CN1806802A - Pharmaceutical composition with acetaminopher, loratadine and pseudoephedrine sulfate as active ingredients, preparation method and uses thereof - Google Patents
Pharmaceutical composition with acetaminopher, loratadine and pseudoephedrine sulfate as active ingredients, preparation method and uses thereof Download PDFInfo
- Publication number
- CN1806802A CN1806802A CN 200610007945 CN200610007945A CN1806802A CN 1806802 A CN1806802 A CN 1806802A CN 200610007945 CN200610007945 CN 200610007945 CN 200610007945 A CN200610007945 A CN 200610007945A CN 1806802 A CN1806802 A CN 1806802A
- Authority
- CN
- China
- Prior art keywords
- loratadine
- pseudoephedrine sulfate
- acetaminophen
- pharmaceutical composition
- active component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a medicinal composition, method of preparation and use, wherein paracetamol, loratadine and pseudoephedrine sulfate are used as the medicinal active constituent, as well as pharmaceutically acceptable auxiliary materials. The composition can be used for treating seasonal allergic rhinitis and common colds, and can be prepared into tablets, capsules, effervescent tablets, chewable tablets, slow release capsules, and slow release capsules.
Description
Technical field
The present invention relates to a kind of is Pharmaceutical composition and preparation method thereof, the purposes of active component with acetaminophen, loratadine and pseudoephedrine sulfate, belongs to medical technical field.
Background technology
Flu is commonly called as " cold ", is a kind of respiratory tract commonly encountered diseases that is caused by multiple virus, and wherein 30%-50% is that rhinovirus by certain serotype causes.Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonal is not just the same yet.It is sporadic that the flu case distributes, do not cause popular, the normal bacterial infection that easily merges.The common cold onset is more anxious, and early symptom has pharyngeal dried itching or burning sensation, sneeze, nasal obstruction, watery nasal discharge, begins to be clear water sample nasal mucus, retrogradation after 2～3 days; Can be with pharyngalgia; General do not have heating and General Symptoms, or low grade fever, headache are only arranged.
Flu causes great harmful effect not only for patient's personal lifestyle and study, and if can not be in time controlled and treat, often develop into other diseases not such as pneumonia easily.Therefore need cause enough attention.
Acetaminophen is an acetophenone amine antipyretic analgesic.By suppressing Cycloxygenase, selectivity suppresses synthesizing of hypothalamus thermotaxic centre prostaglandin, causes the peripheral blood vessel expansion, perspires and reaches the antipyretic effect, and its refrigeration function intensity is similar to aspirin; By suppressing the synthetic of prostaglandin etc. and discharge, improve the threshold of pain and play analgesic activity, belong to the periphery analgesic, effect is than a little less than the aspirin, only to light, moderate pain is effective.This product does not have the obvious anti-inflammatory and anti effect.
Loratadine is the H1 receptor blocking agent, and peripheral H1-receptor is had selectivity highly, a little less than the affinity to maincenter H1 receptor, can suppress mastocyte and discharge leukotriene and histamine.This product is rapid-action, and effect is lasting, and antihistamine effect is all stronger than A Simi azoles and terfenadine, and anti-allergy action is better.Oral absorption rapidly, good, 1.5 hours blood drug level peakings, most of through liver metabolism, its metabolite is still had an activity, original shape medicine and metabolite are from urine and feces discharge.
Pseudoephedrine sulfate is a kind of alkaloid in the natural Herba Ephedrae, can make vasoconstriction after oral, can gradually and continue to alleviate the symptom of upper respiratory tract mucosa hyperemia.Pseudoephedrine hydrochloride mainly by promoting the release of norepinephrine, is brought into play sympatheticomimetic action indirectly; Have and optionally shrink the upper respiratory tract blood capillary, eliminate the hyperemia of nasopharynx part mucosa, swelling, alleviate the nasal obstruction symptom, the blood vessel of other internal organs of whole body is not had obvious contraction, heart rate, the rhythm of the heart, blood pressure and nervus centralis are not had obvious influence
More than three kinds of compositions make compound preparation and can overcome the symptom relevant comprehensively with seasonal allergic rhinitis and common cold, comprise simultaneously with nasal obstruction, sneeze, epistaxis, the pruritus of pain and heating and symptom such as shed tears.
Summary of the invention
Having the purpose of this invention is to provide a kind of is the Pharmaceutical composition and uses thereof of active component with acetaminophen, loratadine and pseudoephedrine sulfate.The present invention for a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that, it is the active component that acetaminophen, loratadine and pseudoephedrine sulfate form, with the Pharmaceutical composition of mixing acceptable accessories formation.
Above-mentioned a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, wherein the consumption of acetaminophen is 100mg-1500mg for per unit dosage.Be preferably 250mg-750mg.
Above-mentioned a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the consumption of described loratadine is 1.0mg-10mg for per unit dosage.Be preferably 1.5mg-5mg.
Above-mentioned a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the consumption of described pseudoephedrine sulfate is 20mg-180mg for per unit dosage.Be preferably 40mg-120mg.
Above-mentioned a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the weight ratio of described acetaminophen, loratadine and pseudoephedrine sulfate is 200: 1: 24.
Described a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the Pharmaceutical composition of described acetaminophen, loratadine and pseudoephedrine sulfate is an oral formulations.
Described a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that described oral formulations can be made into tablet, capsule, effervescent tablet, chewable tablet, slow releasing tablet, slow releasing capsule etc.
The specific embodiment
Come acetaminophen of the present invention, loratadine and pseudoephedrine sulfate preparation done further specifying by following example, but be not limited in following example.
Embodiment 1 acetaminophen, loratadine and pseudoephedrine sulfate tablet
Prescription:
| Component | Consumption |
| Acetaminophen loratadine pseudoephedrine sulfate starch CMS-Na | 500g 2.5g 60g 25g 4g |
| Micropowder silica gel 60% ethanol is made altogether | An amount of 1000 of 4g |
Preparation method:
Acetaminophen, loratadine, microcrystalline Cellulose, pseudoephedrine sulfate, starch are crossed 80 mesh sieves respectively, behind the mix homogeneously, add 60% ethanol and make soft material in right amount, 24 mesh sieves are granulated, drying, 20 mesh sieve granulate add micropowder silica gel, adopt suitable punch die compressed tablets behind the mix homogeneously, promptly.
Embodiment 2: acetaminophen, loratadine and pseudoephedrine sulfate capsule
Prescription:
| Component | Consumption |
| Acetaminophen loratadine pseudoephedrine sulfate microcrystalline Cellulose 2%PVP-k30 alcoholic solution magnesium stearate | An amount of 3.75g of 250g 1.25g 30g 95g |
Preparation method:
Acetaminophen, loratadine, pseudoephedrine sulfate, microcrystalline Cellulose are crossed 80 mesh sieves respectively, behind the mix homogeneously, add the 2%PVP-k30 alcoholic solution and make soft material in right amount, 24 mesh sieves are granulated, dry, 24 mesh sieve granulate add the magnesium stearate of recipe quantity, in the suitable capsule shells of packing into behind the mix homogeneously promptly.
Embodiment 3: acetaminophen, loratadine and pseudoephedrine sulfate effervescent tablet
Prescription:
| Component | Consumption |
| Paracetamol Loratadine pseudoephedrine sulfate sweet mellow wine lactose citric acid sodium acid carbonate Aspartame protein sugar PEG6000 ethanol solution is made altogether | An amount of 1000 of 500g 2.5g 60g 180g 40g 105g 120g 20g 15g 10g |
Preparation method:
Acetaminophen, loratadine, pseudoephedrine sulfate, mannitol, lactose, citric acid, sodium bicarbonate are crossed 80 mesh sieves respectively, behind the mix homogeneously, add ethanol solution and make soft material in right amount, 16 mesh sieves are granulated, drying, 12 mesh sieve granulate add aspartame, protein sugar, PEG6000, tabletting behind the mix homogeneously, promptly.
Embodiment 4: acetaminophen, loratadine and pseudoephedrine sulfate chewable tablet
Prescription:
| Component | Consumption |
| Paracetamol Loratadine pseudoephedrine sulfate microcrystalline cellulose menthol orange flavor Aspartame 2%PVP-k30 ethanolic solution dolomol | An amount of 6g of 500g 2.5g 60g 105g 9g 6g 6g |
Preparation method:
Acetaminophen, loratadine, pseudoephedrine sulfate, microcrystalline Cellulose, orange flavor, aspartame are crossed 80 mesh sieves respectively, behind the mix homogeneously, add the 2%PVP-k30 alcoholic solution and make soft material in right amount, 16 mesh sieves are granulated, drying, 12 mesh sieve granulate add Mentholum, magnesium stearate, tabletting behind the mix homogeneously, promptly.
Embodiment 5: acetaminophen, loratadine and pseudoephedrine sulfate slow releasing tablet
Prescription
| Component | Consumption |
| Acetaminophen loratadine pseudoephedrine sulfate HPMC (K100M) HPMC (K15M) | 500g 2.5g 60g 180g 70g |
| The lactose Pulvis Talci | 28g 12g |
Preparation method:
Acetaminophen, loratadine, pseudoephedrine sulfate, lactose, HPMC (K100M), HPMC (K15M), Pulvis Talci are crossed 80 mesh sieves respectively, and behind the mix homogeneously, controlled pressure adopts the drift direct powder compression of 12mm, promptly at 4-5kgN.
Embodiment 6: acetaminophen, loratadine and pseudoephedrine sulfate slow releasing capsule
Prescription
| Component | Consumption |
| Paracetamol Loratadine pseudoephedrine sulfate HPMC (K100M) microcrystalline cellulose CMC-Na II Eudragit E C | 250g 1.25g 30g 45g 35 30g 4.5g 2.5g |
Preparation method:
Get the II acrylic resin earlier and add dehydrated alcohol and be prepared into 2.5% solution, standby; Other gets EC and adds dehydrated alcohol and be prepared into 2.5% solution, and is standby; Acetaminophen, loratadine, pseudoephedrine sulfate, HPMC (K100M), microcrystalline Cellulose, CMC-Na are crossed 80 mesh sieves respectively, behind the mix homogeneously, with the dehydrated alcohol mixed liquor system soft material of II acrylic resin, EC, cross 18 mesh sieves, the system wet granular, 45-60 ℃ of aeration-drying, granulate.The requirement of and release heavy according to the capsule grain is packed granule in No. 1 capsule into promptly.
Claims (8)
- The present invention for a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that, it is the active component that acetaminophen, loratadine and pseudoephedrine sulfate form, with the Pharmaceutical composition of mixing acceptable accessories formation.
- 2. as claimed in claim 1 a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the consumption of described acetaminophen is 100mg-1500mg for per unit dosage.Be preferably 250mg-750mg.
- 3. as claimed in claim 1 a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the consumption of described loratadine is 1.0mg-10mg for per unit dosage.Be preferably 1.5mg-5mg.
- 4. as claimed in claim 1 a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the consumption of described pseudoephedrine sulfate is 20mg-180mg for per unit dosage.Be preferably 40mg-120mg.
- 5. as claimed in claim 1 a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the weight ratio of described acetyl aminophenol, loratadine and pseudoephedrine sulfate is 200: 1: 24.
- 6. as claimed in claim 1 a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that the Pharmaceutical composition of described acetyl aminophenol, loratadine and pseudoephedrine sulfate is an oral formulations.
- 7. as claimed in claim 6 a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, it is characterized in that described oral formulations can be made into tablet, capsule, effervescent tablet, chewable tablet, slow releasing tablet, slow releasing capsule etc.
- Claim 1-7 described a kind of be the Pharmaceutical composition of active component with acetaminophen, loratadine and pseudoephedrine sulfate, can be used for alleviating the symptom relevant, comprise simultaneously with nasal obstruction, sneeze, epistaxis, the pruritus of pain and heating and symptom such as shed tears with seasonal allergic rhinitis and common cold.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610007945 CN1806802A (en) | 2006-02-23 | 2006-02-23 | Pharmaceutical composition with acetaminopher, loratadine and pseudoephedrine sulfate as active ingredients, preparation method and uses thereof |
| CN 200610140549 CN1935142A (en) | 2006-02-23 | 2006-10-17 | Slow-release capsule using noinclude, loratadine and pseudoephedrinesulfate as effective component, and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610007945 CN1806802A (en) | 2006-02-23 | 2006-02-23 | Pharmaceutical composition with acetaminopher, loratadine and pseudoephedrine sulfate as active ingredients, preparation method and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1806802A true CN1806802A (en) | 2006-07-26 |
Family
ID=36839012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610007945 Pending CN1806802A (en) | 2006-02-23 | 2006-02-23 | Pharmaceutical composition with acetaminopher, loratadine and pseudoephedrine sulfate as active ingredients, preparation method and uses thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1806802A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143138B (en) * | 2006-09-11 | 2010-06-16 | 上海玉安药业有限公司 | Paracetamol and pseudoephedrine hydrochloride tablets made by dry powder direct tabletting |
| CN101890012A (en) * | 2009-09-28 | 2010-11-24 | 江苏亚邦爱普森药业有限公司 | Paracetamol,loratadine and pseudoephedrine sulfate sustained release tablet and preparation method thereof |
| CN102283849A (en) * | 2011-06-29 | 2011-12-21 | 北京阜康仁生物制药科技有限公司 | Medicinal composition containing azatadine |
| EP2727592A1 (en) * | 2012-11-05 | 2014-05-07 | Kücükgüzel, Sükriye Güniz | A combination of desloratadine and paracetamol |
| CN101467988B (en) * | 2007-12-27 | 2014-07-09 | 北京德众万全医药科技有限公司 | Medicament composition containing paracetamol and pseudoephedrine hydrochloride and preparation method thereof |
| CN105801557A (en) * | 2014-12-27 | 2016-07-27 | 辽宁药联制药有限公司 | Novel compound |
| CN107296800A (en) * | 2017-06-01 | 2017-10-27 | 江苏黄河药业股份有限公司 | A kind of Loratadine effervescent tablet and preparation method thereof |
-
2006
- 2006-02-23 CN CN 200610007945 patent/CN1806802A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143138B (en) * | 2006-09-11 | 2010-06-16 | 上海玉安药业有限公司 | Paracetamol and pseudoephedrine hydrochloride tablets made by dry powder direct tabletting |
| CN101467988B (en) * | 2007-12-27 | 2014-07-09 | 北京德众万全医药科技有限公司 | Medicament composition containing paracetamol and pseudoephedrine hydrochloride and preparation method thereof |
| CN101890012A (en) * | 2009-09-28 | 2010-11-24 | 江苏亚邦爱普森药业有限公司 | Paracetamol,loratadine and pseudoephedrine sulfate sustained release tablet and preparation method thereof |
| CN101890012B (en) * | 2009-09-28 | 2013-11-06 | 江苏亚邦爱普森药业有限公司 | Paracetamol,loratadine and pseudoephedrine sulfate sustained release tablet and preparation method thereof |
| CN102283849A (en) * | 2011-06-29 | 2011-12-21 | 北京阜康仁生物制药科技有限公司 | Medicinal composition containing azatadine |
| EP2727592A1 (en) * | 2012-11-05 | 2014-05-07 | Kücükgüzel, Sükriye Güniz | A combination of desloratadine and paracetamol |
| CN105801557A (en) * | 2014-12-27 | 2016-07-27 | 辽宁药联制药有限公司 | Novel compound |
| CN107296800A (en) * | 2017-06-01 | 2017-10-27 | 江苏黄河药业股份有限公司 | A kind of Loratadine effervescent tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1806802A (en) | Pharmaceutical composition with acetaminopher, loratadine and pseudoephedrine sulfate as active ingredients, preparation method and uses thereof | |
| CN101073563B (en) | Chiral composition containing dextrothyroxine buprofenli and levomethadyl cysteliqin and its double slow-releasing tablet | |
| EP1992333B1 (en) | Flurbiprofen and muscle relaxant combinations | |
| CN1709229A (en) | Memantine hydrochloride orally disintegrating tablet and its preparing method | |
| CN1246794A (en) | Lactose-free, non-hyproscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine | |
| CN1736471A (en) | Ginger preparation and preparation process thereof | |
| CN1989960A (en) | Andrographolide dispersed tablet | |
| CN105919967A (en) | Acotiamide hydrochloride preparation and application thereof | |
| CN1943561A (en) | Oral disintegration tablet of prulifloxacin and its preparing method | |
| CN1994278A (en) | Sustained-release preparation using acetaminopher, desloratadine and pseudo ephedrine sulfat as active ingredients and preparation process thereof | |
| CN1771915A (en) | Oral disintegrated Anfenmame tablet for treating children's cold and its prepn | |
| CN1935142A (en) | Slow-release capsule using noinclude, loratadine and pseudoephedrinesulfate as effective component, and its preparing method | |
| JP2005343886A (en) | Ibuprofen-containing pharmaceutical composition | |
| CN100364519C (en) | Chewing tablet of tramado hydrochloride and its preparation method | |
| CN1985807A (en) | Compound Desloratadine-Ambroxol oral disintegrated tablet and its preparing method | |
| CN101612154A (en) | Contain the compositions of pivampicillin and preparation method, purposes | |
| RU2166937C1 (en) | Paracetamol-base drug | |
| CN1994304A (en) | Compound orally disintegrating tablet containing loratadine and ambroxol and preparation process thereof | |
| CN1733084A (en) | Chinese medicinal preparation for clearing pathological heat and toxin and preparation process thereof | |
| CN1813999A (en) | Rukuaixiao medicinal prepration for treating breast tumor and preparing method | |
| CN101596157A (en) | The compound slow release preparation of a kind of pseudoephedrine, chlorphenamine and dextromethorphan | |
| CN101683527A (en) | Compound preparation for treating cold and preparation method thereof | |
| CN1915226A (en) | Oral disintegration tablet of Loratadine ambroxol, and prepartion method | |
| CN101757001B (en) | Compound slow-release preparation of benorilate, pseudoephedrine and chlorphenamine | |
| CN102671197A (en) | Medical composite containing deoxidation phenylephrine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |