CN1748720A - Medicine for anti-fatigue and its preparing method - Google Patents
Medicine for anti-fatigue and its preparing method Download PDFInfo
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- CN1748720A CN1748720A CN 200410066513 CN200410066513A CN1748720A CN 1748720 A CN1748720 A CN 1748720A CN 200410066513 CN200410066513 CN 200410066513 CN 200410066513 A CN200410066513 A CN 200410066513A CN 1748720 A CN1748720 A CN 1748720A
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Abstract
The present invention relates to Chinese medicine preparation, and is especially one kind of anti fatigue medicine and its preparation process. The anti fatigue medicine has obvious effects of raising human body's vitality and resisting fatigue, and no toxic side effect. The anti fatigue medicine is prepared with pine mushroom mycelium, glossy ganoderma mycelium, aweto, and morel mycelium in certain proportion, and through stoving and ozone sterilization. It may be taken by young people and old people.
Description
Technical field
The present invention relates to a kind of raising human body energy, antifatigue medicine, the especially a kind of antifatigue medicine of forming by Chinese patent medicine and the preparation method of this medicine thereof.
Background technology
At present, we see that a lot of health product propagandas claim to improve human body energy, resisting fatigue on market.The product that resisting fatigue is effective has side effect to human body, and reason is that these health product have added chemical agent, and is effective in short-term as analeptic one class, but also big to the human injury; The health product resisting fatigue poor effect that human body is free from side effects.
Summary of the invention
The objective of the invention is to overcome the deficiency of present technology, provide a kind of and have no side effect, make that human body is full of vitality, resisting fatigue and obvious results medicine.
Another object of the present invention is to provide a kind of preparation method of this medicine.
The medicament that a kind of antifatigue medicine of the present invention is made up of Tricholoma matsutake (lto et lmai) Singer mycelium, Ganoderma mycelium, Cordyceps, Morchella esculenta (L.) Pers mycelium; By weight percentage, described Tricholoma matsutake (lto et lmai) Singer mycelium is that 5-50%, Ganoderma mycelium are that 5-55%, Cordyceps are 20-80%, Morchella esculenta (L.) Pers mycelium 3-40%, and four summations are 100%.
By weight percentage, preferred version of the present invention, described Tricholoma matsutake (lto et lmai) Singer mycelium are that 10-30%, Ganoderma mycelium are that 12-28%, Cordyceps are 40-65%, Morchella esculenta (L.) Pers mycelium 7-15%, and four summations are 100%.
Above-mentioned each component is made medicine production method of the present invention is:
1, the preparation method of Tricholoma matsutake (lto et lmai) Singer mycelium: wild Tricholoma matsutake (lto et lmai) Singer obtains Tricholoma matsutake (lto et lmai) Singer mycelium through separate tissue, cultivation, fermentation, oven dry;
2, the preparation method of Ganoderma mycelium: Ganoderma obtains Ganoderma mycelium through cultivating, ferment, drying;
3, method for preparing morchella mycelium: Morchella esculenta (L.) Pers obtains Morchella esculenta (L.) Pers mycelium through cultivating, ferment, drying;
4, described Tricholoma matsutake (lto et lmai) Singer mycelium, Ganoderma mycelium, Morchella esculenta (L.) Pers mycelium, Cordyceps being pulverized is 60 purpose fine powders;
5, even the above-mentioned Tricholoma matsutake (lto et lmai) Singer mycelium that makes, Ganoderma mycelium, Morchella esculenta (L.) Pers mycelium, Cordyceps eucalyptus globulus mixed, through oven dry, sterilization treatment, just make antifatigue powder medicine successively.
Powder after the sterilization treatment also can be reprocessed into the solid block dosage form of similar cookies size, and need add an amount of binding agent this moment again, and compression moulding under negative pressure is dry and with the vacuum mode packing, can wait until bulk block preparation.
Powder after the sterilization treatment also can be reprocessed into capsule particle, and promptly make capsule medicament as long as the powder of handle after sterilization treatment incapsulates in the pipe and seals this moment.The described capsule of making heavily can be 0.5g.
Described wild Tricholoma matsutake (lto et lmai) Singer obtains Tricholoma matsutake (lto et lmai) Singer mycelium through separate tissue, cultivation, fermentation, oven dry, its making step can be that wild Tricholoma matsutake (lto et lmai) Singer obtains original female kind of Tricholoma matsutake (lto et lmai) Singer through separate tissue, cultivating 7 days at 22-28 ℃ of following tube, was shake-flask culture at 22-28 ℃ of following shaken cultivation 2-4 days then; Cultivated 7 days in seed tank, temperature is 22-28 ℃ again; Temperature is 22-28 ℃ and cultivated 2-4 days in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Tricholoma matsutake (lto et lmai) Singer mycelium in 6-10 hour.
Described Ganoderma obtains Ganoderma mycelium through cultivating, ferment, drying, its making step can be that Ganoderma was cultivated 7 days down at 22-30 ℃, obtain the female kind of Ganoderma, the female kind at 22-30 ℃ of Ganoderma cultivated 5-7 days down, was shake-flask culture at 22-30 ℃ of following shaken cultivation 3-5 days then; Cultivated 36-72 hour in seed tank, temperature is 22-30 ℃ again; Temperature is 22-30 ℃ and cultivated 46-72 hour in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Ganoderma mycelium in 6-10 hour.
Described Morchella esculenta (L.) Pers obtains Morchella esculenta (L.) Pers mycelium through cultivating, ferment, drying, making step can be that Morchella esculenta (L.) Pers obtained Gaster caprae seu Ovis starter kind in 5-7 days 22-28 ℃ of cultivation, Gaster caprae seu Ovis starter kind was cultivated 5-7 days at 22-28 ℃ of lower inclined plane, was shake-flask culture at 22-28 ℃ of following shaken cultivation 3-5 days then; Cultivated 42-72 hour in seed tank, temperature is 22-28 ℃ again; Temperature is 22-28 ℃ and cultivated 46-72 hour in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Morchella esculenta (L.) Pers mycelium in 6-10 hour.
Oven dry behind described three kinds of mycelium and the Cordyceps uniform mixing can be meant in baking oven dried by the fire 2 hours with 90 ℃, and powder heap thickness is 2cm; Described thickness was directly proportional with the time of temperature, baking needed; The described sterilization of stating can be an ozone sterilization, and sterilization time is 2 hours, and powder heap thickness is generally 2cm.
Medicine of the present invention is tested mice, get 40 of mices, be divided into four groups, do not eat medicine of the present invention for one group, other group is eaten medicine of the present invention by various dose, takes dosage one month according to body weight, and it has been carried out the swimming with a load attached to the body test, be that the negative lead of every mice is that the result is as follows from 5% of heavy sensation of the whole body:
| Group (mg/Kg) | Number of animals (only) | The swimming with a load attached to the body time (second) |
| Negative control (0) | 10 | 394.9±183.5 |
| Low dosage (5) | 10 | 568.1±172.7 |
| Middle dosage (10) | 10 | 804.4±369.0 |
| High dose (30) | 10 | 557.7±235.3 |
Get 40 of mices, be divided into four groups, eat medicine of the present invention for one group, other group is eaten medicine of the present invention by various dose, takes dosage one month according to body weight, and it has been carried out the pole-climbing test, and the result is as follows:
| Group (mg/Kg) | Number of animals (only) | Accumulative total three pole-climbing times (second) |
| Negative control (0) | 10 | 344.3±124.2 |
| Low dosage (5) | 10 | 586.1±325.5 |
| Middle dosage (10) | 10 | 683.2±133.8 |
| High dose (30) | 10 | 475.3±248.2 |
Get 40 of mices, be divided into four groups, eat medicine of the present invention for one group, other group is eaten medicine of the present invention by various dose, takes dosage one month according to body weight, and mice is put into 30 ℃ water swimming 90 minutes, takes out.Pluck the eyeball blood sampling immediately, centrifuging and taking serum, it is as follows to survey mice serum blood urea nitrogen result:
| Group (mg/Kg) | Number of animals (only) | Serum urea nitrogen (mg/100ml) |
| Negative control (0) | 10 | 20.07±2.08 |
| Low dosage (5) | 10 | 19.67±1.06 |
| Middle dosage (10) | 10 | 17.84±1.03 |
| High dose (30) | 10 | 16.11±2.25 |
The result shows that this antifatigue medicine can obviously prolong swimming time and the pole-climbing time of mice, obviously reduces the content of its post exercise blood urea nitrogen.Thereby, have antifatigue effect.
The general each taking dose of being grown up is 1-1.5g, and take 2-3 every day, can take for a long time.The minor takes to reduce and takes dosage.
Raw material of the present invention is a Chinese crude drug, technology is made the elite that adopts in the biological method extraction Chinese herbal medicine, therefore a kind of antifatigue medicine according to the present invention as described hereinbefore has improving the metabolism that human body energy effect is remarkable, have no side effect, effectively improve health, processing technology is simple, the medicine process ozone sterilization of making, sterilization effect is better, characteristics such as safe and sanitary, no pathogenic bacteria.
The specific embodiment
Below the invention will be further elaborated.
Embodiment one:
Take by weighing raw material (kilogram) by following proportioning:
Tricholoma matsutake (lto et lmai) Singer mycelium 30Kg, Ganoderma mycelium are that 30Kg, Cordyceps are that 30Kg, Morchella esculenta (L.) Pers mycelium are 10Kg.
Production method is as follows:
1, wild Tricholoma matsutake (lto et lmai) Singer separate tissue obtains original female kind of Tricholoma matsutake (lto et lmai) Singer, cultivated 7 days at 22-28 ℃ of following tube, and be shake-flask culture in 3 days 25 ℃ of following shaken cultivation then; Cultivated 7 days in seed tank, temperature is 25 ℃ again; Temperature is 25 ℃ and cultivated 2-4 days in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Tricholoma matsutake (lto et lmai) Singer mycelium in 8 hours;
2, Ganoderma is cultivated in the time of 26 ℃ and got female kind in 7 days, and female the kind at 26 ℃ of lower inclined planes of Ganoderma cultivated 7 days, was shake-flask culture in 4 days 26 ℃ of following shaken cultivation then; Cultivated 2 days in seed tank, temperature is 26 ℃ again; Temperature is 26 ℃ and cultivated 70 hours in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Ganoderma mycelium in 10 hours;
3, Morchella esculenta (L.) Pers is cultivated at 25 ℃ and was got female kind in 6 days, and Gaster caprae seu Ovis starter kind was cultivated 7 days down at 22-28 ℃, was shake-flask culture in 5 days 25 ℃ of following shaken cultivation then; Cultivated 60 hours in seed tank, temperature is 25 ℃ again; Temperature is 25 ℃ and cultivated 72 hours in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Morchella esculenta (L.) Pers mycelium in 10 hours;
4, described Tricholoma matsutake (lto et lmai) Singer mycelium, Ganoderma mycelium, Morchella esculenta (L.) Pers filament and Cordyceps for being ground into 60 purpose fine powders;
Above-mentioned cultivation generally is carrier with the Rhizoma Solani tuber osi; It also can be other material.
Even the above-mentioned Tricholoma matsutake (lto et lmai) Singer mycelium that makes, Ganoderma mycelium, Morchella esculenta (L.) Pers filament, Cordyceps eucalyptus globulus mixed, be 90 ℃ with temperature in baking oven, 2 hours time, powder heap thickness 2cm is dried, through 2 hours sterilization treatment of ozone, just make antifatigue powder medicine again
Powder incapsulates in the pipe and seals, and promptly makes the capsule medicament, the heavy 0.5g of every capsules.
Embodiment two:
Different with embodiment is that proportion of raw materials is different, and production method is the same.
Tricholoma matsutake (lto et lmai) Singer mycelium 5Kg, Ganoderma mycelium are that 5Kg, Cordyceps are that 80Kg, Morchella esculenta (L.) Pers mycelium are 10Kg.
Embodiment three:
Different with embodiment is that proportion of raw materials is different, and production method is the same.
Tricholoma matsutake (lto et lmai) Singer mycelium is that 18Kg, Ganoderma mycelium are that 22Kg, Cordyceps are that 52Kg, Morchella esculenta (L.) Pers mycelium are 8Kg;
Embodiment four:
Different with embodiment is that proportion of raw materials is different, and production method is the same.
Tricholoma matsutake (lto et lmai) Singer mycelium 10Kg, Ganoderma mycelium are that 12Kg, Cordyceps are that 65Kg, Morchella esculenta (L.) Pers mycelium are 13Kg.
Claims (11)
1, a kind of antifatigue medicine is characterized in that: the medicament that it is made up of Tricholoma matsutake (lto et lmai) Singer mycelium, Ganoderma mycelium, Cordyceps, Morchella esculenta (L.) Pers mycelium; By weight percentage, described Tricholoma matsutake (lto et lmai) Singer mycelium is that 5-50%, Ganoderma mycelium are that 5-55%, Cordyceps are 20-80%, Morchella esculenta (L.) Pers mycelium 3-40%, and four summations are 100%.
2, a kind of antifatigue medicine according to claim 1, it is characterized in that: by weight percentage described, described Tricholoma matsutake (lto et lmai) Singer mycelium is that 10-30%, Ganoderma mycelium are that 12-28%, Cordyceps are 40-65%, Morchella esculenta (L.) Pers mycelium 7-15%, and four summations are 100%.
3, a kind of antifatigue medicine according to claim 1, it is characterized in that: by weight percentage described, described Tricholoma matsutake (lto et lmai) Singer mycelium is 18%, Ganoderma mycelium is 22%, Cordyceps is 52%, Morchella esculenta (L.) Pers mycelium 8%, four summation is 100%.
4, according to claim 1,2,3 arbitrary described a kind of antifatigue medicines, it is characterized in that: described medicament is a said dosage form on any pharmaceutics.
5, a kind of antifatigue medicine according to claim 4, it is characterized in that: described medicament is powder or capsule.
6, the preparation method of a kind of antifatigue medicine according to claim 5 is characterized in that:
The preparation method of the first step, Tricholoma matsutake (lto et lmai) Singer mycelium: wild Tricholoma matsutake (lto et lmai) Singer obtains Tricholoma matsutake (lto et lmai) Singer mycelium through separate tissue, cultivation, fermentation, oven dry;
Second step, Ganoderma mycelium preparation method: Ganoderma through cultivation, fermentation, oven dry obtain Ganoderma mycelium;
The 3rd step, method for preparing morchella mycelium: Morchella esculenta (L.) Pers obtains Morchella esculenta (L.) Pers mycelium through cultivating, ferment, drying;
The 4th the step, described Tricholoma matsutake (lto et lmai) Singer mycelium, Ganoderma mycelium, Morchella esculenta (L.) Pers filament and Cordyceps are ground into 60 purpose fine powders;
In the 5th step, even, through oven dry, sterilization treatment, just make antifatigue powder medicine successively the above-mentioned Tricholoma matsutake (lto et lmai) Singer mycelium that makes, Ganoderma mycelium, Morchella esculenta (L.) Pers filament and Cordyceps eucalyptus globulus mixed;
The 6th step, incapsulate the powder after sterilization treatment in the pipe and seal, promptly make the capsule medicament.
7, the preparation method of a kind of antifatigue medicine according to claim 6, it is characterized in that: described wild Tricholoma matsutake (lto et lmai) Singer obtains Tricholoma matsutake (lto et lmai) Singer mycelium through separate tissue, cultivation, fermentation, oven dry, its making step is that wild Tricholoma matsutake (lto et lmai) Singer obtains original female kind of Tricholoma matsutake (lto et lmai) Singer through separate tissue, cultivating 7 days at 22-28 ℃ of following tube, was shake-flask culture at 22-28 ℃ of following shaken cultivation 2-4 days then; Cultivated 7 days in seed tank, temperature is 22-28 ℃ again; Temperature is 22-28 ℃ and cultivated 2-4 days in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Tricholoma matsutake (lto et lmai) Singer mycelium in 6-10 hour.
8, the preparation method of a kind of antifatigue medicine according to claim 6, it is characterized in that: described Ganoderma obtains Ganoderma mycelium through cultivating, ferment, drying, its making step is that Ganoderma was cultivated 7 days down at 22-30 ℃, obtain the female kind of Ganoderma, the female kind at 22-30 ℃ of Ganoderma cultivated 5-7 days down, was shake-flask culture at 22-30 ℃ of following shaken cultivation 3-5 days then; Cultivated 36-72 hour in seed tank, temperature is 22-30 ℃ again; Temperature is 22-30 ℃ and cultivated 46-72 hour in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Ganoderma mycelium in 6-10 hour.
9, the preparation method of a kind of antifatigue medicine according to claim 6, it is characterized in that: described Morchella esculenta (L.) Pers obtains Morchella esculenta (L.) Pers mycelium through cultivating, ferment, drying, making step is that Morchella esculenta (L.) Pers obtained Gaster caprae seu Ovis starter kind in 5-7 days 22-28 ℃ of cultivation, Gaster caprae seu Ovis starter kind was cultivated 5-7 days at 22-28 ℃ of lower inclined plane, was shake-flask culture at 22-28 ℃ of following shaken cultivation 3-5 days then; Cultivated 42-72 hour in seed tank, temperature is 22-28 ℃ again; Temperature is 22-28 ℃ and cultivated 46-72 hour in fermentation tank, obtains fermentation liquid, filter mycelium, the mycelium that obtains dried by the fire at 80 ℃ obtained Morchella esculenta (L.) Pers mycelium in 6-10 hour.
10, the preparation method of a kind of antifatigue medicine according to claim 6 is characterized in that: the oven dry behind described three kinds of mycelium and the Cordyceps uniform mixing is meant that the thickness of mixture in baking oven is 2cm, and temperature is 90 ℃, and the time is 2 hours.
11, the preparation method of a kind of antifatigue medicine according to claim 6 is characterized in that: described sterilization is an ozone sterilization.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410066513 CN1748720A (en) | 2004-09-17 | 2004-09-17 | Medicine for anti-fatigue and its preparing method |
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| CN 200410066513 CN1748720A (en) | 2004-09-17 | 2004-09-17 | Medicine for anti-fatigue and its preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103371367A (en) * | 2012-04-26 | 2013-10-30 | 彭都 | Food for acquired immune deficiency syndrome nutritional therapy |
| CN103392502A (en) * | 2013-06-20 | 2013-11-20 | 姚大军 | Preparation method of toadstool mycelium powder |
| CN105288226A (en) * | 2014-07-15 | 2016-02-03 | 及长城 | Kidney-invigorating and yang-strengthening composition and preparation method thereof |
| CN107223955A (en) * | 2017-06-29 | 2017-10-03 | 四川埕禧循环农业开发有限公司 | Possesses bacterium paddy nutrient powder of nourishing the stomach anti-tumor function and preparation method thereof |
-
2004
- 2004-09-17 CN CN 200410066513 patent/CN1748720A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103371367A (en) * | 2012-04-26 | 2013-10-30 | 彭都 | Food for acquired immune deficiency syndrome nutritional therapy |
| CN103371367B (en) * | 2012-04-26 | 2015-01-07 | 彭都 | Food for acquired immune deficiency syndrome nutritional therapy |
| CN103392502A (en) * | 2013-06-20 | 2013-11-20 | 姚大军 | Preparation method of toadstool mycelium powder |
| CN105288226A (en) * | 2014-07-15 | 2016-02-03 | 及长城 | Kidney-invigorating and yang-strengthening composition and preparation method thereof |
| CN107223955A (en) * | 2017-06-29 | 2017-10-03 | 四川埕禧循环农业开发有限公司 | Possesses bacterium paddy nutrient powder of nourishing the stomach anti-tumor function and preparation method thereof |
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