CN1795923A - Medication composition for treating chronic ulcerative colitis, and preparation method - Google Patents
Medication composition for treating chronic ulcerative colitis, and preparation method Download PDFInfo
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- CN1795923A CN1795923A CN 200410102520 CN200410102520A CN1795923A CN 1795923 A CN1795923 A CN 1795923A CN 200410102520 CN200410102520 CN 200410102520 CN 200410102520 A CN200410102520 A CN 200410102520A CN 1795923 A CN1795923 A CN 1795923A
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Abstract
A Chinese medicine for treating the chronic ulcerativ colitis is an improvement to existing Chinese medicine 'colitis pill' by optimal proportion between raw materials and optimizing extraction process and is prepared from 6 Chinese-medicinal materials including black plum, coptis root, dried ginger, poppy capsule, etc.
Description
One, technical field
The present invention relates to a kind of drug regimen for the treatment of chronic ulcerative colitis and preparation method thereof.
Two, background technology
Chronic ulcerative colitis is commonly encountered diseases, frequently-occurring disease, is that the chronic nonspecific inflammation and the ulcer sexually transmitted disease (STD) of the not bright big intestinal mucosa of reason becomes.The many immunity, inflammation, drinking and eating irregularly, the stimulation of feelings will with body of its pathogenic factors etc. are relevant.With the difficult pus and blood Mucous Stool of healing of prolonged and repeated stomachache, diarrhoea and delay is feature.Belong to categories such as traditional Chinese medical science chronic diarrhea, stomachache, chronic dysentery, hemorrhoidal hamorrhage, dysentery.Generally with Drug therapys such as aminosallcylic acid class and glucocorticoids, so its toxic and side effects is too many, makes the patient can not adhere to taking medicine at present for doctor trained in Western medicine.Chinese medicine has certain curative effect to chronic ulcerative colitis, but adopts oral decoction more, and its weak point is to use big, the unsuitable prolonged application of inconvenience, gastrointestinal reaction.A kind of GUCHANG ZHIXIE WAN (JIECHANGYAN WAN) for the treatment of chronic non-specific ulcerative colitis of the 20 announcement of Ministry of Health of the People's Republic of China's " drug standard Chinese traditional patent formulation preparation ", form by Fructus Mume or Fructus Mume, Rhizoma Coptidis, Rhizoma Zingiberis, the Radix Aucklandiae, Pericarpium Papaveris, Rhizoma Corydalis etc., during preparation, getting Fructus Mume cleans, water decocts secondary (1.5 hours, 1 hour), filters merging filtrate, be concentrated into relative density and be 1.10 (60 ℃), standby; Ground spices such as all the other Rhizoma Coptidis are broken into fine powder, with above-mentioned concentrated solution and an amount of water pill, oven dry, bag charcoal clothing, polishing, promptly.Or, be ground into fine powder with five tastes such as Fructus Mume and all the other Rhizoma Coptidis, and use water pill, drying, promptly.Its weak point is not have drug dose, is difficult to carry out, and in addition, preparation technology is simple and crude, and except that Fructus Mume extracted, all the other medicines were all pulverized and are used as medicine, and quality and curative effect are difficult to guarantee.The present invention is on the basis of former prescription, and the preferred best proportioning of prescription has been optimized extraction process, and quality and curative effect are improved.
Three, summary of the invention
The object of the present invention is to provide a kind of drug regimen and preparation method thereof of treatment chronic ulcerative colitis of optimization, can improve bioavailability and clinical efficacy, steady quality.
Technical scheme of the present invention: a kind of drug regimen of treatment chronic ulcerative colitis of optimization is characterized in that its composition weight proportioning is: 30～70 parts of Fructus Mume, 20～60 parts of Rhizoma Coptidis, 20～60 parts of Rhizoma Zingiberiss, 10～50 parts of the Radix Aucklandiae, 10～50 parts of Pericarpium Papaveriss, 10～50 parts of Rhizoma Corydalis.Preferred weight proportioning of the present invention is: 40～60 parts of Fructus Mume, 30～50 parts of Rhizoma Coptidis, 30～50 parts of Rhizoma Zingiberiss, 20～40 parts of the Radix Aucklandiae, 20～40 parts of Pericarpium Papaveriss, 20～40 parts of Rhizoma Corydalis.Optimum weight proportioning of the present invention is: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis, i.e. Fructus Mume: Rhizoma Coptidis: Rhizoma Zingiberis: the Radix Aucklandiae: Pericarpium Papaveris: Rhizoma Corydalis=5: 4: 4: 3: 3: 3.
A kind of preparation method of drug regimen of treatment chronic ulcerative colitis of optimization is characterized in that it is the medicament that adopts modern pharmaceutical technology to make, and comprises dosage forms such as following tablet, capsule, soft capsule, drop pill.
1, tablet: can obtain by following 3 kinds of process routes: (1) measures raw material by prescription, gets Fructus Mume (or Fructus Mume) and decocts with water secondary, filters, and merging filtrate is concentrated into relative density and is 1.10-1.15 (60 ℃), and is standby; Ground spices such as all the other Rhizoma Coptidis are broken into fine powder, mix with above-mentioned concentrated solution and suitable quantity of water, make granule, drying, compacting in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly.(2) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution filter, and it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, mix with the Rhizoma Corydalis fine powder, make granule, drying evenly is sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule, mixing, compacting in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly.(3) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, and collecting decoction and above-mentioned aqueous solution filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, and leaves standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be that 1.10-1.15 (60 ℃) mixes with the Rhizoma Corydalis fine powder is made granule, dry, the Radix Aucklandiae, Rhizoma Zingiberis volatile oil evenly are sprayed in the granule, mixing, compacting is in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly.
2, capsule: can obtain by following 3 kinds of process routes: (1) measures raw material by prescription, gets Fructus Mume (or Fructus Mume) and decocts with water secondary, filters, and merging filtrate is concentrated into relative density and is 1.10-1.15 (60 ℃), and is standby; Ground spices such as all the other Rhizoma Coptidis are broken into fine powder, mix with above-mentioned concentrated solution and suitable quantity of water, make granule, and drying incapsulates, promptly.(2) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution, filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, mixes with the Rhizoma Corydalis fine powder, make granule, drying evenly is sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule mixing, incapsulate, promptly.(3) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, and collecting decoction and above-mentioned aqueous solution filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, and leaves standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be that 1.10-1.15 (60 ℃) mixes with the Rhizoma Corydalis fine powder is made granule, drying, evenly be sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule, mixing incapsulates, promptly.
3, drop pill: measure raw material by prescription, Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Four flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution, filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, leave standstill, filter filtrate recycling ethanol and to be concentrated into relative density be 1.15-1.20 (60 ℃), drying, pulverize, spray into the Radix Aucklandiae, Rhizoma Zingiberis volatile oil, mixing adds in the fused polyethylene glycol 6000, stir evenly, splash in the liquid Paraffin (or methyl-silicone oil, vegetable oil), take out, drop pill is absorbed condensed fluid, drying, promptly.
The invention has the advantages that: the bioavailability height, absorb rapidly, steady quality, curative effect improves, and dose is little.The dissolution in vitro speed comparative test of berberine hydrochloride in intestine-stabling and anti-diarrheal pill and tablet, capsule, the drop pill.Simulated gastric fluid, simulated intestinal fluid are all according to prescriptive procedure preparation under " Pharmacopoeia of People's Republic of China (version was two ones in 2000) " appendix XC dissolution method item.Measure according to " Pharmacopoeia of People's Republic of China (version was two ones in 2000) " appendix XC dissolution method.Change basket method mensuration with simulated gastric fluid, simulated intestinal fluid according to use respectively in accordance with the law.Since sampling in 30 minutes, once (take a sample altogether 4 times, investigate 60 minutes) every sampling in 10 minutes later on, inject high performance liquid chromatograph, by above-mentioned chromatographic condition, the content of berberine hydrochloride in the working sample.The result shows: the rate of dissolution of main effective ingredient berberine hydrochloride is obviously greater than the rate of dissolution of former GUCHANG ZHIXIE WAN in intestine-stabling and anti-diarrheal coated tablet, Film coated tablets, enteric coated tablet, capsule, soft capsule, enteric coated capsule and the pill prescription, relatively, the two has significant difference (P＜0.05) statistical results show between two groups.The results are shown in following table 1.In order to investigate the clinical efficacy to chronic ulcerative colitis of tablet, capsule, drop pill and pill, 132 routine patients are divided into 3 groups at random, i.e. pill group, capsule group and drop pill group, every group 33 example; Efficacy assessment standard divides 4 grades, promptly cures in the recent period: clinical symptoms, sign disappear, and the fibercolonscopy mucosa infection recovers normal or leaves over cicatrix; Produce effects: symptom, sign disappear substantially, and the only slight inflammatory of colonoscopy intestinal mucosa changes; Effectively: symptom, sign alleviate, and colonoscopy mucosa infection degree alleviates to some extent; Invalid: symptom, sign, the equal no change of colonoscopy or increase the weight of.After the off-test, the case that comes off statistics, tablet group and capsule group respectively have 3 examples, and the pill group has 4 examples, drop pill that 1 example is arranged.Clinical research is the result show, tablet, capsule, drop pill curative effect all are better than pill, and statistical analysis has significant difference (P＜0.05).Concrete outcome sees Table 2.
The dissolution in vitro speed trial of table 1 intestine-stabling and anti-diarrheal pill and tablet, capsule, drop pill
| Berberine hydrochloride stripping quantity (mg/g) | ||||
| 30min | 40min | 50min | 60min | |
| GUCHANG ZHIXIE WAN (simulated gastric fluid) | 5.11 | 6.23 | 8.58 | 10.45 |
| Intestine-stabling and anti-diarrheal coated tablet (simulated gastric fluid) | 6.21 | 7.35 | 9.29 | 12.01 |
| Intestine-stabling and anti-diarrheal Film coated tablets (simulated gastric fluid) | 7.38 | 8.27 | 10.25 | 12.13 |
| Intestine-stabling and anti-diarrheal enteric coated tablet (simulated intestinal fluid) | 5.85 | 6.99 | 9.39 | 11.31 |
| Intestine-stabling and anti-diarrheal capsule (simulated gastric fluid) | 7.08 | 8.31 | 10.23 | 12.22 |
| Intestine-stabling and anti-diarrheal soft capsule (simulated gastric fluid) | 7.05 | 8.24 | 10.26 | 12.18 |
| Intestine-stabling and anti-diarrheal enteric coated capsule (simulated intestinal fluid) | 5.90 | 7.01 | 9.47 | 11.03 |
| Intestine-stabling and anti-diarrheal drop pill (simulated gastric fluid) | 9.85 | 10.13 | 11.18 | 12.54 |
Table 2 intestine-stabling and anti-diarrheal pill and tablet, capsule, drop pill are to the clinical efficacy of chronic ulcerative colitis
| The example number | Cure in the recent period | Produce effects | Effectively | Invalid | Effective percentage % | |
| Pill tablet capsule agent drop pill | 29 31 31 32 | 10 12 11 13 | 7 8 9 9 | 3 5 6 6 | 9 6 5 4 | 69.0 80.6 83.9 87.5 |
Four, the specific embodiment
With specific embodiment the present invention is elaborated below:
Embodiment 1 (tablet 1)
Take by weighing raw material according to following proportioning: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis.
Preparation method: measure raw material by prescription, get Fructus Mume (or Fructus Mume) and decoct with water secondary, filter, merging filtrate is concentrated into relative density and is 1.10-1.15 (60 ℃), and is standby; Ground spices such as all the other Rhizoma Coptidis are broken into fine powder, mix with above-mentioned concentrated solution and suitable quantity of water, make granule, drying, compacting in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly.
Embodiment 2 (tablet 2)
Take by weighing raw material according to following proportioning: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis.
Preparation method: measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution filter, and it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, mix with the Rhizoma Corydalis fine powder, make granule, drying evenly is sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule, mixing, compacting in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly.
Embodiment 3 (tablet 3)
Take by weighing raw material according to following proportioning: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis.
Preparation method: measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, and collecting decoction and above-mentioned aqueous solution filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, and leaves standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be that 1.10-1.15 (60 ℃) mixes with the Rhizoma Corydalis fine powder is made granule, dry, the Radix Aucklandiae, Rhizoma Zingiberis volatile oil evenly are sprayed in the granule, mixing, compacting is in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly.
Embodiment 4 (capsule 1)
Take by weighing raw material according to following proportioning: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis.
Preparation method: measure raw material by prescription, get Fructus Mume (or Fructus Mume) and decoct with water secondary, filter, merging filtrate is concentrated into relative density and is 1.10-1.15 (60 ℃), and is standby; Ground spices such as all the other Rhizoma Coptidis are broken into fine powder, mix with above-mentioned concentrated solution and suitable quantity of water, make granule, and drying incapsulates, promptly.
Embodiment 5 (capsule 2)
Take by weighing raw material according to following proportioning: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis.
Preparation method: measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution, filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, mixes with the Rhizoma Corydalis fine powder, make granule, drying evenly is sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule mixing, incapsulate, promptly.
Embodiment 6 (capsule 3)
Take by weighing raw material according to following proportioning: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis.
Preparation method: measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, and collecting decoction and above-mentioned aqueous solution filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, and leaves standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be that 1.10-1.15 (60 ℃) mixes with the Rhizoma Corydalis fine powder is made granule, drying, evenly be sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule, mixing incapsulates, promptly.
Embodiment 7 (drop pill)
Take by weighing raw material according to following proportioning: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis.
Preparation method: measure raw material by prescription, Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Four flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution, filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, leave standstill, filter filtrate recycling ethanol and to be concentrated into relative density be 1.15-1.20 (60 ℃), drying, pulverize, spray into the Radix Aucklandiae, Rhizoma Zingiberis volatile oil, mixing adds in the fused polyethylene glycol 6000, stir evenly, splash in the liquid Paraffin (or methyl-silicone oil, vegetable oil), take out, drop pill is absorbed condensed fluid, drying, promptly.
Claims (7)
1, a kind of drug regimen for the treatment of chronic ulcerative colitis is characterized in that its composition weight proportioning is: 30～70 parts of Fructus Mume, 20～60 parts of Rhizoma Coptidis, 20～60 parts of Rhizoma Zingiberiss, 10～50 parts of the Radix Aucklandiae, 10～50 parts of Pericarpium Papaveriss, 10～50 parts of Rhizoma Corydalis.
2, the drug regimen of treatment chronic ulcerative colitis according to claim 1, wherein each composition weight proportioning is: 40～60 parts of Fructus Mume, 30～50 parts of Rhizoma Coptidis, 30～50 parts of Rhizoma Zingiberiss, 20～40 parts of the Radix Aucklandiae, 20～40 parts of Pericarpium Papaveriss, 20～40 parts of Rhizoma Corydalis.
3, the drug regimen of treatment chronic ulcerative colitis according to claim 1, wherein each composition weight proportioning is: 50 parts of Fructus Mume, 40 parts of Rhizoma Coptidis, 40 parts of Rhizoma Zingiberiss, 30 parts of the Radix Aucklandiae, 30 parts of Pericarpium Papaveriss, 30 parts of Rhizoma Corydalis, i.e. Fructus Mume: Rhizoma Coptidis: Rhizoma Zingiberis: the Radix Aucklandiae: Pericarpium Papaveris: Rhizoma Corydalis=5: 4: 4: 3: 3: 3.
4, a kind of preparation method for the treatment of the drug regimen of chronic ulcerative colitis, it is the medicament that adopts modern pharmaceutical technology to make, and mainly comprises tablet, capsule, drop pill.
5, a kind of preparation method for the treatment of the drug regimen of chronic ulcerative colitis according to claim 4, the preparation that it is characterized in that tablet is to obtain by following 3 kinds of process routes: (1) measures raw material by prescription, get Fructus Mume (or Fructus Mume) and decoct with water secondary, filter, merging filtrate, be concentrated into relative density and be 1.10-1.15 (60 ℃), standby; Ground spices such as all the other Rhizoma Coptidis are broken into fine powder, mix with above-mentioned concentrated solution and suitable quantity of water, make granule, drying, compacting in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly; (2) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution filter, and it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, mix with the Rhizoma Corydalis fine powder, make granule, drying evenly is sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule, mixing, compacting in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly; (3) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, and collecting decoction and above-mentioned aqueous solution filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, and leaves standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be that 1.10-1.15 (60 ℃) mixes with the Rhizoma Corydalis fine powder is made granule, dry, the Radix Aucklandiae, Rhizoma Zingiberis volatile oil evenly are sprayed in the granule, mixing, compacting is in flakes, perhaps sugar coating, film-coat or enteric coating again, promptly.
6, a kind of preparation method for the treatment of the drug regimen of chronic ulcerative colitis according to claim 4, the preparation that it is characterized in that soft capsule is to obtain by following 3 kinds of process routes: (1) measures raw material by prescription, get Fructus Mume (or Fructus Mume) and decoct with water secondary, filter, merging filtrate, be concentrated into relative density and be 1.10-1.15 (60 ℃), standby; Ground spices such as all the other Rhizoma Coptidis are broken into fine powder, mix with above-mentioned concentrated solution and suitable quantity of water, make granule, and drying incapsulates, promptly; (2) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution, filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, mixes with the Rhizoma Corydalis fine powder, make granule, drying evenly is sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule mixing, incapsulate, promptly; (3) measure raw material by prescription, Rhizoma Corydalis is ground into fine powder; Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Three flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, and collecting decoction and above-mentioned aqueous solution filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, and leaves standstill, filter, filtrate recycling ethanol and to be concentrated into relative density be that 1.10-1.15 (60 ℃) mixes with the Rhizoma Corydalis fine powder is made granule, drying, evenly be sprayed on the Radix Aucklandiae, Rhizoma Zingiberis volatile oil in the granule, mixing incapsulates, promptly.
7, a kind of preparation method for the treatment of the drug regimen of chronic ulcerative colitis according to claim 4, the preparation that it is characterized in that drop pill is to measure raw material by prescription, Rhizoma Zingiberis, Radix Aucklandiae distillating extracting oil, the aqueous solution after the distillation device are in addition collected; Four flavors such as medicinal residues and all the other Fructus Mume (or Fructus Mume) decoct with water secondary, collecting decoction and above-mentioned aqueous solution, filter, it is 1.15-1.20 (60 ℃) that filtrate is concentrated into relative density, adds 2 times of amount ethanol and stirs evenly, leave standstill, filter filtrate recycling ethanol and to be concentrated into relative density be 1.15-1.20 (60 ℃), drying, pulverize, spray into the Radix Aucklandiae, Rhizoma Zingiberis volatile oil, mixing adds in the fused polyethylene glycol 6000, stir evenly, splash in the liquid Paraffin (or methyl-silicone oil, vegetable oil), take out, drop pill is absorbed condensed fluid, drying, promptly.
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| CN 200410102520 CN1795923A (en) | 2004-12-27 | 2004-12-27 | Medication composition for treating chronic ulcerative colitis, and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101121014B (en) * | 2006-08-11 | 2011-04-20 | 王玉梅 | Enteric coated traditional Chinese medicine preparation for intestine-stabling and anti-diarrhea |
| CN103520661A (en) * | 2012-07-06 | 2014-01-22 | 王保安 | Traditional Chinese medicinal enteric-coated tablets for treating proctitis, colitis and irritable bowel syndrome, as well as preparation method and application thereof |
| CN105535498A (en) * | 2016-01-19 | 2016-05-04 | 吕娜娜 | Traditional Chinese medicine preparation for treating chronic ulcerative colitis |
| CN114984100A (en) * | 2022-07-25 | 2022-09-02 | 安徽中医药大学 | Application of dark plum aqueous extract in preparation of products for preventing and treating ulcerative colitis |
-
2004
- 2004-12-27 CN CN 200410102520 patent/CN1795923A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101121014B (en) * | 2006-08-11 | 2011-04-20 | 王玉梅 | Enteric coated traditional Chinese medicine preparation for intestine-stabling and anti-diarrhea |
| CN103520661A (en) * | 2012-07-06 | 2014-01-22 | 王保安 | Traditional Chinese medicinal enteric-coated tablets for treating proctitis, colitis and irritable bowel syndrome, as well as preparation method and application thereof |
| CN105535498A (en) * | 2016-01-19 | 2016-05-04 | 吕娜娜 | Traditional Chinese medicine preparation for treating chronic ulcerative colitis |
| CN114984100A (en) * | 2022-07-25 | 2022-09-02 | 安徽中医药大学 | Application of dark plum aqueous extract in preparation of products for preventing and treating ulcerative colitis |
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