CN1785231A - Zhenqi Fuzheng prepn. contg. glossy privet fruit and Radix astragali for strengthening the body resistance and its prepn. method - Google Patents
Zhenqi Fuzheng prepn. contg. glossy privet fruit and Radix astragali for strengthening the body resistance and its prepn. method Download PDFInfo
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- CN1785231A CN1785231A CN 200510032415 CN200510032415A CN1785231A CN 1785231 A CN1785231 A CN 1785231A CN 200510032415 CN200510032415 CN 200510032415 CN 200510032415 A CN200510032415 A CN 200510032415A CN 1785231 A CN1785231 A CN 1785231A
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Abstract
A Chinese medicine in the form of dispersing tablet or oral liquid for improving immunity and constitution, protecting the function of bone marrow and adrenal cortex, and promoting the function recovery after radiotherapy and chemicotherapy is prepared from lucid ligustrum fruit and astragalus root.
Description
One, technical field:
The present invention relates to a kind of is Chinese medicine preparation of forming of feedstock production and preparation method thereof with Fructus Ligustri Lucidi, the Radix Astragali two flavor Chinese crude drugs.
Two, background technology:
Product of the present invention has the raising immune function of human body, protection bone marrow and adrenal cortex function, and boosting qi and nourishing yin, it is deficient to be used for prolonged illness, deficiency of both vital energy and Yin; What be used for that various diseases causes is deficient, cooperates operation, lonizing radiation, chemotherapy, promotes the recovery of normal function.According to the relevant medicine laws and regulations of China, the dosage form that changes medicine belongs to new drug.Existing ZHENQI FUZHENG KELI and capsule have been listed national drug food Surveillance Authority standard for traditional Chinese medicines in.At present, the preparation that does not still have oral liquid, dispersible tablet.
Three, summary of the invention:
The object of the present invention is to provide a kind of raising immune function of human body; protection bone marrow and adrenal cortex function; boosting qi and nourishing yin; it is deficient to be used for prolonged illness; deficiency of both vital energy and Yin; cooperate operation, lonizing radiation, chemotherapy, the body resistance-strengthening Zhenqi oral liquid of the recovery of promotion normal function, body resistance-strengthening Zhenqi dispersible tablet and preparation method thereof.
Technical scheme of the present invention is: body resistance-strengthening Zhenqi oral liquid, dispersible tablet is characterized in that: by Fructus Ligustri Lucidi, the Radix Astragali two flavor Chinese medicine extract and pharmacy adjuvant are prepared from.
Used medical material weight ratio is: the Radix Astragali 1, Fructus Ligustri Lucidi 0.5-2.
Used medical material optimum weight ratio is: the Radix Astragali 1, Fructus Ligustri Lucidi 1.
Preparation method of the present invention is: the Radix Astragali, Fructus Ligustri Lucidi with 40-95% ethanol alcohol extraction twice, reclaim ethanol earlier, merge extracted twice liquid, concentrate concentrated solution A; Medicinal residues decoct with water secondary again behind the ethanol extraction, and 2-3 hour for the first time, the 2nd time 1-2 hour, collecting decoction filtered, an amount of concentrate concentrated solution B, concentrated solution A mix with B concentrated solution C; 1. concentrated solution C adding purified water and correctives dilution stir into suspendible liquid, and fill becomes bottle promptly to get oral liquid of the present invention; 2. concentrated solution C reconcentration, spray drying get dry extract, add adjuvant filler, disintegrating agent, lubricant of above-mentioned dispersible tablet etc., and mix homogeneously, tabletting promptly get dispersible tablet of the present invention.
Per 6 grams of above component crude drug-25 grams are prepared into 10 milliliters of-100 milliliters of body resistance-strengthening Zhenqi oral liquids.
Dry extract and filler, disintegrating agent, lubricant, the binding agent of per 6 grams of above component crude drug-25 grams are prepared into 1-48 sheet body resistance-strengthening Zhenqi dispersible tablet.
Filler in the dispersible tablet is: one or more of starch or lactose or microcrystalline Cellulose or mannitol or pregelatinized Starch, best is coking starch.
Disintegrating agent is in the dispersible tablet: crosslinked polyethylene pyrrole network alkane ketone, carboxymethyl starch sodium, low substituted hydroxy-propyl pricker dimension element, cross-linked carboxymethyl pricker are tieed up plain sodium, the best is crosslinked polyethylene pyrrole network alkane ketone and plain 4: 3 mixture of low substituted hydroxy-propyl pricker dimension, or above two kinds, three kinds mixture.
Binding agent is in the dispersible tablet: one or more of the alcoholic solution of the alcoholic solution of 40%-95%, starch slurry, polyethylene pyrrole network alkane ketone, the best are 55% alcoholic solution of 2-4% polyethylene pyrrole network alkane ketone.
Lubricant in the dispersible tablet is: magnesium stearate or micropowder silica gel or Pulvis Talci.
Dispersible tablet specification of the present invention can be 0.1 gram-3 gram/sheets.
The specification of the bottled oral liquid of the present invention can be 10-100 milliliter/bottle.
Body resistance-strengthening Zhenqi dispersible tablet, body resistance-strengthening Zhenqi oral liquid taking convenience in of the present invention, release is fast, and medicine thing availability height has improved the curative effect of medicine, has satisfied patient's needs.
Four, the specific embodiment:
Example 1, get the Radix Astragali 6250 gram, Fructus Ligustri Lucidi 6250 grams are prepared into mixed concentrated liquid by the description in the technical solution of the present invention, add an amount of correctives, add water to 10000 milliliters, stirring shakes up and is that it is the oral liquid that 10 milliliters/bottle oral liquid or 500 bottles of specifications are 20 milliliters/bottle that suspension, fill become 1000 bottles of specifications.Sterilization.
Example 2, get the Radix Astragali 6250 gram, Fructus Ligustri Lucidi 6250 grams are prepared into mixed concentrated liquid by the description in the technical solution of the present invention, add an amount of correctives, add water to 20000 milliliters, stirring shakes up and is that it is the oral liquid that 10 milliliters/bottle oral liquid or 1000 bottles of specifications are 20 milliliters/bottle that suspension, fill become 2000 bottles of specifications.Sterilization.
Example 3, get the Radix Astragali 6250 gram, Fructus Ligustri Lucidi 12500 grams are prepared into mixed concentrated liquid by the description in the technical solution of the present invention, add an amount of correctives, add water to 15000 milliliters, stirring shakes up and is that it is the oral liquid that 10 milliliters/bottle oral liquid or 750 bottles of specifications are 20 milliliters/bottle that suspension, fill become 1500 bottles of specifications.Sterilization.
Example 4, get the Radix Astragali 1250 gram, Fructus Ligustri Lucidi 6250 grams are prepared into mixed concentrated liquid by the description in the technical solution of the present invention, add an amount of correctives, add water to 15000 milliliters, stirring shakes up and is that it is the oral liquid that 10 milliliters/bottle oral liquid or 750 bottles of specifications are 20 milliliters/bottle that suspension, fill become 1500 bottles of specifications.Sterilization.
Example 5, get the Radix Astragali 6250 gram, Fructus Ligustri Lucidi 6250 grams are prepared into dry extract by the description in the technical solution of the present invention, add disintegrating agent 300-500 gram described above, lubricant 10-180 gram, binding agent 6-120 gram, add filler to gross weight 6000 grams, mix homogeneously, tabletting is prepared into the dispersible tablet of 6,000 1 gram/sheets or 3,000 2 gram/sheets or 2,000 3 gram/sheets or 12,000 0.5 gram/sheets.
Example 6, get the Radix Astragali 6250 gram, Fructus Ligustri Lucidi 6250 grams are prepared into dry extract by the description in the technical solution of the present invention, add disintegrating agent 150-250 gram described above, lubricant 5-90 gram, binding agent 3-60 gram, add filler to gross weight 3000 grams, mix homogeneously, tabletting is prepared into the dispersible tablet of 6,000 1 gram/sheets or 3,000 2 gram/sheets or 2,000 3 gram/sheets or 12,000 0.5 gram/sheets.
Example 7, get the Radix Astragali 6250 gram, Fructus Ligustri Lucidi 12500 grams are prepared into dry extract by the description in the technical solution of the present invention, add disintegrating agent 300-500 gram described above, lubricant 10-180 gram, binding agent 6-120 gram, add filler to gross weight 6000 grams, mix homogeneously, tabletting is prepared into the dispersible tablet of 6,000 1 gram/sheets or 3,000 2 gram/sheets or 2,000 3 gram/sheets or 12,000 0.5 gram/sheets.
Example 8, get the Radix Astragali 12500 gram, Fructus Ligustri Lucidi 6250 grams are prepared into dry extract by the description in the technical solution of the present invention, add disintegrating agent 300-500 gram described above, lubricant 10-180 gram, binding agent 6-120 gram, add filler to gross weight 6000 grams, mix homogeneously, tabletting is prepared into the dispersible tablet of 6,000 1 gram/sheets or 3,000 2 gram/sheets or 2,000 3 gram/sheets or 12,000 0.5 gram/sheets.
Claims (5)
1, a kind of body resistance-strengthening Zhenqi oral liquid and body resistance-strengthening Zhenqi dispersible tablet Chinese medicine preparation and preparation method thereof is characterized in that preparation contains: the Radix Astragali, Fructus Ligustri Lucidi two flavor Chinese medicines; Used medical material weight ratio is: the Radix Astragali 1: Fructus Ligustri Lucidi 0.5-2;
Used medical material optimum weight ratio is: the Radix Astragali 1: Fructus Ligustri Lucidi 1;
Preparation method of the present invention is: the Radix Astragali, Fructus Ligustri Lucidi with 40-95% ethanol alcohol extraction twice, reclaim ethanol earlier, merge extracted twice liquid, concentrate concentrated solution A; Medicinal residues decoct with water secondary again behind the ethanol extraction, and 2-3 hour for the first time, the 2nd time 1-2 hour, collecting decoction filtered, an amount of concentrate concentrated solution B, concentrated solution A mix with B concentrated solution C; 1. concentrated solution C adding purified water and correctives dilution stir into suspendible liquid, and fill becomes bottle promptly to get oral liquid of the present invention; 2. concentrated solution C reconcentration, spray drying get dry extract, add adjuvant filler, disintegrating agent, lubricant of above-mentioned dispersible tablet etc., and mix homogeneously, tabletting promptly get dispersible tablet of the present invention.
2, Chinese medicine preparation according to claim 1 and preparation method thereof, it is characterized in that: the filler in the dispersible tablet is: one or more of starch or lactose or microcrystalline Cellulose or mannitol or pregelatinized Starch, best mixture for pregelatinized Starch and lactose.
3, Chinese medicine preparation according to claim 1 and preparation method thereof, it is characterized in that: disintegrating agent is in the dispersible tablet: crosslinked polyethylene pyrrole network alkane ketone, carboxymethyl starch sodium, low substituted hydroxy-propyl pricker dimension element, cross-linked carboxymethyl pricker are tieed up plain sodium, the best is crosslinked polyethylene pyrrole network alkane ketone and plain 4: 3 mixture of low substituted hydroxy-propyl pricker dimension, or above two kinds, three kinds mixture.
4, Chinese medicine preparation according to claim 1 and preparation method thereof, it is characterized in that: binding agent is in the dispersible tablet: one or more of the alcoholic solution of the alcoholic solution of 40-95%, starch slurry, polyethylene pyrrole network alkane ketone, the best are 55% alcoholic solution of 2-4% polyethylene pyrrole network alkane ketone.
5, Chinese medicine preparation according to claim 1 and preparation method thereof is characterized in that: the lubricant in the dispersible tablet is: magnesium stearate or micropowder silica gel or Pulvis Talci.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032415 CN1785231A (en) | 2005-11-19 | 2005-11-19 | Zhenqi Fuzheng prepn. contg. glossy privet fruit and Radix astragali for strengthening the body resistance and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032415 CN1785231A (en) | 2005-11-19 | 2005-11-19 | Zhenqi Fuzheng prepn. contg. glossy privet fruit and Radix astragali for strengthening the body resistance and its prepn. method |
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| CN1785231A true CN1785231A (en) | 2006-06-14 |
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|---|---|---|---|
| CN 200510032415 Pending CN1785231A (en) | 2005-11-19 | 2005-11-19 | Zhenqi Fuzheng prepn. contg. glossy privet fruit and Radix astragali for strengthening the body resistance and its prepn. method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103169773A (en) * | 2011-12-20 | 2013-06-26 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine compound preparation for enhancing livestock immunity and preparation method |
| CN103479734A (en) * | 2013-08-27 | 2014-01-01 | 吉林修正药业新药开发有限公司 | Traditional Chinese medicine composition for treating acne |
| CN104013680A (en) * | 2014-05-28 | 2014-09-03 | 王庚禹 | Extractive for preparing astragalus membranaceus-ligustrum healthy-qi-reinforcing preparation |
-
2005
- 2005-11-19 CN CN 200510032415 patent/CN1785231A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103169773A (en) * | 2011-12-20 | 2013-06-26 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine compound preparation for enhancing livestock immunity and preparation method |
| CN103169773B (en) * | 2011-12-20 | 2015-07-15 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine compound preparation for enhancing livestock immunity and preparation method |
| CN103479734A (en) * | 2013-08-27 | 2014-01-01 | 吉林修正药业新药开发有限公司 | Traditional Chinese medicine composition for treating acne |
| CN104013680A (en) * | 2014-05-28 | 2014-09-03 | 王庚禹 | Extractive for preparing astragalus membranaceus-ligustrum healthy-qi-reinforcing preparation |
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Open date: 20060614 |