CN1785358A - Medicine for treating acne and its preparation method - Google Patents
Medicine for treating acne and its preparation method Download PDFInfo
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- CN1785358A CN1785358A CN 200510200694 CN200510200694A CN1785358A CN 1785358 A CN1785358 A CN 1785358A CN 200510200694 CN200510200694 CN 200510200694 CN 200510200694 A CN200510200694 A CN 200510200694A CN 1785358 A CN1785358 A CN 1785358A
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Abstract
A Chinese medicine for treating acne is prepared from 11 Chinese-medicinal materials including rhubarb, rehmannia root, safflower, red peony root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of treatment acne (acne vulgaris) medicine, specifically is the Chinese patent drugs for treatment acne (acne vulgaris) of feedstock production with the Chinese herbal medicine, belongs to field of traditional Chinese.
Background technology
Pent up by pyretic toxicity, the stagnant caused acne vulgaris of the blood vessels stasis of blood is a kind of commonly encountered diseases, this disease of treatment mostly is toiletries or Western medicine at present, this series products curative effect is general, strong to skin irritation, some medicine for external use even calcination skin, the oral medicine side effect is big, curative effect is not good yet, and the patient dare not be used easily.
Summary of the invention
The objective of the invention is to: a kind of have nourishing YIN and clearing away lung-heat, removing damp-heat, removing heat from blood collateral dredging are provided, are applicable to lung-stomach yin deficiency, retention of damp-heat in the interior, the heat in blood stasis of blood hinders Chinese patent medicine of caused acne (acne vulgaris) and preparation method thereof, to address the above problem.
The present invention is achieved in that it is to be prepared from following raw materials according, and the consumption of each crude drug is: Radix Et Rhizoma Rhei 150～300g, the Radix Rehmanniae 150～300g, Radix Ophiopogonis 100～120g, Flos Carthami 50～120g, Fructus Mume 20～60g, Radix Paeoniae Rubra 50～150g, Radix Scrophulariae 100～150g, Herba Equiseti Hiemalis 50～120g, Cortex Mori 50～150g, Radix Salviae Miltiorrhizae 50～100g, sucrose 780～950g.
The preferable amount of each raw material is: Radix Et Rhizoma Rhei 200～250g, the Radix Rehmanniae 150～300g, Radix Ophiopogonis 140～180g, Flos Carthami 70～100g, Fructus Mume 30～50g, Radix Paeoniae Rubra 80～130g, Radix Scrophulariae 120～140g, Herba Equiseti Hiemalis 70～100g, Cortex Mori 80～130g, Radix Salviae Miltiorrhizae 65～110g, sucrose 820～920g.
The optimum amount of each raw material is: Radix Et Rhizoma Rhei 200g, Radix Rehmanniae 200g, Radix Ophiopogonis 150g, Flos Carthami 80g, Fructus Mume 40g, Radix Paeoniae Rubra 100g, Radix Scrophulariae 150g, Herba Equiseti Hiemalis 80g, Cortex Mori 100g, Radix Salviae Miltiorrhizae 100g, sucrose 880g.
This medicine can be made into granule, does not contain sugared granule, powder, tablet, capsule, oral liquid, syrup.
Preparation method: take by weighing raw material by weight ratio, above-mentioned 10 flavor herbal decoction pieces are ground into coarse powder, decoct with water three times, add 10 times of amounts of water for the first time, decocted 2 hours, and added 8 times of amounts of water for the second time, decocted 1.5 hours, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, it is 1.1～1.2 clear paste that filtrate is concentrated into relative density, adds ethanol and makes that to contain the alcohol amount be 60%, staticly settle 12 hours after, filter, reclaim ethanol, again with sucrose, granulate, 60 ℃ of cold drying 8 hours, promptly.
The present invention is screening meticulously from the national folk proved recipe of Guizhou, utilizes modern science and technology, the pure Chinese medicine extract preparation that develops in conjunction with pharmaceutical technology.The present invention compared with prior art has following advantage:
1, show through the clinical verification observation: Radix Et Rhizoma Rhei heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling have antibiosis and antiviral functions; The Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae clearing away heat and cooling blood, YIN nourishing detoxifcation; Flos Carthami, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Fructus Mume removing heat from blood and promoting blood circulation, mass dissipating and swelling eliminating have antifungic action; Herba Equiseti Hiemalis, Cortex Mori wind and heat dispersing, the effect of antiinflammatory convergence is arranged.
2, belong to pure Chinese medicinal preparation, have no side effect, clinical safe in utilization, and treat simple, convenient, fast.
3, the advantage that has short treating period, curative effect height, instant effect, the patient is easy to accept.
Clinical data
300 many cases have been made in clinical observation, are that clinical observation illustrates with one, two attached institutes of Guiyang College of Traditional Chinese Medicine specifically, and two hospitalize acnes are totally 80 examples, and wherein 60 examples are organized in treatment, matched group 20 examples.Observed result, total effective rate are 90%, and the matched group effective percentage is 80%, and existing observed result is verified is summarized as follows:
Treatment group, matched group clinical data (seeing Table 1)
Table 1
| Group | The example number | Age (year) | The course of disease (year) | Chinese medical discrimination | ||||||
| 16-25 | 26-35 | 36-45 | ≤1 | 1-3 | 3-8 | ≥8 | Wind and heat in the lung meridian | Phlegm-damp condenses | ||
| The treatment group | 60 | 39 | 16 | 5 | 27 | 17 | 11 | 5 | 32 | 28 |
| Matched group | 20 | 11 | 5 | 4 | 10 | 5 | 3 | 2 | 10 | 10 |
Two, Therapeutic Method:
The treatment group: granule of the present invention, boiled water is taken after mixing it with water, and each 1 bag, 2 times on the 1st, 15 was 1 course of treatment.
Matched group: MIANKANGJING is oral, and each 1,2 times on the 1st, 15 was 1 course of treatment.
During the treatment: the Chinese and western drugs of all oral administration and externally treatment acnes of stopping using.
Three, curative effect determinate standard:
1, cure: skin lesion is disappeared fully, and subjective symptoms disappears.
2, produce effects: subjective symptoms obviously alleviates, and skin disappears more than 60%.
3, effective: subjective symptoms has necessarily and alleviates, and skin disappears more than the 30-60%.
4, invalid: the equal no change of comparing before skin lesion and symptom and the treatment, or skin disappears not as good as 30%.
Result and analysis
One, clinical curative effect analysis
1, treatment group total effects (seeing Table 2)
Table 2
| The checking unit | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effectively (%) |
| The traditional Chinese medical science one attached institute | 30 | 8(26.7) | 14(46.7) | 4(13.3) | 4(13.3) | 26(86.7) |
| The traditional Chinese medical science two attached institutes | 30 | 7(23.3) | 12(14) | 9(30) | 2(6.67) | 28(93.33) |
| Add up to | 60 | 15(25) | 26(46.3) | 13(21.7) | 6(10) | 54(90) |
2, matched group curative effect (seeing Table 3)
Table 3
| The checking unit | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effectively (%) |
| The traditional Chinese medical science-attached institute | 10 | 2(20) | 4(40) | 2(20) | 2(20) | 8(80) |
| The traditional Chinese medical science-attached institute | 10 | 3(30) | 4(40) | 1(10) | 2(20) | 8(80) |
| Add up to | 20 | 5(25) | 8(40) | 3(15) | 4(20) | 16(80) |
3, treatment group and matched group curative effect relatively see Table 4
Table 4
| Group | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effectively (%) |
| The treatment group | 60 | 15(25) | 26(43.3) | 13(21.7) | 6(10) | 54(90) |
| Matched group | 20 | 5(25) | 8(40) | 3(15) | 4(20) | 16(80) |
Analyze through Pidit, treatment group R value is 0.5, and matched group R value is that 0.4733,95% credibility interval is 0.3442-0.6024, comprises 0.5, so P＞0.05, two group curative effect compares there was no significant difference.Matched group R value illustrates that less than 0.5 the matched group curative effect is not as the treatment group.
4, different pattern of syndrome curative effects compare (seeing Table 5)
Table 5
| The checking pattern of syndrome | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effectively (%) |
| The wind and heat in the lung meridian type | 32 | 9(28.1) | 15(46.9) | 5(15.6) | 3(9.4) | 29(90.6) |
| Phlegm-damp is doubted junction type | 28 | 6(21.4) | 11(39.3) | 8(28.6) | 3(10.7) | 25(89.3) |
Analyze through Pidit, wind and heat in the lung meridian type R value is 0.5, and it is that 0.4286,95% credibility interval is 0.3195-0.5377 that phlegm-damp is doubted junction type R value, comprises 0.5, so P＞0.05, two pattern of syndrome curative effect compares there was no significant difference.
The analysis of 5, the treatment group course of disease and curative effect (seeing Table 6)
Table 6
| The course of disease (year) | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effectively (%) |
| ≤1 | 27 | 9(33.3) | 14(51.9) | 4(14.81) | 0 | 27(100) |
| 1-3 | 17 | 4(23.5) | 8(47.1) | 4(23.5) | 1(5.9) | 16(94.1) |
| 3-8 | 11 | 2(18.2) | 3(27.3) | 3(27.3) | 3(27.3) | 8(72.7) |
| ≥8 | 5 | 1(20) | 2(40) | 2(40) | 3(60) |
Table 6 is the result show, the course of disease is short, good effect, the long then weak curative effect of the course of disease.
The relation of 6, the treatment group course of treatment and curative effect (seeing Table 7)
Table 7
| The course of treatment | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effectively (%) |
| 1 week | 60 | 4(6.7) | 21(35) | 24(40) | 11(18.3) | 49(817) |
| 2 weeks | 60 | 20(33.3) | 28(46.7) | 8(13.3) | 4(6.7) | 56(90.3) |
Table 7 is the result show, the long better efficacy of granule curative effect of the present invention.
7, treatment group treatment back cardinal symptom is improved situation (seeing Table 8)
Table 8
| Symptom | Treatment precedent number | Treatment back doing well,improving situation (routine number %) | |||
| Disappear | Alleviate | No change | Effective percentage (%) | ||
| Erubescence | 46 | 34(73.9) | 9(19.6) | 3(6.5) | 43(93.5) |
| Swelling | 50 | 31(62) | 17(34) | 2(4.0) | 48(96) |
| Pruritus | 47 | 38(80.8) | 9(19.1) | 0 | 47(100) |
| Pain | 43 | 31(72.1) | 10(23.3) | 2(4.7) | 41(95.3) |
| Constipation | 25 | 22(88) | 2(8.0) | 1(4.0) | 24(96) |
| Scorching hot | 8 | 3(37.5) | 5(62.5) | 0 | 8(100) |
Show in the table 8: main clinic symptoms such as treatment back erubescence, swelling, pruritus be improved significantly.
Two, untoward reaction
Treatment is organized 60 routine patients at the treatment viewing duration, untoward reaction such as giddy, headache, nausea and vomiting, cardiopalmus, asthma do not occur.Blood, urine, stool routine examination, liver, kidney function test there is no ANOMALOUS VARIATIONS before and after the treatment, and small number of patients has laxativeness, and drug withdrawal promptly ends.
Three, model case
Example one: Lee * *, man, 17 years old, live the Flos Nelumbinis slope and pass No. 25, book lane, face amount portion and cheeks distributed red pimple 1 year 3 months, went to a doctor on August 31st, 2002, the tongue fur BOHUANG is diagnosed as acne, belongs to the wind and heat in the lung meridian type, give granule of the present invention for oral administration, each 1 bag (12g), 2 times on the 1st, erythra obviously disappears after the week of taking medicine, continue to take a week, erythra disappears fully.
Example two: the king * *, the woman, 23 years old, the university students, because of denomination portion pimple with regard to rash, the course of disease 3 years is surplus.Looking into meeting volume, glabella length has cerise pimple, the tuberosity of comparatively dense, and denomination portion fat secretion is more, is diagnosed as acne (acne vulgaris), the wind and heat in the lung meridian type, take two weeks of granule of the present invention, each 1 bag (12g), 2 times on the 1st, boiled water is taken after mixing it with water, take medicine the back deflorescence of two weeks more than 70%, continue to take a week, erythra disappears substantially, multiple Drug therapy primary disease was once taken in patient's private prosecution in the past, this time best results.
Discuss and conclusion
1, the present invention treats acne (acne vulgaris) curative effect preferably, and total effective rate is 90%, compares there was no significant difference (P＞0.05) with the matched group MIANKANGJING.
2, the present invention treats acne, and its curative effect is relevant with patient's the course of disease, if the course of disease is long, short treating period weak curative effect then; If the course of disease is lacked, grow then good effect the course of treatment.
3, the present invention improves significantly to main clinic symptoms such as erubescence, pain, swelling, prurituss, illustrates that this product has the effect of YIN nourishing and the production of body fluid promoting, heat-clearing and toxic substances removing, dehumidifying eliminating stagnation.
4, the present invention except that the minority case has (drug withdrawal promptly ends) the laxativeness, does not see other untoward reaction and toxic and side effects in the clinical verification process.
In sum, the present invention has the effect of YIN nourishing and the production of body fluid promoting, heat-clearing and toxic substances removing, dehumidifying eliminating stagnation, is that wind and heat in the lung meridian, the phlegm-damp two pattern of syndrome acne patients of condensing have curative effect preferably to Chinese medical discrimination, taking convenience, safely, have no side effect.
The specific embodiment:
Embodiment 1: take by weighing Radix Et Rhizoma Rhei 150g, Radix Rehmanniae 150g, Radix Ophiopogonis 100g, Flos Carthami 50g, Fructus Mume 20g, Radix Paeoniae Rubra 50g, Radix Scrophulariae 100g, Herba Equiseti Hiemalis 50g, Cortex Mori 50g, Radix Salviae Miltiorrhizae 50g is ground into coarse powder, decocts with water three times, add for the first time 10 times of amounts of water, decocted 2 hours, and added 8 times of amounts of water for the second time, decocted 1.5 hours, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, the filter filter is concentrated into the clear paste that relative density is 1.1～1.2 (80 ℃), add ethanol and make that to contain the alcohol amount be 60%, staticly settle 12 hours after, filter, reclaim ethanol, add the multitudinous sugar of 920g again, granulate, 60 ℃ of cold drying 8 hours, make the 1000g granule, packing promptly.
Embodiment 2: take by weighing Radix Et Rhizoma Rhei 200g, Radix Rehmanniae 200g, Radix Ophiopogonis 150g, Flos Carthami 80g, Fructus Mume 40g, Radix Paeoniae Rubra 100g, Radix Scrophulariae 150g, Herba Equiseti Hiemalis 80g, Cortex Mori 100g, Radix Salviae Miltiorrhizae 100g is ground into coarse powder, decocts with water three times, add for the first time 10 times of amounts of water, decocted 2 hours, and added 8 times of amounts of water for the second time, decocted 1.5 hours, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, the filter filter is concentrated into the clear paste that relative density is 1.1～1.2 (80 ℃), add ethanol and make that to contain the alcohol amount be 60%, staticly settle 12 hours after, filter, reclaim ethanol, add the multitudinous sugar of 880g again, granulate, 60 ℃ of cold drying 8 hours, make 1000g powder, packing promptly.
Embodiment 3: take by weighing Radix Et Rhizoma Rhei 300g, Radix Rehmanniae 300g, Radix Ophiopogonis 200g, Flos Carthami 120g, Fructus Mume 60g, Radix Paeoniae Rubra 150g, Radix Scrophulariae 150g, Herba Equiseti Hiemalis 120g, Cortex Mori 150g, Radix Salviae Miltiorrhizae 100g is ground into coarse powder, decocts with water three times, add for the first time 10 times of amounts of water, decocted 2 hours, and added 8 times of amounts of water for the second time, decocted 1.5 hours, add 8 times of amounts of water for the third time, decocted 1 hour, collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.1～1.2 (80 ℃), add ethanol and make that to contain the alcohol amount be 60%, staticly settle 12 hours after, filter, reclaim ethanol, add the multitudinous sugar of 820g again, granulate, 60 ℃ of cold drying 8 hours, make the 1000g sugar-free granule, packing promptly.
The also available common process of the present invention is made tablet, capsule, oral liquid, syrup etc.
Claims (5)
1. medicine for the treatment of acne, it is characterized in that: it is to be prepared from following raw materials according, and the consumption of each crude drug is: Radix Et Rhizoma Rhei 150～300g, the Radix Rehmanniae 150～300g, Radix Ophiopogonis 100～120g, Flos Carthami 50～120g, Fructus Mume 20～60g, Radix Paeoniae Rubra 50～150g, Radix Scrophulariae 100～150g, Herba Equiseti Hiemalis 50～120g, Cortex Mori 50～150g, Radix Salviae Miltiorrhizae 50～100g, sucrose 780～950g.
2. the medicine of treatment acne according to claim 1 is characterized in that: the preferable amount of each raw material is: Radix Et Rhizoma Rhei 200～250g, the Radix Rehmanniae 150～300g, Radix Ophiopogonis 140～180g, Flos Carthami 70～100g, Fructus Mume 30～50g, Radix Paeoniae Rubra 80～130g, Radix Scrophulariae 120～140g, Herba Equiseti Hiemalis 70～100g, Cortex Mori 80～130g, Radix Salviae Miltiorrhizae 65～110g, sucrose 820～920g.
3. the medicine of treatment acne according to claim 1 and 2 is characterized in that: the optimum amount of each raw material is: Radix Et Rhizoma Rhei 200g, Radix Rehmanniae 200g, Radix Ophiopogonis 150g, Flos Carthami 80g, Fructus Mume 40g, Radix Paeoniae Rubra 100g, Radix Scrophulariae 150g, Herba Equiseti Hiemalis 80g, Cortex Mori 100g, Radix Salviae Miltiorrhizae 100g, sucrose 880g.
4. the medicine of treatment acne according to claim 3 is characterized in that: this medicine can be made into granule, does not contain sugared granule, powder, tablet, capsule, oral liquid, syrup.
5. the preparation method of a treatment acne medicine as claimed in claim 3 is characterized in that: take by weighing raw material by weight ratio, above-mentioned 10 flavor herbal decoction pieces are ground into coarse powder, decoct with water three times, for the first time add 10 times of amounts of water, decocted 2 hours, add 8 times of amounts of water for the second time, decocted 1.5 hours, add 8 times of amounts of water for the third time, decocted collecting decoction 1 hour, filter, it is 1.1～1.2 clear paste that filtrate is concentrated into relative density, adds ethanol and makes that to contain the alcohol amount be 60%, staticly settle 12 hours after, filter, reclaim ethanol,, granulate again with sucrose, 60 ℃ of cold drying 8 hours, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005102006944A CN100363044C (en) | 2005-11-11 | 2005-11-11 | Medicine for treating acne and its preparation method |
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| CN1785358A true CN1785358A (en) | 2006-06-14 |
| CN100363044C CN100363044C (en) | 2008-01-23 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204476B (en) * | 2007-12-12 | 2010-12-15 | 陈德顺 | Internal Chinese traditional medicine for acne |
| CN104524165A (en) * | 2014-12-05 | 2015-04-22 | 张岩 | Medicine for treating skin acne and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159926A (en) * | 1996-03-19 | 1997-09-24 | 高贵 | Instant particles for activating blood circulation and eliminating stasis |
| CN1101691C (en) * | 2000-02-18 | 2003-02-19 | 张学明 | Acne-eliminating capsule and liniment for curing acnes |
-
2005
- 2005-11-11 CN CNB2005102006944A patent/CN100363044C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204476B (en) * | 2007-12-12 | 2010-12-15 | 陈德顺 | Internal Chinese traditional medicine for acne |
| CN104524165A (en) * | 2014-12-05 | 2015-04-22 | 张岩 | Medicine for treating skin acne and preparation method thereof |
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| Publication number | Publication date |
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| CN100363044C (en) | 2008-01-23 |
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