CN102660378B - Method for extracting natural coenzyme Q10 by using palm residue - Google Patents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/10—Separation; Purification; Stabilisation; Use of additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/02—Pretreatment
- C11B1/04—Pretreatment of vegetable raw material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Abstract
The invention provides a novel method for extracting a natural coenzyme Q10 by using a palm residue. The novel method comprises the following steps of: a), drying the palm residue to obtain the dried palm residue, and smashing and sieving the palm residue to obtain a raw material for extracting the natural coenzyme Q10; b), extracting the dried palm residue by using a supercritical carbon dioxide as an extracting agent to obtain a carbon dioxide fluid; and c), carrying out decompression separation on the carbon dioxide fluid to obtain oil rich in the coenzyme Q10. By using the novel method, the natural coenzyme Q10 is extracted by using the palm residue as the raw material; the productive rate is high; and the obtained natural coenzyme Q10 is high in content and activity and stable in quality. In the oil rich in the coenzyme Q10, which is obtained by adopting the method provided by the invention, the content of the coenzyme Q10 is more than 30%. Meanwhile, by using the method provided by the invention, a complicated pretreatment process is not necessary to carry out; after the palm residue is dried and smashed, the extraction can be directly carried out; after the extraction is completed, the decompression separation is directly carried out, so that the oil rich in the coenzyme Q10 can be obtained; and a complicated post treatment process is not needed.
Description
Technical field
The invention belongs to technical field of chemistry, relate in particular to a kind of with extracting the method for natural Coenzyme Q10 99.0 in leaf sheath fibres of Fortune Windmillpalm slag or pomace.
Background technology
Coenzyme Q10 99.0, English name are COENZYME Q10, and molecular formula is C59H90O4, has another name called Ubidecarenone, and its similar is in vitamin K, because of the side chain on six of its parent nucleus---and the polymerization degree of polyisoamylene base is 10 to gain the name, and is a kind of quinone lopps compound.Coenzyme Q10 99.0 is found in the U.S. early than nineteen fifty-seven, and the same year, the Peter of Univ Edinburgh UK doctor Mike was because obtaining the Nobel prize in the contribution aspect research Coenzyme Q10 99.0 and cell energy relation.Coenzyme Q10 99.0 is a kind of fat-soluble antioxidant, it is one of indispensable important element of human life, the nutrition of energy human activin cell and cellular energy, have improve body immunity, strengthen anti-oxidant, delay senility and strengthen the function such as human activity, medically be widely used in cardiovascular system diseases, extensively use it for dietary supplements, makeup and foodstuff additive etc. both at home and abroad.In human body, the total content of Coenzyme Q10 99.0 is only 500-1500mg, and gradually reduces with advancing age.The content of Coenzyme Q10 99.0 peaked in the time of 20 years old in people's organ, then reduced rapidly.The minimizing of Coenzyme Q10 99.0 concentration is obvious especially in heart.Coenzyme Q10 99.0 in youngster's cardiac muscle of old man than 20 years old of 77 years old has reduced 57%.Therefore, to food, add Coenzyme Q10 99.0 in the food of especially being grown up particularly necessary.
The method of producing at present Coenzyme Q10 99.0 mainly contains biological extraction method, synthesis method and microbe fermentation method.The technique of generally taking in the biological extraction method is extracted Coenzyme Q10 99.0 in the heart from fresh pig exactly, but because yield is low, and raw material sources are restricted, and product cost is high, expensive, and large-scale production has been subject to certain restriction.existing disclosure of the invention technique and the method for many production Coenzyme Q10 99.0s, the patent that is CN102168115A as publication number discloses a kind of method with mutant strain Rhodobacter sphaeroides Nr-F synthesizing coenzyme Q 10 meta-bolites, principal feature is according to Coenzyme Q10 99.0 biosynthetic pathway and metabolic regulation mechanism, select suitable precursor and promotor to promote the factor to induce the accumulation of Coenzyme Q10 99.0 as key, by to seed, fermention medium and Coenzyme Q10 99.0 biosynthesizing are crucial promotes that the factor is optimized, effectively promote thalli growth, increase the Coenzyme Q10 99.0 metabolic flux, application number is that the Chinese patent literature of CN201110050366.6 discloses the female method of planting fermentation culture of the solid material that utilizes the red bacterium Rhodobacter of class ball sphaeroides Coenzyme Q10 99.0 to produce, application number is CN200910093966.3, CN200910061372.4, and the patent of CN200810116206.5 and CN200710041442.0 all relates to the Production by Microorganism Fermentation Coenzyme Q10 99.0.Fermentation method makes the throughput of Coenzyme Q10 99.0 greatly promote, but the rear extraction process that organic solvent carries out, the aftertreatment technology that not only percentage extraction is low and needs are complicated, and have the extraction agent residue problem, make the Coenzyme Q10 99.0 product that obtains be subject to the pollution of organic solvent.Synthesis method is mainly to pass through bromo take p-methyl phenol as raw material, and etherificate, oxidation obtain methyl dimethoxy oxygen base benzene and wake up, and then obtains Coenzyme Q10 99.0 with extraction solanesol condensation from tobacco or potato leaf.Application number is that the method for a kind of synthesizing coenzyme Q 10 in high efficiency of patent of CN200610001803.4 is exactly the method take solanesol (I) as the raw material synthesizing coenzyme Q 10 in high efficiency; the method is take solanesol (I) as starting raw material; bromo obtains trans-Solanesyl bromide (II); trans-Solanesyl bromide (II) obtains compound (IV) with compound (III) reaction; compound (IV) obtains Coenzyme Q10 99.0 by deprotection base and oxidation.The present technical comparative maturity of chemical synthesis has been realized industrialization, and product cost is low, moderate cost.Although but the product that uses synthesis method to produce has superiority on price, the product of producing than biological extraction method on effect has larger gap.Major cause is that the Coenzyme Q10 99.0 that the biological extraction method obtains is natural, and the conversion that is easily absorbed by the body is the synthetic product of artificial chemistry and chemical synthesis is produced, and the biological activity extreme difference is difficult for being absorbed by the body, and is difficult to fully must wave the pharmacological action of Coenzyme Q10 99.0.At present, the extraction process of Coenzyme Q10 99.0 is mainly organic solvent extraction, the patent No. is that the CN201010293858.3 Chinese patent literature discloses a kind of purifying process for preparing the high purity Coenzyme Q10 99.0, purifying process is exactly through polymeric adsorbent absorption, wash-out, concentrated, crystallization, recrystallization with the Coenzyme Q10 99.0 crude extract, then go up silica gel column chromatography, with sherwood oil-ether or normal hexane-ethyl acetate mixed solvent as the eluent purification refine.The rear extraction process that organic solvent carries out, the aftertreatment technology that not only percentage extraction is low, needs are complicated, and have the extraction agent residue problem, make the Coenzyme Q10 99.0 product that obtains be subject to the pollution of organic solvent.
Summary of the invention
The present invention has overcome the deficiencies in the prior art, a kind of method of extracting natural Coenzyme Q10 99.0 with the palm slag has been proposed, method raw material provided by the invention is cheap and easy to get, flow process is simple, operational path is shorter, energy consumption is lower, in the Coenzyme Q10 99.0 oil that obtains, Coenzyme Q10 99.0 content is higher, and the multiple beneficial such as rich vitamin A, vitamin-E material can be directly as foodstuff additive.
Technical solution of the present invention is: a kind of method of extracting natural Coenzyme Q10 99.0 with the palm slag, described method is at first dry with the palm slag, then take supercritical co as extraction agent, described dry palm slag is extracted, then after the CO 2 fluid that obtains being carried out decompression separation, can obtain being rich in the oil of Coenzyme Q10 99.0, described method comprises following concrete steps:
1) obtain dry palm slag after the palm slag is dried, its water content is 10%～20%;
2) take supercritical co as extraction agent, described dry palm slag is extracted, obtain CO 2 fluid;
3) described CO 2 fluid is carried out decompression separation twice, obtain being rich in the oil of Coenzyme Q10 99.0.
Preferably, described step 2) in, the temperature of described extraction is 35 ℃～60 ℃.
Preferably, described step 2) in, the pressure of described extraction is 15MPa～35MPa.
Preferably, described step 3) comprising:
A) described CO 2 fluid is carried out first step decompression separation, obtain being rich in the oil of Coenzyme Q10 99.0;
B) described CO 2 fluid through first step decompression separation is carried out second stage decompression separation, obtain being rich in the oil of Coenzyme Q10 99.0.
Preferably, the pressure of described first step decompression separation is 5MPa～7MPa.
Preferably, the temperature of described first step decompression separation is 35 ℃～50 ℃.
Preferably, the pressure of described second stage decompression separation is 2MPa～8MPa.
Preferably, the temperature of described second stage decompression separation is 30 ℃～40 ℃.
Compared with prior art, the present invention is at first dry with the palm slag, then take supercritical co as extraction agent, described dry palm slag is extracted, and after then the CO 2 fluid that obtains being carried out decompression separation, can obtain being rich in the oil of Coenzyme Q10 99.0.The present invention extracts the oil that is rich in Coenzyme Q10 99.0 take supercritical co as extraction agent, extraction efficiency is high, and raw material is cheap and easy to get, obtain oily Coenzyme Q10 99.0 content high, productive rate is high, functional component is abundant, active high, steady quality.Experiment shows, adopts in the oil that is rich in Coenzyme Q10 99.0 that method provided by the invention obtains, and the content of Coenzyme Q10 99.0 is greater than 30%, and contains abundant vitamin-E and vitamin A etc.
Simultaneously, method provided by the invention need not to carry out complicated pre-treatment operation, the palm slag is dry, can directly extract after being crushed to 20 orders left and right, extract the complete rear oil that decompression separation can obtain being rich in Coenzyme Q10 99.0 that directly carries out, need not complicated aftertreatment technology, flow process is simple, operational path is short, energy consumption is low.In addition, the present invention does not with an organic solvent extract, and the Coenzyme Q10 99.0 product that obtains can not be subject to the heavy metal contamination of organic solvent residual.
Description of drawings
Accompanying drawing is the extraction process schema that extracts natural Coenzyme Q10 99.0 with the palm slag provided by the invention.
In figure, 1 is gas-holder, and 2 is condenser, and 3 is high-pressure pump, and 4 is preheater, and 5 is extractor, and 6 is the first separating tank, and 7 is the second separating tank, and 8 is blow-off valve.
Embodiment
The invention provides a kind of method of extracting natural Coenzyme Q10 99.0 with the palm slag, comprise the following steps:
A) the palm slag is carried out drying, obtain the raw material of the broken conduct extraction of looking over so as to check of dry palm ground-slag;
B) the palm slag to described drying extracts take supercritical co as extraction agent, obtains being rich in the CO 2 fluid of Coenzyme Q10 99.0 oil;
C) described CO 2 fluid is carried out decompression separation, obtain being rich in the oil of Coenzyme Q10 99.0.
The present invention carries out the extraction of natural Coenzyme Q10 99.0 take palm slag (skin slag and pomace) as raw material take supercritical co as extraction agent, extraction efficiency is high, and the oily active constituent content that is rich in Coenzyme Q10 99.0 that obtains is high, productive rate is high, steady quality.
The present invention extracts the oil that is rich in Coenzyme Q10 99.0 take the palm slag as raw material.Gained palm slag is carried out drying, obtain dry palm slag.
After obtaining dry palm slag, through pulverizing and sieving, take supercritical co as extraction agent, described dry palm slag is extracted.All higher than its critical temperature Tc (31.1 ℃) with during emergent pressure Pc (7.39MPa), be called supercritical co when the temperature T of carbonic acid gas and pressure P.Supercritical co has gas property and liquid property concurrently, has stronger dissolving power, can improve product purity during as extraction agent, increases productive rate.
At first the present invention is condensed into liquid with carbon dioxide take carbon dioxide as extraction agent, after then making carbonic acid gas be in supercritical state by the control temperature and pressure, described dry palm slag is extracted.According to the present invention, the temperature when extracting is preferably 35 ℃～60 ℃, and more preferably 40 ℃～55 ℃, most preferably be 40 ℃～50 ℃, the pressure when extracting is preferably 15MPa～35MPa, more preferably 18MPa～20MPa.
In extraction process, the oil that is rich in Coenzyme Q10 99.0 in dry palm slag is dissolved in supercritical co, separates with cell debris etc., obtains CO 2 fluid.After obtaining CO 2 fluid, it is carried out the oil that decompression separation can obtain being rich in Coenzyme Q10 99.0.
Described decompression separation process preferably includes following steps:
Described CO 2 fluid is carried out first step decompression separation, obtain being rich in the oil of Coenzyme Q10 99.0;
Described CO 2 fluid through first step decompression separation is carried out second stage decompression separation, obtain being rich in the oil of Coenzyme Q10 99.0.
At first described CO 2 fluid is carried out first step decompression separation, obtain being rich in the oil of Coenzyme Q10 99.0.The pressure of described first step decompression separation is preferably 5MPa～12MPa, more preferably 5MPa～7MPa; The temperature of described first step decompression separation is preferably 35 ℃～50 ℃, more preferably 40 ℃～45 ℃.
Through still containing the oil that part is rich in Coenzyme Q10 99.0 in the CO 2 fluid after first step decompression separation, it is carried out second stage decompression separation, obtain being rich in the oil of Coenzyme Q10 99.0.The pressure of described second stage decompression separation is preferably 2MPa～8MPa, more preferably 2.5MPa～4MPa; The temperature of described second stage decompression separation is preferably 30 ℃～40 ℃, more preferably 33 ℃～38 ℃.Through after two-stage decompression separation, the oily major part that is rich in Coenzyme Q10 99.0 is separated.
Below in conjunction with accompanying drawing, the present invention is described with the method that the palm slag extracts natural Coenzyme Q10 99.0.
Referring to accompanying drawing, at first dry palm slag is placed in extractor 5, with extractor 5 sealings;
Open gas-holder 1, carbonic acid gas is converted into liquid through condenser 2, becomes supercritical co after heating via high-pressure pump 3 pressurizations and preheater 4, enters in extractor 5 wherein dry palm slag is extracted;
Extract complete after, be dissolved with the CO 2 fluid that is rich in Coenzyme Q10 99.0 oil and enter the first separating tank 6, make carbonic acid gas and be rich in the separating of oil of Coenzyme Q10 99.0 by step-down, the oil that is rich in Coenzyme Q10 99.0 is discharged by the blow-off valve 8 on the first separating tank 6;
After obtaining being rich in the oil of Coenzyme Q10 99.0, the described oil that is rich in Coenzyme Q10 99.0 is detected, its Coenzyme Q10 99.0 content is greater than 30%.
The present invention extracts the oil that is rich in Coenzyme Q10 99.0 take the palm slag as raw material, productive rate is high, Coenzyme Q10 99.0 content and active high, steady quality.Simultaneously, method raw material provided by the invention is cheap and easy to get and need not to carry out complicated pre-treatment operation through simply pulverizing and sieving, can directly extract after drying, extract the complete rear oil that decompression separation can obtain being rich in Coenzyme Q10 99.0 that directly carries out, need not complicated aftertreatment technology, flow process is simple, operational path is short, energy consumption is low.In addition, the present invention does not with an organic solvent extract, and the Coenzyme Q10 99.0 product that obtains can not be subject to the heavy metal contamination of organic solvent residual.
In order to further illustrate the present invention, below in conjunction with embodiment, the method with the natural Coenzyme Q10 99.0 of palm slag extraction provided by the invention is described in detail.
Embodiment 1
The palm slag is dry, obtain dry palm slag; It was pulverized 20 mesh sieves
The palm slag that adds the described drying and crushing of 1000g in the extractor 5, the sealing extractor; 5 open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 30MPa, the condition of 50 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 10MPa, the condition of 45 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 3MPa, the condition of 40 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 2h, obtain altogether from the first separating tank 6 and the second separating tank 7 oil that 150.9g is rich in Coenzyme Q10 99.0, percentage extraction is 15.09%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 30.20%.
The palm slag is dry, obtain dry palm slag;
The palm slag that adds the described drying of 1000g in the extractor 5, sealing extractor 5; Open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 25MPa, the condition of 50 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 9MPa, the condition of 50 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 3MPa, the condition of 30 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 2h, obtain altogether from the first separating tank 6 and the second separating tank 7 oil that 141.88g is rich in Coenzyme Q10 99.0, percentage extraction is 14.188%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 30.80%.
The palm slag is dry, obtain dry palm slag;
Add the described dry palm slag of 1000g in extractor 5, sealing extractor 5; Open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 18MPa, the condition of 45 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 8MPa, the condition of 45 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 3MPa, the condition of 30 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 2h, obtain altogether from the first separating tank 6 and the second separating tank 7 oil that 121.3g is rich in Coenzyme Q10 99.0, percentage extraction is 12.13%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 30.52%.
The palm slag is dry, obtain dry palm slag;
Add the described dry palm slag of 1000g in extractor 5, sealing extractor 5; Open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 20MPa, the condition of 35 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 8MPa, the condition of 35 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 3MPa, the condition of 30 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 2h, obtain altogether from the first separating tank 6 and the second separating tank 7 oil that 129.6g is rich in Coenzyme Q10 99.0, percentage extraction is 12.96%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 30.99%.
The palm slag is dry, obtain dry palm slag;
The palm slag that adds the described drying of 1000g in the extractor 5, sealing extractor 5; Open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 15MPa, the condition of 60 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 8MPa, the condition of 50 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 3MPa, the condition of 40 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 2h, obtain altogether from the first separating tank 6 and the second separating tank 7 oil that 112.2g is rich in Coenzyme Q10 99.0, percentage extraction is 11.22%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 31.08%.
The palm slag is dry, obtain dry palm slag;
The palm slag that adds the described drying of 5000g in the extractor 5, sealing extractor 5; Open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 20MPa, the condition of 50 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 8MPa, the condition of 45 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 3MPa, the condition of 40 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 6h, obtain altogether from the first separating tank 6 and the second separating tank 7 oil that 134.5g is rich in Coenzyme Q10 99.0, percentage extraction is 13.45%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 31.12%.
The palm slag is dry, obtain dry palm slag;
Add the described dry palm slag of 5000g in extractor 5, sealing extractor 5; Open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 18MPa, the condition of 50 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 8MPa, the condition of 45 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 3MPa, the condition of 40 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 6h, obtain altogether being rich in the oil of Coenzyme Q10 99.0 from the first separating tank 6 and the second separating tank 7, percentage extraction is 12.66%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 30.88%.
The palm slag is dry, obtain dry palm slag;
Add the described dry palm slag of 5000g in extractor 5, sealing extractor 5; Open gas-holder 1, keeping the flow of carbonic acid gas is 480L/h, carbonic acid gas enters described extractor 5 after condenser 2, high-pressure pump 3 and preheater 4, extract under 15MPa, the condition of 60 ℃, CO 2 fluid after extraction enters the first separator, carry out the first step and separate under 10MPa, the condition of 50 ℃, obtain first part of oil that is rich in Coenzyme Q10 99.0; CO 2 fluid after separating through the first step continues to enter the second separator, carries out the second stage and separate under 5MPa, the condition of 40 ℃, obtains second part of oil that is rich in Coenzyme Q10 99.0.
After dynamic extraction 6h, obtain altogether from the first separating tank 6 and the second separating tank 7 oil that 253g is rich in Coenzyme Q10 99.0, percentage extraction is 11.94%, and in the described oil that is rich in Coenzyme Q10 99.0, the content of Coenzyme Q10 99.0 is 31.05%.
The above is only the preferred embodiment of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (2)
1. method of extracting Coenzyme Q10 99.0 with the palm slag, it is characterized in that: its step is as follows:
A) the palm slag is dry, obtain dry palm slag, its water content is 10%～20%;
B) take supercritical co as extraction agent, described palm slag is extracted, the temperature of described extraction is 35 ℃～60 ℃, and the pressure of described extraction is 15MPa～25MPa, obtains CO 2 fluid;
C) described CO 2 fluid is carried out two-stage decompression separation: first step decompression separation, pressure are 9MPa～12MPa, and temperature is 35 ℃～50 ℃, obtain containing the oil of Coenzyme Q10 99.0, and Coenzyme Q10 99.0 content is between 10%-30%;
CO 2 fluid through first step decompression separation is carried out second stage decompression separation, and pressure is 2MPa～8MPa, and temperature is 30 ℃～40 ℃, obtains being rich in the oil of Coenzyme Q10 99.0, and Coenzyme Q10 99.0 content is greater than 30%.
2. extracting method according to claim 1, it is characterized in that: described palm slag is leaf sheath fibres of Fortune Windmillpalm slag and pomace, and it is 20MPa and 50 ℃ that extracting method adopts supercritical carbon dioxide extraction method, most economical extracting pressure and temperature, extraction time is 2h, and the extraction flow is 480L/h.
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| PCT/CN2013/071958 WO2013159593A1 (en) | 2012-04-28 | 2013-02-27 | Method for extracting coenzyme q10 and application of coenzyme q10 |
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| CN105213344A (en) * | 2015-11-12 | 2016-01-06 | 四川巴中普瑞制药有限公司 | A kind of method solving sticking in compound paracetamol tablets tabletting |
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| JPH0310691A (en) * | 1989-06-09 | 1991-01-18 | Sumitomo Heavy Ind Ltd | Method for extracting ubidecarenone |
| MY136397A (en) * | 2002-08-20 | 2008-09-30 | Malaysian Palm Oil Board Mpob | Recovery of palm phytonutrients |
| MY146635A (en) * | 2004-09-01 | 2012-09-14 | Malaysian Palm Oil Board | Specialty palm oil products and other specialty vegetable oil products |
| DE602006013933D1 (en) * | 2006-02-10 | 2010-06-10 | Carotech Sdn Bhd Chemor | A process for obtaining highly enriched natural product fractions from palm oil using supercritical and near supercritical fluid media |
| MY171902A (en) * | 2009-11-16 | 2019-11-06 | Biovites Corp Sdn Bhd | Production of natural ubiquinone and ubiquinol by extraction from palm plant |
| CN102391092B (en) * | 2011-11-22 | 2013-05-01 | 杭州华东医药集团康润制药有限公司 | Method for preparing high-purity coenzyme Q10 in large scale |
| CN102660378B (en) * | 2012-04-28 | 2013-11-06 | 青岛佰福得科技有限公司 | Method for extracting natural coenzyme Q10 by using palm residue |
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| CN102660378A (en) | 2012-09-12 |
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