CN1762415A - Astragalus root pills formula and its preparation method - Google Patents
Astragalus root pills formula and its preparation method Download PDFInfo
- Publication number
- CN1762415A CN1762415A CN 200410155372 CN200410155372A CN1762415A CN 1762415 A CN1762415 A CN 1762415A CN 200410155372 CN200410155372 CN 200410155372 CN 200410155372 A CN200410155372 A CN 200410155372A CN 1762415 A CN1762415 A CN 1762415A
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- China
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- astragalus root
- radix astragali
- substrate
- preparation
- dripping pill
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention relates to the formula of astragalus root drop pill preparation for tonifying energy, promoting diuresis, and reducing blood sugar, and the process for preparation. The drop pill is prepared from astragalus root extract as the main constituent, and right base through a predetermined process combinations.
Description
Technical field
The present invention relates to a kind of invigorating QI to consolidate the body surface resistance, the diuresis detoxification, coronary artery dilating protects the liver blood sugar lowering, evacuation of pus, the prescription of the Chinese medicine preparation of expelling pus and promoting granulation and manufacture method specifically are the dropping pill formulation and the technology manufacture method thereof of main component with the Radix Astragali extract.
Background technology
The Radix Astragali mainly contains triterpene saponin analog derivative, flavone compound, polysaccharide, nitrogen-containing compound, vitamin, other Organic substance and various trace elements.Have invigorating QI to consolidate the body surface resistance, the diuresis detoxification, evacuation of pus, the effect of expelling pus and promoting granulation, it is weak to be usually used in the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.In recent years, day by day go deep into to the pharmacological research of the Radix Astragali and to the research of its various compositions, particularly it is to immune influence, the influence of pair cell metabolism and regulatory mechanism, to the influence of enhancing body nonspecific resistance and to the influence of cardiovascular system, to the influence of digestive system,, very noticeable to the influence of urinary system.Drop pill is a kind of pill that utilizes the solid dispersion technology system of dripping to form, it is purified the effective site or the effective ingredient refine of medical material on the one hand, utilize water-solubility carrier to improve the dissolubility and the dissolution rate of medicine on the one hand, improve the infiltration rate and the absorbtivity of medicine, thereby the raising bioavailability, the curative effect of raising medicine.
Summary of the invention
The object of the present invention is to provide oral administration astragalus dropping pill formulation that a kind of drug effect is fast, bioavailability is high and preparation method thereof, and effectively control its quality.It is molten soon diffusing that the astragalus root dripping pill that this preparation adopts solid dispersion technology and dropping pill formulation Technology to make not only has disintegrate, the dissolution height, steady quality, the pill volume is little, and both can swallow also can buccal, easy to carry and use, onset is characteristics rapidly, but also have working condition and advantage such as production equipment is simple, and production cost is low, demonstrated fully the new drug research exploitation spirit that people-oriented.
The solution of the present invention is: adopt solid dispersion technology, produce little, quick-acting, the pharmaceutical dosage form efficiently of dosage.
Drop pill is the product of solid dispersion technology, is characterized in: adopt fusion method to make medicine be scattered in the physiology inertia with molecularity and in the carrier soluble in water, form disperse system.(3～4um) is also little, thereby improved surface area greatly, and its bioavailability is much higher than the medicine of general dosage form than micronized particles for drug particle (0.001-0.1um).After entering the intestines and stomach, water-solubility carrier dissolves rapidly, because particle is little, the solid dispersion dissolution velocity is fast, can be absorbed by cell rapidly to enter blood circulation, thereby reach efficient and quick-acting effects.
For achieving the above object, the present invention by the following technical solutions: 1 weight portion Radix Astragali extract is added in the 2 weight portion molten matrix, the emulsifying of high speed shear ultra micro, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
Substrate among the present invention includes but not limited to Polyethylene Glycol 12000, polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, Macrogol 600, PEG400 etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, plant wet goods.
Medicine of the present invention is made (consumption is a weight portion) by following component:
1 part of Radix Astragali extract
1～20 part of substrate
The ratio range of the formula optimization weight of preparation medicine of the present invention is:
1 part of Radix Astragali extract
1.5～10 parts of substrate
The optimum weight proportioning of medicine of the present invention is:
1 part of Radix Astragali extract
2 parts of substrate
Said components is made method of the present invention is:
Radix astragali coarse powder decocts with water secondary, and each 2 hours, collecting decoction left standstill 24 hours, filters, and filtrate is concentrated into 1:1, adds ethanol and carries out precipitate with ethanol, makes to contain the alcohol amount and reach 80%, leaves standstill 12h, reclaim ethanol after, be condensed into cream or spray drying.
With substrate heating, fully dissolving.
Radix Astragali extract is joined in the substrate emulsifying of high speed shear ultra micro.
Four, medicinal liquid is splashed in the coolant, rely on surface tension to be shrunk to ball naturally.
The specific embodiment
Embodiment (1000, every 50mg):
Radix Astragali extract: 1 part
Polyethylene Glycol: 2 parts
Make 1000 altogether, every heavy 50mg
Glutinous? the Tan (a state in the Zhou Dynasty) crucible:
Radix Astragali extract by said components joins in the molten matrix, the emulsifying of high speed shear ultra micro,
The system of dripping in 85 ℃ of heat-preservation cylinders.With coolant cools to the 10 ℃ system of dripping, water dropper to the distance of coolant liquid level is 5cm, and medicinal liquid is splashed in the coolant according to certain frequency in cooling column, and messenger drug drips slowly and sinks, and relies on self tension force to be shrunk to ball gradually.After becoming ball, clean the coolant on surface, drying at room temperature or blowing and finished product.
Claims (10)
1. prescription of astragalus root dripping pill and preparation method thereof, the effective ingredient that it is characterized in that it is a Radix Astragali extract, wherein the weight proportion of Radix Astragali extract and substrate is: 1: 1～1: 15.
Wherein said Radix Astragali extract makes through water extract-alcohol precipitation.
2. astragalus root dripping pill preparation according to claim 1 is characterized in that wherein the weight proportion preferable range of Radix Astragali extract and substrate is: 1: 1.5～1: 5.
3. astragalus root dripping pill preparation according to claim 1 is characterized in that wherein the optimum weight proportioning of Radix Astragali extract and substrate is: 1: 2.
4. according to claim 1,2 or 3 described astragalus root dripping pills, it is characterized in that described medicament is a drop pill.
5. manufacture method for preparing the described astragalus root dripping pill of claim 4 is characterized in that:
With radix astragali coarse powder, extract its effective site or effective ingredient, through qualitative, quantitative, be condensed into cream or be dried to powder;
Choose substrate by national standard;
Above-mentioned effective site and effective ingredient are heated to 85 ℃ of fusings in any one described ratio of claim 1-3 with substrate; Then medicine is joined in the substrate, the emulsifying of high speed shear ultra micro, the fluid reservoir insulation is at 85 ℃, inject then and drip the system tube, open switch, adjust pressure and vacuum equipment, splash at regular time and quantity in 5～15 ℃ the coolant, under capillary effect, be shrunk to ball naturally, clean dry after promptly.
6. the preparation method of astragalus root dripping pill according to claim 5 is characterized in that:
The effective site of Radix Astragali extract and effective ingredient are triterpene saponin analog derivative, flavone compound, polysaccharide, nitrogen-containing compound, vitamin, other Organic substance and various trace elements.
7. the preparation method of astragalus root dripping pill according to claim 5 is characterized in that:
The effective site of the used Radix Astragali and effective ingredient are cream or powder.
8. the preparation method of astragalus root dripping pill according to claim 5 is characterized in that:
Drug effective region or effective ingredient are added 85 ℃ of fully substrate high speed shearing ultra micro emulsifyings of fusing of temperature.
9. substrate according to claim 5 includes but not limited to Polyethylene Glycol 12000, polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, Macrogol 600, PEG400 etc.
10. coolant according to claim 5 includes but not limited to dimethicone, liquid paraffin, plant wet goods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410155372 CN1762415A (en) | 2004-10-18 | 2004-10-18 | Astragalus root pills formula and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410155372 CN1762415A (en) | 2004-10-18 | 2004-10-18 | Astragalus root pills formula and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1762415A true CN1762415A (en) | 2006-04-26 |
Family
ID=36746873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410155372 Pending CN1762415A (en) | 2004-10-18 | 2004-10-18 | Astragalus root pills formula and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1762415A (en) |
-
2004
- 2004-10-18 CN CN 200410155372 patent/CN1762415A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20060426 |