CN1739628A - Medicine for raising sexual life quality of middle eged people and old people and its prepn - Google Patents
Medicine for raising sexual life quality of middle eged people and old people and its prepn Download PDFInfo
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- CN1739628A CN1739628A CNA2004100466987A CN200410046698A CN1739628A CN 1739628 A CN1739628 A CN 1739628A CN A2004100466987 A CNA2004100466987 A CN A2004100466987A CN 200410046698 A CN200410046698 A CN 200410046698A CN 1739628 A CN1739628 A CN 1739628A
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Abstract
The present invention relates to one kind of medicine for raising sexual life quality of middle aged people and old people and its preparation process. The medicine consists of desert cistanche extract, cynomorium extract, male silkworm moth extract, cedifil citrate and pentoxifylline, and is prepared through extracting effective components with cistanche, cynomorium and male silkworm moth; mixing the effective components with cedifil citrate, pentoxifylline and supplementary material; and further treatment to form different preparation forms. The present invention combines the advantages of Chinese medicine with less side effects and Western medicine with fast effect and provides male middle aged people and old people with one kind of kidney invigorating and Yang strengthening medicine.
Description
Technical field
The present invention relates to a kind of raising people life quality medicine, in particularly a kind of raising, the medicine of old people's life quality and the preparation method of this medicine.
Carry on the back technology
People in middle age, the various physiological metabolisms of human body begin tangible decline, be subjected to that it influences be in, the elder's health male's decline is at first from sexual function.The principal character of its decline has that hyposexuality, no libido sense, penis dwindle, penis erectile problem or act be not and hard, and the heart is had a surplus and kidney deficiency, collapse behind night sweat or the sexual life before sexual impotence premature ejaculation, seminal emission, the property, tired, asthma or the like.
Medical research thinks that property and sexual life are the first elements of human breeding, healthy sexual life, and not only the heart, the intelligence to human body is useful, and also has antidotal effect.Normal sexual life is the tie that maintains the happy emotion of couple, also is the source of the power of family's combination, is the human important component part of pursuing high-quality life.In, old people is that the youth has been contributed in family, society and child-rearing, also realizes the wonderful interest of sexual life deeply.Yet along with the growth at age, body function is irresistible to fail naturally, gives in numerous health again, the old people has brought sorry.If in the health, the old people can not cross normal sexual life, perhaps life quality is not high, all will have influence on the harmony and the goodwill as between spouses of family, can occur the damaging dysfunction syndrome of non-organic simultaneously, continue development and will have influence on body and mind and the noema's health of oneself.Therefore, how effectively to improve in the health, quality of life of old people, become one of direction of current scientific research.
At present in the health, the treatment of elderly men sexual function, the dialectical therapies of multiclass such as the traditional Chinese medical science is used wet kidney and enhancing body, enriching yin and nourishing kidney, kidney tonifying, essence replenishing, reinforcing the kindey to control nocturnal emission, restoring normal coordination between the heart and kidney, ridging to grow the source, transferred the spleen reinforcing kidney, soothing the liver cold expelling, outer QI and blood regulating, activating blood circulation to dissipate blood stasis, clearing away heat-damp and promoting diuresis, the strange footpath of the kidney invigorating and inner disease outer treat.Its diagnosis is numerous and diverse, and medicine time is long, it is slow to take effect, and makes many medication treatment persons, often loses patience, abandoning cure.Doctor trained in Western medicine adopts the hormonal supplementation method, as injection hormone, testosterone or doping, as papaverine, the stupid propylamine of methyl, yohimbine etc., this class medicine instant effect, but toxic and side effects is big, and life-time service easily causes other diseases, as: coronary heart disease, hypertension, nephritis, diabetes and cancer etc.
To in the health, the treatment of the sexual disorder of elderly men non-organic damage, along with the appearance of viagra (Viagra) medicine, during scientist just clearly recognizes, the true cause of elderly men sexual disorder.People in middle age,, can secrete the chemical constituent of a kind of PDE (biphosphate esterase) in the males along with the growth at age.Excessive PDE can suppress the healthy male body and discharge NO (nitric oxide), NO is the courier of transitivity signal, it is the important component that promotes body secretion CGMP (cyclic guanylic acid), CGMP is the vasodilation of control male penis, allow blood flow into cavernous body of penis, from but the composition of erection (strong).The PDE chemical constituent not only suppresses in the health, old body discharges NO, but also have with in, already present CGMP chemical constituent is degraded into 5 '-GMP (5 '-guanyl) in the old body, 5 '-GMP be cause atrophy of penis, diminish, do not erect, the chemical constituent of soft and hard, sexual impotence, premature ejaculation.Scientific research shows, in the health, old people male's sexual function is not only the shortage gonadal hormone, but and the excessive secretion of PDE chemical constituent substantial connection is arranged.Viagra is not a gonadal hormone, do not participate in intravital normal hormone metabolism, and its mechanism of action is: suppress in the health, the PDE chemical constituent of elderly men excessive secretion, allow take in Viagra normal, elderly men is in the thought of libido, automatically discharge NO courier in the control agent, in sexual sight, promote the secretion of CGMP composition, thereby it is in having realized getting well effectively, fast, the sexual function of elderly men, satisfactory for result.Just as medical circle praise like that, the discovery of Viagra is the twentieth century study of pharmacy in the whole world health, elderly men improves the greatest Gospel of life quality.Yet headache, erythra after being extensive use of Viagra, can occur, feel sick, phenomenons such as nasal obstruction, vision disorder, also have that part has a heart disease, hypertensive male, take Viagra after, the sudden death phenomenon appears in sexual life.These shortcomings, limited Viagra centering, elderly men sexual function improvement and quality of life the aspect popularization and application.
Summary of the invention
One of purpose of the present invention is the mechanism of action according to Viagra, from natural plants, biology, seek, screen, extract the active chemical components of similar Viagra, again with the significant chemical compound of known active component, scientific and reasonable compatibility, make the stronger inhibition PDE excessive secretion of a kind of selectivity, promote NO to discharge, secrete effective CGMP, thereby realize in the health, the medicine of the restorative function of elderly men.
Two of the object of the invention provides the preparation method of this medicine.
One of the object of the invention realizes by following technical measures: in a kind of improve, the medicine of old people's life quality, it is characterized in that including the active constituents of medicine of following percentage by weight:
1.0-1.3% contains the Herba Cistanches extract of cistanche alkaloid 70-90%;
2.0-2.7% contains the Herba Cynomorii extract of the total plain 60-80% of Herba Cynomorii;
1.0-1.5% accounts for the 1.0-1.5% male Bombycis mori extract of crude drug;
The sildenafil citrate of 0.5-1.0% content 〉=99%;
The pentoxifylline of 0.3-0.5% content 〉=99%;
Surplus is a carrier.
Two of the object of the invention realizes by following technical measures: in a kind of the raising, the preparation method of the medicine of old people's life quality, it is characterized in that including following steps:
1, the extraction of Herba Cistanches extract: get the Herba Cistanches dry product, pulverize the back and heat with 80% ethanol, reflux, extract,, each time 2-3 hour, filter extracting solution then, so repeat 3 times; After the extracting solution merging, be decompressed to the 2.5Pa recovered alcohol to the extractum shape; Extractum is dissolved in the deionized water, with D201 type resin treatment, collect 70% ethanol eluent, be decompressed to 2.5Pa recovered alcohol 1/5 o'clock to nothing alcohol flavor and surplus original volume, add deionized water, after treating its dissolving, use ethyl acetate extraction, temperature is 25-30 ℃, so extraction is 5 times, combining extraction liquid is decompressed to 3.0Pa and reclaims ethyl acetate, gets extract powder, use the boschniakine standard substance, survey its extractum total alkaloid content at high-pressure liquid phase HPLC, when its content is 70-90%, be required Herba Cistanches extract;
2, the extraction of Herba Cynomorii extract: get the Herba Cynomorii dry product, pulverizing is back with 80% ethanol heating and refluxing extraction, and each time 2-3 hour, filter extracting solution then, so repeat 3 times; Extracting solution is merged, when being decompressed to the 2.5Pa recovered alcohol to nothing alcohol flavor, mix a small amount of silica gel, after the oven dry, separate with 120 order silicagel columns, collect acetone treatment liquid, getting extract powder, is standard substance with the Herba Cynomorii element, surveys its extractum total chromones content at high-pressure liquid phase HPLC, when its content is 60-80%, be required Herba Cynomorii extract;
3, the extraction of male Bombycis mori extract: get the bright product of male Bombycis mori, with 80% alcohol-pickled, temperature is 60-80 ℃, and the time is each 24 hours, filters ethanol liquid then, so repeats 5 times, and merging ethanol liquid is decompressed to the 2.5Pa recovered alcohol to the extractum shape; With Bombycis mori family planning medicine, when extract accounts for the 1-1.5% of crude drug total amount, be required male Bombycis mori extract;
4, according to the above ratio, Herba Cistanches extract, Herba Cynomorii extract, male Bombycis mori extract, sildenafil citrate, pentoxifylline are mixed and add adjuvant routinely pharmaceutical technology make capsule formulation, oral liquid formulation, tablet, electuary, medicated wine respectively.
The Herba Cistanches that uses among the present invention (Cistanche deserticola) is the medicinal herbs most in use of traditional Chinese medical science kidney invigorating and YANG supporting, the application experience in existing hundreds of years.The distinctive extraction and the separation method that use among the present invention, obtain the alkaloid that Herba Cistanches contains, through pharmaceutical research, confirm the effect that the Herba Cistanches total alkali has significant resisting fatigue and improves blood supply of cardiac muscle mice, having increases the go down to posterity effect of algebraically of fruit bat, enhancing immunity is arranged and promote the effect of mice number of copulations.In combination of the present invention, the Herba Cistanches total alkali has the drug effect of promoting known activity composition sildenafil citrate, can reduce the side reaction of pentoxifylline.
The Herba Cynomorii of using among the present invention (Cynomorium songaricum) is the rare medicinal herbs of traditional Chinese medical science kidney invigorating and YANG supporting.The present invention extracts the total Herba Cynomorii element of distinctive composition from Herba Cynomorii, confirm that through pharmaceutical research it has remarkable oxygen lack resistant function, and the effect that strengthens mice vigor and number of copulations is arranged.In the present invention, the total element of Herba Cynomorii cooperatively interacts with boschniakine, has strengthened known activity composition sildenafil citrate and pentoxifylline drug effect, has reduced the influence of known activity composition to heart and blood pressure significantly.
The known activity composition sildenafil citrate that uses among the present invention is the sure non-hormone of curative effect, the composition of sexual function improvement, but, limited its use because of its side effect.The pentoxifylline that uses among the present invention is the composition of prevention sexual impotence, premature ejaculation, but because of toxic and side effects is big, has limited being extensive use of of it.In the present invention, total element of boschniakine, Herba Cynomorii that natural extract is gone out and male Bombycis mori extract and known activity composition sildenafil citrate, pentoxifylline cooperatively interact, improved the advantage of former composition separately significantly, also reduced simultaneously the shortcoming of known activity composition significantly, improve drug effect, increased the safety of known activity composition.Natural constituent and known activity composition are cooperatively interacted, having drawn original separately advantage, remedied original separately shortcoming, is a kind of safe, comparatively ideal, can allow in the health, elderly men extensively popularizes and to use, can be significantly, sexual function improvement and the medicine of quality of life fast.
The specific embodiment
In a kind of improve, the medicine of old people's life quality, include the active constituents of medicine of following percentage by weight:
1.0-1.3% contains the Herba Cistanches extract of cistanche alkaloid 70-90%;
2.0-2.7% contains the Herba Cynomorii extract of the total plain 60-80% of Herba Cynomorii;
1.0-1.5% accounts for the 1.0-1.5% male Bombycis mori extract of crude drug;
The sildenafil citrate of 0.5-1.0% content 〉=99%;
The pentoxifylline of 0.3-0.5% content 〉=99%;
Surplus is a carrier.
Manufacturing method for above mentioned medicine includes following steps:
1, the extraction of Herba Cistanches extract: get Herba Cistanches dry product 500g, pulverize the back and in water-bath, heat with 80% ethanol 2500ml, reflux, extract,, each time 2-3 hour, filter extracting solution with the Bu Shi pan then, so repeat 3 times; After 3 extracting solution merging, be decompressed to the 2.5Pa recovered alcohol to the extractum shape; Extractum is dissolved in the 1000ml deionized water, with D201 type resin treatment, use earlier the deionized water eluting, collect 70% ethanol eluent 1500ml then, be decompressed to the 2.5Pa recovered alcohol when not having 1/5 (300ml) of alcohol flavor and surplus original volume, add the 200ml deionized water, stir evenly treat its dissolving after, use the 300ml ethyl acetate extraction, temperature is 25-30 ℃, so extracts 5 times, the ethyl acetate of extract is merged, be decompressed to 3.0Pa and reclaim ethyl acetate, get extract powder, yield 0.5-0.8%, use the boschniakine standard substance, survey its extractum total alkaloid content at high-pressure liquid phase HPLC, when its content is 70-90%, be required Herba Cistanches extract;
2, the extraction of Herba Cynomorii extract: get Herba Cynomorii dry product 500g, pulverize the back with 80% ethanol 2500ml heating and refluxing extraction, each time 2-3 hour, be preferably 2 hours, with Bu Shi pan filtration extracting solution, so repeat 3 times then; 3 extracting solution are merged, when being decompressed to the 2.5Pa recovered alcohol (250ml), mix 100g80 order silica gel to nothing alcohol flavor, after the oven dry, separate, earlier with petroleum ether, chloroform defat with 120 order silica gel 1500g posts, collect acetone then, after reclaiming solvent, get extract powder, yield 0.7-1%, with the Herba Cynomorii element is standard substance, survey its extractum total chromones content at high-pressure liquid phase HPLC, when its content is 60-80%, be required Herba Cynomorii extract;
3, the extraction of male Bombycis mori extract: get male Bombycis mori 500g (bright product), soak with 80% ethanol 3000ml, temperature is 60-80 ℃, time is each 24 hours, filters ethanol liquid then, so repeats 5 times, merge alcohol-pickled liquid, be decompressed to the 2.5pa recovered alcohol to the extractum shape; With the Bombycis mori gross weight is crude drug, and extract yield 1-1.5% promptly accounts for the 1-1.5% of crude drug total amount, is required male Bombycis mori extract;
4, according to the above ratio, Herba Cistanches extract, Herba Cynomorii extract, male Bombycis mori extract, sildenafil citrate, pentoxifylline are mixed and add adjuvant routinely pharmaceutical technology make capsule formulation, oral liquid formulation, tablet, electuary, medicated wine respectively.
By screening, can filter out the proportioning of following four kinds of the bests to above-mentioned five kinds of active constituents of medicine:
1, prescription one:
Herba Cistanches extract consumption 1.3%;
Herba Cynomorii extract consumption 2.7%;
Male Bombycis mori extract consumption 1.0%
Sildenafil citrate consumption 0.5%;
Pentoxifylline consumption 0.3%;
The surplus adjuvant.
2, prescription two:
Herba Cistanches extract consumption 1.1%;
Herba Cynomorii extract consumption 2.3%;
Male Bombycis mori extract consumption 1.5%
Sildenafil citrate consumption 0.75%;
Pentoxifylline consumption 0.4%;
The surplus adjuvant.
3, prescription three:
Herba Cistanches extract consumption 1.0%;
Herba Cynomorii extract consumption 2.0%;
Male Bombycis mori extract consumption 1.0%
Sildenafil citrate consumption 1.0%;
Pentoxifylline consumption 0.5%;
The surplus adjuvant.
4, prescription four:
Herba Cistanches extract consumption 1.0%;
Herba Cynomorii extract consumption 2.0%;
Male Bombycis mori extract consumption 1.0%
Sildenafil citrate consumption 0.75%;
Pentoxifylline consumption 0.4%;
The surplus adjuvant.
Preparation below by various dosage forms specifies embodiment of the present invention.
One, the preparation of oral liquid
Example 1: get Herba Cistanches extract 10g, Herba Cynomorii extract 20g, male Bombycis mori extract 10g, sildenafil citrate 10g, pentoxifylline 5g, be dissolved into respectively in the 1000ml distilled water, heated and stirred (boiling), add xylitol 5g, protein sugar 3g, glucide 3g, sucrose 150g, sodium benzoate 15g, after treating its whole dissolvings, filter, be filled in the oral liquid bottle of 10ml * 100, sterilization treatment, after carrying out health examination and quality standard passed examination by the oral liquid standard, be oral liquid product of the present invention.Using method: each 1, preceding 1 hour clothes of sexual life.
Example 2: get Herba Cistanches extract 100g, Herba Cynomorii extract 200g, male Bombycis mori extract 100g, sildenafil citrate 75g, pentoxifylline 40g, be dissolved into respectively in the 10000ml distilled water, heated and stirred (boiling), add sucrose 500g, essence is an amount of, protein sugar 5g, stupid sodium formate 150g, after treating its whole dissolvings, filter, be filled in the oral liquid bottle of 10ml * 100, sterilization treatment, after carrying out health examination and quality standard passed examination by the oral liquid standard, be oral liquid product of the present invention.Using method is the same.
Two, the preparation of medicated wine
Example 3: get Herba Cistanches extract 1.3g, Herba Cynomorii extract 2.7g, male Bombycis mori extract 1.0g, sildenafil citrate 0.5g, pentoxifylline 0.3g, be dissolved into respectively in the 1000ml Chinese liquor (38 degree), heating allows its whole dissolvings, add tea polyphenols 3g, an amount of essence, dissolving after-filtration, be filled in 100ml * 10 bottle, by 38 the degree wine requirements carry out health examination and quality standard passed examination after, be minuent of the present invention, the health care medicated wine, the same oral liquid of using method.
Example 4: get Herba Cistanches extract 10g, Herba Cynomorii extract 20g, male Bombycis mori extract 10g, sildenafil citrate 7.5g, pentoxifylline 4g, be dissolved in the 5000ml wine respectively or in the fruit wine, be heated to the 30-50 degree, treat its whole dissolvings, it is an amount of to add essence, after the filtration, is filled in 100ml * 100 bottle, after carrying out health examination and quality standard passed examination by the requirement of wine or fruit wine, be health wine of the present invention or fruit wine.The same oral liquid of using method.
Three, the preparation of capsule preparations
Example 5, get Herba Cistanches extract 10g, Herba Cynomorii extract 20g, male Bombycis mori extract 10g, sildenafil citrate 10g, pentoxifylline 5.0g, sneak into respectively in the 20g starch, behind the mix homogeneously, sterilization directly pours into (750mg/ grain) in 0# capsule * 100 capsules.Press capsule hygiology and gastric-dissolved capsule quality standard and check, qualified after, be capsule product of the present invention.The same oral liquid of instructions of taking.
Example 6, get Herba Cistanches extract 100g, Herba Cynomorii extract 200g, male Bombycis mori extract 100g, sildenafil citrate 75g, pentoxifylline 40g, be blended into respectively in 150g starch and the 50g dextrin, behind the mix homogeneously, stir and granulate, after crossing 60 mesh sieves, sterilization directly pours into (700mg/ grain) in 1# capsule * 1000 capsules.Press capsule hygiology and gastric-dissolved capsule quality standard and check, qualified after, be capsule product of the present invention.The same oral liquid of instructions of taking.
Four, the preparation of tablet
Example 7: get Herba Cistanches extract 110g, Herba Cynomorii extract 230g, male Bombycis mori extract 150g, sildenafil citrate 75g, pentoxifylline 40g, sneak into 300g starch, 100g dextrin, 30g magnesium stearate, 50gVc, 20g calcium hydrogen phosphate respectively, behind the mix homogeneously, the system granule, cross the 60-80 mesh sieve, tablet hygiology and quality standard inspection are pressed in tabletting 1000mg/ sheet * 1000 slice then, are tablet product of the present invention after qualified.The same oral liquid of instructions of taking.
Example 8, get Herba Cistanches extract 100g, Herba Cynomorii extract 200g, male Bombycis mori extract 100g, sildenafil citrate 100g, pentoxifylline 50g, sneak into 300g starch, 150g dextrin, 30g magnesium stearate, 20g calcium hydrogen phosphate respectively, behind the mix homogeneously, the system granule, cross the 60-80 mesh sieve, after the pressurization of tabletting 1000mg/ sheet * 1000, enter film coating then, press diaphragm hygiology and quality standard inspection, be tablet product of the present invention after qualified.The same oral liquid of instructions of taking.
Five, the preparation of granule
Example 9, get Herba Cistanches extract 130g, Herba Cynomorii extract 270g, male Bombycis mori extract 100g, sildenafil citrate 50g, pentoxifylline 30g, it is an amount of to be blended into 4000g starch, 3000g dextrin, 500g sodium bicarbonate, 100gVc, 200g protein sugar, 1500g sucrose, 20g glucide, 100g tea polyphenols, essence respectively, mix homogeneously, add entry system granule, cross the 40-60 mesh sieve, then by every bag of 5g amount fill * 1000 bag, press electuary hygiology and quality standard inspection, be electuary product of the present invention after qualified.The same oral liquid of instructions of taking.
Claims (8)
1, in a kind of improve, the medicine of old people's life quality, its feature includes the active constituents of medicine of following percentage by weight:
1.0-1.3% contains the Herba Cistanches extract of cistanche alkaloid 70-90%;
2.0-2.7% contains the Herba Cynomorii extract of the total plain 60-80% of Herba Cynomorii;
1.0-1.5% accounts for the 1.0-1.5% male Bombycis mori extract of crude drug;
The sildenafil citrate of 0.5-1.0% content 〉=99%;
The pentoxifylline of 0.3-0.5% content 〉=99%;
Surplus is a carrier.
2, in a kind of improve according to claim 1, the medicine of old people's life quality, it is the active constituents of medicine that includes following percentage by weight that its feature is filled a prescription preferably:
1.0% contains the Herba Cistanches extract of cistanche alkaloid 70-90%;
2.0% contains the Herba Cynomorii extract of the total plain 60-80% of Herba Cynomorii;
1.0% accounts for the 1.0-1.5% male Bombycis mori extract of crude drug;
The sildenafil citrate of 0.75% content 〉=99%;
The pentoxifylline of 0.4% content 〉=99%;
Surplus is a carrier.
3, in a kind of improve according to claim 1, the medicine of old people's life quality, the described medicine of its feature can be made capsule formulation.
4, in a kind of improve according to claim 1, the medicine of old people's life quality, the described medicine of its feature can be made oral liquid formulation.
5, in a kind of improve according to claim 1, the medicine of old people's life quality, the described medicine of its feature can be made tablet.
6, in a kind of improve according to claim 1, the medicine of old people's life quality, the described medicine of its feature can be made electuary.
7, in a kind of improve according to claim 1, the medicine of old people's life quality, the described medicine of its feature can be made medicated wine.
8, a kind ofly prepare in described a kind of improve of claim 1, the pharmaceutical methods of old people's life quality, it is characterized in that including following steps:
(1), the extraction of Herba Cistanches extract: get the Herba Cistanches dry product, pulverize the back with the heating of 80% ethanol, reflux, extract,, time 2-3 hour at every turn, filter extracting solution then, so repeat 3 times; After the extracting solution merging, be decompressed to the 2.5Pa recovered alcohol to the extractum shape; Extractum is dissolved in the deionized water, with D201 type resin treatment, collect 70% ethanol eluent, be decompressed to 2.5Pa recovered alcohol 1/5 o'clock to nothing alcohol flavor and surplus original volume, add deionized water, after treating its dissolving, use ethyl acetate extraction, temperature is 25-30 ℃, so extraction is 5 times, combining extraction liquid is decompressed to 3.0Pa and reclaims ethyl acetate, gets extract powder, use the boschniakine standard substance, survey its extractum total alkaloid content at high-pressure liquid phase HPLC, when its content is 70-90%, be required Herba Cistanches extract;
(2), the extraction of Herba Cynomorii extract: get the Herba Cynomorii dry product, pulverize the back with 80% ethanol heating and refluxing extraction, time 2-3 hour at every turn, filter extracting solution then, so repeat 3 times; Extracting solution is merged, when being decompressed to the 2.5Pa recovered alcohol to nothing alcohol flavor, mix a small amount of silica gel, after the oven dry, separate with 120 order silicagel columns, collect acetone treatment liquid, getting extract powder, is standard substance with the Herba Cynomorii element, surveys its extractum total chromones content at high-pressure liquid phase HPLC, when its content is 60-80%, be the Herba Cynomorii extract that the present invention uses;
(3), the extraction of male Bombycis mori extract: get the bright product of male Bombycis mori, with 80% alcohol-pickled, temperature is 60-80 ℃, and the time is each 24 hours, filters ethanol liquid then, so repeats 5 times, and merging ethanol liquid is decompressed to the 2.5Pa recovered alcohol to the extractum shape; With Bombycis mori family planning medicine, when extract accounts for the 1-1.5% of crude drug total amount, be the male Bombycis mori extract that the present invention uses;
(4), in proportion Herba Cistanches extract, Herba Cynomorii extract, male Bombycis mori extract, sildenafil citrate, pentoxifylline are mixed and add adjuvant routinely pharmaceutical technology make various dosage forms respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100466987A CN1739628A (en) | 2004-08-23 | 2004-08-23 | Medicine for raising sexual life quality of middle eged people and old people and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2004100466987A CN1739628A (en) | 2004-08-23 | 2004-08-23 | Medicine for raising sexual life quality of middle eged people and old people and its prepn |
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| CN1739628A true CN1739628A (en) | 2006-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2004100466987A Pending CN1739628A (en) | 2004-08-23 | 2004-08-23 | Medicine for raising sexual life quality of middle eged people and old people and its prepn |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010241798A (en) * | 2009-03-18 | 2010-10-28 | Daiichi Sankyo Healthcare Co Ltd | Sildenafil citrate-containing oral liquid formulation and vessel containing the liquid formulation |
-
2004
- 2004-08-23 CN CNA2004100466987A patent/CN1739628A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010241798A (en) * | 2009-03-18 | 2010-10-28 | Daiichi Sankyo Healthcare Co Ltd | Sildenafil citrate-containing oral liquid formulation and vessel containing the liquid formulation |
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