CN210812960U

CN210812960U - In-vivo closed-loop sterilization equipment

Info

Publication number: CN210812960U
Application number: CN201920798943.1U
Authority: CN
Inventors: 刘忠英
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-05-29
Filing date: 2019-05-29
Publication date: 2020-06-23
Anticipated expiration: 2029-05-29

Abstract

The utility model discloses an in-vivo closed loop sterilization device, which comprises a blood sampling device, a cell centrifugal separation device, an illumination sterilization device, a feedback device and a medicine injection device; the illumination sterilization device comprises an illumination device and a device to be irradiated, wherein the device to be irradiated is made of a light-transmitting material; the blood sampling device is connected with the cell centrifugal separation device through a first pipeline; the cytocentrifugal separation device is configured for separating blood into a non-treatment part and a part to be treated; the cell centrifugal separation device is connected with the feedback device through a second pipeline; the cell centrifugal separation device is also connected with a device to be irradiated through a third pipeline, the device to be irradiated is configured to be used for receiving a part to be treated, and the illumination device is configured to be used for illuminating the part to be treated received in the device to be irradiated; the device to be irradiated is also connected with the feedback device through a fourth pipeline; the medicine injection device is connected with the third pipeline. The utility model has the technical effects that the whole blood circulation irradiation treatment can be realized.

Description

In-vivo closed-loop sterilization equipment

Technical Field

The utility model relates to the field of medical equipment, more specifically, the utility model relates to an in vivo closed loop sterilization equipment.

Background

In daily life, a human body is likely to be infected with bacteria or viruses for various reasons, so that various diseases are caused, and even the life of people is endangered in serious cases. Currently, the commonly used treatment methods are: antibiotic medicines are adopted for antibacterial treatment, or antiviral medicines are adopted for antiviral treatment. However, most of the treatments with drugs have certain side effects, and the body also has certain drug resistance after long-term use of the drugs. Therefore, it is not suitable to treat with large dose or long time medication. In addition, for some super bacteria existing in hospitals, no effective antibacterial drugs are available for effective treatment.

With the rapid development of medical science and technology, blood phototherapy is more and more widely applied. Specifically, a certain amount of blood is collected from a human body to the outside of the body, the collected blood is conveyed to a blood radiation therapeutic apparatus to be treated by ultraviolet light irradiation, and the blood is re-conveyed to the human body after the treatment is finished. Although hemophototherapy has significant advantages over drug therapy, it has been found to be problematic in long-term use: firstly, the method can only treat a small amount of blood, and the treatment effect is often not ideal; second, this method is an intermittent treatment, which needs to be separated from the body, and is troublesome to operate because it is an extracorporeal treatment and is liable to cause blood contamination or infection during the procedure, and is less safe. It is seen that there is a great need to develop new sterilization or virus killing devices or equipment.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a new technical scheme of closed loop sterilizing installation in vivo.

According to one aspect of the utility model, an in-vivo closed loop sterilization device is provided, which comprises a blood sampling device, a cell centrifugal separation device, an illumination sterilization device and a feedback device; the illumination sterilization device comprises an illumination device and a device to be irradiated, wherein the device to be irradiated is made of a light-transmitting material;

the blood sampling device is connected with the cell centrifugal separation device through a first pipeline;

the cytocentrifugal separation device is configured for separating blood into a non-treatment part and a part to be treated; the cell centrifugal separation device is connected with the feedback device through a second pipeline; the cell centrifugal separation device is also connected with the device to be irradiated through a third pipeline, the device to be irradiated is configured to receive the part to be treated, and the illumination device is configured to illuminate the part to be treated received in the device to be irradiated;

the device to be irradiated is also connected with the feedback device through a fourth pipeline;

still include injection device, injection device with the third tube coupling.

Optionally, the blood sampling device, the cell centrifugal separation device, the illumination device and the feedback device are respectively connected with the control device.

Optionally, the in-vivo closed-loop sterilization apparatus further comprises a collecting device, wherein the collecting device is connected to the third pipeline;

the collection device has an injection port coupled to the drug injection device, the collection device configured to: for collecting in advance a portion to be treated in the blood separated by the cytocentrifugal separation apparatus.

Optionally, the drug injection device is a syringe; in the alternative, the first and second sets of the first,

the medicine injection device is a medicine injection pump, and the medicine injection pump is connected with the control device.

Optionally, the illumination device includes two lamp panels arranged oppositely, and at least one of two opposite surfaces of the two lamp panels is provided with a plurality of illumination light sources;

the device of treating to shine is in between two lamp plates.

Optionally, the device to be irradiated is a blood bag;

the blood bag lifting mechanism is characterized by further comprising a swinging mechanism, wherein the swinging mechanism is made of a light-transmitting material, and the blood bag is arranged on the swinging mechanism;

the irradiation light source is a lamp bead or a lamp tube.

Optionally, the device to be irradiated is a blood cassette;

the blood box comprises a flat box body, and a light-transmitting blood flow channel is arranged in the box body;

the illuminating light source is lamp beads, and a plurality of lamp beads are arranged on the lamp panel in a mode matched with the shape of the blood flow channel.

Optionally, the device to be irradiated is a blood cassette;

the blood box comprises a flat box body, a feeding hole and a discharging hole are respectively formed in the box body, a plurality of partition plates are arranged in the box body, the space in the box body is divided into a plurality of accommodating cavities by the partition plates, each accommodating cavity is provided with a feeding branch hole communicated with the feeding hole, and each accommodating cavity is also provided with a discharging branch hole communicated with the discharging hole;

the illuminating light source is lamp beads, a plurality of lamp beads are arranged on the lamp panel in multiple rows and multiple columns, and the lamp beads in two adjacent rows are arranged in a staggered mode; in the alternative, the first and second sets of the first,

the illuminating light source is a lamp tube, and the lamp tubes are sequentially arranged on the lamp panel to form at least one row of lamp tubes.

Optionally, the device to be irradiated is a blood conveying pipeline, and a section of the blood conveying pipeline extending into the space between the two lamp panels is of a flat structure.

Optionally, the illumination device includes a cylindrical housing with openings at two ends, and a plurality of illumination light sources are uniformly arranged on an inner wall of the cylindrical housing;

the device to be irradiated is disposed inside the cylindrical housing.

Optionally, the device to be irradiated is a blood line.

Optionally, the device to be irradiated is a blood tube, the cross-sectional dimension of one section of the blood tube is larger than the cross-sectional dimensions of the two end portions of the section, a shunt body is arranged in the section, and a shunt channel is formed between the inner wall of the blood tube and the outer wall of the shunt body;

the shunt body is made of a light-transmitting material and is configured to: when the part to be treated enters the blood pipeline, the part to be treated flows through the shunt flow channel.

Optionally, the flow-splitting body is a hollow structure.

Optionally, a flow control pump is arranged on the blood line, and the flow control pump is connected with a control device.

Optionally, the cylindrical housing is mounted by a bayonet or a hinge on a section of the blood line where the shunt is located.

Optionally, pressure sensors are respectively arranged outside the blood sampling device and the feedback device, and the pressure sensors are connected with the control device.

Optionally, a component detection device is connected to the cytocentrifugal separation device, the component detection device is connected to the control device, and the component detection device is configured to: the kind, purity and layering state of each fraction separated by the cell centrifugation apparatus are detected under the control of the control apparatus.

Optionally, the feedback device is further connected with an ultrasonic bubble sensor and a liquid supplementing device respectively, and both the ultrasonic bubble sensor and the liquid supplementing device are connected with the control device.

The embodiment of the utility model provides an at closed loop sterilization equipment of body can form closed loop system with the human body when using, and this at closed loop equipment of body can continuous work, through the specific composition to whole body blood after-separating, can be continuous, the pertinence to wherein treat the treatment part and carry out the light irradiation treatment, have treatment effect good and efficient characteristics, can effectively eliminate bacterium, virus in the blood to and treat other suitable diseases. The whole treatment environment is safe, and the infection can be avoided. The in-vivo closed-loop sterilization equipment is simple in structure and convenient to operate.

Other features of the present invention and advantages thereof will become apparent from the following detailed description of exemplary embodiments of the invention, which proceeds with reference to the accompanying drawings.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate embodiments of the invention and together with the description, serve to explain the principles of the invention.

Fig. 1 is a schematic structural diagram of a first in-vivo closed-loop sterilization apparatus provided in an embodiment of the present invention.

Fig. 2 is a schematic structural diagram of a second in-vivo closed-loop sterilization apparatus provided in an embodiment of the present invention.

Fig. 3 is a schematic structural diagram of a third in-vivo closed-loop sterilization apparatus provided in an embodiment of the present invention.

Fig. 4 is a schematic structural diagram of a fourth in-vivo closed-loop sterilization apparatus provided in an embodiment of the present invention.

Fig. 5 is a schematic structural diagram of a first light sterilization device provided in an embodiment of the present invention.

Fig. 6 is a schematic structural view of a second light sterilization device according to an embodiment of the present invention.

Fig. 7 is a schematic structural diagram of a third light sterilization device according to an embodiment of the present invention.

Fig. 8 is an exploded view of the blood box and the corresponding lamp panel provided by the embodiment of the present invention.

Fig. 9 is an exploded view of another blood box and a corresponding lamp panel provided in the embodiment of the present invention.

Fig. 10 is a schematic structural view of a fourth light sterilization device according to an embodiment of the present invention.

Fig. 11 is a partially enlarged schematic view of fig. 10.

Fig. 12 is a schematic structural view of a fifth light sterilization device according to an embodiment of the present invention.

Fig. 13 is a side view of fig. 12.

Fig. 14 is an internal structural view of fig. 12.

Fig. 15 is a schematic structural diagram of a blood line according to an embodiment of the present invention.

Fig. 16 is a schematic structural diagram of another blood line according to an embodiment of the present invention.

Fig. 17 is a side view of fig. 15.

Fig. 18 is a side view of an illumination device according to an embodiment of the present invention.

Fig. 19 is a side view of another lighting device according to an embodiment of the present invention.

Description of reference numerals:

1-a blood sampling device, 2-a cell centrifugal separation device, 3-a device to be irradiated, 301-a blood flow channel, 302-a shunt body, 303-a feed inlet, 304-a discharge outlet, 305-a feed branch port, 306-a discharge branch port, 307-a flow control pump, 308-a shunt flow channel, 4-an illumination device, 401-a lamp panel, 402-an illumination light source, 403-a cylindrical shell, 404-a bayonet, 405-a hinge, 5-a feedback device, 6-a control device, 7-a drug injection pump, 8-a first pipeline, 9-a second pipeline, 10-a third pipeline, 11-a fourth pipeline, 12-a pressure sensor, 13-an anticoagulant adding device, 14-a fluid infusion device, 15-an ultrasonic bubble sensor, 16-component detection device, 17-collection device, 18-injector, 19-swing mechanism.

Detailed Description

Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that: unless specifically stated otherwise, the relative arrangement of the components and steps, the numerical expressions, and numerical values set forth in these embodiments do not limit the scope of the present invention.

The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses.

Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.

In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

The embodiment of the utility model provides an at closed loop sterilizing installation in vivo can form closed loop system with the health when using, and this at closed loop sterilizing installation in vivo can carry out work in succession, can be used to carry out continuous circulation light irradiation treatment to the whole body blood of patient to bacterium, virus wherein inactivate and other suitable diseases, treatment environment safety, reliable can effectively avoid the condition of blood infection to take place. In the present invention, the term "in vivo" means that the body is integrally connected to the body. The closed loop is a closed system formed by the whole blood processing equipment and the body, so that external bacteria and the like are prevented from invading, and the danger caused by infection is avoided. In addition, the embodiment of the utility model provides an at body closed loop sterilization equipment can be applied to human body, animal body etc. the utility model discloses do not do the restriction to this.

Referring to fig. 1, an in-vivo closed-loop sterilization apparatus provided in an embodiment of the present invention at least includes: a blood sampling device 1, a cell centrifugal separation device 2, a light sterilization device, a back transfusion device 5 and a medicine injection device. Of course, a control device 6 may also be included to enable automated control of the entire apparatus.

The blood collection device 1 of the present invention may include components known to those skilled in the art, such as a blood collection needle, a blood collection pump, a filter, and a blood collection tube, which will not be described in detail herein. In the present invention, referring to fig. 1, the blood sampling device 1 can be connected to the cell centrifugal separation device 2 through the first pipeline 8, and at this time, the blood extracted from the body can be transported to the cell centrifugal separation device 2 through the first pipeline 8 under the action of the blood sampling pump. That is, the blood collecting device 1 is used to draw blood from a body and send the drawn blood into the cytocentrifugal separation device 2. In order to automatically control the operation of the blood collection device 1, the blood collection device 1 may be connected to the control device 6 via a communication control line, i.e., the control device 6 may control operations such as starting and stopping the blood collection device 1.

The cell centrifugal separation device 2 of the utility model mainly separates blood based on the centrifugal separation principle to divide blood into different parts. In the present invention, the cell centrifugal separation device 2 is used to divide blood into a non-treatment part and a part to be treated, so as to treat the separated part to be treated, and inactivate bacteria and viruses therein. Specifically, since bacteria exist in the plasma of blood but not in cells, the plasma in blood can be separated separately by the cytocentrifugal separation apparatus 2 to be treated, and then the plasma can be treated by light irradiation alone by the light irradiation sterilization apparatus, so that the bacteria existing in the plasma can be eliminated. Since viruses may be present in both plasma and nucleated cells, plasma and nucleated cells may be separated from blood by centrifugation, and the separated plasma and nucleated cells may be irradiated with light using a light sterilizing apparatus to inactivate viruses contained therein.

Wherein, the cell centrifugal separation device 2 can be connected with the control device 6 through a communication control line, namely, the control device 6 can reasonably control the centrifugal separation process of the cell centrifugal separation device 2.

In addition, it should be noted that, the cell centrifugal separation device 2 of the present invention is to rely on the centrifugal principle to separate blood components, and the centrifugal part thereof can be, for example, a centrifugal disc, a centrifugal bag, a centrifugal cup, etc., and can be flexibly selected according to specific conditions, which is not limited by the present invention.

Referring to fig. 1, the illumination sterilization apparatus of the present invention includes an illumination device 4 and a device to be irradiated 3, and the whole device to be irradiated 3 is made of a transparent material. Specifically, the illumination device 4 may generate the irradiation treatment light of a predetermined intensity and duration, which may be used to perform the light irradiation treatment. And the device to be irradiated 3 may be used to receive the portion to be treated in the blood separated by the cytocentrifugal separation device 2. The whole device 3 to be irradiated is made of transparent material, so the irradiation treatment light emitted by the illumination device 4 can penetrate through the device 3 to be irradiated to perform light irradiation treatment on the part to be treated in the device, namely, the part to be treated in blood is sterilized and virus-killed.

Wherein, the irradiation treatment light that illumination device 4 launches can choose for use any one or its all combinations in UVA, UVB, UVC, the visible light, can select according to particular case is nimble, the utility model discloses do not do the restriction to this.

The illumination device 4 can be connected to the control device 6 through a communication control line, that is, the control device 6 can reasonably control the illumination intensity, time and the like of the illumination device 4. Specifically, the control device 6 can control the irradiation time, the irradiation intensity, and the like of the irradiation device 4 in accordance with the treatment request. In practice, during the light irradiation by the light irradiation device 4, the irradiation energy J (unit, joule) is W × t, where W is the irradiation power and t is the irradiation time. In the process of the light irradiation treatment by the light irradiation device 4, a specific irradiation energy J (irradiation joule) and a specific irradiation wavelength are selected so that damage to nucleated cells can be prevented when viruses are inactivated.

The utility model discloses in, cell centrifugal separation device 2 can be connected with feedback device 5 through second pipeline 9 for the non-treatment part that will separate out from blood directly sends into feedback device 5 through second pipeline 9, and is internal by feedback device 5 feedback, in order to realize a circulation process. The cell centrifugal separator 2 is also connected to the device 3 to be irradiated via a third line 10, and the device 3 to be irradiated is connected to the return line 5 via a fourth line 11. At this time, the part to be treated separated from the blood may be sent into the device 3 to be irradiated through the third pipeline 10, the part to be treated in the device 3 to be irradiated is subjected to light irradiation treatment by the light irradiation device 4, and after the light irradiation treatment is completed, the part is sent back to the back-infusion device 5 and is returned back to the body by the back-infusion device 5, so as to realize another circulation process. The whole process can be continuously carried out until the whole blood is treated once or for many times, and the whole blood treatment device can be flexibly adjusted according to the actual condition, and the utility model has no limitation.

When the cell centrifugal separation device 2 sends the separated treatment part into the device 3 to be irradiated, a photosensitizer or related treatment medicine needs to be synchronously injected into the third pipeline 10 by the medicine injection device. The use of photosensitizers or related therapeutic agents in therapy can enhance the therapeutic effect. For example, vitamin B2 without toxic and side effects can be used, but whether the matched medicine is needed is determined according to the clinical situation, and the utility model is not limited to the above.

Referring to fig. 2 and 3, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention may further include a collecting device 17. Wherein the collecting device 17 may be connected or arranged on the third conduit 10 communicating the cytocentrifugal separation device 2 and the device to be irradiated 3.

The collecting device 17 has an injection port, which can be connected to a drug injection device. The injection device may inject a photosensitizer or related therapeutic agent through the injection port into the collection device 17. The part to be treated in the blood separated by the cell centrifugal separation device 2 can be conveyed into the collection device 17 for collection, after the accumulation reaches a certain volume, the photosensitizer (or the medicine) is injected into the collection device 10 by the medicine injection device through the injection port, after the photosensitizer (or the medicine) is fully mixed with the part to be treated, the part to be treated mixed with the photosensitizer (or the medicine) is conveyed into the device to be irradiated 3 and is subjected to light irradiation treatment by the illumination device 4, and after the light irradiation treatment is finished, the part to be treated is conveyed to the feedback device 5 by the fourth pipeline 11 and is finally conveyed back into the body.

After the part to be treated collected in the collecting device 17 has been completely delivered to the device to be irradiated 3, the illumination device 4 is turned on again. In this manner, after the portion to be treated in the collecting device 17 is completely inputted to the device to be irradiated 3, a newly separated portion to be treated is inputted into the collecting device 17. The mode has the characteristics of convenient and simple control.

During the process of transferring the part to be treated to the device to be irradiated 3 by the collecting device 17, the transferring speed can be determined by the control device 6 according to the irradiation energy and the irradiation intensity of the irradiation device 4.

The collecting device 17 may be a device with a storage function, such as a storage bag or a storage pool, and may be flexibly selected according to the need in use, which is not limited by the present invention.

Optionally, as shown in fig. 1, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention may not be provided with the collection device 17, at this time, the part to be treated in the blood separated by the cytocentrifugal separation device 2 is transmitted to the device to be irradiated 3, and the transmitted part to be treated is subjected to the light irradiation treatment by the illumination device 4, that is, the transmission and the light irradiation treatment are performed simultaneously. In the case of the mode of irradiating while transmitting, the irradiation time t of the irradiation device 4 is L/v, where L is the transmission length of the device 3 to be irradiated, and v is the transmission speed. The method has high therapeutic efficiency.

Referring to fig. 1 and 2, the injection device of the present invention may adopt an injection pump 7, and the injection pump 7 may be connected to the control device 6 through a communication control line. Under the control of the control device 6, the injection pump 7 can achieve the synchronization in time with the transfer of the part to be treated from the cytocentrifugal separation device 2 to the collection device 17 when the photosensitizer (or the drug) is injected into the collection device 17. Furthermore, the amount of photosensitizer (or drug) injected can be closely controlled. The whole process can realize automatic processing, the precision is higher, and the operation is very convenient.

Referring to fig. 3, the injection device of the present invention may also be a syringe 18. The photosensitizer (or medicine) can be injected into the third pipeline 10 or into the collecting device 17 through the injector 18 by manually operating the injector 18, and the photosensitizer (or medicine) can be flexibly arranged according to whether the collecting device 17 is arranged or not.

The feedback device 5 may include, among other things, a blood transfusion needle, a blood transfusion pump, a filter, and a blood transfusion channel, which are well known to those skilled in the art and will not be described in detail herein. The return device 5 can be used in conjunction with the lancing device 1 to carry out a closed loop circulation process. Furthermore, in the present invention, in order to realize the automatic control (e.g. start or stop) of the operation of the feedback device 5, the feedback device 5 can be connected to the control device 6 through the communication control line, and the control device 6 can reasonably control the working process of the feedback device 5.

The utility model discloses in, can realize carrying out corresponding control respectively to blood sampling device 1, cell centrifugal separation device 2, illumination sterilization apparatus and feedback device 5 etc. through controlling means 6. The in-vivo closed-loop sterilization equipment can have the characteristic of automatic control through the design. Wherein, optionally, the control device 6 may have a display device, and a user may control and observe the operation state of each component and the like by operating the display device. The display device may be, for example, a display device known to those skilled in the art, such as a touch display screen, and the present invention is not limited thereto.

In addition, referring to fig. 4, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention may also adopt a single-needle mode, i.e. the blood sampling device 1 and the feedback device 5 are combined together. In this case, the blood collection and the return can be alternately performed under the control of the control device 6. Specifically, the method comprises the following steps: a needle may be used which may act as a blood collection needle or as a blood transfusion needle. When the needle is connected with the pipeline, blood can not be returned to the body when blood is collected from the body, namely, the blood collection and the blood transfusion work in a time-sharing way, and the mutual interference phenomenon can not be generated. When blood is collected, the blood collecting pump is controlled by the control device 6 to operate, and the feedback pump is controlled to stop working (or low flow rate). When blood is back-transfused, the blood collecting pump is controlled by the control device 6 to stop (the flow is 0 when the blood collecting pump stops, which is equivalent to the closing of a pipeline, and the back-transfusing pump is controlled to run at the same time). When the flow of the blood sampling pump is larger than that of the feedback pump, the blood flows outwards from the needle, and conversely flows inwards.

It should be noted that the first, second, third and

fourth lines

8, 9, 10 and 11 are flexible tubes well known to those skilled in the art, so as to facilitate the transportation of blood. And, the size of above-mentioned these pipelines can be adjusted in a flexible way as required, the utility model discloses do not do the restriction to this.

The utility model discloses a light sterilization apparatus, simple structure, various can be fit for multiple demand. The illumination sterilization device comprises an illumination device 4 and a device to be irradiated 3.

The utility model discloses an illumination device 4, it can include the shell, and is provided with a plurality of irradiation source 402 on the inner wall of this shell, launches the treatment light that shines by irradiation source 402 to realize the light irradiation treatment. The irradiation light source 402 may be any one or a combination of UVA, UVB, UVC, and visible light. In use, the device to be irradiated 3 is disposed inside the housing so that the irradiation light source 402 can irradiate the device to be irradiated 3, thereby performing light irradiation treatment on the portion to be treated inside the device to be irradiated 3.

It should be noted that the housing of the illumination device 4 may have various structures, and may be flexibly selected according to actual situations in the application. The number and arrangement of the light sources 402 may be adjusted flexibly as required. In addition, the illumination source 402 may be disposed directly on the inner wall of the housing, or may be embedded in the inner wall of the housing and protected by a transparent cover.

Referring to fig. 5, one structure of the illumination device 4 is: including the shell, this shell includes two lamp plates 401 of relative setting. A plurality of light sources 402 are uniformly disposed on two opposite surfaces of the two lamp panels 401. The device to be illuminated 3 is disposed between the two lamp panels 401. At this time, the irradiation light sources 402 on the two lamp panels 401 may irradiate the upper and lower surfaces of the device to be irradiated 3 with light. The device 3 to be irradiated can be uniformly irradiated by adopting simultaneous up-and-down light irradiation, so that the part to be treated in the device can be uniformly irradiated and treated well. Note that a plurality of irradiation light sources 402 may be uniformly provided on any one of two opposing surfaces of the two lamp panels 401, that is, a single-sided light irradiation system may be used.

The illuminating light source 402 can be a lamp bead or a lamp tube, and can be flexibly adjusted according to actual needs in specific applications.

When the housing of the illumination device 4 is two lamp panels 401 arranged oppositely, the device to be illuminated 3 may adopt any one of the following structures.

Optionally, the device 3 to be irradiated is a blood bag made of a light-transmitting material. Referring to fig. 6, in order to allow the portion to be treated collected in the blood bag to be uniformly irradiated with light, i.e., the same amount of light energy, a swing mechanism 19 may be added thereto. At this time, the light source for irradiating the blood bag may be lamp beads or lamp tubes, and the lamp beads or the lamp tubes are uniformly distributed on the lamp panel 401, for example, arranged in a matrix shape. Specifically, the swing mechanism 19 may be a swing plate on which the blood bag is directly placed in a flat state when in use. In order to achieve a good light-transmitting effect, the swing mechanism 19 may be made of a material with good light-transmitting property, such as quartz, or may be made of other light-transmitting materials known to those skilled in the art, which is not limited by the present invention.

Alternatively, referring to fig. 7, the device to be irradiated 3 is a blood cassette of a flat structure. The blood cassette has at least two different configurations. Two different configurations of the blood cassette are further described below.

In one embodiment of the present invention, referring to fig. 8, the blood box comprises a flat box body, and a transparent blood channel 301 is disposed in the box body. At this time, the illumination source 402 may select a lamp bead, and the arrangement of the lamp beads on the lamp panel 401 should match the shape of the blood channel 301. The blood flow channel 301 in the blood box has a certain width, the wall is very thin, the light transmittance is good, light can be conveniently irradiated into the blood flow channel, and light irradiation treatment is carried out on a part to be treated flowing in the blood flow channel. Wherein, arrange a plurality of lamp pearls along blood runner 301's shape, be favorable to aiming at blood runner 301 and carry out abundant light irradiation treatment, can make full use of light energy, avoid the waste of light energy. Of course, a plurality of lamp beads can also adopt other arrangement modes on lamp plate 401, for example, a plurality of lamp beads are evenly arranged to form a matrix shape and the like, and can be flexibly adjusted according to specific needs as long as the lamp beads can irradiate the blood flow channel 301.

In another embodiment of the present invention, referring to fig. 9, the blood box comprises a flat box body, which is provided with a feeding port 303 and a discharging port 304, and is provided with a plurality of partitions inside the box body, the partitions are used for dividing the space inside the box body into a plurality of accommodating cavities, wherein each accommodating cavity is provided with a feeding branch port 305 communicated with the feeding port 303, and each accommodating cavity is further provided with a discharging branch port 306 communicated with the discharging port 304. At this time, the irradiation light source 402 may be a lamp bead or a lamp tube. Specifically, the method comprises the following steps: when the lamp beads are adopted, a plurality of lamp beads are arranged on the lamp panel 401 in multiple rows and multiple columns, and the adjacent two rows of lamp beads are arranged in a staggered mode, so that light energy is fully utilized. When the lamp tube is used, the plurality of lamp tubes are sequentially arranged on the lamp panel to form one or more rows of lamp tubes, but the lamp tubes may also be arranged in other shapes, such as rectangular, according to the illumination requirement.

When the part to be treated separated from the blood enters the blood box from the feeding port 303, the part to be treated is fluid and can enter different accommodating cavities through the feeding branch ports 305. Since the fluid flow area is increased, the light receiving area is also increased. In this embodiment, a turn may be provided on the partition, which is designed according to a fluid curve, and may be used for diversion, facilitating the outflow of fluid, to prevent the formation of dead corners. In addition, it is preferable that a plurality of baffles are equidistant and evenly arranged in the blood box, at this moment, the aperture of the feeding branch port 305 close to the feeding port 303 is smaller than the aperture of the feeding branch port 305 far away, that is, the aperture of the feeding branch port gradually increases from the end close to the feeding port to the end far away, which is beneficial to the fluid to respectively circulate in each accommodating cavity, so that the part to be treated can be subjected to light irradiation treatment in a subarea, and the light irradiation treatment effect is improved.

Optionally, the device 3 to be irradiated is a blood transport vessel. When irradiation treatment is performed, the blood transfusion duct is extended between the two lamp panels 401. At this time, two opposite surfaces of the two lamp panels 401 are respectively provided with a row of irradiation light sources 402 corresponding to the positions of the blood conveying vessels. This approach simplifies the structure of the illumination device 4.

Referring to fig. 10 and 11, when a blood transportation duct is adopted, the blood transportation duct may be extended into the illumination device 4, that is, a section extending between the two lamp panels 401 is made into a flat structure, so as to increase the light receiving area, and thus the light irradiation treatment effect may be properly improved. Wherein, the blood pipeline can be directly processed into a flat structure. Or, the part of the blood conveying pipeline which needs to be irradiated is formed into a flat structure by adopting a pressing mode. It should be noted that the blood transfusion tract is generally made of a soft material, and when the blood transfusion tract is extruded, the two lamp panels 401 may be used to directly extrude the blood transfusion tract, or of course, other extrusion methods may be used. In order to prevent the restoration of the deformation of the blood transfusion channel, a transparent support frame can be arranged in the blood transfusion channel, and the blood transfusion channel can be kept flat while the light transmission is not influenced.

Referring to fig. 12 to 14, one structure of the illumination device 4 is: the illumination device includes a cylindrical case 403 having both ends open, and a plurality of irradiation light sources 402 are uniformly provided on the inner wall of the cylindrical case 403. With this configuration, the device to be irradiated 3 protrudes into the cylindrical housing 403, and may be disposed along the central axis of the cylindrical housing 403, for example, that is, the device to be irradiated 3 may be wrapped by the cylindrical housing 403, so that the device to be irradiated 3 is irradiated with light from the irradiation light source 402 in the cylindrical housing 403. The irradiation light source 402 may be a lamp bead or a lamp tube, and may be flexibly selected according to specific conditions.

When the shell of illumination device 4 was cylindric structure, in order to cooperate its structure, waited to shine device 3 and can chooseed for use ordinary blood pipeline, its cross-sectional shape can be for circular, oval etc. the utility model discloses do not do the restriction to this.

However, the blood line is generally thin, the inner diameter is about 1.5-4mm, and when the blood line is irradiated by the light irradiation device 4, the light receiving area is relatively small, which results in unsatisfactory light irradiation treatment effect. In order to increase the light receiving area and improve the light irradiation effect, the radius of the blood pipeline can be increased. In one embodiment, referring to fig. 15-17, a cross-sectional dimension of a segment of the blood line is greater than cross-sectional dimensions of two ends of the segment, and a shunt 302 is disposed within the segment of the blood line, such that a shunt channel 308 is formed between an inner wall of the blood line and an outer wall of the shunt 302.

The flow splitter 302 includes a flow splitter housing, and the flow splitter housing has a cavity therein, i.e., is a hollow structure. Moreover, the entire flow dividing body 302 is made of a transparent material, so that the therapeutic light emitted from the illumination device 4 can pass through. The flow splitter 302 is configured to: when the part to be treated separated from the blood enters the blood pipeline, the part to be treated is fluid and can be used for enabling the part to be treated to flow through along the shunt flow channel, namely the part to be treated passes by being attached to the wall surface of the blood pipeline. When the illumination device 4 is used for illuminating, the illumination device has the characteristics of large light receiving area and more uniform light receiving. Of course, the flow splitter 302 may also be a solid structure, but may be heavier in weight than a hollow structure. In specific application, the device can be flexibly adjusted according to requirements.

It should be noted that the external shape of the fluid distribution housing should help to facilitate fluid flow therethrough. The flow diversion device has the advantages that the flow diversion function is realized while the flow is diverted, and the flow is favorably realized without dead angles. Referring to fig. 15 and 16, the shape of the shunt body housing may be a cube, a tapered cylinder, etc., wherein a tapered cylinder refers to a cylinder with two triangular ends.

In order to stably install the blood line inside the cylindrical case 403 of the irradiation device 4, the cylindrical case 403 may be fixed to the blood line to be irradiated. Referring to fig. 18, the cylindrical housing 403 may be designed into two semicircular structures, and the connecting points of the two semicircular structures are respectively provided with a pair of clamping pins 404, so that the cylindrical housing 403 is clamped on the blood line through the pair of clamping pins 404. Referring to fig. 19, the cylindrical case 403 may be opened and closed, and the cylindrical case 403 may be attached to the blood line after being opened, and then fixed by the hinge 405. The above two modes can be flexibly selected according to the needs, and the utility model discloses do not do the restriction to this. It should be noted that, when the method as shown in fig. 18 and fig. 19 is adopted, a lamp shade may be additionally provided on the lamp bead on the inner wall of the cylindrical shell 403; of course, the lamp shade is not needed, namely the lamp beads directly irradiate outwards.

Referring to fig. 16, a flow control pump 307 may be provided in the blood line. The flow control pump 307 may be connected to the control device 6 via a communication control line. The flow control pump 307 may be controlled by the control device 6 to control the flow rate of the fluid input into the bloodline.

Referring to fig. 1-4, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention may further include an anticoagulant adding device 13. Wherein the anticoagulant addition device 13 is configured to: an anticoagulant may be added to the blood collection set 1. Specifically, when the blood is drawn out into the first line 8 by the blood drawing device 1 and circulation is started, coagulation of the blood being treated can be prevented by adding an anticoagulant, so that smooth progress of the whole blood circulation process can be ensured. It should be noted that the addition amount of the anticoagulant can be flexibly controlled according to the requirement, and the utility model discloses do not limit this.

Wherein the anticoagulant adding device 13 may be directly integrated with the blood sampling device 1. Of course, the anticoagulant adding device 13 may be connected to the blood sampling device 1 through a tube. The two modes can realize the addition of the anticoagulant, and can be flexibly selected according to actual conditions in specific application.

The anticoagulant adding device 13 may be connected to the control device 6 via a communication control line. This design can realize the control of controlling means 6 to anticoagulant adds device 13, can control anticoagulant adds device 13 and adds the anticoagulant in the blood, or stops adding the anticoagulant in the blood. That is, the control device 6 can automatically control the addition of the anticoagulant, and this is convenient to operate and easy to control the addition amount. Of course, the anticoagulant addition device 13 may not be connected to the control device 6, and in this case, the addition and addition amount of the anticoagulant may be manually controlled. Can be flexibly selected according to the requirement in the specific application, and the utility model discloses do not do the restriction to this.

Referring to fig. 1-4, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention further includes a pressure sensor 12. In particular, a pressure sensor 12 may be provided outside the lancing device 1 and the return device 5, respectively. The pressure sensors 12 are all connected with the control device 6 through communication control lines. In order to achieve accurate pressure detection, the pressure sensors 12 are disposed close to the corresponding pipes.

The pressure sensor 12 arranged outside the lancing device 1 is used to detect the pressure at the lancing end, for example, the pressure in the lancing tube in the lancing device, and the pressure in the first line 8 connected to the lancing device 1. Likewise, a pressure sensor 12 arranged outside the return device 5 is used to detect the pressure conditions at the return end, for example in the blood supply line in the return device 5, and in the second line 9 and the fourth line 11 connected to the return device 5. Whether the needle (such as a blood taking needle and a blood transfusion needle) and the corresponding pipeline are blocked or not can be judged through pressure detection. Once the blockage occurs, the pressure in the pipe is easy to be abnormal, and the danger is caused.

The position of the pressure sensor 12 is not limited to the above embodiment, but may be variously set. For example: the pressure sensors 12 are respectively provided on the corresponding pipes. Alternatively, the pressure sensor 12 is arranged inside the corresponding line. Can adjust according to actual conditions is nimble, the utility model discloses do not limit to this. In addition, the number of the pressure sensors 12 is not limited in the present invention, and an appropriate number can be flexibly selected as needed.

Also, each pressure sensor 12 may be connected to the control device 6 via a communication control line. This design enables the control device 6 to control the pressure sensor 12, i.e. the pressure sensor 8 can be controlled to start pressure detection at an appropriate timing, or of course the pressure sensor 12 can be controlled not to perform pressure detection.

Referring to fig. 1-4, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention may further include a component detection device 16. The component detecting means 16 may be connected to the cell centrifugation and separation apparatus 2 through a detection line or a communication control line, and the component detecting means 16 may be further connected to the control means 6 through a detection line or a communication control line. Wherein the component detection device 16 is configured to: the component detecting device 16 can detect the components, purity, and the like of each part separated by the centrifugal cell separator 2 under the control of the control device 6, and can control the component separation process of the centrifugal cell separator 2 so that different components can be well layered, which is advantageous for extracting different components separately. That is, when the centrifugal separator 2 separates blood into different components, the layered state, the type, and the purity of each component can be detected by the component detection unit 16. The component detection device 16 may be selectively provided or not provided as needed.

Referring to fig. 1-4, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention further includes an ultrasonic bubble sensor 15, and the ultrasonic bubble sensor 15 is located at one end of the feedback device 5. The ultrasonic bubble sensor 15 is connected to the feedback device 5. Specifically, the ultrasonic bubble sensor 15 detects whether the returned blood contains bubbles by using ultrasonic waves, and immediately stops the blood returning to the body and gives an alarm once the bubbles in the blood are detected, otherwise, the blood entering the body is dangerous.

And the ultrasonic bubble sensor 15 is also connected with the control device 6 through a communication control line. The design can realize the control of the ultrasonic bubble sensor 15 by the control device 6, namely the ultrasonic bubble sensor 15 can be controlled to start detection at a proper time, and certainly, the ultrasonic bubble sensor 15 can also be controlled not to detect. That is, an automated control of the ultrasonic bubble sensor 15 may be achieved by the control device 6.

Referring to fig. 1-4, the in-vivo closed-loop sterilization apparatus provided in the embodiment of the present invention may further include a fluid infusion device 14. The fluid infusion device 14 is configured to: in the case of blood transfusion, fluid replacement is performed into the blood, and for example, nutrient solution, medicine, or the like can be supplemented into the body. Wherein, the fluid infusion device 14 can be connected with the feedback device 5 through a fluid infusion tube. Of course, the fluid replacement device 14 may also be integrated with the return device 5. Both of the two ways described can be implemented to add nutrient solution or drugs to the reinfused blood.

The fluid infusion device 14 may be connected to the control device 6 via a communication control line. The design can realize the control of the control device 6 on the liquid supplementing device 14 so as to realize the automation of liquid supplementing.

It should be noted that the anticoagulant adding device 13 and the fluid infusion device 14 of the present invention may employ a dedicated pump, and the operation or the stop thereof may be controlled by the control device 6. The utility model provides a pressure sensor 12, supersound bubble sensor 15, composition detection device 16 also are controlled by controlling means 6, have realized the automation of operation.

Although certain specific embodiments of the present invention have been described in detail by way of example, it should be understood by those skilled in the art that the foregoing examples are for purposes of illustration only and are not intended to limit the scope of the invention. It will be appreciated by those skilled in the art that modifications may be made to the above embodiments without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.

Claims

1. An in-vivo closed-loop sterilization device is characterized by comprising a blood sampling device, a cell centrifugal separation device, an illumination sterilization device and a feedback device; the illumination sterilization device comprises an illumination device and a device to be irradiated, wherein the device to be irradiated is made of a light-transmitting material;

still include injection device, injection device with the third tube coupling.

2. The in-vivo closed-loop sterilization apparatus according to claim 1, wherein the blood sampling device, the cytocentrifugal separation device, the illumination device and the feedback device are respectively connected with the control device.

3. The in-vivo closed loop sterilization apparatus according to claim 1, further comprising a collection device connected to said third line;

4. The in-vivo closed-loop sterilization apparatus according to claim 1, wherein said drug injection device is a syringe; in the alternative, the first and second sets of the first,

5. The in-vivo closed loop sterilization equipment according to claim 1, wherein the illumination device comprises two lamp panels arranged oppositely, and at least one of two opposite surfaces of the two lamp panels is provided with a plurality of illumination light sources;

the device of treating to shine is in between two lamp plates.

6. An in-vivo closed-loop sterilization apparatus according to claim 5, wherein said device to be irradiated is a blood bag;

the irradiation light source is a lamp bead or a lamp tube.

7. In-vivo closed-loop sterilization apparatus according to claim 5, wherein the device to be irradiated is a blood cassette;

8. In-vivo closed-loop sterilization apparatus according to claim 5, wherein the device to be irradiated is a blood cassette;

9. The in-vivo closed-loop sterilization equipment according to claim 5, wherein the device to be irradiated is a blood conveying pipeline, and a section of the blood conveying pipeline extending between the two lamp panels is of a flat structure.

10. An in-vivo closed-loop sterilization apparatus according to claim 1, wherein the illumination device comprises a cylindrical housing with two open ends, and a plurality of illumination light sources are uniformly arranged on the inner wall of the cylindrical housing;

the device to be irradiated is disposed inside the cylindrical housing.

11. Closed loop in vivo sterilization apparatus as defined in claim 10, wherein said device to be irradiated is a blood line.

12. An in-vivo closed-loop sterilization apparatus according to claim 10, wherein the device to be irradiated is a blood line, the cross-sectional dimension of one section of the blood line is larger than the cross-sectional dimensions of the two end portions of the section, a shunt fluid is disposed in the section, and a shunt flow channel is formed between the inner wall of the blood line and the outer wall of the shunt fluid;

13. An in-vivo closed-loop sterilization apparatus according to claim 12, wherein said shunt body is a hollow structure.

14. In-vivo closed-loop sterilization apparatus according to claim 12, wherein the blood line is provided with a flow control pump, and the flow control pump is connected with a control device.

15. An in-vivo closed loop sterilization apparatus according to claim 12, wherein cylindrical housing is mounted on a section of said blood line where said shunt fluid is disposed by a bayonet or a hinge.

16. The in-vivo closed-loop sterilization apparatus according to claim 1, wherein the exterior of the blood sampling device and the infusion back device are respectively provided with a pressure sensor, and the pressure sensors are connected with a control device.

17. Closed-loop in vivo sterilization apparatus as defined in claim 1, wherein said cytocentrifugation device is connected with a component detection device, said component detection device is connected with a control device, said component detection device is configured to: the kind, purity and layering state of each fraction separated by the cell centrifugation apparatus are detected under the control of the control apparatus.

18. The in-vivo closed-loop sterilization apparatus according to claim 1, wherein the feedback device is further connected to an ultrasonic bubble sensor and a liquid supplementing device, respectively, and both the ultrasonic bubble sensor and the liquid supplementing device are connected to the control device.