CN1795913A - Medicament drop pills for nourish qi and yin, recovering channels and vessels, and increasing the body fluid, and preparation method - Google Patents
Medicament drop pills for nourish qi and yin, recovering channels and vessels, and increasing the body fluid, and preparation method Download PDFInfo
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- CN1795913A CN1795913A CNA2004100816478A CN200410081647A CN1795913A CN 1795913 A CN1795913 A CN 1795913A CN A2004100816478 A CNA2004100816478 A CN A2004100816478A CN 200410081647 A CN200410081647 A CN 200410081647A CN 1795913 A CN1795913 A CN 1795913A
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Abstract
A Chinese medicine in the form of dripping pill for treating the deficiency of both Qi and Yin, faint pulse, spontaneous sweating, etc is prepared from ginseng, ophiopogon root, schisandra fruit and polyethanediol. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to the pharmaceutical technology field, relate to medicine of a kind of Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting and preparation method thereof or rather.
Background technology
One of main pathological change of epidemic febrile disease, the consumption that is cloudy liquid is hindered, this is that character by epidemic febrile disease is determined, the most ten big symptoms of seeing of epidemic febrile disease are successively: heating, xerostomia be thirsty, antiperspirant, rapid pulse, delirium, aversion to cold, headache, agitation, speckle and unconsciousness are arranged, wherein with heating, xerostomia is thirsty and have the antiperspirant three big symptom frequencies of occurrences the highest, and the thirsty pathogenesis of xerostomia is the result that fever caused by exogenous pathogens consumes impairment of body fluid liquid.
Hinder this pathological change at cloudy liquid consumption, the deficiency that just must adopt the YIN nourishing and the production of body fluid promoting method of " its moon of reality is with tonifying for deficiency syndrome " to replenish cloudy liquid.By this theory, the YIN nourishing and the production of body fluid promoting method should run through in the whole warm property treatment of diseases process, theory and method that this method is actual to be exactly prevention, regulate water, electrolyte balance disorder, be by transfer, adjust adjusting and the compensatory capacity of human body, and reach the purpose of correcting water, electrolyte balance disorder water, electrolyte balance disorder.
If the symptom of the deficiency of vital energy is arranged, QI invigorating simultaneously then, patients with coronary heart disease and old person (comprise women, children, hinder the patient, weakling), season hot summer, outside work person and crowds such as traveller, examination student were prone to deficiency of vital energy symptom, showed as shortness of breath and palpitation, dizzy weak, thirsty vexed, insomnia and dreamful sleep, faint pulse sweating due to debility etc.
Confirmed fatigue, cardiovascular disease such as heart failure, arrhythmia, myocardial infarction, pulmonary heart disease etc., respiratory disorder such as dyspnea, chronic bronchitis etc., and psychasthenia, diabetes etc. all are prone to above-mentioned two kinds of situations, the i.e. phenomenon of QIYINLIANGXU.
Though the medicine of many treatment epidemic febrile diseases is arranged at present on the market, but still can not satisfy patient demand.And some onset is slower, and curative effect is bad; And some injections, though onset is very fast, curative effect is also good, the patient can't oneself implement, and uses and carries all very inconvenient; Liquid oral medicine has the shortcoming of the inconvenience of carrying equally; Also have some chemicalses, can only symptomatic treatment, can not be at the cause of disease, treat not thoroughly, and the side effect that has is bigger.
Summary of the invention
Purpose of the present invention just provides the medicine of a kind of Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting, and onset is very fast when treatment QIYINLIANGXU, shortness of breath and palpitation, faint pulse spontaneous perspiration isothermal disease symptoms, curative effect is better, safety good for this medicine, and takes and carry all more convenient.
The technical solution adopted for the present invention to solve the technical problems is: the medicinal dropping ball of a kind of Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting, its raw material comprises Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis and Polyethylene Glycol, and wherein: Polyethylene Glycol is selected from mean molecule quantity at any one or more than one the Polyethylene Glycol more than 2000.
The weight proportion of each raw material is preferably in the said medicine drop pill: 0.5-2 part Radix Ginseng, 1-4 part Radix Ophiopogonis, 0.5-2 part Fructus Schisandrae Chinensis and 0.2-20 part Macrogol 4000 and/or 6000.More preferably: 0.5-1.5 part Radix Ginseng, 1.5-2.5 part Radix Ophiopogonis, 0.5-1.5 part Fructus Schisandrae Chinensis and 0.5-5 part Macrogol 4000 and/or 6000.More preferably: 1 part of Radix Ginseng, 2 parts of Radix Ophiopogonis, 1 part of Fructus Schisandrae Chinensis and 1-1.5 part Macrogol 4000 and/or 6000.
The preparation method of the medicinal dropping ball of above-mentioned Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting may further comprise the steps:
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, follow the example of or the water extraction alcohol sedimentation method or alcohol extraction water precipitation method are extracted with water extraction method or alcohol extraction: extract again after can be with above-mentioned three kinds of medical materials admixed together, perhaps above-mentioned three kinds of medical materials being extracted the back remix respectively arrives together, drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: get the Polyethylene Glycol of described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, and mix homogeneously obtains waiting to drip a medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
In the preparation method of the medicinal dropping ball of above-mentioned Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting: it can be ethanol reflux extraction or ethanol percolate extraction method etc. that the alcohol extraction during wherein (1) goes on foot is followed the example of.In addition, the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis, before its drying, it is further refining to adopt macroporous adsorbent resin method or organic solvent extractionprocess to carry out.
As required, the medicinal dropping ball of above-mentioned Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting can also have other component in its raw material, and other component optional in gelatin, glycerol, tween, Cera Flava, stearic acid, poloxamer etc. any one or more than one.
The preparation method of the medicinal dropping ball of the above-mentioned Yiqi and vein recovery that also contains other component, YIN nourishing and the production of body fluid promoting may further comprise the steps:
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, follow the example of or the water extraction alcohol sedimentation method or alcohol extraction water precipitation method are extracted with water extraction method or alcohol extraction: extract again after can be with above-mentioned three kinds of medical materials admixed together, perhaps above-mentioned three kinds of medical materials being extracted the back remix respectively arrives together, drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds other component again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
In the preparation method of the medicinal dropping ball of the above-mentioned Yiqi and vein recovery that also contains other component, YIN nourishing and the production of body fluid promoting: wherein to follow the example of can be ethanol reflux extraction or ethanol percolate extraction method etc. to the alcohol extraction in (1) step.In addition, the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis, before its drying, it is further refining to adopt macroporous adsorbent resin method or organic solvent extractionprocess to carry out.
The medicinal dropping ball of above-mentioned Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting, acute due to can be used for accumulateing in the damp and hot malicious heresy, delay property, chronic hepatitis and hepatitis gravis, also can be used for confirmed fatigue, cardiovascular disease such as heart failure, arrhythmia, myocardial infarction, pulmonary heart disease etc., also can be used for respiratory disorder such as dyspnea, chronic bronchitis etc., and psychasthenia, the Comprehensive Treatment of symptoms such as QIYINLIANGXU appears in diabetes etc.
Compared with prior art, the invention has the beneficial effects as follows: (1) medicine of the present invention is at the cause of disease of QIYINLIANGXU, select the Radix Ginseng invigorating the lung and benefiting vital QI for use, with YIN nourishing and the production of body fluid promoting Radix Ophiopogonis, with the Fructus Schisandrae Chinensis hidroschesis of astringing the lung, three medicines share, have the dual function of Yiqi and vein recovery and YIN nourishing and the production of body fluid promoting concurrently, characteristics with treating both the principal and secondary aspects of a disease are used for the treatment of the symptom such as QIYINLIANGXU, shortness of breath and palpitation, faint pulse spontaneous perspiration of various epidemic febrile disease, and onset is very fast, curative effect is better.(2) contain Polyethylene Glycol in the medicine material of the present invention, can promote drug absorption, obviously improve its bioavailability in vivo, curative effect of medication of the present invention is significantly improved.(3) different with chemicals, medicine of the present invention has embodied the treatment theory of Chinese medicine organic conception, not only at etiological treatment, also can integral body improve patient status, patient is obviously improved quality of life, and toxic and side effects is little, safety is good.In addition, medicine of the present invention also has and takes and carry all characteristics eaily.
Definite for showing curative effect of medication of the present invention, toxicity is little, and the inventor has carried out part pharmacodynamics test and acute toxicity test research.The research method and the result of the test that are adopted are as follows:
(1) test material
1, medicine:
Medicine of the present invention (make by following crude drug weight proportion: 1 part of Radix Ginseng, 2 parts of Radix Ophiopogonis, 1 part of Fructus Schisandrae Chinensis and 1.2 parts of Macrogol 4000s, down with) dosage group (0.3g/kg), medicine high dose group of the present invention (0.6g/kg) in the low dose group (0.15g/kg), medicine of the present invention.The drugs compared that does not contain Polyethylene Glycol (makes by following crude drug weight proportion: 1 part of Radix Ginseng, 2 parts of Radix Ophiopogonis and 1 part of Fructus Schisandrae Chinensis; 0.15g/kg).SHENGMAI YIN, Gejiu City Pharmaceutical Industry Co., Ld., Yunnan Prov. produces.
2, instrument: homemade CY-2 type oxygen analyser.
3, animal: Kunming mouse is provided by institute of antibiotics, Sichuan Experimental Animal Center.
(2) test method and result
1. to the influence of mice anoxia enduring and oxygen consumption
Choose 60 Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random by sex and body weight, 10 every group.Press the listed dosage of table 1, administration group lumbar injection relative medicine, capacity normal saline such as matched group lumbar injection, after 30 minutes each treated animal is placed airtight vial respectively, each one, with the variation of oxygen content in the homemade CY-2 type oxygen analyser measurement bottle, until dead mouse.The record mice time-to-live, the surplus oxygen amount when keto consumpting speed in the time of 30 minutes and death in the bottle.The results are shown in Table 1.
The influence of table 1 pair mice anoxia enduring and oxygen consumption (x ± SD)
| Group | Dosage (g/kg) | Mus number (only) | Time-to-live | 30 minutes oxygen consumption |
| Dosage medicine group of the present invention low dosage does not contain the drugs compared SHENGMAI YIN of Polyethylene Glycol in the matched group medicine group of the present invention high dose medicine group of the present invention | - 0.15 0.3 0.6 0.15 1.5 | 10 10 10 10 10 10 | 52.2±2.1 99.4±3.3 ** 87.1±3.2 ** 72.8±4.4 ** 60.6±3.7 * 61.4±2.6 * | 12.5±0.5 8.3±0.4 ** 9.1±0.3 * 9.5±0.4 * 10.6±0.7 10.2±0.5 |
Annotate: each administration group and matched group are relatively
*P＜0.05;
*P＜0.01.
Table 1 shows that medicine of the present invention can significantly improve the ability of mice anoxia enduring, show as the mice time-to-live than matched group and the drugs compared, the SHENGMAI YIN that do not contain Polyethylene Glycol obviously prolong.And 30 minutes oxygen consumption more do not contain the drugs compared of Polyethylene Glycol and SHENGMAI YIN few significantly (
*P＜0.01).
2. to the influence of mice cold resistant
Choose 120 Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random by sex and body weight, 20 every group.Press the listed dosage of table 2, administration group lumbar injection relative medicine, capacity normal saline such as matched group lumbar injection, after 30 minutes each group mice is mixed in the ferrum cage, place-cold environment of 11--12 ℃, when the dead half of control group mice, death toll (seeing Table 2) of each group of record.
The influence of table 2 pair mice cold resistant (x ± SD)
| Group | Dosage (g/kg) | Mus number (only) | Death toll | Mortality rate (%) |
| Dosage medicine group of the present invention low dosage does not contain the drugs compared Shengmai Yin of polyethylene glycol in the control group medicine group of the present invention high dose medicine group of the present invention | - 0.15 0.3 0.6 0.15 1.5 | 20 20 20 20 20 20 | 14 8 8 10 12 11 | 70.0 40.0 ** 40.0 ** 50.0 ** 60.0 55.0 * |
Annotate: each administration group and matched group are relatively
*P＜0.05;
*P＜0.01.
Medicine of the present invention can significantly improve the tolerance to cold of mice, makes mortality rate reduce to 40.0-50.0% respectively by 70.0% of matched group, more do not contain the drugs compared of Polyethylene Glycol and SHENGMAI YIN effective (
*P＜0.01).
The inventor has carried out the acute toxicity test investigation with mice to medicinal dropping ball of the present invention, the result: the maximum dosage-feeding of medicine mouse stomach of the present invention administration is 53g/kg/24h, and maximum administration multiple is intended 530 times of clinical oral administration day dosage (0.1g/kg) for 60kg body weight adult.The result shows that safety of medicine dosage range of the present invention is bigger.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
The weight proportion situation of each raw material sees Table 3 among the embodiment one to ten.
The weight proportion information slip of each raw material among table 3 embodiment one to ten
More than the preparation method of each embodiment as follows:
Embodiment one
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, extract respectively with water extraction method, each extracts 3 times, each 1 hour, merge extractive liquid,, filter, respectively filtrate is condensed into the concentrated solution that every ml contains crude drug 3g, obtain Radix Ginseng extractive solution, Radix Ophiopogonis extract and Fructus Schisandrae Chinensis extractive solution respectively, again that three kinds of extracting solution are admixed together, drying perhaps remerges after the drying respectively, mix homogeneously promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: get the Polyethylene Glycol of described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, and mix homogeneously obtains waiting to drip a medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment two
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, mix, extract with water extraction method, extract 3 times, each 1.5 hours, merge extractive liquid,, filter, filtrate is condensed into the concentrated solution that every ml contains crude drug 3g, and drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: get the Polyethylene Glycol of described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, and mix homogeneously obtains waiting to drip a medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment three
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, mix, extract with ethanol reflux extraction, extract 2 times, each 3 hours, merge extractive liquid,, filter, filtrate is condensed into the concentrated solution that every ml contains crude drug 3g, and drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds the gelatin of described proportioning again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment four
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning respectively, make solvent with 65% ethanol, flood and extract respectively with the percolation extraction method after 24 hours, collect percolate, respectively percolate is condensed into the concentrated solution that every ml contains crude drug 3g, be merged together after the drying, mix homogeneously promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds the gelatin of described proportioning again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment five
(1), the preparation Radix Ginseng, the mixed extract of Radix Ophiopogonis and Fructus Schisandrae Chinensis: the Radix Ginseng of getting described proportioning, Radix Ophiopogonis and schisandra chinensis medicinal material, extract respectively with water extraction method, each extracts 2 times, each 1 hour, merge extractive liquid,, filter, respectively filtrate is condensed into the concentrated solution that every ml contains crude drug 3g, obtain the Radix Ginseng extractive solution respectively, Radix Ophiopogonis extract and Fructus Schisandrae Chinensis extractive solution, add 95% ethanol more respectively and make and contain alcohol amount and reach about 65%, staticly settle more than 12 hours, filter respectively and filtrate is concentrated, obtain Radix Ginseng extract, Radix Ophiopogonis extract and Fructus Schisandrae Chinensis extrat, again that three kinds of extracts are admixed together, drying perhaps remerges after the drying respectively, mix homogeneously promptly makes Radix Ginseng, the mixed extract of Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds the poloxamer of described proportioning again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment six
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: get Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of described proportioning, mix back together water extraction method and extract, extract 3 times, each 0.5 hour, merge extractive liquid, filters, and filtrate is condensed into the concentrated solution that every ml contains crude drug 3g, again concentrated solution is made with extra care by macroporous adsorbent resin, use ethanol elution, collect ethanol elution, concentrate, drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: get the Polyethylene Glycol of described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, and mix homogeneously obtains waiting to drip a medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment seven
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, mix together, extract with ethanol reflux extraction, extract 2 times, each 1 hour, merge extractive liquid,, filter, filtrate is condensed into the concentrated solution that every ml contains crude drug 5g, this concentrated solution is carried out extracting and refining with ethyl acetate, promptly make the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds the glycerol of described proportioning again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment eight
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, follow the example of respectively with alcohol extraction and to extract, each extracts 2 times, each 1.5 hours, merge extractive liquid,, filter, respectively filtrate is condensed into the concentrated solution that every ml contains crude drug 3g, obtain Radix Ginseng extractive solution, Radix Ophiopogonis extract and Fructus Schisandrae Chinensis extractive solution respectively, again that three kinds of extracting solution are admixed together, add water to pure content and be about 10%, concentrate, drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds the Tween 80 of described proportioning again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment nine
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, be merged together, with 80% ethanol with being solvent, extract with the percolation extraction method, collect percolate, percolate is condensed into the concentrated solution that every ml contains crude drug 5g, after this concentrated solution is crossed macroporous adsorbent resin and made with extra care, drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds the Cera Flava of described proportioning again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Embodiment ten
(1), the preparation Radix Ginseng, the mixed extract of Radix Ophiopogonis and Fructus Schisandrae Chinensis: the Radix Ginseng of getting described proportioning, Radix Ophiopogonis and schisandra chinensis medicinal material, extract respectively with water extraction method, each extracts 3 times, each 1 hour, merge extractive liquid,, filter, respectively filtrate is condensed into the concentrated solution that every ml contains crude drug 3g, obtain the Radix Ginseng extractive solution respectively, Radix Ophiopogonis extract and Fructus Schisandrae Chinensis extractive solution add 90% alcoholic solution and make and contain the alcohol amount and reach 70% in above-mentioned each extracting solution, staticly settled 24 hours, filter, be merged together after respectively three kinds of filtrates being concentrated, drying promptly makes Radix Ginseng, the mixed extract of Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds the stearic acid of described proportioning again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
Claims (9)
1, the medicinal dropping ball of a kind of Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting, its raw material comprises Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis and Polyethylene Glycol, wherein: Polyethylene Glycol is selected from mean molecule quantity at any one or more than one the Polyethylene Glycol more than 2000.
2, the medicinal dropping ball of Yiqi and vein recovery according to claim 1, YIN nourishing and the production of body fluid promoting is characterized in that: the weight proportion of described each raw material is: 0.5-2 part Radix Ginseng, 1-4 part Radix Ophiopogonis, 0.5-2 part Fructus Schisandrae Chinensis and 0.2-20 part Macrogol 4000 and/or 6000.
3, the medicinal dropping ball of Yiqi and vein recovery according to claim 2, YIN nourishing and the production of body fluid promoting is characterized in that: the weight proportion of described each raw material is: 0.5-1.5 part Radix Ginseng, 1.5-2.5 part Radix Ophiopogonis, 0.5-1.5 part Fructus Schisandrae Chinensis and 0.5-5 part Macrogol 4000 and/or 6000.
4, the medicinal dropping ball of Yiqi and vein recovery according to claim 3, YIN nourishing and the production of body fluid promoting is characterized in that: the weight proportion of described each raw material is: 1 part of Radix Ginseng, 2 parts of Radix Ophiopogonis, 1 part of Fructus Schisandrae Chinensis and 1-1.5 part Macrogol 4000 and/or 6000.
5, the medicinal dropping ball of Yiqi and vein recovery according to claim 1, YIN nourishing and the production of body fluid promoting, it is characterized in that: also have other component in the described raw material, and other component be selected from gelatin, glycerol, tween, Cera Flava, stearic acid, the poloxamer any one or more than one.
6, the preparation method of the medicinal dropping ball of the described Yiqi and vein recovery of a kind of claim 1, YIN nourishing and the production of body fluid promoting may further comprise the steps:
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, follow the example of or the water extraction alcohol sedimentation method or alcohol extraction water precipitation method are extracted with water extraction method or alcohol extraction: extract again after can be with above-mentioned three kinds of medical materials admixed together, perhaps above-mentioned three kinds of medical materials being extracted the back remix respectively arrives together, drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: get the Polyethylene Glycol of described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, and mix homogeneously obtains waiting to drip a medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
7, the preparation method of the medicinal dropping ball of the Yiqi and vein recovery described in a kind of claim 5, YIN nourishing and the production of body fluid promoting may further comprise the steps:
(1), the mixed extract of preparation Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis: Radix Ginseng, Radix Ophiopogonis and the schisandra chinensis medicinal material of getting described proportioning, follow the example of or the water extraction alcohol sedimentation method or alcohol extraction water precipitation method are extracted with water extraction method or alcohol extraction: extract again after can be with above-mentioned three kinds of medical materials admixed together, perhaps above-mentioned three kinds of medical materials being extracted the back remix respectively arrives together, drying promptly makes the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis;
(2), mix: the Polyethylene Glycol of getting described ratio, heating makes into molten condition, and the mixed extract that above-mentioned (1) is gone on foot the Radix Ginseng, Radix Ophiopogonis and the Fructus Schisandrae Chinensis that make joins in the Polyethylene Glycol of molten condition, adds other component again, mix homogeneously obtains waiting to drip the medicinal liquid of making;
(3), drip system: the medicinal liquid that above-mentioned (2) step is obtained is transferred on the drop pill device, drips and makes pill, and drying promptly makes medicinal dropping ball.
8, according to the preparation method of the medicinal dropping ball of claim 6 or 7 described Yiqi and vein recoveries, YIN nourishing and the production of body fluid promoting, it is characterized in that: ethanol reflux extraction or the ethanol percolate extraction method of being meant followed the example of in the alcohol extraction in described (1) step.
9, according to the preparation method of the medicinal dropping ball of claim 6 or 7 described Yiqi and vein recoveries, YIN nourishing and the production of body fluid promoting, it is characterized in that: the mixed extract of Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae Chinensis in described (1) step, before its drying, it is further refining to adopt macroporous adsorbent resin method or organic solvent extractionprocess to carry out.
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| Application Number | Priority Date | Filing Date | Title |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668468A (en) * | 2015-11-04 | 2017-05-17 | 兰州大学 | Pulse-activating compound extract and application in preparation of medicine or health product for improving memory |
| CN107441475A (en) * | 2017-08-22 | 2017-12-08 | 北京未医堂健康科技有限公司 | Rising Yang QI invigorating adjusts Chinese medicine preparation of member and preparation method thereof |
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2004
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668468A (en) * | 2015-11-04 | 2017-05-17 | 兰州大学 | Pulse-activating compound extract and application in preparation of medicine or health product for improving memory |
| CN107441475A (en) * | 2017-08-22 | 2017-12-08 | 北京未医堂健康科技有限公司 | Rising Yang QI invigorating adjusts Chinese medicine preparation of member and preparation method thereof |
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Open date: 20060705 |