CN1778316A - Degradation of bacterial drug resistance by composite microbial preparation - Google Patents
Degradation of bacterial drug resistance by composite microbial preparation Download PDFInfo
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- CN1778316A CN1778316A CNA2004100523937A CN200410052393A CN1778316A CN 1778316 A CN1778316 A CN 1778316A CN A2004100523937 A CNA2004100523937 A CN A2004100523937A CN 200410052393 A CN200410052393 A CN 200410052393A CN 1778316 A CN1778316 A CN 1778316A
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- lactobacillus
- drug resistance
- bacillus
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Abstract
A method for degradating the resistance of the bacteria in human body to medicine by using the composite microbial preparation includes such steps as conventionally separating the original lactobacillus, yeast and bacillus from the primitive natural environment far from people, conventional culturing to obtain composite preparation, and applying it to human body by large dosage after the antibiotic medicine is applied to said human body.
Description
Technical field:
The invention discloses a brand-new application of complex microorganism preparations, particularly utilize the drug-fast method of complex microorganism preparations bacterium for degrading.
Background technology:
So-called Drug resistance claims drug resistance again, is meant that certain antibacterial contacts the reaction reduction of back to antibacterials repeatedly to certain antibacterials, and is no longer responsive to certain antibiotic, the phenomenon that antibiotic no longer works to them.Be because the life-time service antibacterials, when application dose is not enough, antibacterial by generation make the medicine inactivation enzyme, change the membrane permeability blocking medicine and enter, change target structure or change that original metabolic process produces.In a single day bacterial drug resistance forms, no matter infect on which people's body, antibiotic all can not effectively be killed or suppress them.Therefore, the harm meeting of drug-resistant bacteria constitutes a threat to whole population health, rather than have that the people understands like that: " whose abuse, who is injured ".This science reason groundless rumour is by no means made an overstatement, potential harm put we in face of.Go down human may eating one's own bitter fruit like this;
Moreover, even more serious is that drug-resistant bacteria can be from a zone-transfer to another area or a plurality of areas, transfer to one or more countries from a country, even pass to animal from the people, animal is passed to the people, along with people are alternative frequent and convenient, the process of globalization of world economy, artificial abortion, logistics, flow of information is more unimpeded, the spread speed of drug resistance strain is more and more faster, and scope is more and more wider, so, bacterial drug resistance and drug resistance shift has become serious proposition global, century property, has caused national governments and scientist's great attention.
How to reduce antibacterial antibacterials are developed immunity to drugs, the strict use indication of grasping antibacterials of prior art (1), viral infection should not adopt antibacterial drug therapy; (2) animal or the patient to indication is arranged, medicament categories, consumption and service time all must strict controls, can with narrow spectrum just do not use extensive pedigree antibiotic, can with a kind of effective just needn't be with multiple, to avoid drug resistance and superinfection; (3) be used alternatingly antibiotic medicine; (4) development of quickening new antibiotic medicine; (5) carry out the education of rational Application antibacterials relevant knowledge to the masses.
Prior art is very general to the research and the application of complex micro organism fungicide, these microbial bacterial agents have the compound cultivation of a plurality of strains by some genus to form, also have by the compound cultivation of a plurality of strains in two or more genus and form, use maximum lactobacilluss that has at present, yeast, bacillus, bacillus bifidus etc., the complex micro organism fungicide of these different formulations has been widely applied to livestock breeding industry, a plurality of technical fields such as culture fishery and body-care, the sour milk product of making as lactobacillus that is most widely used, also has the EM microbial inoculum, enzymatic microorganism, probiotic bacteria or the like, the application function of these products all is positioned at the immunocompetence that is used to improve animal and human body basically, the microecological environment of balance intestinal and flora structure, improve microecological environment or the like, also not have a kind of complex microorganism preparations product up to now be main entrance is applied to bacterium for degrading Drug resistance technical field at the Drug resistance that reduces or remove antibacterial.
Summary of the invention:
The purpose of this invention is to provide a kind of drug-fast method of complex microorganism preparations bacterium for degrading of utilizing.
The object of the present invention is achieved like this: isolate the lactobacillus of contacted antibiotic medicine never at first according to a conventional method from the primitive nature environment away from the mankind, yeast and bacillus cereus: as bifidobacterium bifidum Bifidobacterium bifidum, long bifidus bacillus B.longum, short bifidus bacillus B.breve, bifidobacterium adolescentis B.adolescentis, Lactobacillus bulgaricus Lactobacillus.Bulgaricus, bacillus acidophilus L.acidophilus, lactobacillus casei cheese subspecies L.Casei subsp.Casei, streptococcus thermophilus Streptococcus, Lactobacillus reuteri Lactobacillus reuteri thermophilus, beer yeast Saccharomyces cerevisiae, Candida utilis Candida utilis, Rhodopseudomonas palustris Rhodopseudom onas Palustris, a plurality of bacterial strains of bacillus subtilis Bacillus subtilis, these bacterial strains are carried out the Drug resistance test, filter out the minimum bacterial strain of Drug resistance degree as basic bacterial strain, according to a conventional method one or more bacterial strains of these bacterium are cultivated production, formed and comprised viable bacteria, culture medium, metabolite is at interior complex microorganism preparations, this preparation is applied to animal or human's body, the Drug resistance that the interior bacterial antibiotic medicine of the animal or human's body of just can degrading is produced, can be used as and reduce the drug-fast auxiliary medicaments use of bacterial antibiotic medicine, concrete using method: animal or human's body fall ill use the antibiotic medicine to treat the state of getting well after, use this preparation by the dosage that uses 2～3 times of antibiotic dosage immediately, just can reach reduce or remove the antibiotic that uses in animal or human's body, make the drug-fast effect of antibacterial.
The present invention in time utilizes complex microorganism preparations to come bacterium for degrading because the Drug resistance of using antibiotic to produce after using antibiotic to treat owing to falling ill at animal or human's body, prevent the generation of drug resistance antibacterial, suppress the drug resistance number of bacteria, prolonged the service life of antibiotic medicine, to saving life, will producing important effect to the sustainable development of whole biosphere.
The specific embodiment:
Embodiment: from primitive nature environment, isolate never many strains bacillus acidophilus L.acidophilus of contacted antibiotic medicine and the bacterial strain of beer yeast Saccharomycescerevisiae according to a conventional method away from the mankind, these bacterial strains are carried out the Drug resistance test, filter out the minimum bacterial strain of Drug resistance degree as basic bacterial strain, according to a conventional method two kinds of bacterial strains are cultivated production, formed and comprised viable bacteria, culture medium, metabolite is at interior complex microorganism preparations, this preparation is applied to animal or human's body, the Drug resistance that the interior bacterial antibiotic medicine of the animal or human's body of just can degrading is produced, can be used as and reduce the drug-fast auxiliary medicaments use of bacterial antibiotic medicine, concrete using method is: animal or human's body fall ill use the antibiotic medicine to treat the state of getting well after, use this preparation by the dosage that uses 2～3 times of antibiotic dosage immediately, just can reach reduce or remove the antibiotic that uses in animal or human's body, make the drug-fast effect of antibacterial.
Claims (2)
1, the present invention relates to a kind of drug-fast method of complex microorganism preparations bacterium for degrading of utilizing, it is characterized in that from primitive nature environment, isolating at first according to a conventional method the lactobacillus of contacted antibiotic medicine never away from the mankind, yeast and bacillus cereus, these bacterial strains are carried out the Drug resistance test, filter out the minimum bacterial strain of Drug resistance degree as basic bacterial strain, according to a conventional method one or more bacterial strains of these bacterium are cultivated production, formed and comprised viable bacteria, culture medium, metabolite is at interior complex microorganism preparations, this preparation is applied to animal or human's body, the Drug resistance that the interior bacterial antibiotic medicine of the animal or human's body of just can degrading is produced, concrete using method be animal or human's body fall ill use the antibiotic medicine to treat the state of getting well after, use this preparation by the dosage that uses 2～3 times of antibiotic dosage immediately, just can reach reduce or remove the antibiotic that uses in animal or human's body, make the drug-fast effect of antibacterial.
2, the drug-fast method of complex microorganism preparations bacterium for degrading of utilizing according to claim 1 is characterized in that the lactobacillus that is adopted, yeast and bacillus cereus are bifidobacterium bifidum Bifidobacteriumbifidum, long bifidus bacillus B.longum, short bifidus bacillus B.breve, bifidobacterium adolescentis B.adolescentis, Lactobacillus bulgaricus Lactobacillus.Bulgaricus, bacillus acidophilus L.acidophilus, lactobacillus casei cheese subspecies L.Casei subsp.Casei, streptococcus thermophilus Streptococcus, Lactobacillus reuteri Lactobacillus reuteri thermophilus, beer yeast Saccharomyces cerevisiae, Candida utilis Candida utilis, Rhodopseudomonas palustris Rhodopseudom onas Palustris, one or more bacterial strains of bacillus subtilis Bacillus subtilis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100523937A CN1778316A (en) | 2004-11-26 | 2004-11-26 | Degradation of bacterial drug resistance by composite microbial preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100523937A CN1778316A (en) | 2004-11-26 | 2004-11-26 | Degradation of bacterial drug resistance by composite microbial preparation |
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| CN1778316A true CN1778316A (en) | 2006-05-31 |
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| CNA2004100523937A Pending CN1778316A (en) | 2004-11-26 | 2004-11-26 | Degradation of bacterial drug resistance by composite microbial preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204613B (en) * | 2007-12-06 | 2010-12-15 | 宁夏大学 | Method using microorganism for reducing rudimental tylosin in dregs of a decoction |
| CN101259313B (en) * | 2008-04-16 | 2011-04-06 | 宁夏大学 | Method for degrading residual tylosin in medicine slag |
| CN104286408A (en) * | 2014-06-13 | 2015-01-21 | 杨雄 | Application method of biological agent prepared from Lactobacillus acidophilus XD13R on reducing proportion of drug-resistant bacteria in pet body |
-
2004
- 2004-11-26 CN CNA2004100523937A patent/CN1778316A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204613B (en) * | 2007-12-06 | 2010-12-15 | 宁夏大学 | Method using microorganism for reducing rudimental tylosin in dregs of a decoction |
| CN101259313B (en) * | 2008-04-16 | 2011-04-06 | 宁夏大学 | Method for degrading residual tylosin in medicine slag |
| CN104286408A (en) * | 2014-06-13 | 2015-01-21 | 杨雄 | Application method of biological agent prepared from Lactobacillus acidophilus XD13R on reducing proportion of drug-resistant bacteria in pet body |
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