CN1744927B - 用于eeg/meg和ecg/mcg的联机的源再现 - Google Patents
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Abstract
在一个实施例中,本发明包括一套EEG系统,该系统包含了用于从患者身上收集电磁信号的传感器,一套信号处理系统,一套计算机系统。配置计算机系统以支持多线程执行。计算机系统激发第一个线程——测量模块。在这个模块中,数据被过滤并在某些情况下被平均。一般的,这些数据在一个特定的潜伏周期中被过滤。一旦这些数据被过滤和平均,这些结果就传入第二个线程——源再现模块。在这个模块中,过程继续进行并为该试验产生源再现。然后,测试模块从一个新试验中获得并处理新的电磁数据同时从最近的试验进行源再现。
Description
技术领域
概括来说,本发明涉及信息源成像领域。更明确一点说,该发明涉及为连续需求的电磁信号实现联机源再现。
背景技术
研究人员和医生总是设法使电磁活动源定位于神经中枢或者心脏组织上以便诊断疾病或者确定行为模式。源再现过程通常用于局部化这种电磁活动。这个过程一般包括通过脑电图(EEG)、脑磁图(MEG)、心电图(ECG)、心磁图(MCG)等各种不同的形式从病人的神经中枢或者心脏组织中收集电磁信号。然后这些数据被存储并传送至一台用于执行信号源再现的独立的计算机系统中。
这种已知的执行源再现的方法的一个缺点是它不能提供被记录的电磁信号的质量的指示。确定电磁行为源包括有许多变量。测试装置引起的错误或者差的信噪比会对源信号再现产生重大影响。所需的电磁信号数据的瑕疵会阻止一个令人满意的源再现,这就需要患者的重新测试。重复测试会增加手续费用同时也使病人很烦累。
因此,在本技术领域需要一种测试所需的电磁信号数据的方法并且该方法能够得到相对可靠的源再现。
发明概述
本发明是一种执行联机源再现的方法和装置,其中一个电磁信号获取后,马上就会经历源再现。
在一个实施例中,本发明包括一套EEG系统,该系统包含了用于从患者身上收集电磁信号的传感器,一套信号处理系统,一套计算机系统。配置计算机系统的目的在于支持多线程执行。
在一个实施例中,EEG/MMG传感器需要从患者处得到一个电磁信号并且将该信号传输至信号处理系统。采用已知的方法,该信号被过滤、放大和数字化处理进入数据包然后被计算机系统接收。
在一个实施例中,计算机系统激发第一个线程——测量模块。在这个模块中,数据被过滤并在某些情况下被平均。一般的,这些数据在一个特定的潜伏周期(latency period)中被过滤。一旦这些数据被过滤和平均,这些结果就传入第二个线程——源再现模块。在这个模块中,过程继续进行并为该试验产生源再现。然后,测试模块从一个新试验中获得并处理新的电磁数据同时产生新的源再现。
在一个实施例中,一个反馈电路与获取电磁数据的测量装置相联系。当一个特定的稳定标准达到后,该反馈电路会控制获取过程的参数或者终止测试过程。采用从源再现中获取的结果,该测试装置能够被调整使得获得的电磁信号的质量得到提高。
附图说明
基于推动和了解这一寻求保护的主题的目的,附图给出了它们的一个实施例的举例说明。从附图的校验可知,当它们与以下的描述联系时,该受到保护的主题、它的构建和操作以及许多有利条件应该容易理解和领会。
图1显示了带数字EEG系统的联机源再现的一个例子的流程图
图2偶极子分布的散布图的一个例子
具体实施方式
如图1所示,在一个实施例中,本发明集成进一个EEG系统10。运用EEG系统10的根本目的仅仅是为了解释。熟练的技术人员容易了解,本发明能轻易地适应于许多不同的应用,其中一个电磁信号的组织信号源是被确定的。
EEG系统10包含用来从患者处获取一个电磁信号的传感器12。一个用于过滤、放大和数字化处理电磁信号的信号处理系统14。一个计算机系统16包括内存存储器和一个或多个处理信号的处理器。计算机系统16用于支持多线程执行。多个执行线程代表指令的一个信号序列与其他序列被平行的执行,也可能被时间分割或多重处理。与多重任务处理相反,多重线程能够在互相的线程之间直接共享消息、内存和其他资源。而多重任务处理基本上是独立于处理过程运行的。
在一个实施例中,通过一个测试装置获取了一个生理学电磁信号。该测试装置包含一个复杂传感器和一个信号处理系统。EEG/MEG传感器12从患者身上获取一个电磁学信号并且将该信号传输至信号处理系统14。采用已知的方法,该信号被过滤、放大并且被数字化处理成数据包后被计算机系统16所接收。
在一个实施例中,测量到并被数字化处理后的数据在两个集成线程之间进行共享。一个线程包含一个源再现模块18,其中数据被应用于确定源组织的位置,同时形成了一个源组织的图像表示。一个兼容的源再生模块的例子是Neuroscan的软件包。第二条线程包含一个测量软件模块16,它可以用于分析、过滤及测绘、图示出所获得的信号。一个兼容的测量软件模块是Neuroscan的软件包。
在一个实施例中,获取的电磁数据最初进入测量模块16中过滤以及某些情况下求平均。一般的,这些数据在一个特定的潜伏周期中被过滤,而该潜伏周期依赖于所进行的测试的类型。体觉诱发电势(SEPs)的一个信号出现时间或者测试长度为1秒量级。该例子的采样速率为1kHz量级(1ms采样时间)。一旦数据被过滤和平均,其结果被传至信息源再现模块18,然后生成该次实验的源再现。然后测量模块16从一个新试验中获得并处理新的电磁数据,同时对最近的实验产生源再现。
在本领域,有很多已知的能够完成源再现的方法。一般的源再现包括确定电磁行为的类型(如信号的单等价电流偶极子(ECD),移动偶极子,固定偶极子或者地域性偶极子),和创造一个模型。该模型尝试通过描述电磁活动性的电磁场分布的数学公式来确定活动性信号源。一般地,这些模型依赖于信号源的位置和方向、传感器的位置和方向,通过这些位置和方向可以获得电磁信号以及体导体(头,胸腔)组织的几何学和传导特性。在本领域,有几种已知的模型,包括三同心球,边界元方法(BEM),有限元方法(FEM)体导体模型。
由于本底活动性、环境的和放大器的噪声,测量的数据表现出有限的信噪比(SNR)。数据的噪声分布导致在最有可能的信号源位置的周围的信号源空间中的散布的偶极子分布。同样的,再现的偶极子仅仅代表着最有可能的信号源位置。
由于单个运动偶极子的源再现(采用信号源V2)在现有水平的PC(~2GHz)上需要花3ms左右的时间,因此在某一潜伏期(如用于手指或手模拟的20ms刺激后)内运用联机源再现,相对于源再现或稳定性的数据的质量或信噪比能被联机实时检查。在各个测量时间点或试验后,在数据得到平均后,完整的测量或者信号源定位包(SCAN或SOURCE)在一个或数个预先挑选的潜伏期内能够再现偶极子。在某些实例中,需要进行数百甚至数千次的平均以便提高测量的信噪比。由于增强的计算性能、优化的算法以及软件体系(线程),对脑电图/心电图和/或脑磁图/心磁图的联机源再现变得可能了。
除了源再现,源再现模块可能还包括测试信号尖峰探测/事件计数22,信噪比分析24以及覆盖解剖学数据结果26,如图2所示。在一个实施例中,源再现模块首先完成一个事件探测(如探测癫痫性尖峰)或者某一些平均值(如为功能性映射的诱发电位)和/或者信噪比分析。然后源再现功能被唤起,并显示结果(如等价电流的偶极子,或者是对解剖学图像数据的覆盖)。还可以增加可选的结果分析(如癫痫性信号尖峰的簇分析(cluster analysis)28或者功能性映射结果的置信度分析)。
由于不能进行测量数据的平均,癫痫性信号尖峰再现过程是很困难的。普遍的抽样速率是200Hz(5ms)的量级。对于一个具有如上所述的优点的预先选定的周期/范围,在自动尖峰探测/正在进行的脑电图的阈值之后,偶极子就能被联机再现(为了避免数据损失,源再现在采集/再现包中是作为独立的、低周期的线程被执行的),并且使得加速和增强癫痫性病灶定位/诊断变成了可能。
在一个实施例中,反馈电路30与获取电磁数据的测量装备相连通。该反馈电路在一个特定的稳定性准则或者信噪比满足后可以控制获取过程的参数或者中断测量过程。由于它能对测量装置和数据质量以及对象/患者条件提供快速的反馈,联机源再现增强了数字(如神经生理学的)测量的可能性以及为数字测量增加了数值。采用偶极子位置的置信椭圆或者散布图,由于信噪比的增加而引起的信号源位置稳定性的增加在测试过程中就能被监控从而系统组织/结构错误就能被直接找到。
前面所阐述的内容及其插图仅仅是为了举例说明,并非是一个限制。当一个特殊的实施例如前面所述地进行时,很明显,本领域地技术人员可以从该申请的贡献的更宽泛的方面来对其进行改变和修正。当基于现有技术对它们的适当方面进行考察时,寻求保护的真正范围由下面的权利要求所定义。
Claims (20)
1.一种用于获取和分析来自对象的电磁生理学信号的源的方法,包括以下步骤:
通过传感器获取第一电磁生理学信号;
通过处理器对一个潜伏范围过滤该信号;
通过处理器对该信号进行源再现,进行源再现的步骤包括:在每一测量时间点或试验后在一个或数个预定潜伏期上再现偶极子;
通过与所述传感器相联的反馈电路控制获取过程的参数;以及
在通过处理器对第一电磁生理学信号进行源再现的同时通过传感器获取第二电磁生理学信号,用于对所述第二电磁生理学信号进行源再现。
2.根据权利要求1的方法,其中再现偶极子的步骤包括计算一个单等价电流偶极子。
3.根据权利要求1的方法,其中再现偶极子的步骤包括计算一个移动的偶极子。
4.根据权利要求1的方法,其中再现偶极子的步骤包括计算一个旋转的偶极子。
5.根据权利要求1的方法,其中再现偶极子的步骤包括计算一个地域性偶极子。
6.根据权利要求1的方法,其中再现偶极子的步骤包括计算一个固定偶极子。
7.根据权利要求1的方法,其中再现偶极子的步骤包括使用一个同心球体导体模型。
8.根据权利要求1的方法,其中再现偶极子的步骤包括使用一种边界元方法体导体模型。
9.根据权利要求1的方法,其中再现偶极子的步骤包括使用一种有限元方法模型。
10.根据权利要求1的方法,进一步包含通过处理器平均已过滤的数据的步骤。
11.根据权利要求1的方法,进一步包含通过处理器将一个偶极子应用到解剖学图像上的步骤。
12.根据权利要求1-11中任一项的方法,进一步包含通过处理器产生一个偶极子定位的散布图。
13.根据权利要求1的方法,进一步包含通过处理器对所获取的神经生理学数据进行信噪分析。
14.一种用于获取和分析来自对象的电磁生理学信号的源的装置,包括:
获取电磁生理学信号的传感器;
与传感器相连的信号处理电路;
与传感器相连的反馈电路,用于控制获取过程的参数;以及
一个与该信号处理电路相连的处理器,该处理器配置为支持多个并行的信号处理序列,其中一个信号处理序列作为测量模块,而第二信号处理序列作为源再现模块,该源再现模块在每一测量时间点或试验后在一个或数个预定潜伏期上再现偶极子。
15.根据权利要求14的装置,进一步包括一个显示覆盖解剖学数据上的源再现结果的显示设备。
16.根据权利要求14的装置,其中所述传感器获取MEG数据。
17.根据权利要求14的装置,其中所述传感器获取EEG数据。
18.根据权利要求14的装置,其中所述传感器获取ECG数据。
19.根据权利要求14的装置,其中所述传感器获取MCG数据。
20.一种用于电磁生理学信号源识别的测试方法,包括以下步骤:
通过传感器获取经过测试装置的第一电磁生理学信号;
通过信号处理系统对所述第一电磁生理学信号数字化;
通过处理器确定所述信号的潜伏期;
通过传感器在预定的潜伏期范围内进行数字化的第一电磁生理学信号的源再现,进行源再现的步骤包括:在每一测量时间点或试验后在一个或数个预定潜伏期上再现偶极子;以及
在通过处理器运用所述源再现来修改所述测试装置的同时通过传感器获取第二电磁生理学信号,用于对所述第二电磁生理学信号进行源再现,其中运用所述源再现来修改所述测试装置利用与传感器相连的反馈电路控制对第一电磁生理学信号的获取过程的参数。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US44323403P | 2003-01-27 | 2003-01-27 | |
US60/443,234 | 2003-01-27 | ||
PCT/US2004/002392 WO2004068313A2 (en) | 2003-01-27 | 2004-01-27 | Online source reconstruction for eeg/meg and ecg/mcg |
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Publication Number | Publication Date |
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CN1744927A CN1744927A (zh) | 2006-03-08 |
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