CN1762420A - Pulse invigorating pill prescription and its preparation method - Google Patents
Pulse invigorating pill prescription and its preparation method Download PDFInfo
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- CN1762420A CN1762420A CN 200410155391 CN200410155391A CN1762420A CN 1762420 A CN1762420 A CN 1762420A CN 200410155391 CN200410155391 CN 200410155391 CN 200410155391 A CN200410155391 A CN 200410155391A CN 1762420 A CN1762420 A CN 1762420A
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- salviae miltiorrhizae
- rhizoma chuanxiong
- preparation
- pulse invigorating
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Abstract
The invention relates to the formula of pulse-invigorating drop pill preparation for the treatment of cardiovascular and cerebrovascular diseases, arteriosclerosis, cerebral thrombus, coronary heart disease and angina pectoris, and its preparing process. The drop pill is prepared from red sage root, Chuanxiong rhizome and kudzu root as the main constituents, and right base through a predetermined process combinations.
Description
Technical field
The present invention relates to a kind of blood circulation and channel invigorating, be used for the treatment of ischemic cardio cerebrovascular diseases, arteriosclerosis, cerebral thrombosis, cerebral ischemia, coronary heart disease, the prescription of the compound preparation of anginal Chinese medicine and manufacture method are the dropping pill formulation and the technology manufacture method thereof of main component with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae three flavor Chinese medicine extract specifically.
Background technology
Pulse invigorating pill is to be made by the effective site that Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae three flavor Chinese crude drugs extract.Have the effect of blood circulation and channel invigorating, be usually used in ischemic cardio cerebrovascular diseases, arteriosclerosis, cerebral thrombosis, cerebral ischemia, coronary heart disease, angina pectoris.Drop pill is a kind of pill that utilizes the solid dispersion technology system of dripping to form, it is purified the effective site or the effective ingredient refine of medical material on the one hand, utilize water-solubility carrier to improve the dissolubility and the dissolution rate of medicine on the one hand, thereby improve bioavailability, improve the curative effect of medicine.
Summary of the invention
The object of the present invention is to provide oral pulse invigorating pill preparation that a kind of drug effect is fast, bioavailability is high and preparation method thereof, and effectively control its quality.It is molten soon diffusing that the pulse invigorating pill that this preparation adopts solid dispersion technology and dropping pill formulation Technology to make not only has disintegrate, the dissolution height, steady quality, the pill volume is little, both can swallow also can buccal, and easy to carry and use, onset is characteristics rapidly, but also has working condition and advantage such as production equipment is simple, and production cost is low.
The solution of the present invention is: adopt solid dispersion technology, produce little, quick-acting, the pharmaceutical dosage form efficiently of dosage.
Drop pill is the product of solid dispersion technology, is characterized in: adopt fusion method to make medicine be scattered in the physiology inertia with molecularity and in the carrier soluble in water, form disperse system.(3～4um) is also little, thereby improved surface area greatly, and its bioavailability is much higher than the medicine of general dosage form than micronized particles for drug particle (0.001-0.1um).After entering the intestines and stomach, water-solubility carrier dissolves rapidly, because particle is little, the solid dispersion dissolution velocity is fast, can be absorbed by cell rapidly to enter blood circulation, thereby reach efficient and quick-acting effects.
Substrate among the present invention includes but not limited to Polyethylene Glycol 12000, polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, Macrogol 600, PEG400, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, plant wet goods.
Medicine of the present invention is made (consumption is a weight portion) by following component:
Radix Salviae Miltiorrhizae 500g
Rhizoma Chuanxiong 500g
Radix Puerariae 500g
Substrate 350～1500g
The ratio range of the formula optimization weight of preparation medicine of the present invention is:
Radix Salviae Miltiorrhizae 500g
Rhizoma Chuanxiong 500g
Radix Puerariae 500g
Substrate 550～950g
The optimum weight proportioning of medicine of the present invention is:
Radix Salviae Miltiorrhizae 500g
Rhizoma Chuanxiong 500g
Radix Puerariae 500g
Substrate 900g
Said components is made method of the present invention is:
Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae coarse powder decoct with water secondary, and each 1 hour, collecting decoction filtered, and filtrate decompression concentrates, and adds ethanol to concentrated solution, make to contain the alcohol amount and reach 60%, and standing over night is got supernatant and reclaimed ethanol, is condensed into cream or spraying drying powder-forming.
With substrate heating, fully dissolving.
Extract is joined in the substrate emulsifying of high speed shear ultra micro.
Four, medicinal liquid is splashed in the coolant, rely on surface tension to be shrunk to ball naturally.
The specific embodiment
Embodiment (1000, every 50mg):
Radix Salviae Miltiorrhizae 500g
Rhizoma Chuanxiong 500g
Radix Puerariae 500g
Substrate 900g
Make 1000 altogether, every heavy 50mg
Extract by said components joins in the molten matrix, and the emulsifying of high speed shear ultra micro is incubated in 85 ℃ of fluid reservoirs.With coolant cools to the 10 ℃ system of dripping, water dropper to the distance of coolant liquid level is 5cm in cooling column, opens and by-pass cock, and medicinal liquid is splashed in the coolant according to certain frequency, and messenger drug drips slowly and sinks, and relies on self tension force to be shrunk to ball gradually.After becoming ball, clean the coolant on surface, drying at room temperature or blowing and finished product.
Claims (9)
1. prescription of pulse invigorating pill and preparation method thereof, the effective ingredient that it is characterized in that it are to be made by the extract of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae three flavor Chinese medicines, it is characterized in that the weight proportion of its Chinese medicine and substrate:
Radix Salviae Miltiorrhizae 500g
Rhizoma Chuanxiong 500g
Radix Puerariae 500g
Substrate 350～1500g
Wherein Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae make through water extract-alcohol precipitation.
2. pulse invigorating pill preparation according to claim 1 is characterized in that the weight proportion of its Chinese medicine and substrate:
Radix Salviae Miltiorrhizae 500g
Rhizoma Chuanxiong 500g
Radix Puerariae 500g
Substrate 550～950g
3. pulse invigorating pill preparation according to claim 1 is characterized in that the optimum weight proportioning of its Chinese medicine and substrate:
Radix Salviae Miltiorrhizae 500g
Rhizoma Chuanxiong 500g
Radix Puerariae 500g
Substrate 900g
4. according to claim 1,2 or 3 described pulse invigorating pills, it is characterized in that described medicament is a drop pill.
5. manufacture method for preparing the described pulse invigorating pill of claim 4 is characterized in that:
(1) Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae water extract-alcohol precipitation are made extract;
National standard is chosen substrate;
Above-mentioned effective site in any one described ratio of claim 1-3, is heated to 85 ℃ of fusings with substrate; Then medicine is joined in the substrate, the emulsifying of high speed shear ultra micro is injected fluid reservoir and insulation at 85 ℃, open and by-pass cock, adjust vacuum and pressure apparatus, splash at regular time and quantity in 5～15 ℃ the coolant, under capillary effect, be shrunk to ball naturally, clean dry after promptly.
6. the preparation method of pulse invigorating pill according to claim 5 is characterized in that:
The effective site of used three kinds of medicines is cream or fine powder.
7. the preparation method of pulse invigorating pill according to claim 5 is characterized in that:
Drug effective region is added 85 ℃ of fully substrate high speed shearing ultra micro emulsifyings of fusing of temperature.
8. substrate according to claim 5 includes but not limited to Polyethylene Glycol 12000, polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, Macrogol 600, PEG400, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
9. coolant according to claim 5 includes but not limited to dimethicone, liquid paraffin, plant wet goods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410155391 CN1762420A (en) | 2004-10-21 | 2004-10-21 | Pulse invigorating pill prescription and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410155391 CN1762420A (en) | 2004-10-21 | 2004-10-21 | Pulse invigorating pill prescription and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1762420A true CN1762420A (en) | 2006-04-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410155391 Pending CN1762420A (en) | 2004-10-21 | 2004-10-21 | Pulse invigorating pill prescription and its preparation method |
Country Status (1)
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| CN (1) | CN1762420A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623109A (en) * | 2013-11-03 | 2014-03-12 | 崔合芳 | Traditional Chinese medicine composition for treating ischemic cerebrovascular disease and preparation method thereof |
| CN105832818A (en) * | 2016-06-08 | 2016-08-10 | 四川泰华堂制药有限公司 | Traditional Chinese medicinal preparation for activating blood to dredge vessels and preparation method of traditional Chinese medicinal preparation |
| CN105878815A (en) * | 2016-06-24 | 2016-08-24 | 凌云 | Traditional Chinese medicinal self-microemulsion fast-release drop pill for treating coronary heart disease and preparation method |
| CN105943687A (en) * | 2016-06-24 | 2016-09-21 | 赵晶晶 | Traditional Chinese medicine self-microemulsion instant release pill for treating angina pectoris and preparation method thereof |
| CN106038930A (en) * | 2016-06-24 | 2016-10-26 | 凌云 | Traditional Chinese medicine fast release droppill for treating venomous snake bite and preparation method thereof |
-
2004
- 2004-10-21 CN CN 200410155391 patent/CN1762420A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623109A (en) * | 2013-11-03 | 2014-03-12 | 崔合芳 | Traditional Chinese medicine composition for treating ischemic cerebrovascular disease and preparation method thereof |
| CN103623109B (en) * | 2013-11-03 | 2015-06-03 | 崔合芳 | Traditional Chinese medicine composition for treating ischemic cerebrovascular disease and preparation method thereof |
| CN105832818A (en) * | 2016-06-08 | 2016-08-10 | 四川泰华堂制药有限公司 | Traditional Chinese medicinal preparation for activating blood to dredge vessels and preparation method of traditional Chinese medicinal preparation |
| CN105878815A (en) * | 2016-06-24 | 2016-08-24 | 凌云 | Traditional Chinese medicinal self-microemulsion fast-release drop pill for treating coronary heart disease and preparation method |
| CN105943687A (en) * | 2016-06-24 | 2016-09-21 | 赵晶晶 | Traditional Chinese medicine self-microemulsion instant release pill for treating angina pectoris and preparation method thereof |
| CN106038930A (en) * | 2016-06-24 | 2016-10-26 | 凌云 | Traditional Chinese medicine fast release droppill for treating venomous snake bite and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20060426 |