CN1782696A - Lens type detector on micro biochemical chip - Google Patents
Lens type detector on micro biochemical chip Download PDFInfo
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- CN1782696A CN1782696A CN 200510125244 CN200510125244A CN1782696A CN 1782696 A CN1782696 A CN 1782696A CN 200510125244 CN200510125244 CN 200510125244 CN 200510125244 A CN200510125244 A CN 200510125244A CN 1782696 A CN1782696 A CN 1782696A
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- lens
- detector
- sample cell
- biochemical chip
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Abstract
The present invention belongs to the field of micro mechanics and integral optics, and is optical detector on micro biochemical chip. The detector includes end cap, support structure, detector lens, light source, mixed channel, sample cell and the second lens. The lens type detector has small lens, small diameter of collimated beam and small sample cell volume. Altering the optical path between two lenses can change the detection sensitivity directly. The lens type detector of the present invention may be applied in the spectrophotometric analysis of absorption spectrum in biochemical chip.
Description
Technical field: the invention belongs to micromechanics and integrated optics field, relate to the photo-detector on the micro biochemical chip.
Background technology: it is a kind of widely used universal optical detection method that absorbance detects, and it successfully is applied in the measurement of the structure analysis of biological sample and concentration.
Miniature biochemical chip is expected a sample cell, and probe unit and other parts are integrated on the chip, to realize microminiaturization, portability, the consumption sample size traceization of system.Be used to miniature biochemical chip though absorbance detects, because micro biochemical chip detection pond is little, it is short to cause absorbing light path, and the relative sensitivity of absorption spectrum is low, and application is very restricted.Utilize optical waveguide coupled difficulty on the micro biochemical chip, cost of manufacture is higher.
Detailed content of the present invention:
Detect the problem that sample cell is little, light path is short, sensitivity is low, optical waveguide is made and coupling is difficult that exists at the absorbance on the biochemical chip, the objective of the invention is can be on micro-fluid chip integrated photometry detector, can further reduce to survey the pond volume, solution requires the little and highly sensitive contradiction of sample cell, for this reason, the present invention will provide the lens detector on the high micro biochemical chip of microminiaturization, portability, consumption sample size traceization, detection sensitivity.
The present invention utilizes absorption spectrophotometry integrated light detector on micro-fluid chip.
The principle of surveying detector is that lens directly absorb, and its structure is as implementing shown in the illustration 1,2: lens one, supporting construction, end cap, mixing raceway groove, sample cell, lens two, light source.On supporting construction, be equipped with lens one, lens two, end cap, preparation mixes raceway groove on the supporting construction body, there is the lensed optical fiber end of a band to be connected in light source, the minute surface of lens is fixed in sample cell one side, the minute surface of lens two is fixed in the opposite side of sample cell, and the fiber-optic output of lens two is connected with spectrometer or other photoelectric sensor.
Light scioptics one optical fiber of light source imports lens one, lens one become directional light to the optical fiber input optical alignment, and directional light is by behind the sample cell, and the light after the decay enters another lens two, two pairs of directional lights of lens are assembled, and converge light and enter in the optical fiber lead-in light optical fiber spectrograph of lens two again.Because the absorption of sample, the light intensity of the different wave length correspondence of incident light weakens to some extent, detects the spectrum of putting into before and after the sample by spectrometer, just can determine the absorbance of sample, and then the concentration of certain composition in definite sample.
Lens detector of the present invention, because lens are less, the diameter of collimated light beam is also less, light beam passes sample cell like this, makes sample cell that less volume be arranged.By adjusting the light path between two lens, can directly change the sensitivity of detection.
Solve the absorbance on the biochemical chip and detected the problems such as sample cell is little, light path is short, sensitivity is low that exist.The present invention is integrated photometry detector on micro-fluid chip, can further reduce to survey the pond volume, solution requires the little and highly sensitive contradiction of sample cell, the invention provides the photo-detector on the high micro biochemical chip of microminiaturization, portability, consumption sample size traceization, detection sensitivity.
The present invention is applied to the absorption spectrum spectrophotometric analysis on the biochemical chip.
Description of drawings
Fig. 1 is the front view that lens directly absorb inventive embodiments
Fig. 2 is the vertical view that lens directly absorb inventive embodiments
Embodiment:
Shown in Figure 2 as Fig. 1, detector comprises: end cap 6, supporting construction 7, lens 1, light source 9, mixing raceway groove 10, sample cell 11, lens 2 12.
Lens 1 and lens 2 12 adopt GRIN Lens or lenticule etc., also can adopt GRIN Lens and lenticule, or lens 1 and 2 12 two on lens all adopt lenticule.Supporting construction 7 adopts silicon, glass or plastic or other material.End cap 6 and sample cell 11 adopt materials such as PDMS polymkeric substance, plastics, glass.Preparation has the raceway groove 10 of mixing on end cap 6 bodies, mixes the size of raceway groove 10 and selects according to actual needs, and present embodiment is chosen as 300 microns * 200 microns.Light source 9 can adopt halogen tungsten lamp or LASER Light Source.
Claims (1)
1, lens detector on the micro biochemical chip, comprise: end cap (6), light source (9), sample cell (11), it is characterized in that also comprising: supporting construction (7), lens one (8), mix raceway groove (10), lens two (12), on supporting construction (7), be equipped with lens one (8), lens two (12), end cap (6), preparation mixes raceway groove (10) on supporting construction (7) body, there is an optical fiber end that has lens (8) to be connected in light source (9), the minute surface of lens (8) is fixed in sample cell (11) one sides, the minute surface of lens two (12) is fixed in the opposite side of sample cell (11), and the fiber-optic output of lens two (12) is connected with spectrometer or other photoelectric sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510125244 CN1782696A (en) | 2003-12-11 | 2003-12-11 | Lens type detector on micro biochemical chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510125244 CN1782696A (en) | 2003-12-11 | 2003-12-11 | Lens type detector on micro biochemical chip |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310115909 Division CN1258082C (en) | 2003-12-11 | 2003-12-11 | Photodetector on micro biochemical chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1782696A true CN1782696A (en) | 2006-06-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510125244 Pending CN1782696A (en) | 2003-12-11 | 2003-12-11 | Lens type detector on micro biochemical chip |
Country Status (1)
| Country | Link |
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| CN (1) | CN1782696A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102507528A (en) * | 2011-12-02 | 2012-06-20 | 徐州雷奥医疗设备有限公司 | Micro-fluid detection system based on self-focusing lens |
| CN106370613A (en) * | 2016-11-10 | 2017-02-01 | 广东电网有限责任公司电力科学研究院 | Spectrum system and method for directly measuring concentration of furfural in transformer oil |
-
2003
- 2003-12-11 CN CN 200510125244 patent/CN1782696A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102507528A (en) * | 2011-12-02 | 2012-06-20 | 徐州雷奥医疗设备有限公司 | Micro-fluid detection system based on self-focusing lens |
| CN106370613A (en) * | 2016-11-10 | 2017-02-01 | 广东电网有限责任公司电力科学研究院 | Spectrum system and method for directly measuring concentration of furfural in transformer oil |
| CN106370613B (en) * | 2016-11-10 | 2024-01-19 | 广东电网有限责任公司电力科学研究院 | Spectrum system and method for directly measuring concentration of furfural in transformer oil |
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