CN1810267A - Puerariae Decoction mixture preparing process - Google Patents
Puerariae Decoction mixture preparing process Download PDFInfo
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- CN1810267A CN1810267A CN 200510038279 CN200510038279A CN1810267A CN 1810267 A CN1810267 A CN 1810267A CN 200510038279 CN200510038279 CN 200510038279 CN 200510038279 A CN200510038279 A CN 200510038279A CN 1810267 A CN1810267 A CN 1810267A
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Abstract
The present invention relates to Chinese medicine mixture preparation, and is especially the preparation process of Puerariae Decoction mixture. The preparation process includes the steps of leaching, separating, purifying, and concentrating. The preparation process features its effective Chinese medicine component separating step, which is ultrafiltering separation adopting organic membrane or inorganic ceramic membrane of molecular weight 10-50 KDa; and its concentrating step, which includes nanofiltering purification and concentration with organic membrane of molecular weight 150-200 Da. Thus prepared Puerariae Decoction mixture is clear, transparent, reddish brown and accurate in effective components, and has unique smell, high storage stability and accurate curative effect.
Description
Relate to the field
The present invention relates to a kind of manufacturing process of herb mixture, be in particular a kind of puerariae Decoction mixture preparing process.
Background technology
Traditional Chinese medicine preparation composition complexity except that containing effective substances such as alkaloid, glycoside, flavonoid, a large amount of inert matters also occurs in manufacture process, as starch, and tree limb, protein etc.In in the production technology of routine, handling, often can't guarantee the accurate separation of active ingredient, also can't remove invalid element completely.So when making herb mixture with conventional production technology, the outer rule of product are poor, and are dark excessively as the medicinal liquid color and luster, the medicinal liquid muddiness, the patient is difficult for accepting, simultaneously, the inherent quality of product also is difficult to control, precipitates problems such as pH value variation as product in the as easy as rolling off a log generation of lay up period.These present situations have caused Chinese medicine preparation to move towards modern difficulty, have influenced the excavation of Chinese medicine ancient prescription and have been the service of modern society.Puerariae Decoction mixture comes from the famous ancient prescription in the Zhang Zhongjing treatise on Febrile Diseases of Han dynasty " doctor is holy ".Radix Puerariae in the prescription, its main medicinal component is a puerarin, belongs to Flavonoid substances.Herba Ephedrae, its main medicinal component is an ephedrine, belongs to alkaloids substance.Ramulus Cinnamomi, its main medicinal component is a cinnamic aldehyde, belongs to aldehyde material.Radix Glycyrrhizae, its main medicinal component is a glycyrrhizic acid.The Radix Paeoniae Alba, its main medicinal component is a Radix Paeoniae Alba glycosides, belongs to the glycoside material.Pueraria lobota soup mixture is relieving the exterior syndrome by diaphoresis rapidly clinically, expelling pathogenic factors from muscles pain relieving, the effective treatment flu of enduring cold, nape shoulder pain.The extraction of its active ingredient also has above-mentioned defective, and traditional extraction process is: 1. if when feeding intake medical material total amount 100Kg, and the about 100Kg of its water extract (first concentration).When 2. selecting alcohol precipitation concentration 75%, adding alcoholic acid amount is 375Kg, and adding the back total amount is 475Kg.3. during concentrating under reduced pressure, must distillation reclaim ethanol 375Kg after, concentrated solution 100Kg.4. needing approximately during precipitate with ethanol needed to increase Alcohol-settling tank more than 24 hours, 5. needed concentrating under reduced pressure equipment one cover during concentrating under reduced pressure, needed the ethanol recovery tower, needed alcoholic acid storage requirement, needed to consume steam, and production environment needs requirement of explosion proof.The medical material of above-mentioned prescription, when water extraction, its active ingredient is gone out by water logging, as puerarin, Radix Paeoniae Alba glycosides etc.; Invalid element, as gummy class, starch based, protein etc. show and exist simultaneously in the water extract.At this moment, above-mentioned various compositions can be at light, and air produces the hydrolytic polymerization effect and forms precipitation under the Temperature Influence, and pH value descends, and this is the reason of Chinese medicine preparation poor stability.When selecting alcohol precipitation process for use, the part active ingredient in the medicinal liquid also can be dissolved in the ethanol, and causes the decline of active ingredient.It is to cause the medicinal liquid appearance poor that invalid element is difficult to remove, and easily precipitate storage period, the major reason of product stability difference.
Summary of the invention
Purpose of the present invention is exactly to provide a kind of membrane technology that utilizes to the separation of effective components of Chinese medicinal and the puerariae Decoction mixture preparing process of purifying technique for the above-mentioned defective that solves prior art.
Purpose of the present invention realizes by following technical solution:
A kind of manufacturing process of puerariae Decoction mixture, it includes lixiviate operation, separation, purification and enrichment process, described separation circuit to effective components of Chinese medicinal is the ultra-filtration and separation operation, the ultra-filtration and separation operation is to adopt organic membrane or inorganic ceramic membrance separation, and the molecular weight of organic membrane or inorganic ceramic film is 10KD～50KD; Described enrichment process is nanofiltration purification and enrichment process, and nanofiltration purification and enrichment process adopt organic membrane to concentrate, and the organic membrane molecular weight is 150D～200D.
The object of the invention also can be advanced a realization by following technology solution:
Aforesaid a kind of puerariae Decoction mixture preparing process, the pressure of wherein said ultra-filtration and separation operation are 0.05～0.15Mpa.
Aforesaid a kind of puerariae Decoction mixture preparing process, wherein said through the isolating penetrating fluid of ultra-filtration and separation operation, through nanofiltration purification and enrichment process, under the condition of pressure 1.0Mpa～2.0Mpa, when purifying to penetrating fluid and reach, purify and the enrichment process EO to relative density 1.06～1.08 (60 ℃ of surveys).
The invention has the advantages that owing in the production of puerariae Decoction mixture, used membrane technology that the active ingredient of product is separated and purify, thorough through the puerariae Decoction mixture medicinal liquid clarification that this method is made, be fixed rufous, active ingredient in the prescription is accurate, mouthfeel has kept the distinctive smell of prescription Chinese crude drug, product is stored steady quality, has guaranteed the accurate curative effect of puerariae Decoction mixture.
Purpose of the present invention, advantage and characteristics will illustrate by the non-limitative illustration of following preferential embodiment and explain that these embodiment only provide as an example with reference to accompanying drawing.
Description of drawings
Fig. 1 is a process schematic representation of the present invention.
The specific embodiment
As shown in Figure 1, the manufacturing process of a kind of puerariae Decoction mixture of the present invention, it includes lixiviate operation, separation, purification and enrichment process, described separation circuit to effective components of Chinese medicinal is the ultra-filtration and separation operation, the ultra-filtration and separation operation is to adopt organic membrane or inorganic ceramic membrance separation, and the molecular weight of organic membrane or inorganic ceramic film is 10KD～50KD; Described enrichment process is nanofiltration purification and enrichment process, and nanofiltration purification and enrichment process adopt organic membrane to concentrate, and the organic membrane molecular weight is 150D～200D.The Chinese medicine extraction liquid of gained is under the condition of pressure 0.05～0.15Mpa in the lixiviate operation, organic membrane with molecular weight 10KD～50KD carries out hyperfiltration treatment, medicinal liquid is the cross flow filter state, under this state, the molecular weight of active ingredient is at 10000～50000 o'clock, sees through organic membrane and reaches and cause separation with tangential manner, get qualified penetrating fluid, and the molecular weight of invalid element discards holding back more than 50000 and by organic membrane, more than constantly operation, reach the separation of Chinese medicine extraction liquid active ingredient.Through the isolating qualified penetrating fluid of ultra-filtration and separation operation, under the condition of pressure 1.0Mpa～2.0Mpa, organic membrane NF membrane with molecular weight 150～200D is purified and concentration, medicinal liquid is the cross flow filter state, under this state, its molecular weight of the solvent in the penetrating fluid discards and constantly see through the NF membrane discharge below 150～200D, when purifying to penetrating fluid and reach, purify and the enrichment process EO to relative density 1.06～1.08 (60 ℃ of surveys).
Embodiment one:
Select prescription for use: Radix Puerariae 13.3%; Herba Ephedrae 10%; Ramulus Cinnamomi 6.7%; Radix Glycyrrhizae 6.7%, the Radix Paeoniae Alba 6.7%; Fructus Jujubae 6.7%; Rhizoma Zingiberis Recens 10%.The medical material of above-mentioned prescription, when water extraction, lixiviate 5-6 hour, its active ingredient was gone out by water logging, invalid element, as gummy class, starch based, protein etc. show and exist simultaneously in the water extract.When 1. feeding intake total amount 100Kg as if medical material, the about 100Kg of its water extract (concentration).2. during ultrafiltration, add the about 300Kg of water, add that total amount is 400Kg behind the water, ultrafiltration takes 1.25 hours.When 3. nanofiltration concentrated, the about 300Kg of the isolated for disposal water yield took about 30 minutes, the concentration of concentrated solution be 1: 1 promptly 1 gram extracting solution be equivalent to crude drug 1 and restrain.4. this technology is when ultrafiltration and nanofiltration, and medicine does not have phase transformation deeply, does not have heating by ultrafiltration, so ultrafiltrate still keeps original characteristic after nanofiltration, its ultrafiltrate is selected different concentration of alcohol tests, does not all have precipitation and produces, and has removed effectively and has caused the medicinal liquid appearance poor, easily precipitate storage period, the invalid element of product stability difference has guaranteed the quality of product, and gained medicinal liquid clarification of the present invention is thorough, be fixed rufous, the active ingredient in the prescription is accurate.
In addition to the implementation, the present invention can also have other embodiments.All employings are equal to the technical scheme of replacement or equivalent transformation formation, all drop in the protection domain of requirement of the present invention.
Claims (3)
1. puerariae Decoction mixture preparing process, it includes lixiviate operation, separation, purification and enrichment process, it is characterized in that described separation circuit to effective components of Chinese medicinal is the ultra-filtration and separation operation, the ultra-filtration and separation operation is to adopt organic membrane or inorganic ceramic membrance separation, and the molecular weight of organic membrane or inorganic ceramic film is 10KD～50KD; Described enrichment process is nanofiltration purification and enrichment process, and nanofiltration purification and enrichment process adopt organic membrane to concentrate, and the organic membrane molecular weight is 150D～200D.
2. a kind of puerariae Decoction mixture preparing process according to claim 1, the pressure that it is characterized in that the ultra-filtration and separation operation is 0.05～0.15Mpa.
3. a kind of puerariae Decoction mixture preparing process according to claim 1, it is characterized in that through the isolating penetrating fluid of ultra-filtration and separation operation, through nanofiltration purification and enrichment process, under the condition of pressure 1.0Mpa～2.0Mpa, when purifying to penetrating fluid and reach, purify and the enrichment process EO to relative density 1.06～1.08 (60 ℃ of surveys).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100382793A CN100394931C (en) | 2005-01-28 | 2005-01-28 | Puerariae Decoction mixture preparing process |
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| CNB2005100382793A CN100394931C (en) | 2005-01-28 | 2005-01-28 | Puerariae Decoction mixture preparing process |
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| CN1810267A true CN1810267A (en) | 2006-08-02 |
| CN100394931C CN100394931C (en) | 2008-06-18 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829501A (en) * | 2010-04-21 | 2010-09-15 | 周滨江 | Combined membrane filtering method for Chinese traditional medicine extraction, separation and concentration |
| CN102784193A (en) * | 2012-08-16 | 2012-11-21 | 魏舒畅 | Method for preparing hedysarum polybotrys extract by adopting coupling technology |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197613C (en) * | 2003-05-16 | 2005-04-20 | 南风龙 | Medicine for treating neck, shoulder, waist and leg pains |
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2005
- 2005-01-28 CN CNB2005100382793A patent/CN100394931C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829501A (en) * | 2010-04-21 | 2010-09-15 | 周滨江 | Combined membrane filtering method for Chinese traditional medicine extraction, separation and concentration |
| CN102784193A (en) * | 2012-08-16 | 2012-11-21 | 魏舒畅 | Method for preparing hedysarum polybotrys extract by adopting coupling technology |
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| CN100394931C (en) | 2008-06-18 |
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Assignee: Shenzhen Xingyin Pharmaceutical Co.,Ltd. Assignor: Nanjing Xingyin Pharmaceutical Co., Ltd. Contract record no.: 2010440020124 Denomination of invention: Puerariae Decoction mixture preparing process Granted publication date: 20080618 License type: Exclusive License Open date: 20060802 Record date: 20100729 |
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Owner name: NANJING XINGYIN PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: NANJING XINGYIN PHARMACEUTICAL INDUSTRY CO., LTD. |
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Address after: 211200, No. 28, Airport Road, Lishui Economic Development Zone, Nanjing, Jiangsu Patentee after: Nanjing Xingyin Pharmaceutical Group Co.,Ltd. Address before: 211200, No. 28, Airport Road, Lishui Economic Development Zone, Nanjing, Jiangsu Patentee before: Nanjing Xingyin Pharmaceutical Co., Ltd. |