plasma through photo-irradiation treatment exports buffer unit 18 to by light processor 30, carries out feedback again operate by buffer unit.Fluid infusion bag can carry out fluid infusion by machine in due course, in case Hemostatic Oral Liquid frozen plug syringe needle.
As mentioned above, plasma treatment device provided by the present invention is mainly used in methylene blue photochemistry blood-plasma virus killing, it is a kind of system of with the principle of plasmapheresis, blood plasma being carried out to process in real time, it can realize real-time feedback while process, greatly improve treating capacity and treatment effeciency, have broad application prospects.
The above; be only preferred embodiment of the present invention; not to any formal and substantial restriction of the present invention; should be understood that; for those skilled in the art; under the prerequisite not departing from the inventive method, also can make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.All those skilled in the art, without departing from the spirit and scope of the present invention, a little change made when utilizing disclosed above technology contents, the equivalent variations of modifying and developing, be Equivalent embodiments of the present invention; Meanwhile, all according to substantial technological of the present invention to the change of any equivalent variations that above-described embodiment is done, modify and differentiation, all still belong in the scope of technical scheme of the present invention.
Claims (19)
1. the blood processor for blood-plasma virus killing, it is characterized in that, comprise blood separating mechanism (20) and light processor (30), described blood separating mechanism (20) and light processor (30) are respectively equipped with input port and delivery outlet, the delivery outlet of blood separating mechanism (20) is connected with the input port of light processor (30) by the first conduit (15), described first conduit (15) is provided with the first transport pump (4) and chemicals dosing plant (40), also comprise the second conduit (16) and the 3rd conduit (17), described light processor (30) delivery outlet is connected with the second conduit (16) one end with the 3rd conduit (17) respectively with the input port of blood separating mechanism (20), described second conduit (16) is provided with the second transport pump (3), described 3rd conduit (17) is provided with the 3rd transport pump (2).
2. blood processor as claimed in claim 1, it is characterized in that, described light processor (30) comprises illumination pipeline (31), and to the light source (32) that illumination pipeline (31) irradiates, the input port of described illumination pipeline (31) and delivery outlet are respectively input port and the delivery outlet of light processor (30).
3. blood processor as claimed in claim 2, it is characterized in that, described light processor (30) also comprises casing (33), and described light source (32) and illumination pipeline (31) are all positioned at casing (33).
4. blood processor as claimed in claim 3, is characterized in that, described light processor (30) also comprises and carries out temperature controlled attemperating unit (34) to casing (33) interior space.
5. blood processor as claimed in claim 2, it is characterized in that, described illumination pipeline (31) comprises illumination container and/or illumination conduit.
6. blood processor as claimed in claim 5, it is characterized in that, described illumination conduit is the roundabout shape with multiple straightway.
7. blood processor as claimed in claim 2, is characterized in that, described illumination pipeline (31) is also provided with oscillation device (35).
8. blood processor as claimed in claim 1, it is characterized in that, described chemicals dosing plant (40) is solid methylene blue or liquid methylene blue chemicals dosing plant, described chemicals dosing plant (40) comprises and loads thin film (42) with the medicine container (41) of hollow cavity and medicine, described medicine loads thin film (42) and is positioned at medicine container (41), and described medicine container (41) is provided with import and outlet.
9. blood processor as claimed in claim 8, it is characterized in that, described medicine container (41) is made up of the upper base (44) with outlet of going to the bottom (43) and corresponding with import, and described medicine loads the import department that thin film (42) is positioned at hollow cavity.
10. blood processor as claimed in claim 1, it is characterized in that, the first conduit (15) between described blood separating mechanism (20) and chemicals dosing plant (40) is provided with stop valve (6), and the first conduit (15) between described chemicals dosing plant (40) and light processor (30) is provided with stop valve (11).
11. blood processor as claimed in claim 1, it is characterized in that, described first conduit (15) is parallel with multiple described chemicals dosing plant (40), the inlet ductwork place of each chemicals dosing plant (40) is equipped with stop valve (6,7,8,9,10), and the first conduit (15) between described chemicals dosing plant (40) and light processor (30) is provided with stop valve (11).
12. blood processor as claimed in claim 1, is characterized in that, the second conduit (16) between the second transport pump (3) and light processor (40) is also provided with buffer unit (18).
13. blood processor as claimed in claim 12, it is characterized in that, the second conduit (16) between described light processor (40) and buffer unit (18) is also provided with stop valve (12), the second conduit (16) between described buffer unit (18) and the second transport pump (3) is also provided with stop valve (13).
14. blood processor as claimed in claim 1, is characterized in that, also comprise fluid infusion bag (19), the delivery outlet of described fluid infusion bag (19) is connected with the second transport pump (3) entrance.
15. blood processor as claimed in claim 14, is characterized in that, the conduit between described fluid infusion bag (19) and the second transport pump (3) is also provided with stop valve (14).
16. blood processor as claimed in claim 1, is characterized in that, described 3rd transport pump (2) is two-way pump, and described 3rd conduit (17) is two-way conduit.
17. blood processor as claimed in claim 16, is characterized in that, described 3rd conduit (17) is provided with stop valve (5).
Blood processor as described in 18. claim as arbitrary in claim 1-16, is characterized in that, described each transport pump and stop valve are all electrically connected with central control system.
The purposes of blood processor in methylene blue photochemistry blood-plasma virus killing field as described in 19. claim as arbitrary in claim 1-18.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410667647.XA CN104399135A (en) | 2014-11-20 | 2014-11-20 | Processing device for plasma virus inactivation |
| US14/946,285 US11013844B2 (en) | 2014-11-20 | 2015-11-19 | Treatment device for plasma virus inactivation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410667647.XA CN104399135A (en) | 2014-11-20 | 2014-11-20 | Processing device for plasma virus inactivation |
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| CN104399135A true CN104399135A (en) | 2015-03-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410667647.XA Pending CN104399135A (en) | 2014-11-20 | 2014-11-20 | Processing device for plasma virus inactivation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107715211A (en) * | 2017-11-01 | 2018-02-23 | 杭州蕙新医疗科技有限公司 | A kind of plasma exchange loading photochemical virus inactivation device and its application apparatus |
| CN108143623A (en) * | 2017-12-29 | 2018-06-12 | 武汉佰美斯医疗科技有限公司 | A kind of suspension arrangement with positive and reverse return pivoted frame |
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