CN1724492A - Method of extracting jianiol from tobacco - Google Patents
Method of extracting jianiol from tobacco Download PDFInfo
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- CN1724492A CN1724492A CN 200510010172 CN200510010172A CN1724492A CN 1724492 A CN1724492 A CN 1724492A CN 200510010172 CN200510010172 CN 200510010172 CN 200510010172 A CN200510010172 A CN 200510010172A CN 1724492 A CN1724492 A CN 1724492A
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- tobacco
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- hydrocarbon solvent
- buddhist nun
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Abstract
Disclosed is a process for extracting solanesol from tobacco which comprises, using moldy cigarette with moisture percentage below 50%, minced cigarette or residue tobacco leaf after collection as raw material, return flow extracting with alcohol-containing solvent, obtaining extract liquid through filtration, charging hydrocarbon solvent and alkali into the extract for saponification reaction, isolating hydrocarbon solvent phase after end of reaction, then washing the hydrocarbon solvent phase with water and 80% ethanol in sequence, finally concentrating the extracted hydrocarbon solvent phase. The extracting process requires no drying procedure and less energy consumption, the saponification and abstraction can be completed simultaneously.
Description
Affiliated technical field:
The present invention relates to the natural product chemistry field, particularly relate to a kind of method of from tobacco, extracting eggplant Buddhist nun alcohol.
Background technology:
At industrial eggplant Buddhist nun alcohol is synthesizing coenzyme Q
10And vitamin K
2Essential raw material.Ubiquinone
10Be the natural antioxidants that cell self produces, the activator of cellular metabolism can improve organic immunizing power.Studies show that in recent years, ubiquinone
10Aspect the treatment cardiovascular disorder unique curative effect is being arranged, aspect treatment vitamin C deficiency, duodenal ulcer and stomach ulcer, gangrenosum acne periodontitis, the viral hepatitis significant curative effect is being arranged, the experimentation on animals result shows ubiquinone
10Having antitumor action is used to clinically cure and changes acute cancer patients late period certain curative effect, ubiquinone are arranged
10Tablet is used for the treatment of circular baldness effectively, and pulmonary emphysema also have certain curative effect to the treatment of dysacousis, and find more that recently it has significant auxiliary curative effect to acquired immune deficiency syndrome (AIDS).Therefore as ubiquinone
10Extraction, the purifying of eggplant Buddhist nun alcohol that must synthesis material also more and more cause people's attention.
The content of eggplant Buddhist nun alcohol in tobacco leaf was separated (J.Am.Chem.Soc., 1956,78,4780) by people such as R.L.Rowland and P.H.Latime the earliest from flue-cured tobacco in 1956 about about 0.5～3%.
Japanese Patent (clear 54-138510, clear 63-190840) having introduced with the tobacco leaf is raw material, make the extracting method of extraction solvent with normal hexane, by heated and stirred extracting 2～3 times, filter, concentrate and to make solanesol extract, obtain the product of higher degree again through saponification, liquid-liquid extraction, but this method exists shortcomings such as the raw material consumption amount is big, productive rate is low, cost height.
United States Patent (USP) (USP 3526669) has extracted eggplant Buddhist nun alcohol from the ight soil of mulberry leaf and silkworm, the main technique flow process is acetone extraction saponification, solvent extraction, subcooling (40 ℃) filtration, molecular distillation etc., and the lurid oily matter that obtains contains 10% the eggplant Buddhist nun alcohol of having an appointment.
Publication number is that the Chinese patent of CN1056486A and CN1087076A has been introduced the method that the mould cigarette of a kind of usefulness or broken offal prepare eggplant Buddhist nun alcohol, industrial normal hexane with 60～80% content is an extraction solvent, through twice extracting, concentrate the eggplant Buddhist nun alcohol that can obtain pasty state, purity can reach 20%.This method requires the water ratio of mould cigarette or offal about 2%, therefore must carry out drying treatment to raw material, and energy consumption is bigger.
Publication number is that the Chinese patent of CN1108641A has been introduced a kind of preparation method and equipment thereof that adopts the spraying and extracting method to extract eggplant Buddhist nun alcohol from tobacco.This method as extracting solvent, requires the water ratio of raw material to be not more than 2% with industrial normal hexane or No. 6 solvent oils, must carry out drying treatment to raw material, and energy consumption is bigger.
Publication number is the production method that the Chinese patent of CN1118775A has been introduced a kind of eggplant Buddhist nun alcohol, it will be interrupted extracting and change continuous extracting into, increase by twice settling process, tail gas and absorbed treating processes, but this method requires the water ratio of raw material to be not more than 2.1%, must carry out drying treatment to raw material, energy consumption is bigger.
Publication number is that the patent of CN1115751A has been introduced a kind of method of extracting eggplant Buddhist nun alcohol from the tobacco of extracting nicotine, will extract the tobacco oven dry of nicotine, pulverize, and be solvent extraction with the fat alkane of C5～C12.United extraction liquid is concentrated, and adds pure alkaline solution saponification.This method needs drying treatment, and energy consumption is big.
Publication number is that the patent of CN1400300A has been introduced a kind of molecular distillation and minor axis distillation technique, but this technology energy consumption is higher, and very limited to the concentration effect of eggplant Buddhist nun alcohol, and purity improves not obvious.
Publication number is that the patent of CN1294111A and CN1302568A uses supercritical liquid extraction technique to extract eggplant Buddhist nun alcohol, but this technology pollution is little, no solvent residue, but because the restriction of equipment manufacturing cost and safety in utilization is difficult to form industrially scalable.
In sum, the raw material that extracts eggplant Buddhist nun alcohol at present is dry tobacco leaf, extraction solvent mostly is industrial normal hexane or No. 6 organic solvents such as solvent, these class methods have following defective: do raw material with tobacco leaf, before extracting, need oven dry, this has not only increased cost, and a part of eggplant Buddhist nun alcohol is degraded; Because the extraction solvent consumption is big, and boiling point is low, is difficult for reclaiming, and causes solvent use cost height, and there is the problem of fire safety evaluating hidden danger and air severe contamination simultaneously near and product cost height.
Summary of the invention:
The object of the present invention is to provide a kind of method of from tobacco, extracting eggplant Buddhist nun alcohol.
In order to achieve the above object, the technical solution used in the present invention comprises: adopt mould cigarette, broken assorted offal or the harvesting residue tobacco leaf of water ratio below 50%, handle with containing the alcoholic solvent refluxing extraction without any drying process, filter extracting solution, extracting solution adds hydrocarbon solvent and alkali is made saponification reaction, reaction finishes to isolate the hydrocarbon solvent phase, more respectively water and 80% alcohol extraction hydrocarbon solvent mutually, the hydrocarbon solvent after the extraction concentrates mutually and obtains product.
Advantage of the present invention is:
1. the present invention has changed traditional production technique, uses alcoholic solvent to replace traditional hydro carbons such as normal hexane as extracting solvent, and raw material does not need dry direct the use, less energy consumption, and eggplant Buddhist nun alcohol yield height, fire safety evaluating hidden danger is low.
2, saponification and extraction are finished simultaneously, have avoided the degraded of eggplant Buddhist nun alcohol because of the highly basic condition effectively, save the usage quantity of operation sequence and solvent, and production cost is low, the yield height.
3, the adaptive faculty to raw material is strong, both can be mould cigarette, broken assorted offal, also can be to pluck remaining tobacco leaf.
Embodiment:
Below the invention process is described in further detail:
With mould cigarette, broken assorted offal or the harvesting residue tobacco leaf of water ratio below 50%, handle with containing the alcoholic solvent refluxing extraction without any drying process, filter extracting solution, extracting solution adds hydrocarbon solvent and alkali is made saponification reaction, reaction finishes to isolate the hydrocarbon solvent phase, again water and 80% washing with alcohol hydrocarbon solvent mutually, the hydrocarbon solvent after the extraction concentrates mutually and obtains product.
Below, the present invention will be further detailed with embodiment, but it is not limited to any or the similar example of these embodiment.
Embodiment 1:
The broken assorted offal 80% ethanol 680kg of 100kg moisture 16.5%, 85 ℃ of refluxing extraction 2h, add NaOH10kg after the solid-liquid separation, No. 6 solvent oil 380kg, 82 ℃ of saponification, extraction 2.5h isolate oil phase, and oil phase is used 5kg 80% washing with alcohol after adding water 27kg washing again, oil phase after the washing reclaims solvent and gets liquid dope 2kg, and eggplant Buddhist nun alcohol content is 25.6%.
Embodiment 2:
The mould pipe tobacco of 100kg moisture 14.2% adds 85% ethanol 600kg, 85 ℃ of refluxing extraction 1.5h, add KOH 6kg after the solid-liquid separation, No. 6 solvent oil 300kg, 82 ℃ of saponification, extraction 2h isolate oil phase, and oil phase is used 5kg 80% washing with alcohol after adding water 30kg washing again, oil phase after the washing reclaims solvent and gets liquid dope 2.5kg, and eggplant Buddhist nun alcohol content is 23.5%.
Embodiment 3:
After adding methyl alcohol 400kg homogenate, the harvesting residue tobacco leaf of 200kg moisture 50.6% adds methyl alcohol 600kg again, 65 ℃ of refluxing extraction 1.5h, add NaOH 12kg after the solid-liquid separation, No. 6 solvent oil 500kg, 65 ℃ of saponification, extraction 2h isolate oil phase, and oil phase is used 5kg 80% washing with alcohol after adding water 35kg washing again, oil phase after the washing reclaims solvent and gets liquid dope 3kg, and eggplant Buddhist nun alcohol content is 26.5%.
Claims (7)
1, a kind of method of from tobacco, extracting eggplant Buddhist nun alcohol, it is characterized in that: tobacco is used the alcoholic solvent refluxing extraction, filter extracting solution, extracting solution adds hydrocarbon solvent and alkali is made saponification reaction, reaction finishes to isolate the hydrocarbon solvent phase, respectively water and 80% washing with alcohol hydrocarbon solvent mutually, the hydrocarbon solvent after the extraction concentrates mutually and obtains product.
2, according to the described method of extracting eggplant Buddhist nun alcohol from tobacco of claim 1, it is characterized in that: tobacco is mould cigarette, broken assorted offal or the harvesting residue tobacco leaf of water ratio below 50%.
3, according to the described method of extracting eggplant Buddhist nun alcohol from tobacco of claim 1, it is characterized in that: raw material needn't be handled through any drying process.
4, according to the described method of extracting eggplant Buddhist nun alcohol from tobacco of claim 1, it is characterized in that: alcoholic solvent contains the alcohol amount more than 50% for containing ethanol or methanol solvent.
5, according to the described method of extracting eggplant Buddhist nun alcohol from tobacco of claim 1, it is characterized in that: hydrocarbon solvent is normal hexane, hexanaphthene, sherwood oil, 6# solvent oil, and the ratio of hydrocarbon solvent and extracting solution is 7: 3～3: 7.
6, according to the described method of extracting eggplant Buddhist nun alcohol from tobacco of claim 1, it is characterized in that: saponification alkali is sodium hydroxide or potassium hydroxide, and usage quantity is in 5～15% of over dry raw material.
7, according to the described method of extracting eggplant Buddhist nun alcohol from tobacco of claim 1, it is characterized in that: the saponification of extracting solution and hydrocarbon solvent extraction are finished simultaneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510010172 CN1724492A (en) | 2005-07-12 | 2005-07-12 | Method of extracting jianiol from tobacco |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510010172 CN1724492A (en) | 2005-07-12 | 2005-07-12 | Method of extracting jianiol from tobacco |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1724492A true CN1724492A (en) | 2006-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510010172 Pending CN1724492A (en) | 2005-07-12 | 2005-07-12 | Method of extracting jianiol from tobacco |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101857527A (en) * | 2010-06-10 | 2010-10-13 | 成都市翻鑫家科技有限公司 | Method for extracting Solanesol from waste and poor tobacco leave extract |
| CN102816050A (en) * | 2012-09-13 | 2012-12-12 | 王星敏 | Method for extracting solanesol by activating waste and defective tobacco by enzyme catalysis |
| CN105566086A (en) * | 2016-02-26 | 2016-05-11 | 广西北部湾制药股份有限公司 | Method for extracting coenzyme Q 10 from tobacco |
| CN105566085A (en) * | 2016-02-26 | 2016-05-11 | 广西北部湾制药股份有限公司 | Process for extracting coenzyme Q10 from tobacco leaves |
-
2005
- 2005-07-12 CN CN 200510010172 patent/CN1724492A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101857527A (en) * | 2010-06-10 | 2010-10-13 | 成都市翻鑫家科技有限公司 | Method for extracting Solanesol from waste and poor tobacco leave extract |
| CN101857527B (en) * | 2010-06-10 | 2013-02-27 | 成都市翻鑫家科技有限公司 | Method for extracting Solanesol from waste and poor tobacco leave extract |
| CN102816050A (en) * | 2012-09-13 | 2012-12-12 | 王星敏 | Method for extracting solanesol by activating waste and defective tobacco by enzyme catalysis |
| CN105566086A (en) * | 2016-02-26 | 2016-05-11 | 广西北部湾制药股份有限公司 | Method for extracting coenzyme Q 10 from tobacco |
| CN105566085A (en) * | 2016-02-26 | 2016-05-11 | 广西北部湾制药股份有限公司 | Process for extracting coenzyme Q10 from tobacco leaves |
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