CN1718220A - method for discerning tablets of tonifying stomach and promoting digestion - Google Patents
method for discerning tablets of tonifying stomach and promoting digestion Download PDFInfo
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- CN1718220A CN1718220A CN 200510068644 CN200510068644A CN1718220A CN 1718220 A CN1718220 A CN 1718220A CN 200510068644 CN200510068644 CN 200510068644 CN 200510068644 A CN200510068644 A CN 200510068644A CN 1718220 A CN1718220 A CN 1718220A
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Abstract
A Chinese medicine in the form of tablets for invigorating the function of stomach and helping digestion is prepared from pseudostellaris root, tangerine peel, yam, germinated barley and haw. Its discrimination method features that the thin-layer chromatography is used to descriminate the liposoluble components of pseudostellaris root and the ninhydrin chromotest is used to discriminate its water-soluble components.
Description
Technical field
The present invention relates to the discrimination method of the JIANWEI XIAOSHI PIAN made by Radix Pseudostellariae, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Hordei Germinatus and Fructus Crataegi, be specifically related to the discrimination method of the JIANWEI XIAOSHI PIAN that Different Preparation makes.
Technical background
JIANWEI XIAOSHI PIAN is ministry standard (WS
3-B-0379-90 and WS
3-B-3086-98-2004) and the national drug standards (2001ZFB0022) record kind, form by Radix Pseudostellariae, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Hordei Germinatus and Fructus Crataegi, preparation technology extracts half decocting of medical material Radix Pseudostellariae, half pulverizing is used as medicine, extractum after the extraction concentrates, conventional wet or dry granulation, and loss of effective components is big, utilization rate is low, and the tablet appearance of making is coarse, mouthfeel is relatively poor; Patent documentation (country origin China, publication number are 1584586) discloses another preparation method: Rhizoma Dioscoreae powder is broken into fine powder, Radix Pseudostellariae, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegi decoct with water, filter, the filtrate cryoconcentration becomes clear paste, spray drying, and it is an amount of to add above-mentioned Rhizoma Dioscoreae fine powder, Icing Sugar and dextrin, mixing, boiling granulating, tabletting makes the invigorating the stomach and promoting digestion tablet.
Radix Pseudostellariae is the principal agent that the JIANWEI XIAOSHI PIAN preparation prescription is formed, another name Radix Ginseng (" decoction pieces is newly joined "), it is the dried root of pinkwort Radix Ginseng Pseudostellaria heterophylla (Miq.) Paxex Pax et Hoffm., effect with replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, clinically be usually used in that insufficiency of the spleen body is tired, inappetence, symptom such as thirsty, dryness of the lung dry cough of weakness, deficiency of both vital energy and Yin, spontaneous perspiration after being ill, the strong tonic of Chang Zuowei among the people, traditionally, Radix Pseudostellariae generally not in addition cutting be used as medicine, effective ingredient can not be utilized fully.
The Radix Pseudostellariae water-soluble chemical component is its main effective ingredient, comprise: glycoside such as Radix Pseudostellariae Saponin A (PseudostellarinosideA) etc., saccharide such as Radix Pseudostellariae polysaccharide PHP-A and PHP-B etc., cyclic peptide such as heterophyllinA (I) (Radix pseudostellariae cyclic peptides A) etc., 7 kinds of essential amino acids such as amino acids such as lysine and arginine, 2 kinds of human body semi-dispensable amino acids of histidine.
Summary of the invention
The objective of the invention is to: a kind of discrimination method of invigorating the stomach and promoting digestion tablet Different Preparation is provided, can identifies the product that adopts Different Preparation to make.
JIANWEI XIAOSHI PIAN is made by Chinese crude drug Radix Pseudostellariae, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Hordei Germinatus and Fructus Crataegi, and the preparation method of existing tablet has 2 kinds:
Method one: medical material Radix Pseudostellariae half and Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegi decocting are extracted, and second half Radix Pseudostellariae and Rhizoma Dioscoreae are pulverized and are used as medicine, and the extractum after the extraction is condensed into thick paste, conventional wet or dry granulation, loss of effective components is big, and utilization rate is low, and the tablet appearance of making is coarse, mouthfeel is relatively poor.
Method two: Rhizoma Dioscoreae powder is broken into fine powder, Radix Pseudostellariae, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegi decoct with water, filter, the filtrate cryoconcentration becomes clear paste, spray drying, it is an amount of to add above-mentioned Rhizoma Dioscoreae fine powder, Icing Sugar and dextrin, mixing, boiling granulating, tabletting, make the invigorating the stomach and promoting digestion tablet, this method can improve the content of effective ingredient such as water soluble ingredients such as glycoside and aminoacid by to than decoctings such as valuable medicinal Radix Pseudostellariae and Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegis, improves the utilization rate of medical material, reduce taking dose, improve the mouthfeel of preparation; By spray drying, loss of effective components is little, semi-finished product composition and color even, and contain that moisture is low to be easy to deposit; Make uniform particles by boiling granulating, yield rate significantly improves.
The desirable Rhizoma Dioscoreae 171.4g of concrete preparation method for method two is ground into fine powder; Radix Pseudostellariae 228.6g, Pericarpium Citri Reticulatae 22.9g, Fructus Hordei Germinatus (stir-fry) 171.4g, Fructus Crataegi 114.3g decoct with water twice, each 2 hours, collecting decoction filters, and filtrate cryoconcentration to relative density is the clear paste of 1.05～1.12 (65 ℃), spray drying, it is an amount of to add above-mentioned Rhizoma Dioscoreae fine powder, Icing Sugar and dextrin, boiling granulating, drying, compacting is made 1000 of JIANWEI XIAOSHI PIAN (0.8g/ sheet) or 1600 (0.5g/ sheet) in flakes.
Can adopt any or 2 kinds of discrimination methods in the following discrimination method to differentiate the tablet that above-mentioned Different Preparation makes:
(1) get JIANWEI XIAOSHI PIAN 8-16g, porphyrize adds petroleum ether 25-100ml, and reflux, extract, 0.5-2 hour, filter, filtrate evaporate to dryness, residue add ethyl acetate 0.5-2ml makes dissolving, as need testing solution; Other gets Radix Pseudostellariae control medicinal material 2-5g, shines medical material solution in pairs with legal system; According to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia), draw each 5-20 μ l of above-mentioned need testing solution and control medicinal material solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction (or normal hexane, benzene, toluene, petroleum ether)-ethyl acetate (8.5: 1) or (9: 1) or (9: 0.5) is developing solvent, launch, take out, dry, spray is with 0.5%-5% vanillin sulfuric acid solution or 5-10% ethanol solution of sulfuric acid, and it is clear to be heated to the speckle colour developing at 80-120 ℃;
In the Radix Pseudostellariae control medicinal material solution chromatogram, 5 feature speckles are arranged, by the descending 1-5 that is numbered of Rf value, the need testing solution chromatograph that adopts preparation technology one to make has 1,2,3,5 four clear speckle, have only 1,5 two speckle more clear in the need testing solution chromatograph that adopts preparation technology two to make, other speckle is unintelligible;
(2) get JIANWEI XIAOSHI PIAN fine powder 2-4g, add water 50-200ml, stir evenly, supersound extraction 20-60 minute, centrifugal 5-30 minute (800-4000 rev/min), supernatant discards, and precipitation adds water 5-20ml, stirs evenly, supersound extraction 20-60 minute, centrifugal 5-30 minute (800-4000 rev/min) gets supernatant, as need testing solution;
Get need testing solution 1-20ml, drip 1-5% ethanol solution of ninhydrin 1-10 and drip, shake up, put and be heated to colour developing in the boiling water bath, be bluish violet in the test sample 4min that adopts preparation technology one to make, bluish violet do not occur in the need testing solution 4min that adopts preparation technology two to make.
Optimized technical scheme can be with any or 2 kinds in the following discrimination method:
(1) get JIANWEI XIAOSHI PIAN 12g (24 of 15 of sheets or small pieces), porphyrize adds petroleum ether (60-90 ℃) 50ml, and reflux, extract, 1 hour filters, and filtrate evaporate to dryness, residue add ethyl acetate 1ml makes dissolving, as need testing solution; Get Radix Pseudostellariae control medicinal material 3.5g, shine medical material solution in pairs with legal system; According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia B), draw each 15 μ l of above-mentioned need testing solution and control medicinal material solution, put respectively on same silica gel g thin-layer plate, (or normal hexane, benzene, toluene, petroleum ether)-ethyl acetate (9: 1) is developing solvent with cyclohexane extraction, launch, take out, dry, spray is with 1% vanillin sulfuric acid solution, and it is clear to be heated to the speckle colour developing at 105 ℃;
In the Radix Pseudostellariae control medicinal material solution chromatogram, 5 feature speckles are arranged, by the descending 1-5 that is numbered of Rf value; The JIANWEI XIAOSHI PIAN need testing solution chromatograph that adopts preparation method one to make has 1,2,3,5 four clear speckle, and has only 1,5 two speckle more clear in the JIANWEI XIAOSHI PIAN need testing solution chromatograph that adopts preparation method two to make, and other speckle is unintelligible.
(2) get JIANWEI XIAOSHI PIAN fine powder 3g, add water 80ml, stir evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins), supernatant discards, and precipitation adds water 10ml, stirs evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins) get supernatant, as need testing solution; Get need testing solution 2ml, drip 2 of 2% ethanol solution of ninhydrin, shake up, put and be heated to colour developing in the boiling water bath, be bluish violet in the JIANWEI XIAOSHI PIAN test sample 4min that adopts preparation method one to make, and bluish violet do not occur in the test sample 4min that adopts preparation method two to make.
For the preparation that two kinds of different preparation technologies make, the beneficial effect of following medical effect experiment shows method two:
Adopt to give mice a large amount of, frequent gavage the situation that refined lard is simulated the insufficiency of the spleen patient of intemperance of taking food clinically, the result by preparation technology two make JIANWEI XIAOSHI PIAN can obviously improve " insufficiency of the spleen " symptom of mice, behind drug treatment, its various insufficiency of the spleen symptoms are taken on a new look to some extent.With former technology contrast, there was no significant difference.As shown in table 1.
Table 1, JIANWEI XIAOSHI PIAN are to the influence (P＜0.05) of mice with spleen deficiency body weight
| Group | Before the moulding (g) | After the moulding (g) | After the administration (g) | Difference (g) before and after the administration |
| Blank group | 25.14±2.67 | 22.43±2.37 | 23.14±2.27 | 0.71±0.49 |
| New technology | 25.22±2.22 | 22.78±1.99 | 24.89±1.69 | 2.11±0.60 * |
| Former technology | 24.60±1.51 | 21.80±1.55 | 23.90±1.45 | 2.10±0.57 * |
The general variation: moulding group mice just occurred having loose bowels from the 8th day, mostly was the sticky thing of white adipose sample, went into action slowly in the 9th day, bradykinesia, in disorder, lackluster by hair, and body weight begins to alleviate, behind the drug treatment, drinking-water, material all obviously increase, and it is gradually normal to defecate, weight increase.From the general variation of above mice and body weight change as can be known, JIANWEI XIAOSHI PIAN can obviously be improved the insufficiency of the spleen symptom of mice, and can recover the mice body weight.And the drug effect no significant difference between two groups of medicines.
The specific embodiment
Embodiment 1
Prescription: Radix Pseudostellariae 228.6g Rhizoma Dioscoreae 171.4g Pericarpium Citri Reticulatae 22.9g Fructus Hordei Germinatus 171.4g Fructus Crataegi 114.3g
Preparation method one: get Radix Pseudostellariae 114.3g and Rhizoma Dioscoreae 171.4g, be ground into fine powder, other gets Pericarpium Citri Reticulatae 22.9g, Fructus Hordei Germinatus 171.4g, Fructus Crataegi 114.3g and residue Radix Pseudostellariae 114.3g decoct with water twice, add 10 times of amounts of water for the first time, add for the second time 8 times of amounts of water, each 2 hours, collecting decoction, filter, the filtrate cryoconcentration is to thick paste shape (proportion is 1.30,60 ℃), it is an amount of to add above-mentioned fine powder and Icing Sugar, makes granule, drying, add magnesium stearate 16g, be pressed into 1000 (0.8g/ sheets), promptly.
Preparation method two: get Rhizoma Dioscoreae 171.4g, be ground into fine powder; Radix Pseudostellariae 228.6g, Pericarpium Citri Reticulatae 22.9g, Fructus Hordei Germinatus (stir-fry) 171.4g, Fructus Crataegi 114.3g decocts with water twice, add for the first time 10 times of amounts of water, add each 2 hours of 8 times of amounts of water for the second time, collecting decoction, filter, filtrate cryoconcentration to relative density is the clear paste of 1.05～1.12 (65 ℃), spray drying, and it is an amount of to add above-mentioned Rhizoma Dioscoreae fine powder, Icing Sugar and dextrin, boiling granulating, drying, compacting is made 1000 (0.8g/ sheets) in flakes.
The tablet that distinct methods makes can be differentiated with following method:
Get 15 in the tablet that above-mentioned preparation method makes, porphyrize adds petroleum ether (60-90 ℃) 50ml, and reflux, extract, 1 hour filters, and filtrate evaporate to dryness, residue add ethyl acetate 1ml makes dissolving, as need testing solution; Other gets Radix Pseudostellariae control medicinal material 3.5g, shines medical material solution in pairs with legal system; According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia B), draw each 15 μ l of above-mentioned need testing solution and control medicinal material solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction-ethyl acetate (9: 1) is developing solvent, launch, take out, dry, spray is with 1% vanillin sulfuric acid solution, and it is clear to be heated to the speckle colour developing at 105 ℃.
In the Radix Pseudostellariae control medicinal material solution chromatogram, 5 feature speckles are arranged, by the descending 1-5 that is numbered of Rf value, the need testing solution chromatograph that preparation method one makes has 1,2,3,5 four clear speckle, have only 1,5 two speckle more clear in the need testing solution chromatograph that preparation method two makes, other speckle is unintelligible.
Embodiment 2
Prescription, preparation method are with embodiment 1
The tablet that distinct methods makes can be differentiated with following method:
Get tablet fine powder 3g, add water 80ml, stir evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins), supernatant discards, and precipitation adds water 10ml, stirs evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins) get supernatant, as need testing solution.
Get need testing solution 2ml, drip 2 of 2% ethanol solution of ninhydrin, shake up, put and be heated to colour developing in the boiling water bath; Promptly be bluish violet in the test sample 4min that preparation method one makes, bluish violet do not occur in the test sample 4min that preparation method two makes.。
Embodiment 3
Prescription, preparation method are with embodiment 1
Adopt different preparation technologies respectively to make 1600 (0.5g/ sheets), adopt following method to differentiate: (1) gets 24 in tablet, porphyrize, add petroleum ether (60-90 ℃) 50ml, reflux, extract, 1 hour filters, filtrate evaporate to dryness, residue add ethyl acetate 1ml makes dissolving, as need testing solution.Other gets Radix Pseudostellariae control medicinal material 3.5g, shines medical material solution in pairs with legal system.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia B), draw each 15 μ l of above-mentioned need testing solution and control medicinal material solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction-ethyl acetate (9: 1) is developing solvent, launch, take out, dry, spray is with 1% vanillin sulfuric acid solution, and it is clear to be heated to the speckle colour developing at 105 ℃.
In the Radix Pseudostellariae control medicinal material solution chromatogram, 5 feature speckles are arranged, by the descending 1-5 that is numbered of Rf value, the need testing solution chromatograph that preparation method one makes has 1,2,3,5 four clear speckle, have only 1,5 two speckle more clear in the need testing solution chromatograph that preparation method two makes, other speckle is unintelligible.
(2) get tablet fine powder 3g, add water 80ml, stir evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins), supernatant discards, and precipitation adds water 10ml, stirs evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins) get supernatant, as need testing solution.
Get need testing solution 2ml, drip 2 of 2% ethanol solution of ninhydrin, shake up, put and be heated to colour developing in the boiling water bath; Promptly be bluish violet in the test sample 4min that preparation method one makes, preparation method two makes and does not occur bluish violet in the test sample 4min.
Claims (3)
1, a kind of discrimination method of the JIANWEI XIAOSHI PIAN Different Preparation of making by Chinese crude drug Radix Pseudostellariae, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Hordei Germinatus and Fructus Crataegi, preparation technology one: Radix Pseudostellariae half and Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegi decocting extract, second half Radix Pseudostellariae and Rhizoma Dioscoreae are pulverized and are used as medicine, extractum after the extraction concentrates, conventional wet or dry granulation, drying, tabletting; Preparation technology two: be broken into fine powder by Rhizoma Dioscoreae powder, Radix Pseudostellariae, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegi decoct with water, and filter, and filtrate is condensed into clear paste, spray drying adds Rhizoma Dioscoreae fine powder and right amount of auxiliary materials, mixing, boiling granulating, drying, tabletting is characterized in that discrimination method comprises:
Get JIANWEI XIAOSHI PIAN 8-16g, porphyrize adds petroleum ether 25-100ml, and reflux, extract, 0.5-2 hour, filter, filtrate evaporate to dryness, residue add ethyl acetate 0.5-2ml makes dissolving, as need testing solution; Other gets Radix Pseudostellariae control medicinal material 2-5g, shines medical material solution in pairs with legal system; According to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia), draw each 5-20 μ l of above-mentioned need testing solution and control medicinal material solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction (or normal hexane, benzene, toluene, petroleum ether)-ethyl acetate (8.5: 1) or (9: 1) or (9: 0.5) is developing solvent, launch, take out, dry, spray is with 0.5%-5% vanillin sulfuric acid solution or 5-10% ethanol solution of sulfuric acid, and it is clear to be heated to the speckle colour developing at 80-120 ℃;
In the Radix Pseudostellariae control medicinal material solution chromatogram, 5 feature speckles are arranged, by the descending 1-5 that is numbered of Rf value, the need testing solution chromatograph that adopts preparation technology one to make has 1,2,3,5 four clear speckle, have only 1,5 two speckle more clear in the need testing solution chromatograph that adopts preparation technology two to make, other speckle is unintelligible;
2, a kind of discrimination method of the JIANWEI XIAOSHI PIAN Different Preparation of making by Chinese crude drug Radix Pseudostellariae, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Hordei Germinatus and Fructus Crataegi, preparation technology one: Radix Pseudostellariae half and Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegi decocting extract, second half Radix Pseudostellariae and Rhizoma Dioscoreae are pulverized and are used as medicine, extractum after the extraction concentrates, conventional wet or dry granulation; Preparation technology two: be broken into fine powder by Rhizoma Dioscoreae powder, Radix Pseudostellariae, Pericarpium Citri Reticulatae, Fructus Hordei Germinatus and Fructus Crataegi decoct with water, and filter, and filtrate is condensed into clear paste, spray drying adds Rhizoma Dioscoreae fine powder and right amount of auxiliary materials, mixing, boiling granulating, drying, tabletting is characterized in that discrimination method comprises:
Get JIANWEI XIAOSHI PIAN fine powder 2-4g, add water 50-200ml, stir evenly, supersound extraction 20-60 minute, centrifugal 5-30 minute (800-4000 rev/min), supernatant discards, and precipitation adds water 5-20ml, stirs evenly, supersound extraction 20-60 minute, centrifugal 5-30 minute (800-4000 rev/min) gets supernatant, as need testing solution;
Get need testing solution 1-20ml, drip 1-5% ethanol solution of ninhydrin 1-10 and drip, shake up, put and be heated to colour developing in the boiling water bath, be bluish violet in the test sample 4min that adopts preparation technology one to make, bluish violet do not occur in the need testing solution 4min that adopts preparation technology two to make.
3,, it is characterized in that discrimination method comprises any or 2 kinds in the following discriminating according to the Different Preparation discrimination method of claim 1 and 2 described JIANWEI XIAOSHI PIAN:
(1) get JIANWEI XIAOSHI PIAN 12g, porphyrize adds petroleum ether (60-90 ℃) 50ml, and reflux, extract, 1 hour filters, and filtrate evaporate to dryness, residue add ethyl acetate 1ml makes dissolving, as need testing solution; Get Radix Pseudostellariae control medicinal material 3.5g, shine medical material solution in pairs with legal system; According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia B), draw each 15 μ l of above-mentioned need testing solution and control medicinal material solution, put respectively on same silica gel g thin-layer plate, with cyclohexane extraction-ethyl acetate (9: 1) is developing solvent, launch, take out, dry, spray is with 1% vanillin sulfuric acid solution, and it is clear to be heated to the speckle colour developing at 105 ℃;
In the Radix Pseudostellariae control medicinal material solution chromatogram, 5 feature speckles are arranged, by the descending 1-5 that is numbered of Rf value, the need testing solution chromatograph that adopts preparation technology one to make has 1,2,3,5 four clear speckle, have only 1,5 two speckle more clear in the need testing solution chromatograph that adopts preparation technology two to make, other speckle is unintelligible.
(2) get JIANWEI XIAOSHI PIAN fine powder 3g, add water 80ml, stir evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins), supernatant discards, and precipitation adds water 10ml, stirs evenly, supersound extraction 30 minutes, centrifugal 15 minutes (4000 rev/mins) get supernatant, as need testing solution;
Get need testing solution 2ml, drip 2 of 2% ethanol solution of ninhydrin, shake up, put and be heated to colour developing in the boiling water bath, be bluish violet in the test sample 4min that adopts preparation technology one to make, bluish violet do not occur in the need testing solution 4min that adopts preparation technology two to make.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101210915B (en) * | 2007-12-24 | 2011-05-11 | 王志敏 | Cabrite medicinal materials discrimination method |
| CN103083585A (en) * | 2012-08-31 | 2013-05-08 | 农桂标 | Manufacturing method of stomach-invigorating and digestion-improving tablet |
| CN104824767A (en) * | 2014-02-12 | 2015-08-12 | 于汇 | Hericium erinaceus fermentation appetite-enhancing and digestion-promoting beverage |
| CN105497686A (en) * | 2015-12-26 | 2016-04-20 | 悦康药业集团安徽天然制药有限公司 | Stomach invigorating and digestion promoting medicine |
| CN105521362A (en) * | 2015-12-26 | 2016-04-27 | 悦康药业集团安徽天然制药有限公司 | Preparation method of stomach strengthening and food digesting tablet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327217C (en) * | 2004-05-26 | 2007-07-18 | 江西江中药业股份有限公司 | Quality control of Jianweixiaoshi tablets for promotnig digest |
-
2005
- 2005-04-26 CN CN 200510068644 patent/CN1718220B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101210915B (en) * | 2007-12-24 | 2011-05-11 | 王志敏 | Cabrite medicinal materials discrimination method |
| CN103083585A (en) * | 2012-08-31 | 2013-05-08 | 农桂标 | Manufacturing method of stomach-invigorating and digestion-improving tablet |
| CN104824767A (en) * | 2014-02-12 | 2015-08-12 | 于汇 | Hericium erinaceus fermentation appetite-enhancing and digestion-promoting beverage |
| CN105497686A (en) * | 2015-12-26 | 2016-04-20 | 悦康药业集团安徽天然制药有限公司 | Stomach invigorating and digestion promoting medicine |
| CN105521362A (en) * | 2015-12-26 | 2016-04-27 | 悦康药业集团安徽天然制药有限公司 | Preparation method of stomach strengthening and food digesting tablet |
| CN105521362B (en) * | 2015-12-26 | 2019-05-28 | 悦康药业集团安徽天然制药有限公司 | A kind of preparation method of digestion-promoting stomachic |
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| Publication number | Publication date |
|---|---|
| CN1718220B (en) | 2010-05-12 |
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