CN108721961B - Blood filtering device - Google Patents

Blood filtering device Download PDF

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Publication number
CN108721961B
CN108721961B CN201810601221.2A CN201810601221A CN108721961B CN 108721961 B CN108721961 B CN 108721961B CN 201810601221 A CN201810601221 A CN 201810601221A CN 108721961 B CN108721961 B CN 108721961B
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China
Prior art keywords
blood
filtering
plate
flow distribution
top plates
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CN201810601221.2A
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Chinese (zh)
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CN108721961A (en
Inventor
杨翔
陈锦河
楼建荣
谢桂华
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Guangzhou Leide Biotechnology Co ltd
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Guangzhou Leide Biotechnology Co ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D29/00Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D29/00Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/88Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor having feed or discharge devices
    • B01D29/90Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor having feed or discharge devices for feeding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2201/00Details relating to filtering apparatus
    • B01D2201/20Pressure-related systems for filters
    • B01D2201/202Systems for applying pressure to filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2221/00Applications of separation devices
    • B01D2221/10Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2313/00Details relating to membrane modules or apparatus
    • B01D2313/10Specific supply elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2313/00Details relating to membrane modules or apparatus
    • B01D2313/24Specific pressurizing or depressurizing means

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention belongs to the technical field of medical instruments and discloses a blood filtering device. The filtering device comprises: the inlet end of the liquid suction pipe component can hermetically extend into a test tube containing blood; the cross-section flow distribution assembly comprises a flow distribution plate and a plurality of top plates arranged on the flow distribution plate, the outlet end of the liquid suction pipe assembly is arranged on the flow distribution plate and is movably connected with a baffle plate, and the top plates are respectively positioned around the baffle plate and can guide blood to the edge of the flow distribution plate; the filter membrane covers the cross-section flow dividing assembly and is arranged on the top surface of the top plate. By adopting the filtering mode, the blood circulation is smooth, the filtering pressure and the filtering time are reduced, the plasma formed after filtering can flow into the collector, and the filtering effect is further enhanced.

Description

Blood filtering device
Technical Field
The invention relates to the technical field of medical instruments, in particular to a blood filtering device.
Background
Medical institutions generally collect blood from veins, arteries, or fingers of the human body to obtain blood samples.
Typically, a blood sample includes whole blood and plasma, where the upper yellowish liquid is plasma after the whole blood is filtered through a filter membrane. Because blood contains various macromolecular components such as erythrocytes, blood fat, fibrin and the like, the components often cause the blockage of a filter membrane, so that the blood flows smoothly, and the filtering effect of the blood is further influenced. In addition, the prior art needs a plurality of steps such as injection, centrifugation and extraction during filtration, and the operation is very complicated.
Disclosure of Invention
The invention aims to provide a blood filtering device, which avoids the situation that certain components cannot pass through a filter membrane to cause the blockage of the filter membrane, so that the blood flows smoothly, the filtering pressure and the filtering time are reduced, and the filtering effect is further enhanced.
In order to achieve the purpose, the invention adopts the following technical scheme:
a blood filtration device comprising: the inlet end of the liquid suction pipe component can hermetically extend into a test tube containing blood; the cross-section flow distribution assembly comprises a flow distribution plate and a plurality of top plates arranged on the flow distribution plate, the outlet end of the liquid suction pipe assembly is arranged on the flow distribution plate and is movably connected with a baffle plate, and the top plates respectively positioned around the baffle plate can guide blood to the edge of the flow distribution plate; and the filter membrane covers the section flow dividing assembly and is arranged on the top surface of the top plate.
Preferably, one end of the liquid suction pipe assembly, which is far away from the section flow dividing assembly, is provided with a liquid suction cover, and the liquid suction cover is of a conical structure.
Preferably, the imbibition pipe subassembly includes first connecting pipe and second connecting pipe, the one end of first connecting pipe communicate in imbibition cover, the other end communicate in the second connecting pipe, just the exit end of second connecting pipe set up in on the flow distribution plate.
Preferably, the second connection pipe is disposed to be inclined with respect to the first connection pipe.
Preferably, the number of the top plates is two, and the two top plates are respectively positioned on two sides of the baffle and are obliquely arranged.
Preferably, the two top plates are in a trumpet shape, and one end with a small diameter is arranged towards the baffle plate.
Preferably, the top plate has a rectangular shape.
Preferably, the plurality of top plates are circumferentially and uniformly arranged on the flow distribution plate.
Preferably, the top plate has a circular arc structure or a trapezoidal structure.
Preferably, the device further comprises a collector positioned above the filter membrane.
The invention has the beneficial effects that:
1) the inlet end of the liquid suction pipe component can be hermetically extended into a test tube containing blood, when the filter device is used, the whole filter device is pressed downwards, so that the filter device is hermetically extended into the test tube containing blood, and the blood can be pressed into the liquid suction pipe component under the action of air pressure; through a plurality of roof that set up on the flow distribution plate, the exit end of imbibition pipe subassembly sets up on the flow distribution plate and swing joint has the baffle, and a plurality of roof that are located around the baffle respectively can lead the edge to the flow distribution plate with the blood in the imbibition pipe subassembly.
2) Through setting up the filter membrane cover in cross-section reposition of redundant personnel subassembly and set up on the top surface of roof, when certain composition leads to the filter membrane jam of certain position owing to can not pass through the filter membrane, blood passes through after the reposition of redundant personnel flows, upwards permeates to the filter membrane again, realizes the filtration of blood. By adopting the filtering mode, the blood circulation is smooth, the filtering pressure and the filtering time are reduced, the plasma formed after filtering can flow into the collector, and the filtering effect is further enhanced.
3) The filtering device overcomes the defects of multiple using tools and complex operation in the prior art, and has simple structure and convenient and fast operation.
Drawings
FIG. 1 is a schematic view of the structure of the blood filtration device of the present invention;
FIG. 2 is a top view of a cross-sectional flow diversion assembly in accordance with one embodiment of the present invention;
FIG. 3 is a schematic view of the direction of blood flow in FIG. 2;
FIG. 4 is a top view of a cross-sectional flow diversion assembly in a second embodiment of the present invention;
fig. 5 is a top view of a cross-sectional flow manifold assembly according to a third embodiment of the present invention.
In the figure:
1. a pipette assembly; 2. a cross-sectional flow diversion assembly; 3. filtering the membrane;
11. a baffle plate; 12. a liquid suction cover; 13. a first connecting pipe; 14. a second connecting pipe;
21. a flow distribution plate; 22. a top plate.
Detailed Description
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.
Example one
The present embodiment provides a blood filtering device, as shown in fig. 1 to 3, comprising: the utility model discloses a blood vessel, including pipette assembly 1, pipette assembly 2 and filter membrane 3, pipette assembly 1's entrance point can stretch into the test tube that holds blood hermetically in, wherein cross-section shunt assembly 2 includes flow distribution plate 21 and a plurality of roof 22 that set up on flow distribution plate 21, and pipette assembly 1's exit end sets up on flow distribution plate 21 and swing joint has baffle 11, and a plurality of roofs 22 are located respectively around baffle 11 and can lead blood to flow distribution plate 21's edge. Meanwhile, the filter membrane 3 covers the cross-sectional flow dividing assembly 2 and is disposed on the top surface of the top plate 22.
The inlet end of the pipette component 1 can be hermetically extended into a test tube containing blood, when in use, the whole filtering device is pressed downwards, so that the filtering device hermetically extends into the test tube containing blood, and the blood can be pressed into the pipette component 1 under the action of air pressure; by providing a plurality of top plates 22 respectively located around the baffle 11 and disposed on the dividing plate 21, the outlet end of the pipette assembly 1 is disposed on the dividing plate 21, and the plurality of top plates 22 can guide the blood in the pipette assembly 1 to the edge of the dividing plate 21.
By arranging the filter membrane 3 to cover the cross-section flow dividing assembly 2 and to be arranged on the top surface of the top plate 22, when some components are blocked by the filter membrane 3 at a certain position due to being unable to pass through the filter membrane 3, blood flows through the flow dividing and then upwards permeates into the filter membrane 3, so that the blood is filtered. By adopting the filtering mode, the blood circulation is smooth, the filtering pressure and the filtering time are reduced, the plasma formed after filtering can flow into the collector, and the filtering effect is further enhanced.
The filtering device overcomes the defects of multiple using tools and complex operation in the prior art, and has simple structure and convenient and fast operation.
It should be noted that the pipette assembly 1, the section diversion assembly 2 and the filter membrane 3 may be disposed inside a sealing plug (not shown) as a whole, and the sealing plug may be inserted into the test tube in a sealing manner because the outer diameter of the sealing plug matches the inner diameter of the test tube. In addition, the sealing plug can also be set up in the bottom of pipette subassembly 1 as independent individual, because the external diameter and the length of sealing plug all match with the test tube, the sealing plug in the in-process of pushing down can be with the blood pressfitting in the test tube in the pipette subassembly 1. Therefore, the shape and position of the sealing plug are not limited in this embodiment, and can be adjusted according to actual production needs.
It should be noted that the filter device further includes a collector (not shown) above the filter membrane 3, and the plasma filtered by the filter membrane 3 can be collected for later storage or experiment.
As shown in fig. 1, the end of the pipette assembly 1 remote from the cross-sectional flow splitter assembly 2 is provided with a suction hood 12, wherein the suction hood 12 is of a conical configuration and the angle of taper of the suction hood 12 is 60 °. Because the conical pipette tip 12 has a bunching action, it pushes the red blood cells or macromolecular components of the blood forward and into the pipette assembly 1.
As shown in fig. 1, the second connection tube 14 of the pipette assembly 1 is inclined relative to the first connection tube 13, so as to avoid the situation that the blood passes through the pipette assembly 1 too fast to cause the filter membrane 3 to be too late to filter the blood, reduce the filtering pressure and facilitate the plasma formed after filtering to flow into the collector.
As shown in fig. 2-3, the above-mentioned cross-section flow dividing assembly 2 includes two top plates 22 respectively located at two sides of the baffle 11 and disposed obliquely, wherein the two top plates 22 are rectangular, and the two top plates 22 are trumpet-shaped, and one end of the small diameter is disposed toward the baffle 11. Because the outlet end of the second connecting pipe 14 is disposed on the cross-section flow dividing assembly 2 and movably connected to the baffle 11 at the outlet end, the blood flowing through the second connecting pipe 14 flows to the edge of the cross-section flow dividing assembly 2 in the direction with a larger distance between the two top plates 22 under the blocking effect of the baffle 11, and then is divided around the side walls of the two top plates 22, so that less blood flows back to the position of the baffle 11. Specifically, as shown in FIG. 3, the trajectory of the blood flow is A-B-C-D, forming a closed loop.
Because the front end of two roof 22 sets up baffle 11 and carries out the separation for the rear end of two roof 22 forms open endless space, and the structure of horn shape is adopted in arranging of two roof 22, not only can cushion filtering pressure, can also part blockage thing and plasma effectively, and then improved the filter effect.
It should be noted that the blood filtering apparatus provided in this embodiment can be used independently, and can also be mounted on any filter to reduce the filtering pressure and achieve the purpose of optimal filtering effect.
The working process of the blood filtering device provided by the embodiment is as follows:
firstly, the whole filtering device is pressed downwards, the sealing plug is hermetically extended into a test tube containing blood, and the blood can be pressed into the first connecting tube 13 and the second connecting tube 14 in sequence through the liquid absorption cover 12 under the action of air pressure;
secondly, the blood flowing through the second connecting tube 14 flows to the edge position of the cross-section flow splitting assembly 2 in the direction of larger distance between the two top plates 22 under the blocking effect of the baffle plate 11, and then is split along the side walls of the two top plates 22, so that less blood flows back to the position of the baffle plate 11 to form a closed loop;
thirdly, since the filter membrane 3 is covered on the cross-sectional flow dividing assembly 2 and is disposed on the top surface of the top plate 22, when some components are blocked by the filter membrane 3 at a certain position due to being unable to pass through the filter membrane 3, the blood flows through the reciprocating circulation and then permeates upward to the filter membrane 3, thereby realizing the filtration of the blood.
Example two
The difference between this embodiment and the first embodiment is only the shape and number of the top plate 22, and the rest is not described herein. In this embodiment, the top plates 22 are uniformly arranged on the flow dividing plate 21 along the circumferential direction of the second connecting pipe 14, specifically, as shown in fig. 4, the number of the top plates 22 is preferably four, and the top plates 22 have an arc-shaped structure.
Because the space formed between the two top plates 22 is also in the circular arc structure, the distance between the two top plates 22 is gradually increased along the direction away from the outlet end of the second connecting pipe 14, so that the blood flowing through the second connecting pipe 14 is conveniently shunted along the side wall of the top plate 22 to be guided to the edge of the shunt plate 21, the filtering pressure is reduced, and the situation that certain components cannot pass through the filter membrane 3 to cause the filter membrane 3 at a certain position to be blocked is effectively avoided.
The working process of the blood filtering device provided by the embodiment is as follows:
firstly, the whole filtering device is pressed downwards, the sealing plug is hermetically extended into a test tube containing blood, and the blood can be pressed into the first connecting tube 13 and the second connecting tube 14 in sequence through the liquid absorption cover 12 under the action of air pressure;
secondly, the blood flowing through the second connecting pipe 14 flows between two adjacent top plates 22 under the blocking action of the baffle plate 11, and is respectively divided along the side walls of the top plates 22 and guided to the edge of the dividing plate 21;
thirdly, since the filter membrane 3 is covered on the cross-sectional flow dividing assembly 2 and is disposed on the top surface of the top plate 22, when some components are blocked by the filter membrane 3 at a certain position due to being unable to pass through the filter membrane 3, the blood flows through the flow dividing and then permeates upward to the filter membrane 3, thereby realizing the filtration of the blood.
EXAMPLE III
The difference between this embodiment and the second embodiment is only the shape and number of the top plate 22, and the rest is not described herein. In this embodiment, the plurality of top plates 22 are uniformly arranged on the flow distribution plate 21 along the circumferential direction of the second connection pipe 14. Specifically, as shown in fig. 5, the number of the top plates 22 is preferably eight, and the shape of the top plate 22 is a trapezoidal structure. Because the space formed between the two top plates 22 is also in a trapezoid structure, the distance between the two top plates 22 is gradually increased along the direction away from the outlet end of the second connecting pipe 14, so that the blood flowing through the second connecting pipe 14 is conveniently shunted along the side wall of the top plate 22 to be guided to the edge of the shunt plate 21, the filtering pressure is reduced, and the situation that some components cannot pass through the filter membrane 3 to cause the filter membrane 3 at a certain position to be blocked is effectively avoided.
Wherein the number of the top plates 22 can be adjusted according to the actual production requirement, and when the time for filtering blood is required to be prolonged to increase the filtering effect, the number of the top plates 22 can be increased appropriately.
The working process of the blood filtering device provided by the embodiment is as follows:
firstly, the whole filtering device is pressed downwards, the sealing plug is hermetically extended into a test tube containing blood, and the blood can be pressed into the first connecting tube 13 and the second connecting tube 14 in sequence through the liquid absorption cover 12 under the action of air pressure;
secondly, the blood flowing through the second connecting pipe 14 flows between two adjacent top plates 22 under the blocking action of the baffle plate 11, and is divided along the side walls of the two top plates 22 and guided to the edge of the dividing plate 21;
thirdly, since the filter membrane 3 is covered on the cross-sectional flow dividing assembly 2 and is disposed on the top surface of the top plate 22, when some components are blocked by the filter membrane 3 at a certain position due to being unable to pass through the filter membrane 3, the blood flows through the flow dividing and then permeates upward to the filter membrane 3, thereby realizing the filtration of the blood.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims (10)

1. A blood filtration device, comprising:
a pipette assembly (1), the inlet end of the pipette assembly (1) being capable of sealingly protruding into a test tube containing blood;
the cross-section flow distribution component (2) comprises a flow distribution plate (21) and a plurality of top plates (22) arranged on the flow distribution plate (21), the outlet end of the liquid suction pipe component (1) is arranged on the flow distribution plate (21) and is movably connected with a baffle plate (11), and the top plates (22) are respectively positioned around the baffle plate (11) and can guide blood to the edge of the flow distribution plate (21);
the filter membrane (3) covers the section diversion assembly (2) and is arranged on the top surface of the top plate (22).
2. The blood filtering device according to claim 1, characterized in that the end of the pipette assembly (1) away from the cross-sectional flow splitting assembly (2) is provided with a pipette hood (12), and the pipette hood (12) has a conical structure.
3. The blood filtering device according to claim 2, wherein the pipette assembly (1) comprises a first connecting tube (13) and a second connecting tube (14), one end of the first connecting tube (13) is connected to the suction cover (12), the other end is connected to the second connecting tube (14), and the outlet end of the second connecting tube (14) is disposed on the splitter plate (21).
4. A device for filtering blood according to claim 3, wherein said second connection tube (14) is arranged obliquely with respect to said first connection tube (13).
5. The device for filtering blood according to claim 1, characterized in that said top plates (22) are two in number, two of said top plates (22) being respectively located on both sides of said baffle (11) and being disposed obliquely.
6. A device for filtering blood according to claim 5, characterised in that said two top plates (22) are arranged in a trumpet shape, the end of which with a small diameter is arranged towards said baffle (11).
7. A blood filtering device according to claim 5, wherein the top plate (22) is shaped as a rectangular structure.
8. The device for filtering blood according to claim 3, wherein a plurality of said top plates (22) are uniformly arranged on said flow distribution plate (21) along the circumference of said second connection pipe (14).
9. A blood filtering device according to claim 8, wherein the top plate (22) has a circular arc-shaped configuration or a trapezoidal configuration.
10. A device for filtering blood according to claim 1, further comprising a collector located above said filter membrane (3).
CN201810601221.2A 2018-06-12 2018-06-12 Blood filtering device Active CN108721961B (en)

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CN108721961B true CN108721961B (en) 2021-01-01

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CN109507178B (en) * 2018-12-25 2021-03-19 菏泽学院 Environment-friendly microbial indole tester

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453927A (en) * 1979-02-07 1984-06-12 Gesco International Method and apparatus for microfiltration of blood
US4923620A (en) * 1987-10-20 1990-05-08 Pall Corporation Device for depletion of the leukocyte content of blood and blood components
EP0630675A1 (en) * 1993-06-27 1994-12-28 Terumo Kabushiki Kaisha Leukocyte or leukocyte/platelet remover and filter therefor
CN1814310A (en) * 2005-02-06 2006-08-09 淄博中保康医疗器具有限公司 Disposable viral inactivating blood transfusion filting device
CN202155092U (en) * 2011-07-15 2012-03-07 李国钰 Needle filter
CN202490233U (en) * 2012-03-02 2012-10-17 四川南格尔生物医学股份有限公司 Novel blood fat filtration device
CN203763551U (en) * 2013-12-26 2014-08-13 中原大学 Blood filtering device
CN204656105U (en) * 2014-11-18 2015-09-23 笙特科技股份有限公司 Elastic shell type blood filter
CN207307359U (en) * 2017-08-28 2018-05-04 广州市雷德生物科技有限公司 A kind of piston filter column

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453927A (en) * 1979-02-07 1984-06-12 Gesco International Method and apparatus for microfiltration of blood
US4923620A (en) * 1987-10-20 1990-05-08 Pall Corporation Device for depletion of the leukocyte content of blood and blood components
EP0630675A1 (en) * 1993-06-27 1994-12-28 Terumo Kabushiki Kaisha Leukocyte or leukocyte/platelet remover and filter therefor
CN1814310A (en) * 2005-02-06 2006-08-09 淄博中保康医疗器具有限公司 Disposable viral inactivating blood transfusion filting device
CN202155092U (en) * 2011-07-15 2012-03-07 李国钰 Needle filter
CN202490233U (en) * 2012-03-02 2012-10-17 四川南格尔生物医学股份有限公司 Novel blood fat filtration device
CN203763551U (en) * 2013-12-26 2014-08-13 中原大学 Blood filtering device
CN204656105U (en) * 2014-11-18 2015-09-23 笙特科技股份有限公司 Elastic shell type blood filter
CN207307359U (en) * 2017-08-28 2018-05-04 广州市雷德生物科技有限公司 A kind of piston filter column

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