CN1810318A - Bundling electrode with integrated positive pole and negative pole of shape memory alloy - Google Patents
Bundling electrode with integrated positive pole and negative pole of shape memory alloy Download PDFInfo
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- CN1810318A CN1810318A CN 200510057470 CN200510057470A CN1810318A CN 1810318 A CN1810318 A CN 1810318A CN 200510057470 CN200510057470 CN 200510057470 CN 200510057470 A CN200510057470 A CN 200510057470A CN 1810318 A CN1810318 A CN 1810318A
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Abstract
The bundling electrode with integrated positive pole and negative pole of shape memory alloy for reversible and irreversible electrically perforating treatment instrument includes mainly electrode tube, Ti-Ni shape memory alloy bundling electrode needle, inside and outside insulating casing, steel needle, fixing handle, controlling handle with movable pull rod, conducting reed, piston, power supply connector, etc. The bundling electrode has simple structure, high curative effect and high safety. It may be inserted into deep tumor inside body and its bundling electrode needle may be developed in the treating area into umbrella-shaped electrode array to form homogeneous electric field between the bundling electrode needle and the electrode tube. The bundling electrode may be used widely in treating disease, especially deep tumor, of human and mammal.
Description
Technical field:
The invention belongs to biological tissue's electroporation therapy technical field, particularly the treatment electrode of reversibility and irreversibility electroporation treatment instrument.
Background technology:
Electroporation therapy is the new technique of the treatment tumor that grows up of recent two decades, mainly be divided into two kinds: reversible electroporation therapy (reversible electroporation therapy, REPT) and irreversible electroporation therapy (irreversible electroporation therapy, IEPT).The reversible electroporation therapy is to utilize impulse electric field adjuvant chemotherapy Drug therapy tumor, its treatment mechanism is the electric pulse (peak value 1～2kV/cm of doses, pulsewidth 100 μ s, frequency 1～4Hz, 4～10 of pulse numbers) cause that membrane structure changes, producing temporary transient reversibility membrane permeability increases, occurring the hydrophilic duct on the film is the reversibility electroporation, the chemotherapeutics that is difficult for through bimolecular lamellar lipid membrane is entered in the cell, its cytotoxic effect can strengthen tens to hundred times, can reduce the whole body using dosage of chemotherapeutics, reduced simultaneously other Normocellular toxic and side effects, overcome the regenerated problem in chemotherapy resistance and main tumor treatment back.The reversible electroporation therapy has obtained remarkable result in I, II clinical trial phase on a large amount of zooperal bases at present.Irreversible electroporation therapy is the new technique of fast-developing in recent years treatment malignant tumor of getting up, its treatment mechanism is to inject chemotherapeutics, to have high steepness (10～100ns), (5～10kV/cm) impulse electric field is incorporated in the tumor tissues high field intensity, make its cell that irreversible electroporation take place, induce the anti-angiogenic and lymphatic vessel of body to generate effect, immunological effect and the accent effect of dying simultaneously, destroy the conditions of existence of tumor, thereby reach the purpose of killing tumor cell.Irreversible electroporation therapy has been finished zoopery, is carrying out clinical trial at present, and effect is obvious.
The needed electroporation treatment instrument of electroporation therapy comprises two parts: impulse electric field generator and treatment electrode.Existing how tame research unit and medical institutions have developed the impulse voltage generator that is applicable to electroporation therapy both at home and abroad, are Pulased power supply unit.Slab construction or needle electrode array structure are greatly all adopted in existing treatment electricity consumption, owing to the needs that need between the positive and negative electrode to keep certain insulation distance and treat big tumor clinically, usually the diameter of needle electrode array is all bigger, so the class electrode generally only is applicable to treatment human body shallow tumor, as head and neck cancer, the treatment of skin carcinoma etc., after then needing to operate on (or opening abdomen) operation for human body deep tumor (as hepatocarcinoma etc.), under doctor's direct-view, carry out treatment, this brings very big wound to the patient, especially to the old man, weak and sickly people is abnormally dangerous, also totally unfavorable to the cosmetic result after the treatment, therefore greatly limited electroporation therapy applying clinically.The application number of Japan's Iwada Kiyohito application is that the therapeutic electrode in 03145907.2 the Chinese patent electroporation device of expansion electrode spacing " can " mainly comprises: two electrode needle, guide barrel, injection device etc., this therapeutic electrode utilizes the piston in the injection device that two electrode needle are given prominence to or regained at the front end of guide barrel, when two electrode needle are outstanding, utilize the electric field that produces between two electrode needle that tumor is carried out electroporation treatment or electroporation is led the medicine treatment, but because this electrode only adopts two needle constructions, what produce between two electrode needle is severe non-uniform electric field, and the curative effect of therefore treating tumor is low.The application number of U.S. gene Te Lunni company application is that the treatment of device mainly comprised some electrode needle, multiconductor cable, shank and compressing mechanism etc. with electrode during 98801461.0 Chinese patent " utilized the apparatus and method of electroporation mediated delivery of drugs and gene ".Every electrode needle is connected with different conductor in the multiconductor cable respectively, electrode needle is contracted in the shank by compressing mechanism or stretches out the shank end and form square or the hexagon electrod-array, and adopt the gating mode that two pinwheels in the electrod-array are flowed and pulse power conducting, between two pins of conducting, set up severe non-uniform electric field, the curative effect of tumor being carried out electroporation treatment is low, complex structure, the manufacturing process complexity.
Summary of the invention:
The objective of the invention is to use the weak point of electrode at treatment in the existing electroporation treatment instrument, a kind of bundling electrode with integrated positive pole and negative pole of shape memory alloy is provided, it is a kind of medical Wicresoft electrode, it is simple in structure, can go deep into the tumor in deep in the body, produce the uniform distribution electric field in area for treatment, curative effect height, security performance are good.
The object of the present invention is achieved like this: a kind of bundling electrode with integrated positive pole and negative pole of shape memory alloy mainly comprises two electrodes, insulated sleeve, draw point, handle, power connection, conductive reed, piston etc.One of them electrode is the hollow needle tubing of rustless steel, and another electrode is titanium-nickel (Ti-Ni) memorial alloy bundling electrode pin, and insulated sleeve and external insulation casing pipe in its insulated sleeve is divided into, its handle are divided into the joystick of fixed handle and band active pull rod.The external diameter of rustless steel coreless armature needle tubing of the present invention is 2～3mm, and total length is 140～250mm, and the length of the working portion that wherein exposes is 10～15mm.Make a labelling every 10mm on the electrode needle tubing, be beneficial to observe entering the degree of depth in the body, an end of an electrode fairlead of the rear end of electrode needle tubing and power connection flexibly connects by 3～6 conductive reeds.The interior insulated sleeve of electrode of the present invention is the ultrathin alumina porcelain bushing, has very strong hardness, anti-wear performance and good electrical insulation properties, is fixed on the inwall of electrode needle tubing, as the dielectric between two electrodes.There is 30 °～45 ° puncture acute angle at interior insulated sleeve tip, is beneficial to electrode can thrust the human body deep smoothly under the guiding of medical imaging instrument (as B ultrasonic, CT, endoscope or peritoneoscope etc.) tumor.The external insulation casing pipe of electrode of the present invention is the thermal contractible plastic pipe, be fixed on the electrode needle tubing outer wall, its surface is very smooth, this had both helped puncturing into human body skin and muscular tissue smoothly with the electrode needle tubing of external insulation casing pipe, again impulse electric field only is confined to guarantee patient and doctor's safety between electrode needle tubing and the bundling electrode pin.The Ti-Ni memorial alloy bundling electrode pin of electrode of the present invention is 3～10 pieces, be arranged on the centerline of electrode needle tubing, the bundling electrode pin is fixed in the front end of stainless pin, stainless pin passes the center of electrode needle tubing and hollow piston, thereafter the end is connected with the input of an electrode of power connection, and the rearward end of stainless pin is cemented on the macaroni of hollow piston.Power connection is arranged in the rearward end of the joystick of being with active pull rod, the electrode fairlead of power connection is cemented on the interior macaroni of joystick of the lateral surface of hollow piston and band active pull rod, thereby realize that joystick is connected with the draw point of bundling electrode pin by the piston drive and the electrode fairlead of power connection moves in C, B interval vertically, this remains the electrode needle pipe racks by conductive reed on the one hand, make the bundling electrode pin stretch out interior insulated sleeve on the other hand and be the umbrella shape expansion, or be retracted in the interior insulated sleeve.The other end of power connection is connected with the pulse power by coaxial cable.Fixed handle of the present invention is that front end is a hollow cone, the stage casing is the hollow thin-wall annulus, back segment is the handle of hollow thick ring, the interior hollow rear end that is fixed in the anelectrode needle tubing that has external insulation casing pipe of its nose circle cone, the interior space of middle thin wall circular is the active pull rod of conductive reed and joystick and the sliding space of piston, hollow active pull rod with joystick flexibly connects in the thick ring of rear end, fixed handle punctures in the human body therapeutic electrode of the present invention by operator's hand-power on the one hand, and fixedly joystick can only move along the axis direction of electrode needle tubing by piston drive draw point on the other hand.
After the present invention adopts technique scheme, mainly contain following advantage:
1, simple in structure, produce electric field relatively uniformly.Electrode structure of the present invention is simple, and manufacturing process is simple, and cost is low.Electrode of the present invention is under the effect of its fixed handle, after the electrode needle tubing thrusts in the tumor in deep in the body, under the effect of joystick, the bundling electrode pin stretches out expansion, be umbrella and form electrod-array, when behind the make pulse power supply just producing relative uniform electric field between bundling electrode array and the electrode needle tubing, tumor is carried out electroporation treatment and electrochemistry auxiliary treatment.
2, adaptability is strong.Adopt the ultrathin alumina insulant, improved two interelectrode electric insulation levels, make this electrode structure both be applicable to the electrochemistry auxiliary treatment of reversibility electroporation, be applicable to that again the irreversibility electroporation treats separately.This electrode supply interface adopts standard interface, goes for various pulse wave generators and dc source.
3, the curative effect height is safe.Because of adopting the positive-negative integral structure, form shielding in umbrella the district in, make the Electric Field Distribution in the umbrella district more even, the electric field outside the umbrella district, current potential decay to zero rapidly, but that this not only can improve in the umbrella district outside effective electric field but also the umbrella district normal structure was unaffected.
Electrode of the present invention can be widely used in human body and mammal treatment disease, is specially adapted to the electroporation treatment or the electrochemistry auxiliary treatment of deep tumor in human body and the mammalian body.
Description of drawings:
Fig. 1 is a system construction drawing of the present invention;
Fig. 2 is a structural representation of the present invention;
Fig. 3 is that boundling negative electrode of the present invention launches sketch map;
Fig. 4 shrinks sketch map for boundling negative electrode of the present invention.
Among the figure: 1 bundling electrode pin, 2 interior insulated sleeve (ultrathin alumina porcelain bushing), 3 electrode needle tubings, 4 external insulation casing pipes, 5 fixed handles, 6 active pull rods, 7 joysticks, 8 draw points, 9 coaxial cables, 10 pulse powers, 11 conductive reeds, 12 electrode fairleads, 13 pistons.
The specific embodiment:
Below in conjunction with the specific embodiment, further specify the present invention.
Shown in Fig. 1～4, a kind of positive-negative integral memorial alloy bundling electrode mainly comprises: joystick 7, stainless pin 8, conductive reed 11, piston 13 and the power connection etc. of electrode needle tubing 3, bundling electrode pin 1, interior insulated sleeve 2, external insulation casing pipe 4, fixed handle 5, band active pull rod 6.Electrode needle tubing 3 is the hollow needle tubing of rustless steel, and its external diameter is 2.3mm, and total length is 150mm, and the length of the working portion that wherein exposes is 10mm, and the electrode fairlead 12 of the rear end of electrode needle tubing 3 and power connection flexibly connects by 3 conductive reeds 11.By hot jacket, be connected with the interior insulated sleeve 2 that the ultrathin alumina porcelain bushing is made on the inwall of electrode needle tubing 3, its tip has 45 ° of puncture acute angles.On the outer wall of electrode needle tubing 3, be coated with thermal contractible plastic external insulation casing pipe 4.On the outer surface that is connected with inside and outside insulating electrode needle tubing 3, make a density bullet every 10mm.Bundling electrode pin 1 is made up of 6 pieces of Ti-Ni memorial alloy pins, be arranged on the centerline of electrode needle tubing 3, the tail end of bundling electrode pin 1 is welded on the front end of stainless pin 8, stainless pin 8 passes the center of electrode needle tubing 3 and hollow piston 13, and the rearward end of stainless pin 8 tightly is enclosed within on the macaroni of hollow piston 13.Power connection is arranged in the rearward end of the joystick 7 of being with active pull rod 6, the electrode fairlead 12 of power connection is inserted between the interior macaroni of joystick 7 of the lateral surface of hollow piston 13 and band active pull rod 6, the other end of power connection is connected with the pulse power 10 by coaxial cable 9, and the inner surface of fixed handle 5 front ends tightly is enclosed within the rearward end of the anelectrode needle tubing 3 of external insulation casing pipe 4.The active pull rod 6 of the rear end of fixed handle 5 and joystick 7 is by being slidingly connected.
Claims (3)
1, a kind of positive-negative integral memorial alloy bundling electrode, mainly comprise two electrodes, insulated sleeve, stainless pin (8), handle, power connection, piston (13), it is characterized in that conductive reed (11) in addition, one of them electrode is the hollow needle tubing of rustless steel, another electrode is titanium-nickel memorial alloy bundling electrode pin (1), its insulated sleeve is divided into interior insulated sleeve (2) and external insulation casing pipe (4), its handle is divided into the joystick (7) of fixed handle (5) and band active pull rod (6), the external diameter of rustless steel coreless armature needle tubing (3) is 2～3mm, total length is 140～250mm, the length of the working portion that wherein exposes is 10～15mm, the front end of the electrode fairlead (12) of the rear end of electrode needle tubing (3) and power connection flexibly connects by 3～6 conductive reeds (11), on the inwall of electrode needle tubing (3), be connected with interior insulated sleeve (2), there are 30 °～45 ° puncture acute angles at its tip, the outer wall of electrode needle tubing (3) is provided with external insulation casing pipe (4), in being connected with, make a density bullet every 10mm on the outer surface of the electrode needle tubing (3) of external insulation, bundling electrode pin (1) is arranged on the centerline of electrode needle tubing (3), its tail end is fixed in the front end of stainless pin (8), stainless pin (8) passes the center of electrode needle tubing (3) and hollow piston (13), thereafter the end is connected with the input of an electrode of power connection, the rearward end of stainless pin (8) is cemented on the macaroni of hollow piston, power connection is arranged in the rearward end of the joystick (7) of being with active pull rod (6), the electrode fairlead (12) of power connection is fixed on the interior macaroni of joystick (7) of the lateral surface of hollow piston (13) and band active pull rod (6), the other end of power connection is connected with the pulse power (10) by coaxial cable (9), the front end of fixed handle (5) is fixed in the rearward end of the electrode needle tubing (3) of external insulation casing pipe (4), and the active pull rod (6) of the rear end of fixed handle (5) and joystick (7) flexibly connects.
2,, it is characterized in that described interior insulated sleeve (2) is the ultrathin alumina porcelain bushing according to the described positive-negative integral memorial alloy of claim 1 bundling electrode; Described external insulation casing pipe (4) is the thermal contractible plastic pipe.
3, according to the described positive-negative integral memorial alloy of claim 1 bundling electrode, it is characterized in that a kind of positive-negative integral memorial alloy bundling electrode mainly comprises: electrode needle tubing (3), bundling electrode pin (1), interior insulated sleeve (2), external insulation casing pipe (4), fixed handle (5), the joystick (7) of band active pull rod (6), stainless pin (8), conductive reed (11), piston (13) and power connection, electrode needle tubing (3) is the hollow needle tubing of rustless steel, its external diameter is 2.3mm, total length is 150mm, wherein protruded length is the electrode working portion of 10mm, the electrode fairlead (12) of the rear end of electrode needle tubing (3) and power connection flexibly connects by 3 conductive reeds (11), on the inwall of electrode needle tubing (3), be connected with the interior insulated sleeve (2) that the ultrathin alumina porcelain bushing is made by hot jacket, its tip has 45 ° of puncture acute angles, on the outer wall of electrode needle tubing (3), be coated with thermal contractible plastic external insulation casing pipe (4), in being connected with, make a density bullet every 10mm on the outer surface of the electrode needle tubing (3) of external insulation, bundling electrode pin (1) is made up of 6 pieces of Ti-Ni memorial alloy pins, be arranged on the centerline of electrode needle tubing (3), the tail end of bundling electrode pin (1) is welded on the front end of stainless pin (8), stainless pin (8) passes the center of electrode needle tubing (3) and hollow piston (13), the rearward end of stainless pin (8) tightly is enclosed within on the macaroni of hollow piston (13), power connection is arranged in the joystick (7) of band active pull rod (6), the electrode fairlead (12) of power connection is inserted on the lateral surface of hollow piston (13) and on the interior macaroni of the joystick (7) of band active pull rod (6), the other end of power connection is connected with the pulse power (10) by coaxial cable (9), the front end of fixed handle (5) tightly is enclosed within the rearward end of the electrode needle tubing (3) of external insulation casing pipe (4), and the active pull rod (6) of the rear end of fixed handle (5) and joystick (7) is by being slidingly connected.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100574702A CN100475287C (en) | 2005-12-27 | 2005-12-27 | Bundling electrode with integrated positive pole and negative pole of shape memory alloy |
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| CNB2005100574702A CN100475287C (en) | 2005-12-27 | 2005-12-27 | Bundling electrode with integrated positive pole and negative pole of shape memory alloy |
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| CN101954147A (en) * | 2010-08-30 | 2011-01-26 | 王晓舟 | Electrode with intrakardial pace-making device |
| CN102284132A (en) * | 2011-06-30 | 2011-12-21 | 杭州电子科技大学 | High-voltage pulse electric field treatment device based on multiple needle electrodes |
| CN102772251A (en) * | 2012-06-28 | 2012-11-14 | 王兴林 | Ablation adsorption electrode |
| CN105434040A (en) * | 2016-01-11 | 2016-03-30 | 王洪奎 | Umbrella-shaped radiofrequency ablation electrode needle for endoscopes |
| CN105455897A (en) * | 2015-12-30 | 2016-04-06 | 迈德医疗科技（上海）有限公司 | Flexible radiofrequency ablation electrode |
| CN105595998A (en) * | 2016-01-27 | 2016-05-25 | 北京华科恒生医疗科技有限公司 | Positioning puncture electrode |
| CN106388933A (en) * | 2016-09-14 | 2017-02-15 | 上海睿刀医疗科技有限公司 | Electrode for irreversible electroporation equipment |
| CN109009423A (en) * | 2018-09-04 | 2018-12-18 | 江苏昊普生物医学科技有限公司 | Surgery electrode assembly |
| CN109259855A (en) * | 2018-09-12 | 2019-01-25 | 中国科学院理化技术研究所 | Nano-knife probe and minimally invasive equipment |
| CN113499125A (en) * | 2021-06-25 | 2021-10-15 | 南京航空航天大学 | Auxiliary electrode implantation system and electrode implantation method capable of adjusting needle insertion depth for organism |
| CN114126183A (en) * | 2021-10-11 | 2022-03-01 | 核工业西南物理研究院 | Detachable ion beam accelerating tube |
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2005
- 2005-12-27 CN CNB2005100574702A patent/CN100475287C/en active Active
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954147A (en) * | 2010-08-30 | 2011-01-26 | 王晓舟 | Electrode with intrakardial pace-making device |
| CN102284132A (en) * | 2011-06-30 | 2011-12-21 | 杭州电子科技大学 | High-voltage pulse electric field treatment device based on multiple needle electrodes |
| CN102772251A (en) * | 2012-06-28 | 2012-11-14 | 王兴林 | Ablation adsorption electrode |
| CN102772251B (en) * | 2012-06-28 | 2014-12-31 | 王兴林 | Ablation adsorption electrode |
| CN105455897A (en) * | 2015-12-30 | 2016-04-06 | 迈德医疗科技（上海）有限公司 | Flexible radiofrequency ablation electrode |
| CN105434040A (en) * | 2016-01-11 | 2016-03-30 | 王洪奎 | Umbrella-shaped radiofrequency ablation electrode needle for endoscopes |
| CN105595998A (en) * | 2016-01-27 | 2016-05-25 | 北京华科恒生医疗科技有限公司 | Positioning puncture electrode |
| CN106388933A (en) * | 2016-09-14 | 2017-02-15 | 上海睿刀医疗科技有限公司 | Electrode for irreversible electroporation equipment |
| WO2018050025A1 (en) * | 2016-09-14 | 2018-03-22 | 上海睿刀医疗科技有限公司 | Electrode utilized in irreversible electroporation apparatus |
| CN108472077A (en) * | 2016-09-14 | 2018-08-31 | 上海睿刀医疗科技有限公司 | Electrode for irreversible electroporation device |
| CN109009423A (en) * | 2018-09-04 | 2018-12-18 | 江苏昊普生物医学科技有限公司 | Surgery electrode assembly |
| CN109259855A (en) * | 2018-09-12 | 2019-01-25 | 中国科学院理化技术研究所 | Nano-knife probe and minimally invasive equipment |
| CN113499125A (en) * | 2021-06-25 | 2021-10-15 | 南京航空航天大学 | Auxiliary electrode implantation system and electrode implantation method capable of adjusting needle insertion depth for organism |
| CN114126183A (en) * | 2021-10-11 | 2022-03-01 | 核工业西南物理研究院 | Detachable ion beam accelerating tube |
| CN114126183B (en) * | 2021-10-11 | 2022-10-18 | 核工业西南物理研究院 | Detachable ion beam accelerating tube |
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| CN100475287C (en) | 2009-04-08 |
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Effective date of registration: 20200803 Address after: 400044 Shapingba District Sha Street, No. 174, Chongqing Patentee after: Yao Chenguo Address before: Research Office of Chongqing University, 174 Zhengjie, Shapingba District, Chongqing Patentee before: Chongqing University |
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Effective date of registration: 20200928 Address after: Room a0101-21, building 2, No. 452, No. 6 street, Baiyang street, Qiantang New District, Hangzhou City, Zhejiang Province Patentee after: Hangzhou viatech Medical Technology Co., Ltd Address before: 400044 Shapingba District Sha Street, No. 174, Chongqing Patentee before: Yao Chenguo |