CN1762237A - Health care food capable of preventing osteoprosis and preparation method thereof - Google Patents
Health care food capable of preventing osteoprosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health care food capable of preventing osteoprosis and preparation method, which is prepared mainly from prepared rehmannia root 80-800 weight parts, root bark of tree peony 30-300 weight parts, Chinese yam 40-400 weight parts, poria cocos wolf 30-300 weight parts, alisol 30-300 weight parts, cornus officinalis 40-400 weight parts, wolfberry 50-300 parts, medicinal sodium 50-300 weight parts, vitamin A 0.015-0.075 weight part, vitamin C 10-50 weight parts, vitamin D 0.015-0.075 weight part, vitamin E 1.25-10.0 weight parts, zinc gluconate 8-17 weight parts, carotene-beta 0.015-0.075 weight part, vitamin B1 0.125-0.50 weight part, vitamin B2 0.125-0.50 weight part, vitamin B6 0.125-0.50 weight part, folic acid 0.025-0.050 weight part, and sodium selenite 0.015-0.025 weight part.
Description
Technical field
The present invention relates to a kind of prevention of osteoporosis disease health food, particularly a kind of health food that adds the energy prevention of osteoporosis disease of Chinese medicine and nutrient the invention still further relates to the preparation method of this health food.
Background technology
Osteoporosis is one of common frequently-occurring disease of present the elderly in the world, and patient's sum reaches people more than 200,000,000.The reason of senile osteoporosis: general and endocrine disturbance, calcium malabsorption and to lack movable exercise relevant.Modern medicine thinks that the one gonad axis hypofunction of middle-aged and old hypothalamus one hypophysis, sex hormone level descend, and causes that osteogenesis function descends, and unit volume in-seam tissue content is reduced, and is the basic reason that osteoporosis takes place.For this disease, the method that present doctor trained in Western medicine adopts sex hormone to add calcium is mostly treated, but result of treatment is unsatisfactory, and sex hormone is very big to the side effect of human body, often loses more than gain with gonadotherapy.Traditional Chinese medicine is thought, the main diseases of osteoporosis is because of being to suffer from a deficiency of the kidney, with the pathology of liver spleen substantial connection is arranged also, the percentage of suffering from a deficiency of the kidney is with the increase at age and increases progressively trend, have closely related property between nephrasthenia syndrome and the bone density, and the card marquis who suffers from a deficiency of the kidney performance is identical with osteoporotic clinical manifestation, so suffer from a deficiency of the kidney and osteoporosis is fallen ill direct relation is arranged, especially for the premature menopause women, the principal element of its osteoporosis morbidity especially of suffering from a deficiency of the kidney then.
Kidney-nourishing tcm drug can be kept the balance of bone calcium-blood calcium by improving enteron aisle to the absorbing state of calcium ion and regulate blood calcium concentration and make body to the absorption of calcium ion with utilize and increase, and prevents that a large amount of bone calcium mobilizations from going into blood, the generation of delaying osteoporosis.Kidney-nourishing tcm drug is by suppressing the activity of osteoclast, the osteoclast activity being weakened; Or directly promote osteoblastic propagation or differentiation, and make the movable enhancing of skeletonization, bring into play function of resisting osteoporosis in vivo.Contain trace element in the kidney-nourishing tcm drug, trace element plays important effect in bone metabolism and bone conversion.The contained various trace elements of Chinese medicine is by influencing the balance that multiple biochemical function enzyme is brought into normal play function and then regulated the internal milieu trace element, and the effect of performance enriching yin and nourishing kidney promotes bone to form or suppresses the function that bone absorbs to reach.
At the reason of osteoporosis generation, the many at present employings of prevention and treatment osteoporosis are replenished the calcium and are regulated endocrine method.Prevent in the market and to treat the medicine and the health food of osteoporosis a lot, through patent retrieval, publication number CN1076088A, the patent documentation of by name " a kind of compound method of preventing and treating the functional food of sclerotin sulphur pine disease " disclose a kind of health food that adopts the prevention of osteoporosis disease that the fruit of Chinese wolfberry, Poria cocos, Gorgon fruit, lotus seeds, Huai Shan, calcium gluconate powder, milk powder, vitamin C, D etc. make; Granted publication CN1055853C, the patent disclosure of by name " a kind of treatment osteoporosis Chinese patent drug " a kind of treatment osteoporosis Chinese patent drug that contains animal bone, tortoise plastron, cultivated land, golden cypress, matrimony vine, asparagus fern etc.; Publication number CN1089155A, by name " patent of " Tiansuijianguling " of treatment osteoporosis, its prescription is disconnected by the river, cultivated land, Chinese yam, dogwood fruit, tortoiseshell, the rhizome of davallia, pilose antler, sealwort, Ligusticum wallichii, Radix Angelicae Sinensis etc. ten simply medicine form.Publication number CN 1096204A, by name " anti-primary drinking medicine for primary osteoporosis and processing method thereof " patent, mainly contain following component: astragalus root, RADIX ACONITI LATERALIS PREPARATA, the bark of eucommia, prepared rhizome of rehmannia, HERBA EPIMEDII, Psoralea corylifolia, RADIX POLYGONI MULTIFLORI PREPARATA, the fruit of Chinese wolfberry, frutus cnidii, PORIA ALBA, fructus amomi, satin oyster, zinc sulfate..Granted publication CN 1038813C, by name " a kind of Chinese medicine for the treatment of osteoporosis " patent, by prepared rhizome of rehmannia (cultivated land), dogwood fruit, Chinese yam, rhizoma alismatis, the root bark of tree peony, Poria cocos, rhizoma cibotii, Radix Angelicae Sinensis, barrenwort (HERBA EPIMEDII), oyster (calcium activated) totally 10 the flavor medicines form, the shared ratio of each medicine of distinguishing the flavor of is 2: 1: 1: 0.75: 0.75: 0.75: 1: 1: 0.5: 0.25, as long as the above-mentioned medicine of respectively distinguishing the flavor of is assorted in proportion, get final product in incapsulating behind the crushing screening during preparation.Publication number CN1493325A, the patent of by name " curing mainly the Chinese medicine and preparation method thereof of the primary osteoporosis of kidney deficiency and liver card ", its composition is made up of prepared rhizome of rehmannia, Fructus Corni, rhizoma cibotii, barrenwort, Chinese yam, Radix Angelicae Sinensis, moutan bark, oyster (forging) eight Chinese medicines of distinguishing the flavor of.Granted publication CN1209133C, by name " preventing and treating medicine of rickets and osteoporosis and preparation method thereof ", this medicine by Radix Codonopsis, the Radix Astragali, the tuber of dwarf lilyturf, the bighead atractylodes rhizome, Chinese yam, the fruit of Chinese magnoliavine, tortoiseshell, keel, oyster, the membrane of a chicken's gizzard powder, vitamin D and pharmaceutically acceptable calcium in proportion assembly form.Granted publication CN 1094053C, the patent of by name " a kind of Chinese medicine preparation for the treatment of osteoporosis " is formulated by cultivated land, Chinese cassia tree, dogwood fruit, fructus psoaleae, the bark of eucommia, the seed of Chinese dodder, Chinese yam, rhizoma alismatis, Morinda officinalis, Poria cocos.
Through patent retrieval and non-patent retrieval, not seeing is filled a prescription with nutrients such as pharmaceutically acceptable calcium, vitamin A, vitamin C, vitamin D, vitamin E, zinc gluconates by cultivated land, Fructus Corni, moutan bark, Chinese yam, Poria cocos, rhizoma alismatis and matrimony vine etc. seven flavor Chinese medicines is used for the report of prevention of osteoporosis disease.
Summary of the invention
The present invention is directed to the reason that osteoporosis takes place, to people provide that a kind of determined curative effect, active force are lasting, the health food of the prevention of osteoporosis disease of giving consideration to both the incidental and fundamental and preparation method thereof.
Cultivated land is the process of preparing Chinese medicine processed goods of radix rehmanniae recen, and radix rehmanniae recen is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch., the tool nourishing yin and supplementing blood, and beneficial essence is filled out the effect of marrow; Fructus Corni is the drying and ripening pulp of Cornaceae plant Fructus Corni Cornusofficinalis Sieb.Et Zucc., the effect that tool tonifies the liver and kidney, puckery essence is taken off admittedly; Moutan bark is the dry root skin of ranunculaceae peony Paeonia suffruticosaAndr., tool clearing heat and cooling blood, effect promoting blood circulation and removing blood stasis; Chinese yam is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb., tool tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the effect of the puckery essence of kidney tonifying; Rhizoma alismatis is the dry tuber of Alismataceae plant rhizoma alismatis Alisma orientalis (Sam.) Juzep., tool diuresis, the effect of clearing away damp-heat; Poria cocos is the dry sclerotia of Polyporaceae fungi Poria cocos Poria cocos (Schw.) Wolf, tool clearing damp and promoting diuresis, the effect of the peaceful heart of invigorating the spleen; The fruit of Chinese wolfberry is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L., and tool is nourishing liver and kidney, the effect of benefiting shrewd head.
Technical scheme of the present invention:
Make by raw material prepared rhizome of rehmannia 80-800 weight portion, root bark of tree peony 30-300 weight portion, Chinese yam 40-400 weight portion, Poria cocos 30-300 weight portion, rhizoma alismatis 30-300 weight portion, Fructus Corni 40-400 weight portion, matrimony vine 50-300 weight portion, pharmaceutically acceptable calcium 50-300 weight portion.
Technical scheme of the present invention can also be:
Make by raw material prepared rhizome of rehmannia 300-600 weight portion, root bark of tree peony 100-250 weight portion, Chinese yam 150-300 weight portion, Poria cocos 100-250 weight portion, rhizoma alismatis 100-250 weight portion, Fructus Corni 150-300 weight portion, matrimony vine 100-200 weight portion, pharmaceutically acceptable calcium 200-300 weight portion.
Optimized technical scheme of the present invention is:
Make by raw material prepared rhizome of rehmannia 500 weight portions, the root bark of tree peony 200 weight portions, Chinese yam 250 weight portions, Poria cocos 200 weight portions, rhizoma alismatis 200 weight portions, Fructus Corni 250 weight portions, matrimony vine 10 weight portions, pharmaceutically acceptable calcium 250 weight portions.
The more excellent technical scheme of the present invention can be:
Can also make with raw material prepared rhizome of rehmannia 80-800 weight portion, root bark of tree peony 30-300 weight portion, Chinese yam 40-400 weight portion, Poria cocos 30-300 weight portion, rhizoma alismatis 30-300 weight portion, Fructus Corni 40-400 weight portion, matrimony vine 50-400 weight portion, pharmaceutically acceptable calcium 50-300 weight portion, vitamin A 0.015-0.075 weight portion, vitamin C 10-50 weight portion, vitamin D 0.015-0.075 weight portion, vitamin E 1.25-10.0 weight portion, zinc gluconate 8-17 weight portion.
The more excellent technical scheme of the present invention can be:
Beta carotene 0.015-0.075 weight portion, the Cobastab that also can comprise following weight parts in the above-mentioned more excellent technical scheme
10.125-0.50 weight portion, Cobastab
20.125-0.50 weight portion, Cobastab
60.125-0.50 weight portion, folic acid 0.025-0.050 weight portion, sodium selenite 0.015-0.025 weight portion.
The most preferred technical scheme of the present invention can be:
By raw material prepared rhizome of rehmannia 500 weight portions, the root bark of tree peony 200 weight portions, Chinese yam 250 weight portions, Poria cocos 200 weight portions, rhizoma alismatis 200 weight portions, Fructus Corni 250 weight portions, matrimony vine 100 weight portions, pharmaceutically acceptable calcium 250 weight portions, vitamin A 0.05 weight portion, vitamin C 25 weight portions, vitamin D 0.05 weight portion, vitamin E 3.75 weight portions, zinc gluconate 8.75 weight portions, beta carotene 0.05 weight portion, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, folic acid 0.0375 weight portion, sodium selenite 0.0166 weight portion is made.
The parts by weight that the present invention also contains auxiliary material are: disintegrant 10-200 weight portion, lubricant 2-12 weight portion.
Disintegrant provided by the present invention is microcrystalline cellulose, sodium carboxymethyl starch, PVPP, the mixture of any in the sodium carboxymethylcellulose or two kinds, wherein disintegrant microcrystalline cellulose 28 weight portions, sodium carboxymethyl starch 48 weight portions; Lubricant is the mixture of any or two kinds in talcum powder, dolomol, the lauryl sodium sulfate; Dolomol 6 weight portions wherein.
Medicinal calcium provided by the present invention is meant one or more the combination in calcium gluconae, calcium lactate, calcium acetate, calcium citrate, calcium levulinate, Calcium Ascorbate, calcium malate, Aminoacid sequestration calcium, the calcium carbonate.
Vitamin D provided by the present invention is meant one or more the combination in calciferol, cholecalciferol, 25 1 (OH) cholecalciferol, 1,25 one (OH), 2 cholecalciferols.
Preparation method of the present invention comprises the steps:
(1) take by weighing prepared rhizome of rehmannia, the root bark of tree peony, Chinese yam, Poria cocos, rhizoma alismatis, Fructus Corni, matrimony vine seven flavor medicine material by weight and add an amount of water heating and decoct 1-4 time, decocting time is 0.25-3 hour at every turn, merging decocting liquid;
(2) to be concentrated to relative density be 1.00-1.30 (50 ℃ of heat are surveyed) to the decompression of above-mentioned decocting liquid, carry out alcohol precipitation, make it contain the alcohol amount, left standstill 12-48 hour for 50-85%, after getting the supernatant decompression recycling ethanol, reducing pressure and being concentrated to relative density is 1.05-1.20 (50 ℃ of heat are surveyed);
(3) get above-mentioned (2) concentrate, carry out spray-drying, 100-170 ℃ of EAT control, leaving air temp 80-150 ℃, charging rate is 1-20ml/ minute, gets spray dried powder, it is standby to cross 100 mesh sieves;
(4) take by weighing other supplementary materials and above-mentioned extract powder mixing by weight, granulate, add lubricant, compress tablet coating promptly.
The invention has the advantages that Six-element Chinese medicines such as cultivated land in the raw material, Fructus Corni, moutan bark, Chinese yam, Poria cocos, rhizoma alismatis are the composition flavour of a drug of traditional kidney tonifying good recipe six drugs containing rehmanniae side, six drugs containing rehmanniae side has nourishing liver and kidney effect, matrimony vine also has nourishing liver and kidney, the effect of benefiting shrewd head; And nutrient composition and the pharmaceutically acceptable calcium class compositions such as vitamin that are added, make this drug effect more rapid, more lasting, remedied the slow shortcoming of simple employing Chinese herbal medicine curative effect, recover that bone absorbs and the dynamic equilibrium of bone between forming by adjusting, keep the bone amount effectively, reach the increase bone density systemic-functions such as organism endocrine, alcium and phosphor metabolization, immunity, trace elements, the effect of prevention of osteoporosis disease, taking total amount every day is 2.4 grams.
The specific embodiment
Embodiment 1
Prescription:
Prepared rhizome of rehmannia 500 weight portions, the root bark of tree peony 200 weight portions, Chinese yam 250 weight portions, Poria cocos 200 weight portions, rhizoma alismatis 200 weight portions, Fructus Corni 250 weight portions, matrimony vine 100 weight portions, calcium carbonate 250 weight portions, vitamin(e) A acetate (10%) 0.50 weight portion, vitamin D
2(100,000 units/gram) 0.5 weight portion, Catergen 5 weight portions, Vitwas E (50%) 7.5 weight portion, zinc gluconate 8.75 weight portions, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, beta carotene (10%) 0.50 weight portion, folic acid 0.0375 weight portion, sodium selenite 0.0166 weight portion, sodium carboxymethyl starch 48 weight portions, microcrystalline cellulose 28 weight portions, dolomol 6 weight portions
Method for making:
(1) take by weighing prepared rhizome of rehmannia, the root bark of tree peony, Chinese yam, Poria cocos, rhizoma alismatis, Fructus Corni, matrimony vine, heating decocts secondary, adds 9 times of water gagings for the first time, decocts 1.5 hours, adds 7 times of water gagings for the second time, decocts 1 hour, merges decocting liquid;
(2) to be concentrated to relative density be 1.20 (50 ℃ of heat are surveyed) to the decompression of above-mentioned decocting liquid, carries out alcohol precipitation, and making it contain the alcohol amount is 70%, leaves standstill 24 hours, get the supernatant decompression recycling ethanol after, to be concentrated to relative density be 1.10 (50 ℃ of heat are surveyed) in decompression again;
(3) get above-mentioned (2) concentrate, carry out spray-drying, 130 ℃ of EAT controls, 105 ℃ of leaving air temps, atomizer rotating speed 50HZ, charging rate is 5ml/ minute, gets spray dried powder 212g, it is standby to cross 100 mesh sieves; (4) take by weighing calcium carbonate, vitamin(e) A acetate, vitamin D
2, vitamin C, Vitwas E, zinc gluconate, Cobastab
1, Cobastab
2, Cobastab
6, beta carotene, folic acid, sodium selenite, sodium carboxymethyl starch, microcrystalline cellulose and above-mentioned extract powder mixing, granulate, add magnesium stearate lubricant, be pressed into 1000.
Embodiment 2
Prescription:
Prepared rhizome of rehmannia 400 weight portions, the root bark of tree peony 150 weight portions, Chinese yam 200 weight portions, Poria cocos 150 weight portions, rhizoma alismatis 150 weight portions, Fructus Corni 200 weight portions, matrimony vine 50 weight portions, calcium citrate 250 weight portions, microcrystalline cellulose 41.2 weight portions, sodium carboxymethylcellulose 36 weight portions, vitamin(e) A acetate (10%) 0.50 weight portion, beta carotene (10%) 0.50 weight portion, Cobastab
10.25 weight portion, Cobastab
20.25 weight portion, Cobastab
60.25 weight portion, vitamin C 50 weight portions, vitamin D
2(100,000 units/gram) 0.50 weight portion, Vitwas E (50%) 7.5 weight portion, folic acid 0.0375 weight portion, zinc gluconate 17 weight portions, sodium selenite 0.0166 weight portion, talcum powder 12 weight portions
(1) take by weighing prepared rhizome of rehmannia, the root bark of tree peony, Chinese yam, Poria cocos, rhizoma alismatis, Fructus Corni, matrimony vine seven flavor medicine material, heating decocts three times, adds 8 times of water gagings for the first time, decocted 1 hour, and added 7 times of water gagings for the second time, decocted 0.5 hour, add 7 times of water gagings for the third time, decocted 0.5 hour, merge decocting liquid.
(2) to be concentrated to relative density be 1.05 (50 ℃ of heat are surveyed) to the decompression of above-mentioned decocting liquid, carries out alcohol precipitation, and making it contain the alcohol amount is 75%, leaves standstill 48 hours, get the supernatant decompression recycling ethanol after, to be concentrated to relative density be 1.15 (50 ℃ of heat are surveyed) in decompression again;
(3) get above-mentioned (2) concentrate, carry out spray-drying, 150 ℃ of EAT controls, 130 ℃ of leaving air temps, atomizer rotating speed 50HZ, charging rate is 10ml/ minute, gets spray dried powder 172g, it is standby to cross 100 mesh sieves;
(4) take by weighing calcium citrate, microcrystalline cellulose, sodium carboxymethylcellulose, vitamin(e) A acetate, beta carotene, Cobastab
1, Cobastab
2, Cobastab
6, vitamin C, vitamin D
2, Vitwas E, folic acid, zinc gluconate, sodium selenite, with above-mentioned extract powder mixing, granulate, add the lubricant talcum powder, be pressed into 1000.
Embodiment 3
Prescription:
Prepared rhizome of rehmannia 80 weight portions, the root bark of tree peony 30 weight portions, Chinese yam 40 weight portions, Poria cocos 30 weight portions, rhizoma alismatis 30 weight portions, Fructus Corni 40 weight portions, matrimony vine 400 weight portions, calcium gluconae 300 weight portions, microcrystalline cellulose 56.2 weight portions, PVPP 15 weight portions, vitamin(e) A acetate (10%) 0.75 weight portion, beta carotene (10%) 0.75 weight portion, Cobastab
10.5 weight portion, Cobastab
20.5 weight portion, Cobastab
60.5 weight portion, vitamin C 25 weight portions, vitamin D
2(100,000 units/gram) 0.75 weight portion, Vitwas E (50%) 20 weight portion, folic acid 0.05 weight portion, zinc gluconate 8 weight portions, sodium selenite 0.015 weight portion, dolomol 2 weight portions
(1) take by weighing prepared rhizome of rehmannia, the root bark of tree peony, Chinese yam, Poria cocos, rhizoma alismatis, Fructus Corni, matrimony vine seven flavor medicine material, heating decocts secondary, adds 10 times of water gagings for the first time, decocts 3 hours, adds 8 times of water gagings for the second time, decocts 2 hours, merges decocting liquid.
(2) to be concentrated to relative density be 1.10 (50 ℃ of heat are surveyed) to the decompression of above-mentioned decocting liquid, carries out alcohol precipitation, and making it contain the alcohol amount is 50%, leaves standstill 12 hours, get the supernatant decompression recycling ethanol after, to be concentrated to relative density be 1.20 (50 ℃ of heat are surveyed) in decompression again.
(3) get above-mentioned (2) concentrate, carry out spray-drying, 100 ℃ of EAT controls, 80 ℃ of leaving air temps, atomizer rotating speed 50HZ, charging rate is 2ml/ minute, gets spray dried powder 158g, it is standby to cross 100 mesh sieves.
(4) take by weighing calcium gluconae, microcrystalline cellulose, PVPP, vitamin(e) A acetate, beta carotene, Cobastab
1, Cobastab
2, Cobastab
6, vitamin C, vitamin D
2, Vitwas E, folic acid, zinc gluconate, sodium selenite, with above-mentioned extract powder mixing, granulate, add magnesium stearate lubricant, be pressed into 1000.
Embodiment 4
Prescription:
Prepared rhizome of rehmannia 300 weight portions, the root bark of tree peony 100 weight portions, Chinese yam 150 weight portions, Poria cocos 100 weight portions, rhizoma alismatis 100 weight portions, Fructus Corni 150 weight portions, matrimony vine 50 weight portions, calcium lactate 200 weight portions, microcrystalline cellulose 108.9 weight portion PVPPs 30 weight portions, vitamin(e) A acetate (10%) 0.50 weight portion, beta carotene (10%) 0.50 weight portion, Cobastab
10.5 weight portion, Cobastab
20.5 weight portion, Cobastab
60.5 weight portion, vitamin C 25 weight portions, vitamin D
2(100,000 units/gram) 0.15 weight portion, Vitwas E (50%) 15 weight portion, folic acid 0.025 weight portion, zinc gluconate 8.75 weight portions, sodium selenite 0.025 weight portion, lauryl sodium sulfate 6 weight portions
(1) take by weighing prepared rhizome of rehmannia, the root bark of tree peony, Chinese yam, Poria cocos, rhizoma alismatis, Fructus Corni, matrimony vine seven flavor medicine material, heating decocts once, adds 12 times of water gagings, decocts leaching decocting liquid 3 hours;
(2) to be concentrated to relative density be 1.10 (50 ℃ of heat are surveyed) to the decompression of above-mentioned decocting liquid, carries out alcohol precipitation, and making it contain the alcohol amount is 60%, leaves standstill 36 hours, get the supernatant decompression recycling ethanol after, to be concentrated to relative density be 1.10 (50 ℃ of heat are surveyed) in decompression again.
(3) get above-mentioned (2) concentrate, carry out spray-drying, 170 ℃ of EAT controls, 150 ℃ of leaving air temps, atomizer rotating speed 50HZ, charging rate is 20ml/ minute, gets spray dried powder 192g, it is standby to cross 100 mesh sieves.
(4) take by weighing calcium lactate, microcrystalline cellulose, PVPP, vitamin(e) A acetate, beta carotene, Cobastab
1,, Cobastab
2, Cobastab
6, vitamin C, vitamin D
2, Vitwas E, folic acid, zinc gluconate, sodium selenite, with above-mentioned extract powder mixing, granulate, add the lubricant lauryl sodium sulfate, be pressed into 1000.
Embodiment 5
Prepared rhizome of rehmannia 800 weight portions, the root bark of tree peony 300 weight portions, Chinese yam 400 weight portions, Poria cocos 300 weight portions, rhizoma alismatis 300 weight portions, Fructus Corni 400 weight portions, matrimony vine 50 weight portions, Aminoacid sequestration calcium 50 weight portions, microcrystalline cellulose 135 weight portions, PVPP 57.7 weight portions, vitamin(e) A acetate (10%) 0.50 weight portion, beta carotene (10%) 0.15 weight portion, Cobastab
10.125 weight portion, Cobastab
20.125 weight portion, Cobastab
60.125 weight portion, vitamin C 10 weight portions, vitamin D
2(100,000 units/gram) 0.75 weight portion, Vitwas E (50%) 2.5 weight portion, folic acid 0.025 weight portion, zinc gluconate 17 weight portions, sodium selenite 0.025 weight portion, dolomol 8 weight portions
(1) take by weighing prepared rhizome of rehmannia, the root bark of tree peony, Chinese yam, Poria cocos,, rhizoma alismatis, Fructus Corni, matrimony vine seven flavor medicine material, heating decocts 4 times, for the first time add 7 times of water gagings, decocted 1.5 hours, add 7 times of water gagings for the second time, decocted 1 hour, add 5 times of water gagings for the third time, decocted 0.5 hour, add 3 times of water gagings the 4th time, decocted 15 minutes, and merged decocting liquid.
(2) to be concentrated to relative density be 1.30 (50 ℃ of heat are surveyed) to the decompression of above-mentioned decocting liquid, carries out alcohol precipitation, and making it contain the alcohol amount is 85%, leaves standstill 48 hours, get the supernatant decompression recycling ethanol after, to be concentrated to relative density be 1.05 (50 ℃ of heat are surveyed) in decompression again.
(3) get above-mentioned (2) concentrate, carry out spray-drying, 140 ℃ of EAT controls, 115 ℃ of leaving air temps, atomizer rotating speed 50HZ, charging rate is 10ml/ minute, gets spray dried powder 306g, it is standby to cross 100 mesh sieves.
(4) take by weighing Aminoacid sequestration calcium, microcrystalline cellulose, PVPP, vitamin(e) A acetate, β-Hu Luo element, Cobastab
1, Cobastab
2Cobastab
6, vitamin C, vitamin D
2, Vitwas E, folic acid, zinc gluconate, sodium selenite, with above-mentioned extract powder mixing, granulate, add magnesium stearate lubricant, be pressed into 1000.
Claims (11)
1. the health food of a prevention of osteoporosis disease, it is characterized in that: it is made by raw material prepared rhizome of rehmannia 80-800 weight portion, root bark of tree peony 30-300 weight portion, Chinese yam 40-400 weight portion, Poria cocos 30-300 weight portion, rhizoma alismatis 30-300 weight portion, Fructus Corni 40-400 weight portion, matrimony vine 50-300 weight portion, pharmaceutically acceptable calcium 50-300 weight portion basically.
2. the health food of prevention of osteoporosis disease according to claim 1 is characterized in that the weight ratio of raw material is: prepared rhizome of rehmannia 300-600 weight portion, root bark of tree peony 100-250 weight portion, Chinese yam 150-300 weight portion, Poria cocos 100-250 weight portion, rhizoma alismatis 100-250 weight portion, Fructus Corni 150-300 weight portion, matrimony vine 100-200 weight portion, pharmaceutically acceptable calcium 200-300 weight.
3. the health food of prevention of osteoporosis disease according to claim 2 is characterized in that the weight ratio of raw material is: 500 parts of prepared rhizomes of rehmannia, 200 parts of the root barks of tree peony, 250 parts of Chinese yams, 200 parts in Poria cocos, 200 parts of rhizoma alismatis, 250 parts of Fructus Cornis, 100 parts of matrimony vines, 250 parts of pharmaceutically acceptable calciums.
4. according to the health food of the arbitrary described prevention of osteoporosis disease of claim 1-3, it is characterized in that: vitamin A 0.015-0.075 part, vitamin C 10-50 part, vitamin D 0.015-0.075 part vitamin E 1.25-10.0 part, zinc gluconate 8-17 part of also comprising following weight parts in its raw material.
5. the health food of prevention of osteoporosis disease according to claim 4 is characterized in that: the beta carotene 0.015-0.075 part, the Cobastab that also comprise following weight parts in its raw material
10.125-0.50 part, Cobastab
20.125-0.50 part, Cobastab
60.125-0.50 part, folic acid 0.025-0.050 part, sodium selenite 0.015-0.025 part.
6. the health food of prevention of osteoporosis disease according to claim 5 is characterized in that: it is 0.05 part of 8.75 parts of 3.75 parts of 0.05 part of 25 parts of 0.05 part of 250 parts of 100 parts of 250 parts of 200 parts of 200 parts in 250 parts of 200 parts of 500 parts of raw material prepared rhizomes of rehmannia, the root barks of tree peony, Chinese yams, Poria cocos, rhizoma alismatis, Fructus Cornis, matrimony vines, pharmaceutically acceptable calciums, vitamin A, vitamin Cs, vitamin D, vitamin Es, zinc gluconates, beta carotene, Cobastab by following weight parts
10.25 part, Cobastab
20.25 part, Cobastab
60.25 0.0375 part in part, folic acid, sodium selenite is made for 0.0166 part.
7. according to the health food of the arbitrary described prevention of osteoporosis disease of claim 1-6, it is characterized in that: it also contains auxiliary material disintegrant 10-200 weight portion, lubricant 2-12 weight portion; Disintegrant wherein is microcrystalline cellulose, sodium carboxymethyl starch, PVPP, the mixture of any in the sodium carboxymethylcellulose or two kinds; Lubricant is the mixture of any or two kinds in talcum powder, dolomol, the lauryl sodium sulfate.
8. the health food of prevention of osteoporosis disease according to claim 7 is characterized in that: 28 parts of disintegrant microcrystalline celluloses, 48 parts of sodium carboxymethyl starches; 6 parts of magnesium stearate lubricants.
9. according to the health food of the arbitrary described prevention of osteoporosis disease of claim 1-6, it is characterized in that: pharmaceutically acceptable calcium is meant one or more the combination in calcium gluconae, calcium lactate, calcium acetate, calcium citrate, calcium levulinate, Calcium Ascorbate, calcium malate, Aminoacid sequestration calcium, the calcium carbonate in the raw material.
10. according to the health food of claim 4 or 6 arbitrary described prevention of osteoporosis diseases, it is characterized in that: vitamin D is meant one or more the combination in calciferol, cholecalciferol, 25 1 (OH) cholecalciferol, 1,25 one (OH), 2 cholecalciferols in the raw material.
11. the preparation method according to the health food of the arbitrary described prevention of osteoporosis disease of claim 1-10 is characterized in that comprising the steps:
(1) take by weighing prepared rhizome of rehmannia, the root bark of tree peony, Chinese yam, Poria cocos, rhizoma alismatis, Fructus Corni, matrimony vine seven flavor medicine material by weight and add an amount of water heating and decoct 1-4 time, decocting time is 0.25-3 hour at every turn, merging decocting liquid;
(2) to be concentrated to relative density be 1.00-1.30 (50 ℃ of heat are surveyed) to the decompression of above-mentioned decocting liquid, carry out alcohol precipitation, make it contain the alcohol amount, left standstill 12-48 hour for 50-85%, after getting the supernatant decompression recycling ethanol, reducing pressure and being concentrated to relative density is 1.05-1.20 (50 ℃ of heat are surveyed);
(3) get above-mentioned (2) concentrate, carry out spray-drying, 100-170 ℃ of EAT control, leaving air temp 80-150 ℃, charging rate is 1-20ml/ minute, gets spray dried powder, it is standby to cross 100 mesh sieves;
(4) take by weighing other supplementary materials and above-mentioned extract powder mixing by weight, granulate, add lubricant, compress tablet coating promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100614269A CN1762237A (en) | 2005-11-02 | 2005-11-02 | Health care food capable of preventing osteoprosis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100614269A CN1762237A (en) | 2005-11-02 | 2005-11-02 | Health care food capable of preventing osteoprosis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1762237A true CN1762237A (en) | 2006-04-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005100614269A Pending CN1762237A (en) | 2005-11-02 | 2005-11-02 | Health care food capable of preventing osteoprosis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1762237A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103340341A (en) * | 2013-07-03 | 2013-10-09 | 山西大学 | Functional food with bone strengthening effect and preparation method thereof |
| CN103690874A (en) * | 2013-12-27 | 2014-04-02 | 张振刚 | Traditional Chinese medicine for treating osteoporosis |
| CN104872683A (en) * | 2015-06-12 | 2015-09-02 | 广东岭南职业技术学院 | Fructus lycii containing six traditional Chinese medicinal materials and preparation method of fructus lycii |
| CN104958506A (en) * | 2015-07-30 | 2015-10-07 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treating osteoporosis diabetes of old people |
| CN106237021A (en) * | 2016-08-29 | 2016-12-21 | 吉林万通药业有限公司 | A kind of composite type formulation for replenishing calcium and preparation method thereof |
| CN112754019A (en) * | 2020-12-23 | 2021-05-07 | 河南九天生物科技有限公司 | Composition containing 25 hydroxyl d3 and calcium gluconate and preparation method thereof |
-
2005
- 2005-11-02 CN CNA2005100614269A patent/CN1762237A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103340341A (en) * | 2013-07-03 | 2013-10-09 | 山西大学 | Functional food with bone strengthening effect and preparation method thereof |
| CN103690874A (en) * | 2013-12-27 | 2014-04-02 | 张振刚 | Traditional Chinese medicine for treating osteoporosis |
| CN103690874B (en) * | 2013-12-27 | 2015-12-09 | 孙振刚 | One treats osteoporotic Chinese medicine |
| CN104872683A (en) * | 2015-06-12 | 2015-09-02 | 广东岭南职业技术学院 | Fructus lycii containing six traditional Chinese medicinal materials and preparation method of fructus lycii |
| CN104958506A (en) * | 2015-07-30 | 2015-10-07 | 济南邦文医药科技有限公司 | Traditional Chinese medicine for treating osteoporosis diabetes of old people |
| CN106237021A (en) * | 2016-08-29 | 2016-12-21 | 吉林万通药业有限公司 | A kind of composite type formulation for replenishing calcium and preparation method thereof |
| CN106237021B (en) * | 2016-08-29 | 2019-09-13 | 吉林万通药业有限公司 | A kind of composite type formulation for replenishing calcium and preparation method thereof |
| CN112754019A (en) * | 2020-12-23 | 2021-05-07 | 河南九天生物科技有限公司 | Composition containing 25 hydroxyl d3 and calcium gluconate and preparation method thereof |
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Open date: 20060426 |