CN1759849A - Chinese angelica dripping pill and its preparing method - Google Patents
Chinese angelica dripping pill and its preparing method Download PDFInfo
- Publication number
- CN1759849A CN1759849A CN 200410155354 CN200410155354A CN1759849A CN 1759849 A CN1759849 A CN 1759849A CN 200410155354 CN200410155354 CN 200410155354 CN 200410155354 A CN200410155354 A CN 200410155354A CN 1759849 A CN1759849 A CN 1759849A
- Authority
- CN
- China
- Prior art keywords
- substrate
- radix angelicae
- angelicae sinensis
- dripping pill
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006187 pill Substances 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims abstract description 8
- 241000213006 Angelica dahurica Species 0.000 title claims description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 239000000758 substrate Substances 0.000 claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 7
- 230000000694 effects Effects 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims description 15
- 239000009188 angelicae sinensis extract Substances 0.000 claims description 13
- 239000002826 coolant Substances 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 claims description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 3
- 229950009789 cetomacrogol 1000 Drugs 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 229960003511 macrogol Drugs 0.000 claims description 3
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 3
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 3
- 229940093430 polyethylene glycol 1500 Drugs 0.000 claims description 3
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 239000002552 dosage form Substances 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 230000000857 drug effect Effects 0.000 abstract description 2
- 241000125175 Angelica Species 0.000 abstract 3
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 3
- 230000005906 menstruation Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 8
- 239000007962 solid dispersion Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 206010018498 Goitre Diseases 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 201000003872 goiter Diseases 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a formula of a medicine-zhao angelica dripping pill preparation for enriching blood, promoting blood circulation, regulating menstruation and relieving pain and a preparation method thereof. The dripping pill is prepared by using angelica extract as a main component and combining the angelica extract with a proper substrate according to a certain proportion and a certain process. Compared with other dosage forms, the dripping pill preparation of the present invention has the advantages of short technological process, low production cost, quick drug effect, unique prescription and preparation method, and obvious treatment effect.
Description
Technical field
The present invention relates to a kind of enriching blood and invigorate blood circulation, the prescription of the Chinese medicine preparation of menstruction regulating and pain relieving and manufacture method specifically are the dropping pill formulation and the technology manufacture method thereof of main component with the Radix Angelicae Sinensis extract.
Background technology
Radix Angelicae Sinensis, having enriches blood invigorates blood circulation, and the effect of menstruction regulating and pain relieving is usually used in blood deficiency and yellow complexion, and is dizzy, scrofula, goiter, acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.In recent years, Radix Angelicae Sinensis is noticeable day by day to the extensive effect of each system of body, day by day gos deep into to the pharmacological research of Radix Angelicae Sinensis and to the research of its various compositions.Drop pill is a kind of pill that utilizes the solid dispersion technology system of dripping to form, it is purified the effective site or the effective ingredient refine of medical material on the one hand, utilize water-solubility carrier to improve the dissolubility and the dissolution rate of medicine on the one hand, improve the infiltration rate and the absorbtivity of medicine, thereby the raising bioavailability, the curative effect of raising medicine.
Summary of the invention
The object of the present invention is to provide oral Chinese angelica root dripping pill preparation that a kind of drug effect is fast, bioavailability is high and preparation method thereof, and effectively control its quality.It is molten soon diffusing that the Chinese angelica root dripping pill that this preparation adopts solid dispersion technology and dropping pill formulation Technology to make not only has disintegrate, the dissolution height, steady quality, the pill volume is little, and both can swallow also can buccal, easy to carry and use, onset is characteristics rapidly, but also have working condition and advantage such as production equipment is simple, and production cost is low, demonstrated fully the new drug research exploitation spirit that people-oriented.The solution of the present invention is: in motherland's medicine treasure-house, the advantage of performance conventional medicament, in conjunction with modern science new technology, new method, it is carried out comprehensive qualitative and quantitative analysis, on this basis, extract its effective site and effective ingredient, adopt solid dispersion technology, produce little, quick-acting, the pharmaceutical dosage form efficiently of dosage.
Drop pill is the product of solid dispersion technology, is characterized in: adopt fusion method to make medicine be scattered in the physiology inertia with molecularity and in the carrier soluble in water, form disperse system.(3～4um) is also little, thereby improved surface area greatly, and its bioavailability is much higher than the medicine of general dosage form than micronized particles for drug particle (0.001-0.1um).After entering the intestines and stomach, water-solubility carrier dissolves rapidly, because particle is little, the solid dispersion dissolution velocity is fast, can be absorbed by cell rapidly to enter blood circulation, thereby reach efficient and quick-acting effects.
For achieving the above object, the present invention by the following technical solutions: 1 weight portion Radix Angelicae Sinensis extract is added in the 2 weight portion molten matrix,, splashes into and be condensed into ball in the coolant, remove coolant through the emulsifying of high pressure homogenize ultra micro, drying, promptly.
Substrate among the present invention includes but not limited to Polyethylene Glycol 12000, polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, Macrogol 600, PEG400 etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, plant wet goods.
Medicine of the present invention is made (consumption is a weight portion) by following component:
1 part of Radix Angelicae Sinensis extract
1～9 part of substrate
The ratio range of the formula optimization weight of preparation medicine of the present invention is:
1 part of Radix Angelicae Sinensis extract
1.5～3 parts of substrate
The optimum weight proportioning of medicine of the present invention is:
1 part of Radix Angelicae Sinensis extract
2 parts of substrate
Said components is made method of the present invention is:
One, Radix Angelicae Sinensis coarse powder adds 70% soak with ethanol reflux, extract, secondary; Extracting solution filters, and merging filtrate carries out ethanol with filtrate and reclaims, and the liquid concentrating under reduced pressure after the recovery becomes cream, and its relative density (55～60 ℃) is 1.10; The concentrated solution spraying drying powder-forming.
Two, with substrate heating, fully dissolving.
Three, Radix Angelicae Sinensis extract is joined in the substrate emulsifying of high speed shear ultra micro.
Four, medicinal liquid is splashed in the coolant, rely on surface tension to be shrunk to ball naturally.
The specific embodiment
Embodiment (1000, every 50mg):
Radix Angelicae Sinensis extract: 1 part
Polyethylene Glycol: 2 parts
Make 1000 altogether, every heavy 50mg
Radix Angelicae Sinensis extract by said components joins in the molten matrix, and the emulsifying of high speed shear ultra micro is dripped insulation in the jar at 85 ℃
With coolant cools to 10 ℃, water dropper to the distance of coolant liquid level is 10cm, and medicinal liquid is splashed in the coolant according to certain frequency in cooling column, and medicine drips slowly and sinks, and relies on self tension force to be shrunk to ball naturally.After becoming ball, clean the coolant on surface, drying at room temperature or blowing and finished product.
Claims (10)
1. prescription of Chinese angelica root dripping pill and preparation method thereof is characterized in that it is to be made by the extract and the substrate combination of single medicinal material Radix Angelicae Sinensis, and wherein the weight proportion of Radix Angelicae Sinensis extract and substrate is: 1: 1～1: 9.
Wherein said Radix Angelicae Sinensis extract can extract with diverse ways and make.
2. Chinese angelica root dripping pill preparation according to claim 1 is characterized in that wherein the weight proportion preferable range of Radix Angelicae Sinensis extract and substrate is: 1: 1.5～1: 3.
3. Chinese angelica root dripping pill preparation according to claim 1 is characterized in that wherein the optimum weight proportioning of Radix Angelicae Sinensis extract and substrate is: 1: 2
4. according to claim 1,2 or 3 described Chinese angelica root dripping pills, it is characterized in that described medicament is a drop pill.
5. manufacture method for preparing the described Chinese angelica root dripping pill of claim 4 is characterized in that:
With the Radix Angelicae Sinensis coarse powder, extract its effective site or effective ingredient, through qualitative, quantitative, be condensed into cream or be spray dried to fine powder;
Choose substrate by national standard;
Above-mentioned effective site and effective ingredient in any one described ratio of claim 1-3, are joined in the substrate that is heated to 85 ℃; Through the emulsifying of high speed shear ultra micro, fully melting together.Inject fluid reservoir insulation then at 85 ℃, regulate the water dropper switch, splash at regular time and quantity in 5～15 ℃ the coolant, under capillary effect, be shrunk to ball naturally, clean dry after promptly.
6. the preparation method of Chinese angelica root dripping pill according to claim 5 is characterized in that:
Wherein the Radix Angelicae Sinensis extract qualitative, quantitative is condensed cream or spray-dired fine powder.
7. the preparation method of Chinese angelica root dripping pill according to claim 5 is characterized in that:
The effective site of used Radix Angelicae Sinensis and effective ingredient are volatile oil component and organic acid composition.
8. the preparation method of Chinese angelica root dripping pill according to claim 5 is characterized in that: through being condensed into cream or being spray dried to the drug effective region of fine powder or effective ingredient adds in 85 ℃ of substrate that fully melt of temperature and stirs fusion.
9. substrate according to claim 5 includes but not limited to Polyethylene Glycol 12000, polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, Macrogol 600, PEG400 etc.
10. substrate according to claim 5 includes but not limited to Polyethylene Glycol 12000, polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, Macrogol 600, PEG400 etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410155354 CN1759849A (en) | 2004-10-15 | 2004-10-15 | Chinese angelica dripping pill and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410155354 CN1759849A (en) | 2004-10-15 | 2004-10-15 | Chinese angelica dripping pill and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1759849A true CN1759849A (en) | 2006-04-19 |
Family
ID=36706156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410155354 Pending CN1759849A (en) | 2004-10-15 | 2004-10-15 | Chinese angelica dripping pill and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1759849A (en) |
-
2004
- 2004-10-15 CN CN 200410155354 patent/CN1759849A/en active Pending
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20060419 |